Abe Kiyomi 阿部清美

… Alternative Names

阿部清美アベキヨミ

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Researcher Number	30594973
Other IDs	https://orcid.org/0000-0002-8038-5144
Affiliation (Current)	2026: 慶應義塾大学, 医学部(信濃町), 共同研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 慶應義塾大学, 医学部(信濃町), 共同研究員 2016: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Endocrinology
Keywords	Principal Investigator 先天性甲状腺機能低下症 / Pax8変異 / 腺腫様甲状腺腫 / Nkx2-1欠損ヘテロ変異マウス / 甲状腺形成不全 / PAX8遺伝子改変マウス / Nkx2-1変異 / 甲状腺濾胞形成不全 / PAX8変異マウスモデル / 甲状腺腺腫 … More / 甲状腺低形成 / PAX8遺伝子変異 / 胎児甲状腺 / Nkx2.1 / Nkx2.1変異 / 転写因子 / 遺伝子改変マウス / 未熟濾胞 / 甲状腺形成異常 / PAX8 / FRTL-5細胞 / DUOXA2 / TPO / DUOX2 / 甲状腺ホルモン合成障害 / ゲノム編集 Less

PAX8G56S変異甲状腺機能低下マウスを用いた濾胞形成不全と甲状腺腫発生機序の解明Principal Investigator
- Principal Investigator
  
  阿部清美
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
Molecular, histological, and functional analysis of the transcription factor PAX8 mutant G56S with a distinctive clinical picturePrincipal Investigator
- Principal Investigator
  
  Abe Kiyomi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
ゲノム編集技術を用いた甲状腺機能低下症原因遺伝子の新規機能解析系の確立Principal Investigator
- Principal Investigator
  
  阿部清美
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation Book

[Book] 内分泌代謝疾患クリニカルクエスチョン100　改訂第2版2023
- Author(s)
  成瀬光栄、田辺晶代、方波見卓行、高橋裕、田上哲也、竹内靖博、阿部清美、長谷川奉延　他
- Total Pages
  232
- Publisher
  診断と治療社
- ISBN
  9784787826121
- Data Source
  KAKENHI-PROJECT-20K16936
[Book] 遺伝性甲状腺疾患のすべて2021
- Author(s)
  深田修司、菱沼　昭、小飼貴彦、大江秀美、鳴海覚志、阿部清美
- Total Pages
  408
- Publisher
  日本医事新報社
- ISBN
  9784784959853
- Data Source
  KAKENHI-PROJECT-20K16936
[Journal Article] Familial Non-autoimmune Hyperthyroidism Caused by an Extracellular Domain Variant (p.Leu267Phe) of the TSH Receptor.2025
- Author(s)
  Shimura K, Ichihashi Y, Abe K, Ishii T, Hasegawa T, and Narumi S
- Journal Title
  
  Hormone Research in Paediatrics
  
  Volume: - Pages: 1-17
- DOI
  10.1159/000544836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K11052
[Journal Article] Two Novel SLC5A5 Variants (Q263L and G350D) Causing Congenital Hypothyroidism2025
- Author(s)
  Abe K, Koizumi M, Kogai T, Ida S, Sugisawa C, Kawai M, Hasegawa T, Narumi S
- Journal Title
  
  Thyroid
  
  Volume: 35 Issue: 3 Pages: 335-337
- DOI
  10.1089/thy.2024.0716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07881, KAKENHI-PROJECT-23K27576, KAKENHI-PROJECT-24K11052
[Journal Article] Functional variants in a TTTG microsatellite on 15q26.1 cause familial nonautoimmune thyroid abnormalities2024
- Author(s)
  Narumi Satoshi、Nagasaki Keisuke、... Nishihara Eijun、Ito Yuka、Kogai Takahiko、Kameyama Kaori、Nakabayashi Kazuhiko、Hata Kenichiro、Fukami Maki、Shima Hirohito、Kikuchi Atsuo、Takayama Jun、Tamiya Gen、Hasegawa Tomonobu
- Journal Title
  
  Nature Genetics
  
  Volume: 56 Issue: 5 Pages: 869-876
- DOI
  10.1038/s41588-024-01735-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07325, KAKENHI-PROJECT-23K27576, KAKENHI-PROJECT-23K07288, KAKENHI-PROJECT-24K11052, KAKENHI-PROJECT-23K15400
[Journal Article] Genotype-Phenotype Correlations in 30 Japanese Patients With Congenital Hypothyroidism Attributable to TG Defects2024
- Author(s)
  Tanase-Nakao K., Iwahashi-Odano M., Abe K., Muroya K., Hasegawa T., Hishinuma A., Narumi S et.al.
- Journal Title
  
  The Journal of Clinical Endocrinology and Metabolism
  
  Volume: - Issue: 9 Pages: 2358-2365
- DOI
  10.1210/clinem/dgae098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16936, KAKENHI-PROJECT-22K16420, KAKENHI-PROJECT-23K27576, KAKENHI-PROJECT-24K11052
[Journal Article] Molecular and Clinical Features of Congenital Hypothyroidism Due to Multiple DUOX2 Variants2024
- Author(s)
  Uehara Erika, Abe Kiyomi, Tanase-Nakao Kanako, Muroya Koji, Hattori Atsushi, Matsubara Keiko, Fukami Maki, Narumi Satoshi
- Journal Title
  
  Thyroid
  
  Volume: 34 Issue: 7 Pages: 827-836
- DOI
  10.1089/thy.2024.0046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27576, KAKENHI-PROJECT-24K11052
[Journal Article] GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling2022
- Author(s)
  Narumi Satoshi、Opitz Robert、Nagasaki Keisuke、Muroya Koji、Asakura Yumi、Adachi Masanori、Abe Kiyomi、Sugisawa Chiho、Kuhnen Peter、Ishii Tomohiro、Nothen Markus M、Krude Heiko、Hasegawa Tomonobu
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 31 Issue: 23 Pages: 3967-3974
- DOI
  10.1093/hmg/ddac093
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16936
[Journal Article] Thyroid Hormone mediated Histone Modification Protects Cortical Neurons From the Toxic Effects of Hypoxic Injury2022
- Author(s)
  Abe Kiyomi、Li Jianrong、Liu Yan Yun、Brent Gregory A
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 6 Issue: 11 Pages: 1-13
- DOI
  10.1210/jendso/bvac139
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16936
[Journal Article] A patient with congenital hypothyroidism due to a <i>PAX8</i> frameshift variant accompanying a urogenital malformation2022
- Author(s)
  Tanase-Nakao Kanako、Muroya Koji、Adachi Masanori、Abe Kiyomi、Hasegawa Tomonobu、Narumi Satoshi
- Journal Title
  
  Clinical Pediatric Endocrinology
  
  Volume: 31 Issue: 4 Pages: 250-255
- DOI
  10.1297/cpe.2022-0030
- ISSN
  0918-5739, 1347-7358
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16936
[Journal Article] Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production2021
- Author(s)
  Ke Sujie、Liu Yan-Yun、Karthikraj Rajendiran、Kannan Kurunthachalam、Jiang Jingjing、Abe Kiyomi、Milanesi Anna、Brent Gregory A.
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 16 Pages: 24105-17
- DOI
  10.1172/jci.insight.149425
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16936
[Journal Article] Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores2021
- Author(s)
  Liu Yan-Yun、Jiang Jingjing、Ke Sujie、Milanesi Anna、Abe Kiyomi、Gastelum Gilberto、Li Jianrong、Brent Gregory A.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-03491-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] SLC5A5新規バリアント（Q263L/G350D）による先天性甲状腺機能低下症の兄弟例2025
- Author(s)
  阿部清美、小泉美紀子、小飼貴彦、位田忍、杉澤千穂、川井正信、長谷川奉延、鳴海覚志
- Organizer
  第40回甲状腺病態生理研究会
- Data Source
  KAKENHI-PROJECT-24K11052
[Presentation] マウスモデルによる新規PAX8 G56Sバリアントの時間依存的な甲状腺表現型推移の検討2024
- Author(s)
  阿部清美、西岡淳子、小田野めぐみ、岩野麗子、室谷浩二、藏本純子、金井弥栄、秋葉和壽、高田修治、寺尾美穂、石井智弘、鳴海覚志、長谷川奉延
- Organizer
  第57回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-24K11052
[Presentation] マウスモデルによる新規PAX8 G56Sバリアントの時間依存的な甲状腺表現型推移の検討2024
- Author(s)
  阿部清美、西岡淳子、小田野めぐみ、岩野麗子、室谷浩二、藏本純子、金井弥栄、秋葉和壽、高田修治、寺尾美穂、石井智弘、鳴海覚志、長谷川奉延
- Organizer
  第56回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 特異な甲状腺表現型を示したPAX8 G56Sバリアントの多階層的解析：in vitroおよびin vivo複合アプローチによる検討2024
- Author(s)
  阿部清美
- Organizer
  第67回日本甲状腺学会
- Data Source
  KAKENHI-PROJECT-24K11052
[Presentation] 4世代にわたり特異的甲状腺表現型を示した家系とその病因PAX8新規バリアントG56Sの多階層的機能解析2024
- Author(s)
  阿部清美
- Organizer
  第97回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 4世代にわたり特異的甲状腺表現型を示した家系とその病因PAX8新規バリアントG56Sの多階層的機能解析2024
- Author(s)
  阿部清美、西岡淳子、小田野めぐみ、岩野麗子、室谷浩二、藏本純子、金井弥栄、秋葉和壽、高田修治、寺尾美穂、石井智弘、鳴海覚志、長谷川奉延
- Organizer
  第97回日本内分泌学会
- Data Source
  KAKENHI-PROJECT-24K11052
[Presentation] 15q26.1における非コード配列変化を病因とする家族性先天性甲状腺機能低下症の新病型の同定2023
- Author(s)
  鳴海覚志、長崎啓祐、上原絵理香、秋葉和壽、中尾佳奈子、志村和浩、阿部清美、杉澤千穂、桐谷光夫、都研一、長谷川行洋、室谷浩二、丸尾良浩、中林一彦、秦健一郎、高山順、島彦仁、菊池敦生、長谷川奉延
- Organizer
  第56回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 特異な甲状腺表現型を示したPAX8 G56S バリアントの多階層的解析：in vitroおよびin vivo複合アプローチによる検討2023
- Author(s)
  阿部清美
- Organizer
  第66回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 低酸素曝露下の神経細胞への甲状腺ホルモン投与によるヒストン修飾変化2023
- Author(s)
  阿部清美、Li Jianrong 、Liu Yan-Yun 、Brent Gregory A
- Organizer
  第56回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 甲状腺ホルモンはヒストン修飾を介し、大脳皮質ニューロンを低酸素性障害から保護する2023
- Author(s)
  阿部清美;Li Jianrong;Liu Yan-Yun;Brent Gregory A.
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] シンポジウム 1 小児バセドウ病：ゆりかごから AYA 世代まで「思春期から始めたいバセドウ病のプレコンセプションケア」2022
- Author(s)
  阿部清美
- Organizer
  第 55 回日本小児内分泌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] DUOX2 異常症 36 名の縦断的臨床経過2022
- Author(s)
  阿部清美, 鳴海覚志, 室谷浩二, 安達昌功, 朝倉由美, 杉澤千穂, 濃沼政美, 長谷川奉延
- Organizer
  第 55 回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 新生児マススクリーニング導入以降に出生したサイログロブリン欠損症28名の臨床像2022
- Author(s)
  中尾佳奈子, 小田野めぐみ, 阿部清美, 杉澤千穂, 長谷川奉延, 鳴海覚志
- Organizer
  第 55 回日本小児内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] シンポジウム２　甲状腺ホルモン合成障害を単一遺伝子疾患の視点から紐解く2021
- Author(s)
  阿部清美
- Organizer
  第64回日本甲状腺学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 先天性甲状腺機能低下症原因遺伝子　ヘテロ変異症例の臨床像2021
- Author(s)
  阿部清美、鳴海覚志、室谷浩二、朝倉由美、安達昌功、小田野めぐみ、中尾佳奈子、杉澤千穂、長谷川奉延
- Organizer
  第64回日本甲状腺学会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 先天性甲状腺機能低下症原因遺伝子　ヘテロ変異症例の臨床像2021
- Author(s)
  阿部清美、鳴海覚志、室谷浩二、朝倉由美、安達昌功、小田野めぐみ、中尾佳奈子、杉澤千穂、長谷川奉延
- Organizer
  第54回小児内分泌学会
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] 内分泌・代謝セミナー「かかりつけ医が日常診療で知っておきたい知識」日常診療における甲状腺腫大の診かた2021
- Author(s)
  阿部清美
- Organizer
  第32回小児科医会総合フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] Thyroid Hormone Receptor Alpha Sumoylation Is Important for the Development of Adipose Tissue2020
- Author(s)
  Kiyomi Abe, Gilberto Gastelum, Chengju Li, Harmie Rubinos, Alexandr Yamada, Yan-Yun Liu, Gregory A. Brent
- Organizer
  第102回米国内分泌学会；ENDO Online 2020: The Endocrine Society Annual Meeting, 2020, Online
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16936
[Presentation] Traumatic Brain Injury（TBI）に対する甲状腺ホルモンの有効性2020
- Author(s)
  阿部　清美
- Organizer
  第63回日本甲状腺学会学術集会（Web開催）基礎系シンポジウム　基礎甲状腺学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K16936

1. 藏本純子 (60571677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. NARUMI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小飼貴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 川井正信(カワイマサノブ)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Abe Kiyomi 阿部 清美

阿部 清美 アベ キヨミ

Research Projects

Research Products

Co-Researchers

PAX8G56S変異甲状腺機能低下マウスを用いた濾胞形成不全と甲状腺腫発生機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular, histological, and functional analysis of the transcription factor PAX8 mutant G56S with a distinctive clinical picturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム編集技術を用いた甲状腺機能低下症原因遺伝子の新規機能解析系の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 内分泌代謝疾患クリニカルクエスチョン100 改訂第2版2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 遺伝性甲状腺疾患のすべて2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Familial Non-autoimmune Hyperthyroidism Caused by an Extracellular Domain Variant (p.Leu267Phe) of the TSH Receptor.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Novel SLC5A5 Variants (Q263L and G350D) Causing Congenital Hypothyroidism2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional variants in a TTTG microsatellite on 15q26.1 cause familial nonautoimmune thyroid abnormalities2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genotype-Phenotype Correlations in 30 Japanese Patients With Congenital Hypothyroidism Attributable to TG Defects2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular and Clinical Features of Congenital Hypothyroidism Due to Multiple DUOX2 Variants2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thyroid Hormone mediated Histone Modification Protects Cortical Neurons From the Toxic Effects of Hypoxic Injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A patient with congenital hypothyroidism due to a <i>PAX8</i> frameshift variant accompanying a urogenital malformation2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production2021

Author(s)

Journal Title

Abe Kiyomi 阿部清美

阿部清美アベキヨミ

[Book] 内分泌代謝疾患クリニカルクエスチョン100　改訂第2版2023

[Presentation] 特異な甲状腺表現型を示したPAX8 G56S バリアントの多階層的解析：in vitroおよびin vivo複合アプローチによる検討2023

[Presentation] シンポジウム 1 小児バセドウ病：ゆりかごから AYA 世代まで「思春期から始めたいバセドウ病のプレコンセプションケア」2022

[Presentation] シンポジウム２　甲状腺ホルモン合成障害を単一遺伝子疾患の視点から紐解く2021

[Presentation] 先天性甲状腺機能低下症原因遺伝子　ヘテロ変異症例の臨床像2021

[Presentation] 先天性甲状腺機能低下症原因遺伝子　ヘテロ変異症例の臨床像2021