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TANAKA Tomohisa  田中 智久

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Tanaka Tomohisa  田中 智久

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Researcher Number 30585310
Other IDs
Affiliation (Current) 2025: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help 2025: 山梨大学, 大学院総合研究部, 准教授
2023: 山梨大学, 大学院総合研究部, 准教授
2019 – 2022: 山梨大学, 大学院総合研究部, 助教
2017: 山梨大学, 大学院総合研究部, 特任助教
2017: 山梨大学, 大学院総合研究部, 助教 … More
2016: 山梨大学, 総合研究部, 特任助教
2014 – 2015: 山梨大学, 総合研究部, 助教
2013: 山梨大学, 医学工学総合研究部, 助教 Less
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related / Veterinary medical science / Virology
Except Principal Investigator
Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields / Virology
Keywords
Principal Investigator
抗ウイルス薬 / ゲノム複製 / ウイルス / 病原性発現 / スクリーニング / レプリコン / COVID-19 / SARS-CoV-2 / 阻害剤 / エントリー … More / B型肝炎 / HBV / C型肝炎ウイルス / 翻訳開始 / 疫学 / ヘパシウイルス / 非翻訳領域 / 多様性 / 翻訳 / へパシウイルス / 翻訳阻害 / RNA / 感染症 / ナンセンスRNA分解 / 宿主因子 / コロナウイルス / RNA分解 / 病原性 / RNAウイルス … More
Except Principal Investigator
感染実験 / 古代DNA / HBVゲノム / 抗ウイルス化合物 / 宿主因子 / 宿主蛋白質 / 抗ウイルス剤 / B型肝炎 / HBV / C型肝炎 / HCV Less
  • Research Projects

    (7 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (8 People)
  •  ヘパシウイルス持続感染における自然免疫系の機能解析Principal Investigator

    • Principal Investigator
      田中 智久
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      University of Yamanashi
  •  新型コロナウイルスのnsp1依存性細胞傷害機構の解明とレプリコンモデルへの応用Principal Investigator

    • Principal Investigator
      田中 智久
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      University of Yamanashi
  •  History of humans and pathogens revealed by ancient viral genome analysis

    • Principal Investigator
      安達 登
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
    • Research Institution
      University of Yamanashi
  •  Study on the molecular mechanism of HBV entry and screening of HBV entry inhibitorsPrincipal Investigator

    • Principal Investigator
      Tanaka Tomohisa
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      University of Yamanashi
  •  Analysis of genetic diversity and host-specificity of non-primate hepacivirusPrincipal Investigator

    • Principal Investigator
      TANAKA Tomohisa
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      University of Yamanashi
  •  Development of anti-hepatitis virus strategy based on proteomics

    • Principal Investigator
      MORIISHI Kohji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      University of Yamanashi
  •  The analysis of the mechanism of SARS coronavirus nsp1-mediated mRNA decayPrincipal Investigator

    • Principal Investigator
      TANAKA Tomohisa
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      University of Yamanashi

All 2023 2021 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Other

  • [Journal Article] Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry2021

    • Author(s)
      Tanaka Tomohisa、Okuyama-Dobashi Kaori、Motohashi Ryoji、Yokoe Hiromasa、Takahashi Kazunori、Wiriyasermkul Pattama、Kasai Hirotake、Yamashita Atsuya、Maekawa Shinya、Enomoto Nobuyuki、Ryo Akihide、Nagamori Shushi、Tsubuki Masayoshi、Moriishi Kohji
    • Journal Title

      Antiviral Research

      Volume: 194 Pages: 105165-105165

    • DOI

      10.1016/j.antiviral.2021.105165

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07574, KAKENHI-PROJECT-19K08439, KAKENHI-PROJECT-20K08281, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-21H03365
  • [Journal Article] Roles of the 5' Untranslated Region of Nonprimate Hepacivirus in Translation Initiation and Viral Replication.2018

    • Author(s)
      Tanaka T, Otoguro T, Yamashita A, Kasai H, Fukuhara T, Matsuura Y, Moriishi K.
    • Journal Title

      Journal of Virology

      Volume: 92 Issue: 7

    • DOI

      10.1128/jvi.01997-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-15K18779
  • [Journal Article] Seroepidemiology of non-primate hepacivirus (NPHV) in Japanese native horses2018

    • Author(s)
      Hayashi Shizuka、Tanaka Tomohisa、Moriishi Kohji、Hirayama Kazuhiro、Yamada Akio、Hotta Kozue
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 1 Pages: 186-189

    • DOI

      10.1292/jvms.17-0527

    • NAID

      130006331060

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Journal Article] Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress.2017

    • Author(s)
      Amano R, Yamashita A, Kasai H, Hori T, Miyasato S, Saito S, Yokoe H, Takahashi K, Tanaka T, Otoguro T, Maekawa S, Enomoto N, Tsubuki M, Moriishi K.
    • Journal Title

      Antiviral Research

      Volume: 145 Pages: 123-130

    • DOI

      10.1016/j.antiviral.2017.07.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09348, KAKENHI-PROJECT-16K09349, KAKENHI-PROJECT-15K08493
  • [Journal Article] Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity.2016

    • Author(s)
      Otoguro T, Tanaka T, Kasai H, Yamashita A, Moriishi K.
    • Journal Title

      Microbiol Immunol.

      Volume: 60 Issue: 11 Pages: 740-753

    • DOI

      10.1111/1348-0421.12448

    • NAID

      40021031203

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-16K09348
  • [Journal Article] Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation2016

    • Author(s)
      T. Tanaka, K. Okuyama-Dobashi, S. Murakami, W. Chen, T. Okamoto, K. Ueda, T. Hosoya, Y. Matsuura, A. Ryo, Y. Tanaka, M. Hagiwara and K. Moriishi
    • Journal Title

      Antiviral Research

      Volume: 133 Pages: 156164-156164

    • DOI

      10.1016/j.antiviral.2016.08.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04736, KAKENHI-PROJECT-15K08493
  • [Journal Article] Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.2015

    • Author(s)
      Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.
    • Journal Title

      Scientific reports

      Volume: 5 Issue: 1 Pages: 17047-17047

    • DOI

      10.1038/srep17047

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-15H04735, KAKENHI-PROJECT-25460985
  • [Journal Article] Identification of antiviral agents targeting hepatitis B virus promoter from extracts of Indonesian marine organisms by a novel cell-based screening assay.2015

    • Author(s)
      Yamashita A, Fujimoto Y, Tamaki M, Setiawan A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, de Voogd NJ, Maekawa S, Enomoto N, Tanaka J, Moriishi K
    • Journal Title

      Marine Drug

      Volume: 13 Issue: 11 Pages: 6759-6773

    • DOI

      10.3390/md13116759

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493, KAKENHI-PROJECT-26350973, KAKENHI-PROJECT-26460565, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-25460985
  • [Presentation] HBV/HCV共感染による宿主代謝・遺伝子発現への影響2023

    • Author(s)
      赤池康範、田中智久、山下篤哉、葛西宏威、森石恆司
    • Organizer
      第70回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19343
  • [Presentation] 古代ウイルスゲノムが明らかにする後期旧石器時代人の日本列島への渡来ルート2023

    • Author(s)
      深澤眞楠、神澤秀明、河合洋介、田中智久、森石恆司、安達 登
    • Organizer
      第77回日本人類学会大会
    • Data Source
      KAKENHI-PROJECT-22K19343
  • [Presentation] 大腸菌人工染色体を使ったSARS-CoV-2レプリコンモデルの変異株への適用2023

    • Author(s)
      田中智久
    • Organizer
      第1回新型コロナウイルス研究集会
    • Data Source
      KAKENHI-PROJECT-22K07098
  • [Presentation] 大腸菌人工染色体を使ったSARS-CoV-2レプリコンモデルの変異株への適用2023

    • Author(s)
      田中智久、森石恆司
    • Organizer
      第1回新型コロナウイルス研究集会
    • Data Source
      KAKENHI-PROJECT-22K07098
  • [Presentation] HBV Enhancer I-X promoterをターゲットとした抗HBV化合物の同定2021

    • Author(s)
      山下 篤哉, 田中 智久, 葛西 宏威, 森石 恆司
    • Organizer
      第68回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07574
  • [Presentation] B型および C型肝炎ウイルス感染を許容する培養細胞の樹立2019

    • Author(s)
      乙黒光姫、田中智久、葛西宏威、山下篤哉、福原崇介、松浦善治、森石恆司
    • Organizer
      第67回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07574
  • [Presentation] HBV感染に関与する cyclin-dependent kinaseの解析2019

    • Author(s)
      田中智久、乙黒光姫、葛西宏威、山下篤哉、福原崇介、松浦善治、森石恆司
    • Organizer
      第67回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07574
  • [Presentation] HBV core promoter をターゲットとした新規抗HBV化合物4,4'-bis(cyclohexylmethyl)biphenyl-2,2',5,5'-tetraol2019

    • Author(s)
      山下篤哉、田中智久、乙黒光姫、葛西宏威、森石恆司
    • Organizer
      第67回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07574
  • [Presentation] Involvement of a novel cyclin-dependent kinase in HBV infection2019

    • Author(s)
      Tomohisa Tanaka, Kohji Moriishi
    • Organizer
      2019 International HBV Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07574
  • [Presentation] 国内におけるげっ歯類へパシウイルスの遺伝的特徴とへパシウイルス非翻訳領域の機能比較2018

    • Author(s)
      田中智久
    • Organizer
      第6回肝炎ウイルス研修会
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Presentation] 5’-terminal stem-loop of equine hepacivirus RNA permits miR-122-independent replication2017

    • Author(s)
      Tomohisa Tanaka, Teruhime Otoguro, Kaori Okuyama-Dobashi, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Presentation] Establishment of hepatitis B and C virus co-infection cell line.2017

    • Author(s)
      Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
    • Organizer
      第65回日本ウイルス学会総会
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Cross-species compatibility of hepacivirus 5’ untranslated region2016

    • Author(s)
      Tomohisa Tanaka, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi and Kohji Moriishi
    • Organizer
      日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌)
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Presentation] Hepatitis C virus infection impairs mono-ubiquitination of histone H2A and activates expression of homeobox genes.2016

    • Author(s)
      Kasai H, Tanaka T, Yamashita A, Dobashi-Okuyama K, Moriishi K.
    • Organizer
      第64回日本ウイルス学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌白石区)
    • Year and Date
      2016-10-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Establishment of highly HBV-permissible HepG2 cell line to facilitate screening of antiviral compounds2016

    • Author(s)
      Otoguro T, Tanaka T, Chen W, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K
    • Organizer
      第64回日本ウイルス学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌白石区)
    • Year and Date
      2016-10-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Inhibition of HBV propagation by treatment with CDK9 inhibitor FIT-0392016

    • Author(s)
      Tanaka T, Okuyama-Dobashi K, Chen W, Okamoto T, Ueda K, Hosaya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M and Moriishi K
    • Organizer
      2016 International HBV meeting
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] CDK9 inhibitor FIT-039 suppresses HBV propagation2016

    • Author(s)
      Moriishi K, Tanaka T, Okuyama-Dobashi K, Chen W, Okamoto T, Ueda K, Hosaya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M
    • Organizer
      第64回日本ウイルス学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌白石区)
    • Year and Date
      2016-10-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Cross-species compatibility of hepacivirus 5’ untranslated region2016

    • Author(s)
      Tanaka T, Otoguro T, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K
    • Organizer
      第64回日本ウイルス学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌白石区)
    • Year and Date
      2016-10-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Functional homology of hepacivirus 5’ UTRs in IRES activity and replication2016

    • Author(s)
      Tomohisa Tanaka, Teruhime Otoguro, Atsuya Yamashita, Hirotake Kasai, and Kohji Moriishi
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Presentation] Characterization of the IRES activity in equine hepacivirus 5’UTR2015

    • Author(s)
      Tomohisa Tanaka, Wenjia Chen, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] ウマヘパシウイルスが有するIRES活性の特徴2015

    • Author(s)
      田中智久、陳文家、乙黒光姫、葛西宏威、山下篤哉、森石恆司
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡県・福岡市
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Presentation] プレセニリン阻害剤のC型肝炎ウイルス増殖抑制効果の検討2015

    • Author(s)
      乙黒光姫、田中智久、葛西宏威、山下篤哉、森石恆司
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Characterization of equine hepacivirus 5’ UTR regarding IRES activity2015

    • Author(s)
      田中智久、森石恆司
    • Organizer
      22nd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2015-10-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18779
  • [Presentation] Infection of equine hepacivirus in a closed colony of Japanese native hors(2015

    • Author(s)
      Tomohisa Tanaka, Wenjia Chen, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi
    • Organizer
      22nd International meeting on hepatitis C virus and related viruses
    • Place of Presentation
      Palais de la Musique et des Congres (フランス、ストラスブール)
    • Year and Date
      2015-10-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08493
  • [Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter2015

    • Author(s)
      Atsuya Yamashita, Tomohisa Tanaka, Kaori Okuyama-Dobashi, Hirotake Kasai, Koichi Watashi, Takaji Wakita,, Masaaki Toyama, Masanori Baba, Mayumi Tamaki, Junichi Tanaka, Kohji Moriishi
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08493
  • []

  • 1.  MORIISHI Kohji (90260273)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 2.  YAMASHITA Atsuya (00334871)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 3.  KASAI Hirotake (20324189)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 4.  安達 登 (60282125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  神澤 秀明 (80734912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  ENOMOTO Nobuyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  OKAMOTO Toru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  松浦 善治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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