MACHIDA Takashi 町田崇

Researcher Number	30586144
Other IDs
Affiliation (based on the past Project Information) *help	2013: 福岡大学, 薬学部, 助教 2012: 福岡大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator トロンビン / 脳ペリサイト / 糖尿病 / 脳内炎症 / 薬理学 Except Principal Investigator シクロフィリンＡ / 視床下部神経 / 脂質ラフト / メチルグリオキサール / 糖尿病 … More / シクロフィリンA / インスリン抵抗性 / GT1-7 / ペリサイト / 脳インスリン抵抗性 / cyclophilin A / 脳ペリサイト Less

Brain pericytes induce the brain inflammation that derived from chronic peripheral inflammation in diabetic mellitus via PAR-1 signalPrincipal Investigator
- Principal Investigator
  
  MACHIDA Takashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Fukuoka University
Involvement of pericytes-derived cyclophilin A in the development of insulin resistanse in the brain
- Principal Investigator
  
  TAKATA Fuyuko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Fukuoka University

All 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.2013
- Author(s)
  Takata, F
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: 55166-55166
- DOI
  10.1371/journal.pone.0055166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240034, KAKENHI-PROJECT-21700422, KAKENHI-PROJECT-22590163, KAKENHI-PROJECT-22590255, KAKENHI-PROJECT-23790113, KAKENHI-PROJECT-23790287
[Journal Article] Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.2013
- Author(s)
  Takata F, Dohgu S, Matsumoto J, Machida T, Kaneshima S, Matsuo M, Sakaguchi S, Takeshige Y, Yamauchi A, Kataoka Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 19; 433(4) Issue: 4 Pages: 586-590
- DOI
  10.1016/j.bbrc.2013.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790113, KAKENHI-PROJECT-25460236
[Journal Article] Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells.2012
- Author(s)
  Matsumoto J, Dohgu S, Takata F, Nishioku T, Sumi N, Machida T, Takahashi H, Yamauchi A, Kataoka Y.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 524(1) Issue: 1 Pages: 45-8
- DOI
  10.1016/j.neulet.2012.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590163, KAKENHI-PROJECT-22590255, KAKENHI-PROJECT-23790113, KAKENHI-PROJECT-23790311
[Journal Article] Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro2011
- Author(s)
  Takata F, Dohgu S, Matsumoto J, Takahashi H, Machida T, Wakigawa T, Harada E, Miyaji H, Koga M, Nishioku T, Yamauchi A, Kataoka Y.
- Journal Title
  
  J Neuroinflammation.
  
  Volume: 8 Issue: 1 Pages: 106-106
- DOI
  10.1186/1742-2094-8-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590255, KAKENHI-PROJECT-23790113, KAKENHI-PROJECT-23790311
[Presentation] メトホルミンによる血液脳関門機能強化2013
- Author(s)
  高田芙友子、道具伸也、松本純一、町田崇、山内淳史、片岡泰文
- Organizer
  第15回応用薬理シンポジウム
- Place of Presentation
  コクヨホール
- Data Source
  KAKENHI-PROJECT-23790113
[Presentation] 脳ペリサイト由来液性因子による血液脳関門障害2013
- Author(s)
  道具伸也、高田芙友子、松本純一、町田崇、高橋弘之、山内淳史、片岡泰文
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23790113
[Presentation] トロンビン誘発性血液脳関門障害における脳ペリサイトの関与2013
- Author(s)
  町田崇、道具伸也、高田芙友子、松本純一、竹之下恭代、山内淳史、片岡泰文
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-24790102
[Presentation] 脳ペリサイトは血液脳関門構成細胞のなかで最大のTNF-α誘発性MMP-9産生能と細胞遊走能を有する2012
- Author(s)
  高田芙友子、道具伸也、松本純一、町田崇、高橋弘之、山内淳史、片岡泰文
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23790113
[Presentation] 脳ペリサイトはマクロファージの脳実質内浸潤を阻害する2012
- Author(s)
  道具伸也、高田芙友子、松本純一、高橋弘之、町田崇、一木奈津子、関菜摘子、山内淳史、片岡泰文
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23790113
[Presentation] 脳ペリサイトに特異的なTNF-α誘発性MMP-9産生における活性酸素種およびERK1/2・Aktの遅延的活性化の関与2012
- Author(s)
  町田崇、道具伸也、高田芙友子、松本純一、高橋弘之、宮地晴樹、園木優唯、山内淳史、片岡泰文
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23790113
[Presentation] トロンビン誘発性血液脳関門障害における脳ペリサイトの関与
- Author(s)
  町田　崇
- Organizer
  第86回　日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790102

1. TAKATA Fuyuko (70412575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. KATAOKA Yasufumi (70136513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. DOHGU Shinya (60399186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. MATSUMOTO Junichi (10550064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

MACHIDA Takashi 町田 崇

Research Projects

Research Products

Co-Researchers

Brain pericytes induce the brain inflammation that derived from chronic peripheral inflammation in diabetic mellitus via PAR-1 signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of pericytes-derived cyclophilin A in the development of insulin resistanse in the brain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] メトホルミンによる血液脳関門機能強化2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 脳ペリサイト由来液性因子による血液脳関門障害2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] トロンビン誘発性血液脳関門障害における脳ペリサイトの関与2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 脳ペリサイトは血液脳関門構成細胞のなかで最大のTNF-α誘発性MMP-9産生能と細胞遊走能を有する2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 脳ペリサイトはマクロファージの脳実質内浸潤を阻害する2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 脳ペリサイトに特異的なTNF-α誘発性MMP-9産生における活性酸素種およびERK1/2・Aktの遅延的活性化の関与2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] トロンビン誘発性血液脳関門障害における脳ペリサイトの関与

Author(s)

Organizer

Place of Presentation

Data Source

MACHIDA Takashi 町田崇