Miyamae Yusaku 宮前友策

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MIYAMAE Yusaku 宮前友策

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Researcher Number	30610240
Other IDs
Affiliation (Current)	2025: 筑波大学, 生命環境系, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 筑波大学, 生命環境系, 准教授 2014 – 2017: 京都大学, 生命科学研究科, 助教 2012: 京都大学, 大学院・生命科学研究科, 助教 2011 – 2012: 京都大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Complex systems / Chemical biology / Biomolecular chemistry / Bioproduction chemistry/Bioorganic chemistry Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 38050:Food sciences-related / Food science
Keywords	Principal Investigator PPARγ / タンパク質分解制御 / 共有結合性アゴニスト / テトランドリン / オートファジー / コバレントドラッグ / ユビキチン / 脱ユビキチン化酵素 / デグロン / タンパク質安定性制御 … More / オプトケミカルツール / 細胞内合成 / 生体直交型反応 / 光化学 / 生体直交化学 / 核内受容体 / パートナーリガンド / 抗炎症活性 / フラグメント分子 / 化合物スクリーニング / 共有結合型リガンド / 標的分子 / 肝線維化 / perilipin / 脂肪滴 / daphnolon / Thymelaea hirsuta / 脂肪滴蓄積 / 肝星細胞 / リポファジー / 脂肪蓄積 … More Except Principal Investigator 金属生物学 / メタルTPP / メタルスイッチ / メタレーション / 必須微量金属 / HGF / SAMP8 / clovamide / ヒト膵島アミロイドポリペプチド / アミロイドβ / 肝細胞増殖因子 / 認知機能改善 / ADモデルマウス / イメージングMS / アルツハイマー型認知症 / 食素材由来化合物 / アミロイドポリペプチド / 亜鉛吸収促進因子 / 亜鉛トランスポーター / マーカー酵素 / ZNT1 / ZIP4 / 栄養改善 / 亜鉛要求性酵素 / 高齢者 / ソヤサポニンBb / 大豆抽出物 / Zip4 / トランスポーター / 亜鉛欠乏 Less

Establishing the concept of a new mechanism for protein function regulation: Metal Switch
- Principal Investigator
  
  神戸大朋
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Kyoto University
コバレント・スタビライザーが拓く細胞内タンパク質発現制御技術の新展開Principal Investigator
- Principal Investigator
  
  宮前友策
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Elucidation of the mechanism of action of compounds derived from dietary ingredients in improving cognitive function using multidimensional evaluation methods
- Principal Investigator
  
  繁森英幸
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  University of Tsukuba
脱ユビキチン化酵素の切断機構を活用した細胞内タンパク質発現制御法の開発Principal Investigator
- Principal Investigator
  
  宮前友策
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
Development of an optochemical tool that regulate the intracellular synthesis of PPARgamma ligandPrincipal Investigator
- Principal Investigator
  
  Miyamae Yusaku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Design, synthesis, and mechanism elucidation of novel covalent PPARgamma agonists that mimic the endogenous ligandsPrincipal Investigator
- Principal Investigator
  
  MIYAMAE Yusaku
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Tsukuba
Studies on a feed for improving zinc nutrition by the use of zinc transporters
- Principal Investigator
  
  Kambe Taiho
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Analysis of mechanism by which tetrandrine modulates lipid degradation via blockade of autophagyPrincipal Investigator
- Principal Investigator
  
  MIYAMAE Yusaku
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  University of Tsukuba
  Kyoto University
Study on natural bioactive substance that modulate autophagyPrincipal Investigator
- Principal Investigator
  
  MIYAMAE Yusaku
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University

[Book] カフェオイルキナ酸は神経細胞保護作用を持つ2012
- Author(s)
  韓〓奎、宮前友策、繁森英幸、礒田博子
- Data Source
  KAKENHI-PROJECT-23880015
[Journal Article] Effects of Degree of Polymerization of B-Type Procyanidins on Amyloid Aggregation2023
- Author(s)
  Shigemori Hideyuki、Tanaka Taisei、Fukushima Hirono、V. Betkekar Vipul、Ohmori Ken、Suzuki Keisuke、Miyamae Yusaku
- Journal Title
  
  HETEROCYCLES
  
  Volume: 106 Issue: 11 Pages: 1845-1845
- DOI
  10.3987/com-23-14888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K23547
[Journal Article] Cyanidin 3-Glucoside Induces Hepatocyte Growth Factor in Normal Human Dermal Fibroblasts through the Activation of β2-Adrenergic Receptor2022
- Author(s)
  Krama Annisa、Tokura Natsu、Isoda Hiroko、Shigemori Hideyuki、Miyamae Yusaku
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 26 Pages: 22889-22895
- DOI
  10.1021/acsomega.2c02659
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23547
[Journal Article] Strategies for Post-Translational Control of Protein Expression and Their Applications2021
- Author(s)
  Utsugi Yuki、Miyamae Yusaku
- Journal Title
  
  Applied Sciences
  
  Volume: 11 Issue: 18 Pages: 8300-8300
- DOI
  10.3390/app11188300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00271
[Journal Article] Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris2021
- Author(s)
  Hasegawa Tokio、Osaka Mayo、Miyamae Yusaku、Nishino Katsutoshi、Isoda Hiroko、Kawada Kiyokazu、Neffati Mohamed、Irie Kazuhiro、Nagao Masaya
- Journal Title
  
  Chemistry
  
  Volume: 3 Issue: 2 Pages: 647-657
- DOI
  10.3390/chemistry3020045
- NAID
  120007183475
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05742
[Journal Article] 小分子化合物による細胞内タンパク質の分解制御技術2021
- Author(s)
  宇津木優樹、鈴木琢海、宮前友策
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 79 Pages: 200-204
- NAID
  40022572020
- Data Source
  KAKENHI-PUBLICLY-21H00271
[Journal Article] Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications2021
- Author(s)
  Miyamae Yusaku
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 9 Pages: 1185-1195
- DOI
  10.1248/bpb.b21-00263
- NAID
  130008082331
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05742
[Journal Article] Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR12020
- Author(s)
  Nishino Katsutoshi、Uesugi Haruka、Hirasawa Akira、Ohtera Anna、Miyamae Yusaku、Neffati Mohamed、Isoda Hiroko、Kambe Taiho、Masuda Seiji、Irie Kazuhiro、Nagao Masaya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 1 Pages: 68-73
- DOI
  10.1016/j.bbrc.2019.11.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05768, KAKENHI-PROJECT-19H02883, KAKENHI-PROJECT-17K13264
[Journal Article] A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form2020
- Author(s)
  Miyamae Yusaku、Chen Ling-chun、Utsugi Yuki、Farrants Helen、Wandless Thomas J.
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27 Issue: 12 Pages: 1573-1581.e3
- DOI
  10.1016/j.chembiol.2020.09.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05742, KAKENHI-PROJECT-17K13264
[Journal Article] Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists2019
- Author(s)
  Utsugi, Y., Kobuchi, H., Kawamura, Y., Atito, A.S.A., Nagao, M., Isoda, H., Miyamae, Y.
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 10 Pages: 2019-2019
- DOI
  10.3390/molecules24102019
- NAID
  120007133399
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13264
[Journal Article] Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites2019
- Author(s)
  Kurata Masashi、Fujiwara Naoko、Fujita Ken-ichi、Yamanaka Yasutaka、Seno Shigeto、Kobayashi Hisato、Miyamae Yusaku、Takahashi Nobuyuki、Shibuya Yasuyuki、Masuda Seiji
- Journal Title
  
  iScience
  
  Volume: 22 Pages: 336-352
- DOI
  10.1016/j.isci.2019.11.033
- NAID
  120007132694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22280, KAKENHI-PROJECT-19K15807, KAKENHI-PROJECT-19H02884, KAKENHI-PROJECT-17K13264
[Journal Article] Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton2017
- Author(s)
  Kurata M, Morimoto M, Kawamura Y, Mursi IFA, Momma K, Takahashi M, Miyamae Y, Kambe T, Nagao N, Narita H, Shibuya Y and Masuda S
- Journal Title
  
  Biochemistry and Molecular Biology
  
  Volume: 2 Issue: 4 Pages: 46-53
- DOI
  10.11648/j.bmb.20170204.13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19232, KAKENHI-PROJECT-17K13264
[Journal Article] The isoflavone fraction from soybean presents mRNA maturation inhibition activity2017
- Author(s)
  Kurata M, Murata Y, Momma K, Fouad Ali Mursi I, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, Masuda S
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 81 Issue: 3 Pages: 551-554
- DOI
  10.1080/09168451.2016.1249451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-17K19232
[Journal Article] 核内受容体PPARγのユニークな特性と新奇リガンド開発への新展開2016
- Author(s)
  宮前友策、永尾雅哉
- Journal Title
  
  化学と生物
  
  Volume: 54 Pages: 791-793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870309
[Journal Article] Structure-Activity Relationship of Phenylpropanoid Glycosides on the Inhibition of Amyloid β2016
- Author(s)
  Kidachi, E.; Kurisu, M.; Miyamae, Y.; Hanaki, M.; Murakami, K.; Irie, K.; Shigemori, H.
- Journal Title
  
  Heterocycles
  
  Volume: 92 Issue: 11 Pages: 1976-1982
- DOI
  10.3987/com-16-13533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870309
[Journal Article] Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line2016
- Author(s)
  Miyamae Y, Nishito Y, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, Nagao M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 477 Issue: 1 Pages: 40-46
- DOI
  10.1016/j.bbrc.2016.06.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-26430140
[Journal Article] The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation2016
- Author(s)
  Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T
- Journal Title
  
  Biochem. J
  
  Volume: 473 Issue: 17 Pages: 2611-2621
- DOI
  10.1042/bcj20160324
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26850037, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-16K09764
[Journal Article] Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting2015
- Author(s)
  2)Hashimoto, A., Ohkura, K., Takahashi, M., Kizu, K., Narita, H., Enomoto, S., Miyamae, Y., Masuda, S., Nagao, M., Irie, K., Ohigashi, H., Andrews, G. K., Kambe, T.
- Journal Title
  
  Biochemical Journal
  
  Volume: 472 Issue: 2 Pages: 183-193
- DOI
  10.1042/bj20150862
- NAID
  120006305978
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-14J06743, KAKENHI-PROJECT-26660086
[Journal Article] Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy2015
- Author(s)
  Ohtera, A., Miyamae, Y.*, Yoshida, K., Maejima, K., Akita, T., Kakizuka, A., Irie, K., Masuda, S., Kambe, T., Nagao, M.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 10 Issue: 12 Pages: 2794-2804
- DOI
  10.1021/acschembio.5b00628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870309, KAKENHI-PUBLICLY-15H01181
[Journal Article] Promoting effects on hepatocyte growth factor production of daphnane diterpenoids from Daphne Odora2013
- Author(s)
  Nakasone, R.; Kurisu, M.; Onodera, M.; Miyamae, Y.; Matsuura, D.; Kanatani, H.; Yano, S.; Shigemori, H
- Journal Title
  
  Heterocycles
  
  Volume: (in press) Issue: 5 Pages: 1087-1092
- DOI
  10.3987/com-13-12687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015, KAKENHI-PROJECT-24580156
[Journal Article] カフェオイルキナ酸は神経細胞保護作用をもつ2012
- Author(s)
  韓〓奎、宮前友策、繁森英幸、礒田博子
- Journal Title
  
  化学と生物
  
  Volume: 50 Pages: 77-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015
[Journal Article] Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of 42-residue amyloid βprotein2012
- Author(s)
  Miyamae, Y.; Kurisu, M.; Murakami, K.; Han, J.; Isoda, H.; Irie, K.; Shigemori, H
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 19 Pages: 5844-5849
- DOI
  10.1016/j.bmc.2012.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015
[Journal Article] Establishment of a Monitoring System to Detect Inhibition of mRNA Processing2012
- Author(s)
  Fujita, K.; Okamura, M.; Nishimoto, S.; Kurihara, T.; Momma, K.; Miyamae, Y.; Kambe, T.; Nagao, M.; Narita, H.; Masuda, S
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 6 Pages: 1248-1251
- DOI
  10.1271/bbb.120226
- NAID
  10030818658
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015
[Patent] 新規ポリペプチド及びその利用2022
- Inventor(s)
  宮前友策、宇津木優樹
- Industrial Property Rights Holder
  宮前友策、宇津木優樹
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-060191
- Filing Date
  2022
- Data Source
  KAKENHI-PUBLICLY-21H00271
[Presentation] 褐藻ノコギリモク由来メロテルペノイド化合物のアミロイドポリペプチド凝集阻害活性2024
- Author(s)
  戸澤悠太、堀内真郁、篠田清哉、栗本慎一郎、関口光広、宮前友策、繁森英幸
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K23547
[Presentation] Clovamideのアミロイドポリペプチド凝集および神経細胞保護に対する作用2023
- Author(s)
  繁森英幸、角田達彦、野本悌吾、藤井七彩、池本光志、宮前友策
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-23K23547
[Presentation] 植物由来スチルべノイド化合物のアミロイドポリペプチド凝集阻害活性2023
- Author(s)
  繁森英幸、三瓶達矢、呉　映雪、宮前友策
- Organizer
  第10回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K23547
[Presentation] カカオ由来ポリフェノール化合物のアミロイドポリペプチド凝集ならびに神経細胞に対する効果2023
- Author(s)
  藤井七彩、野本悌吾、角田達彦、池本光志、宮前友策、繁森英幸
- Organizer
  健幸イノベーション開発研究センター第3回シンポジウム
- Data Source
  KAKENHI-PROJECT-23K23547
[Presentation] Effect of Cyanidin 3-Glucoside on the Production of Hepatocyte Growth Factor in Normal Human Dermal Fibroblasts2022
- Author(s)
  Annisa Krama, Natsu Tokura, Hiroko Isoda, Hideyuki Shigemori, Yusaku Miyamae
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] 生細胞中の脱ユビキチン化酵素の活性を検出する準生体直交型バイオセンサータンパク質の開発2022
- Author(s)
  鈴木琢海、宇津木優樹、礒田博子、宮前友策
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PUBLICLY-21H00271
[Presentation] リガンド結合ポケットの特性を利用したフラグメント分子スクリーニングと核内受容体リガンドの創製2022
- Author(s)
  宮前友策
- Organizer
  日本薬学会第142年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] Analysis of subcellular localization of tetrandrine that modulates autophagy-lysosome pathway2022
- Author(s)
  ZHE YANG, Tomoki Takahashi, Tatsuya Yamamoto, Hiroko Isoda, Hideyuki Shigemori, Yusaku Miyamae
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] 生体直交型反応を示す官能基を付加した PPARγ リガンドの合成と活性評価2021
- Author(s)
  安彩伽、大前勇馬、有本光江、加香孝一郎、礒田博子、深水昭吉、繁森英幸、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] 共有結合型PPARγリガンドとその類縁化合物に拠る抗炎症活性の検証2021
- Author(s)
  大前勇馬、礒田博子、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] 共有結合型PPARγリガンドとその類縁化合物に拠る抗炎症活性の検証2021
- Author(s)
  大前勇馬、礒田博子、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] 生体直交型反応を示す官能基を付加した PPARγ リガンドの合成と活性評価2021
- Author(s)
  安彩伽、大前勇馬、有本光江、加香孝一郎、礒田博子、深水昭吉、繁森英幸、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] 脱ユビキチン化酵素の切断活性を利用した細胞内標的タンパク質発現制御法の構築2020
- Author(s)
  宮前友策; 宇津木優樹; 礒田博子; Ling-Chun Chen; Thomas J. Wandless
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] フラグメントユニットの近接性と配向性が異なる共有結合型PPARγリガンドの合成と活性評価2020
- Author(s)
  宇津木優樹; 小渕裕菜; 河村幸雄; 永尾雅哉; 礒田博子; 宮前友策
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Effect of a covalent PPARγ agonist on inflammatory pathway2020
- Author(s)
  Yuma Omae, Hiroko Isoda, Yusaku Miyamae
- Organizer
  JAACT2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Effect of a covalent PPARγ agonist on inflammatory pathway2020
- Author(s)
  Yuma Omae, Hiroko Isoda, Yusaku Miyamae
- Organizer
  JAACT2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製と生物活性評価2019
- Author(s)
  宮前友策; 宇津木優樹; 大寺杏奈; 小渕裕菜; 吉田光多郎; 大前勇馬; 神戸大朋; 増田誠司; 河村幸雄; 永尾雅哉; 礒田博子
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] 脱ユビキチン化酵素の切断機構を利用した細胞内標的タンパク質発現制御法の開発2019
- Author(s)
  宮前友策; 宇津木優樹; 礒田博子; Ling-Chun Chen; Thomas J. Wandless
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Biological evaluation of cinnamate-GW9662 hybrid compounds as a novel class of covalent PPARγ agonist2018
- Author(s)
  Yuki Utsugi, Hirona Kobuchi, Yukio Kawamura, Ahmed Salahelden Aboelhamd Atito, Masaya Nagao, Hiroko Isoda, Yusaku Miyamae
- Organizer
  JAACT2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] 新規共有結合性PPARγアゴニストの構造活性相関及び推定結合様式の解析2018
- Author(s)
  宇津木優樹、小渕裕菜、河村幸雄、Ahmed Salahelden Aboelhamd Atito, 永尾雅哉、礒田博子、宮前友策
- Organizer
  日本農芸化学会関東支部大会2018年度大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy2018
- Author(s)
  Yusaku Miyamae, Anna Ohtera, Kotaro Yoshida, Kazuhiro Maejima, Toru Akita, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao
- Organizer
  JAACT2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] オートファジー阻害剤テトランドリンの新規作用機序2015
- Author(s)
  ○宮前友策、西藤有希奈、仲井奈緒美、増田誠司、神戸大朋、永尾雅哉
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26870309
[Presentation] リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製2015
- Author(s)
  ○宮前友策、大寺杏奈、吉田光多郎、前嶋一宏、秋田徹、垣塚彰、入江一浩、増田誠司、神戸大朋、永尾雅哉
- Organizer
  第10回日本ケミカルバイオロジー学会
- Place of Presentation
  東北大学
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26870309
[Presentation] ヤセウツボ(Orobanche miner)由来化合物のアミロイドβ凝集阻害活性に関する研究2012
- Author(s)
  栗栖真奈美、宮前友策、村上一馬、Han Junkyu、礒田博子、入江一浩、繁森英幸
- Organizer
  日本農芸化学会2012 年度大会
- Place of Presentation
  京都女子大学(京都府)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御2012
- Author(s)
  宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、入江一浩、永尾雅哉
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御2012
- Author(s)
  宮前友策
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  京都大学百周年記念ホール
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御2012
- Author(s)
  宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、増田誠司、入江一浩、永尾雅哉
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都大学(京都府)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御2012
- Author(s)
  宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、入江一浩、永尾雅哉
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学(京都府)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] バンウコンからのPPARγアンタゴニスト変換活性物質の探索2012
- Author(s)
  宮前友策、吉田光多郎、大寺杏奈、仲井奈緒美、王健一、秋田徹、前嶋一宏、森直樹、入江一浩、神戸大朋、増田誠司、永尾雅哉
- Organizer
  新規素材探索研究会
- Place of Presentation
  新横浜フジビューホテル(神奈川県)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構2011
- Author(s)
  宮前友策、栗栖真奈美、村上一馬、入江一浩、Han Junkyu、礒田博子、繁森英幸
- Organizer
  第53回天然有機化合物討論会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] Cooperative activation of PPARgamma by combination of irreversible antagonist and partial agonists: implication for novel activation mechanism based on covalent modification
- Author(s)
  Yusaku Miyamae, Anna Ohtera, Kotaro Yoshida, Toru Akita, Kazuhiro Maejima, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao
- Organizer
  International Chemical Biology Society, 3rd annual meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-11-17 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26870309
[Presentation] 肝線維化抑制物質テトランドリンによるオートファジー経路制御機構の解明
- Author(s)
  西藤有希奈、宮前友策、仲井奈緒美、Han Junkyu、礒田博子、増田誠司、神戸大朋、永尾雅哉
- Organizer
  第９回日本ケミカルバイオロジー学会
- Place of Presentation
  大阪大学
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26870309

1. Kambe Taiho (90303875)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 繁森英幸 (70202108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 落石知世 (30356729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平修 (30416672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 根本理子 (30625926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西村健 (80500610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 若森晋之介 (90788134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山中聡士 (50853884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 増田誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 瀬尾茂人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyamae Yusaku 宮前 友策

MIYAMAE Yusaku 宮前 友策

Research Projects

Research Products

Co-Researchers

Establishing the concept of a new mechanism for protein function regulation: Metal Switch

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コバレント・スタビライザーが拓く細胞内タンパク質発現制御技術の新展開Principal Investigator

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Elucidation of the mechanism of action of compounds derived from dietary ingredients in improving cognitive function using multidimensional evaluation methods

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脱ユビキチン化酵素の切断機構を活用した細胞内タンパク質発現制御法の開発Principal Investigator

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Development of an optochemical tool that regulate the intracellular synthesis of PPARgamma ligandPrincipal Investigator

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Design, synthesis, and mechanism elucidation of novel covalent PPARgamma agonists that mimic the endogenous ligandsPrincipal Investigator

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Studies on a feed for improving zinc nutrition by the use of zinc transporters

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Analysis of mechanism by which tetrandrine modulates lipid degradation via blockade of autophagyPrincipal Investigator

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Study on natural bioactive substance that modulate autophagyPrincipal Investigator

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[Book] カフェオイルキナ酸は神経細胞保護作用を持つ2012

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[Journal Article] Effects of Degree of Polymerization of B-Type Procyanidins on Amyloid Aggregation2023

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[Journal Article] Cyanidin 3-Glucoside Induces Hepatocyte Growth Factor in Normal Human Dermal Fibroblasts through the Activation of β2-Adrenergic Receptor2022

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[Journal Article] Strategies for Post-Translational Control of Protein Expression and Their Applications2021

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[Journal Article] Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris2021

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Miyamae Yusaku 宮前友策

MIYAMAE Yusaku 宮前友策