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Hosokawa Tomohisa  細川 智永

ORCIDConnect your ORCID iD *help
Researcher Number 30602883
Other IDs
Affiliation (Current) 2022: 名古屋大学, 理学研究科, 講師
Affiliation (based on the past Project Information) *help 2020 – 2022: 名古屋大学, 理学研究科, 講師
2017 – 2019: 京都大学, 医学研究科, 特定研究員
2018: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Neurophysiology / General neuroscience / Basic Section 46010:Neuroscience-general-related
Except Principal Investigator
Basic Section 46030:Function of nervous system-related
Keywords
Principal Investigator
シナプス可塑性 / シナプス / 長期増強 / 記憶 / 液液相分離 / synaptic plasticity / learning and memory / synaptic structure
Except Principal Investigator
シナプス可塑性 / 相分離 … More / ポストシナプス / 光操作 / 液-液相分離 / 長期増強現象 / CaMKII / 記憶 Less
  • Research Projects

    (4 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (3 People)
  •  記憶形成に伴うシナプスタンパク質の集積・維持の制御機構

    • Principal Investigator
      実吉 岳郎
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 46030:Function of nervous system-related
    • Research Institution
      Kyoto University
  •  Structural role of CaMKII in PSD and the induction of LTP by optpgenetics.Principal Investigator

    • Principal Investigator
      細川 智永
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      Nagoya University
      Kyoto University
  •  Reconstitution of synaptic plasticity in vitroPrincipal Investigator

    • Principal Investigator
      細川 智永
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Nagoya University
      Kyoto University
  •  CaMKII acts as a protein hub to accumulate and activate synaptic proteinsPrincipal Investigator

    • Principal Investigator
      Hosokawa Tomohisa
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      Kyoto University

All 2021 2020 2018 2017

All Journal Article Presentation

  • [Journal Article] Novel mechanism of synaptic plasticity mediated by CaMKII2021

    • Author(s)
      林 康紀、細川 智永、劉 品吾、實吉 岳郎
    • Journal Title

      生化学

      Volume: 93 Issue: 2 Pages: 191-202

    • DOI

      10.14952/SEIKAGAKU.2021.930191

    • ISSN
      0037-1017
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421
  • [Journal Article] CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation2021

    • Author(s)
      Hosokawa Tomohisa、Liu Pin-Wu、Cai Qixu、Ferreira Joana S.、Levet Florian、Butler Corey、Sibarita Jean-Baptiste、Choquet Daniel、Groc Laurent、Hosy Eric、Zhang Mingjie、Hayashi Yasunori
    • Journal Title

      Nature Neuroscience

      Volume: -

    • DOI

      10.1038/s41593-021-00843-3

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-ORGANIZER-18H05428
  • [Journal Article] Regulation of synaptic nanodomain by liquid?liquid phase separation: A novel mechanism of synaptic plasticity2021

    • Author(s)
      Liu Pin-Wu、Hosokawa Tomohisa、Hayashi Yasunori
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 69 Pages: 84-92

    • DOI

      10.1016/j.conb.2021.02.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-20K21462, KAKENHI-PROJECT-18KK0421
  • [Journal Article] Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms2020

    • Author(s)
      Cai Qixu、Hosokawa Tomohisa、Zeng Menglong、Hayashi Yasunori、Zhang Mingjie
    • Journal Title

      Structure

      Volume: 28

    • DOI

      10.1016/j.str.2019.11.018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421
  • [Journal Article] Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif2020

    • Author(s)
      Eriksen MS, Nikolaienko O, Hallin EI, Grodem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuellar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR.
    • Journal Title

      The FEBS Journal

      Volume: 288 Pages: 2930-2955

    • DOI

      10.1111/febs.15618

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421
  • [Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      Neuroscience2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      Neuroscience2020
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020

    • Author(s)
      Tomohisa Hosokawa
    • Organizer
      Neuroscience2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020

    • Author(s)
      Tomohisa Hosokawa
    • Organizer
      Neuroscience2020
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020

    • Author(s)
      Tomohisa Hosokawa
    • Organizer
      Japan Neurochemistry
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] CaMKIIの液液相分離によるグルタミン酸受容体のシナプス内区画化2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      第63回日本神経化学会大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] CaMKIIの液液相分離によるグルタミン酸受容体のシナプス内区画化2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      第63回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] シナプスの構造および構造可塑性におけるCaMKIIの構造的役割2018

    • Author(s)
      細川智永
    • Organizer
      日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K14947
  • [Presentation] シナプスの構造および構造可塑性におけるCaMKIIの構造的役割2018

    • Author(s)
      細川智永
    • Organizer
      日本神経科学会大会
    • Data Source
      KAKENHI-PROJECT-17K14947
  • [Presentation] シナプスタンパク質のリン酸化の化学量論およびシナプス構造の新しいモデル2017

    • Author(s)
      細川智永
    • Organizer
      日本神経科学会大会
    • Data Source
      KAKENHI-PROJECT-17K14947
  • 1.  実吉 岳郎 (00556201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  林 康紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 3.  林 朗子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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