IWASAKI Yukiko 岩崎由希子

Researcher Number	30592935
Other IDs	https://orcid.org/0000-0002-5786-0760
Affiliation (Current)	2026: 埼玉医科大学, 医学部, 准教授 2026: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2026: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員 2021 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員 2018 – 2020: 東京大学, 医学部附属病院, 助教 2017: 東京大学, 医学部附属病院, その他 2013 – 2016: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 全身性エリテマトーデス / B細胞 / 自然免疫シグナル / I型インターフェロン / SLE / 制御性T細胞 / IL-27 / 代謝変容 / 自然免疫 / トランスオミクス … More / １型インターフェロン / 抗体産生細胞 / マルチオミックス解析 / 代謝制御機構 / FAM167A / 抗体産生細胞分化 / トランスオミクス解析 / アミノ酸 / 免疫代謝 / Toll like receptor / STAT1 / 活性酸素 / インターフェロンシグナル / SNPs / B cell / type I IFN / STAT4 / Ebi3 / p28 / IL-6 / TGF-beta3 / LAG3 / 制御性Ｔ細胞 / Egr2 … More Except Principal Investigator 細胞・組織 / 生体分子 / 組織・細胞 / 免疫学 / 内科 / ゲノム Less

I型IFNとTLR9によるB細胞の代謝変容のトランスオミクス解析からSLE病態解明へPrincipal Investigator
- Principal Investigator
  
  岩崎由希子
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Institute of Physical and Chemical Research
Type I IFNとTLR9による抗体産生細胞分化誘導機構のトランスオミクス解析による解明Principal Investigator
- Principal Investigator
  
  岩崎由希子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Institute of Physical and Chemical Research
Investigation of metabolic regulation and role of FAM167A in SLE B cells using trans-omics analysisPrincipal Investigator
- Principal Investigator
  
  Iwasaki Yukiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Institute of Physical and Chemical Research
  The University of Tokyo
Investigation on type I IFN signal regulation by STAT4 -toward elucidation of SLE pathogenesis-Principal Investigator
- Principal Investigator
  
  Iwasaki Yukiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Elucidation of the mechanism and significance of TGF-beta3 production in CD4+ T cellsPrincipal Investigator
- Principal Investigator
  
  IWASAKI YUKIKO
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Elucidation of the regulatory T cell induction mechanism by IL-27 -towards novel therapy for SLE-Principal Investigator
- Principal Investigator
  
  IWASAKI Yukiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Development of rheumatoid arthritis-directed human immunology
- Principal Investigator
  
  YAMAMOTO KAZUHIKO
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo

All 2025 2022 2020 2015 2013 Other

All Journal Article Presentation

[Journal Article] Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis2022
- Author(s)
  Iwasaki Yukiko、Takeshima Yusuke、Nakano Masahiro、Okubo Mai、Ota Mineto、Suzuki Akari、Kochi Yuta、Okamura Tomohisa、Endo Takaho、Miki Ichiro、Sakurada Kazuhiro、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Rheumatology
  
  Volume: 62 Issue: 2 Pages: 905-913
- DOI
  10.1093/rheumatology/keac338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08799
[Journal Article] Role of TGF-β3 in the regulation of immune responses2015
- Author(s)
  Okamura T, Morita K, Iwasaki Y, Inoue M, Komai T, Fujio K, Yamamoto K
- Journal Title
  
  Clin Exp Rheumatol
  
  Volume: 33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007
[Journal Article] TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses2015
- Author(s)
  Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/ncomms7329
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J04186, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803, KAKENHI-PROJECT-25860804, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-15H05787
[Journal Article] Interleukin-27 in T cell immunity.2015
- Author(s)
  Iwasaki Y, Fujio K, Okamura T, Yamamoto K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 16 Issue: 2 Pages: 2851-63
- DOI
  10.3390/ijms16022851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803
[Journal Article] IL-27による免疫制御機構2013
- Author(s)
  岩崎由希子
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 59 Pages: 282-287
- Data Source
  KAKENHI-PROJECT-25860803
[Journal Article] Toward therapeutic application of IL-10-producing regulatory T cells2013
- Author(s)
  Yukiko Iwasaki, Keishi Fujio, Tomohisa Okamura, Atsushi Yanai, Kazuhiko Yamamoto
- Journal Title
  
  Nihon Rinsho Meneki Gakkai Kaishi
  
  Volume: 36 Pages: 40-46
- Data Source
  KAKENHI-PROJECT-25860803
[Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013
- Author(s)
  Iwasaki, Y.
- Journal Title
  
  Eur J Immunol
  
  Volume: undefined Issue: 4 Pages: 1063-73
- DOI
  10.1002/eji.201242942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590435, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590343, KAKENHI-PROJECT-23659492, KAKENHI-PROJECT-23791106, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24390246, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25460594, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860803
[Journal Article] The power Doppler twinkling artefact associated with periarticular calcification induced by intra-articular corticosteroid injection in patients with rheumatoid arthritis.2013
- Author(s)
  Nagafuchi Y, Sumitomo S, Soroida Y, Kanzaki T, Iwasaki Y, Michishita K, Iwai T, Ikeda H, Fujio K, Yamamoto K.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72 Issue: 7 Pages: 1267-9
- DOI
  10.1136/annrheumdis-2012-202897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007
[Presentation] A trans-omic characterization of metabolic reprogramming underlying differentiation of antibody producing cells2025
- Author(s)
  Ayana Shinomiya, Yukiko Iwasaki, Junichi Maruyama, Qiunan Zhu, Katsuyuki Yugi
- Organizer
  DGFI 21th B CELL FORUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07886
[Presentation] Multi-omics approaches to immune cell subsets in PBMCs reveal novel insights into type I IFN signature in SLE2020
- Author(s)
  岩崎由希子
- Organizer
  第3回日本免疫不全・自己炎症学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09997
[Presentation] Novel IL-10 induction pathway mediated by Egr-2 in IL-27-stimulated T cells2013
- Author(s)
  Yukiko Iwasaki, Keishi Fujio, Tomohisa Okamura, Atsushi Yanai, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25860803
[Presentation] Transcription factor Egr-2 mediates IL-27-induced IL-10 production in CD4+ T cells2013
- Author(s)
  Yukiko Iwasaki, Keishi Fujio, Tomohisa Okamura, Atsushi Yanai, Shuji Sumitomo, Tomohiko Tamura, Hiroki Yoshida, Kazuhiko Yamamoto
- Organizer
  第5回EAGOR (East Asian Group of Rheumatology) meeting
- Place of Presentation
  The Plaza, Seoul, Korea
- Data Source
  KAKENHI-PROJECT-25860803
[Presentation] IL-27 induces regulatory T cells that suppress B cell responses
- Author(s)
  Y. Iwasaki, T. Okamura, K.Morita, M. Inoue, S. Sumitomo, K. Fujio, K. Yamamoto1
- Organizer
  第43会日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860803

1. YAMAMOTO KAZUHIKO (80191394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. OKAMURA TOMOHISA (10528996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. SHODA HIROFUMI (20529036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUMITOMO SHUJI (20392996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SHIBUYA MIHOKO (20366363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡本明子 (40431861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Teruya Shuzo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJIO Keishi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IWASAKI Yukiko 岩崎 由希子

Research Projects

Research Products

Co-Researchers

I型IFNとTLR9によるB細胞の代謝変容のトランスオミクス解析からSLE病態解明へPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Type I IFNとTLR9による抗体産生細胞分化誘導機構のトランスオミクス解析による解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of metabolic regulation and role of FAM167A in SLE B cells using trans-omics analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation on type I IFN signal regulation by STAT4 -toward elucidation of SLE pathogenesis-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism and significance of TGF-beta3 production in CD4+ T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the regulatory T cell induction mechanism by IL-27 -towards novel therapy for SLE-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of rheumatoid arthritis-directed human immunology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of TGF-β3 in the regulation of immune responses2015

Author(s)

Journal Title

Data Source

[Journal Article] TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-27 in T cell immunity.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-27による免疫制御機構2013

Author(s)

Journal Title

Data Source

[Journal Article] Toward therapeutic application of IL-10-producing regulatory T cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The power Doppler twinkling artefact associated with periarticular calcification induced by intra-articular corticosteroid injection in patients with rheumatoid arthritis.2013

Author(s)

IWASAKI Yukiko 岩崎由希子