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Miyamae Yusaku  宮前 友策

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MIYAMAE Yusaku  宮前 友策

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Researcher Number 30610240
Other IDs
Affiliation (Current) 2023: 筑波大学, 生命環境系, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 筑波大学, 生命環境系, 准教授
2016 – 2018: 筑波大学, 生命環境系, 准教授
2014 – 2017: 京都大学, 生命科学研究科, 助教
2012: 京都大学, 大学院・生命科学研究科, 助教
2011 – 2012: 京都大学, 生命科学研究科, 助教
Review Section/Research Field
Principal Investigator
Bioproduction chemistry/Bioorganic chemistry / Bioorganic chemistry / Biomolecular chemistry / Chemical biology / Complex systems / Basic Section 37030:Chemical biology-related
Except Principal Investigator
Food science / Basic Section 38050:Food sciences-related
Keywords
Principal Investigator
PPARγ / オートファジー / テトランドリン / 共有結合性アゴニスト / 脂肪蓄積 / リポファジー / 肝星細胞 / 脂肪滴蓄積 / Thymelaea hirsuta / daphnolon … More / 脂肪滴 / perilipin / 肝線維化 / 標的分子 / 共有結合型リガンド / 化合物スクリーニング / フラグメント分子 / 抗炎症活性 / タンパク質安定性制御 / デグロン / 脱ユビキチン化酵素 / ユビキチン / 生体直交型反応 / 細胞内合成 / オプトケミカルツール … More
Except Principal Investigator
亜鉛欠乏 / トランスポーター / Zip4 / 大豆抽出物 / ソヤサポニンBb / 高齢者 / 亜鉛要求性酵素 / 栄養改善 / ZIP4 / ZNT1 / マーカー酵素 / 亜鉛トランスポーター / 亜鉛吸収促進因子 / アミロイドポリペプチド / 食素材由来化合物 / アルツハイマー型認知症 / イメージングMS / ADモデルマウス / 認知機能改善 Less
  • Research Projects

    (7 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (5 People)
  •  Elucidation of the mechanism of action of compounds derived from dietary ingredients in improving cognitive function using multidimensional evaluation methods

    • Principal Investigator
      繁森 英幸
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      University of Tsukuba
  •  脱ユビキチン化酵素の切断機構を活用した細胞内タンパク質発現制御法の開発Principal Investigator

    • Principal Investigator
      宮前 友策
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      University of Tsukuba
  •  PPARγリガンドの細胞内合成を光で制御するオプトケミカルツールの開発Principal Investigator

    • Principal Investigator
      宮前 友策
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      University of Tsukuba
  •  Design, synthesis, and mechanism elucidation of novel covalent PPARgamma agonists that mimic the endogenous ligandsPrincipal Investigator

    • Principal Investigator
      MIYAMAE Yusaku
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical biology
    • Research Institution
      University of Tsukuba
  •  Studies on a feed for improving zinc nutrition by the use of zinc transporters

    • Principal Investigator
      Kambe Taiho
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Food science
    • Research Institution
      Kyoto University
  •  Analysis of mechanism by which tetrandrine modulates lipid degradation via blockade of autophagyPrincipal Investigator

    • Principal Investigator
      MIYAMAE Yusaku
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bioorganic chemistry
      Biomolecular chemistry
    • Research Institution
      University of Tsukuba
      Kyoto University
  •  Study on natural bioactive substance that modulate autophagyPrincipal Investigator

    • Principal Investigator
      MIYAMAE Yusaku
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Kyoto University

All 2022 2021 2020 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] カフェオイルキナ酸は神経細胞保護作用を持つ2012

    • Author(s)
      韓〓奎、宮前友策、繁森英幸、礒田博子
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Journal Article] Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris2021

    • Author(s)
      Hasegawa Tokio、Osaka Mayo、Miyamae Yusaku、Nishino Katsutoshi、Isoda Hiroko、Kawada Kiyokazu、Neffati Mohamed、Irie Kazuhiro、Nagao Masaya
    • Journal Title

      Chemistry

      Volume: 3 Issue: 2 Pages: 647-657

    • DOI

      10.3390/chemistry3020045

    • NAID

      120007183475

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Journal Article] Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications2021

    • Author(s)
      Miyamae Yusaku
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 44 Issue: 9 Pages: 1185-1195

    • DOI

      10.1248/bpb.b21-00263

    • NAID

      130008082331

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2021-09-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Journal Article] A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form2020

    • Author(s)
      Miyamae Yusaku、Chen Ling-chun、Utsugi Yuki、Farrants Helen、Wandless Thomas J.
    • Journal Title

      Cell Chemical Biology

      Volume: 27 Issue: 12 Pages: 1573-1581.e3

    • DOI

      10.1016/j.chembiol.2020.09.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05742, KAKENHI-PROJECT-17K13264
  • [Journal Article] Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton2017

    • Author(s)
      Kurata M, Morimoto M, Kawamura Y, Mursi IFA, Momma K, Takahashi M, Miyamae Y, Kambe T, Nagao N, Narita H, Shibuya Y and Masuda S
    • Journal Title

      Biochemistry and Molecular Biology

      Volume: 2 Issue: 4 Pages: 46-53

    • DOI

      10.11648/j.bmb.20170204.13

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19232, KAKENHI-PROJECT-17K13264
  • [Journal Article] The isoflavone fraction from soybean presents mRNA maturation inhibition activity2017

    • Author(s)
      Kurata M, Murata Y, Momma K, Fouad Ali Mursi I, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, Masuda S
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 81 Issue: 3 Pages: 551-554

    • DOI

      10.1080/09168451.2016.1249451

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-17K19232
  • [Journal Article] 核内受容体PPARγのユニークな特性と新奇リガンド開発への新展開2016

    • Author(s)
      宮前友策、永尾雅哉
    • Journal Title

      化学と生物

      Volume: 54 Pages: 791-793

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26870309
  • [Journal Article] Structure-Activity Relationship of Phenylpropanoid Glycosides on the Inhibition of Amyloid β2016

    • Author(s)
      Kidachi, E.; Kurisu, M.; Miyamae, Y.; Hanaki, M.; Murakami, K.; Irie, K.; Shigemori, H.
    • Journal Title

      Heterocycles

      Volume: 92 Issue: 11 Pages: 1976-1982

    • DOI

      10.3987/com-16-13533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26870309
  • [Journal Article] Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line2016

    • Author(s)
      Miyamae Y, Nishito Y, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, Nagao M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 477 Issue: 1 Pages: 40-46

    • DOI

      10.1016/j.bbrc.2016.06.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-26430140
  • [Journal Article] The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation2016

    • Author(s)
      Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T
    • Journal Title

      Biochem. J

      Volume: 473 Issue: 17 Pages: 2611-2621

    • DOI

      10.1042/bcj20160324

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26850037, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-16K09764
  • [Journal Article] Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting2015

    • Author(s)
      2)Hashimoto, A., Ohkura, K., Takahashi, M., Kizu, K., Narita, H., Enomoto, S., Miyamae, Y., Masuda, S., Nagao, M., Irie, K., Ohigashi, H., Andrews, G. K., Kambe, T.
    • Journal Title

      Biochemical Journal

      Volume: 472 Issue: 2 Pages: 183-193

    • DOI

      10.1042/bj20150862

    • NAID

      120006305978

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-14J06743, KAKENHI-PROJECT-26660086
  • [Journal Article] Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy2015

    • Author(s)
      Ohtera, A., Miyamae, Y.*, Yoshida, K., Maejima, K., Akita, T., Kakizuka, A., Irie, K., Masuda, S., Kambe, T., Nagao, M.
    • Journal Title

      ACS Chemical Biology

      Volume: 10 Issue: 12 Pages: 2794-2804

    • DOI

      10.1021/acschembio.5b00628

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26870309, KAKENHI-PUBLICLY-15H01181
  • [Journal Article] Promoting effects on hepatocyte growth factor production of daphnane diterpenoids from Daphne Odora2013

    • Author(s)
      Nakasone, R.; Kurisu, M.; Onodera, M.; Miyamae, Y.; Matsuura, D.; Kanatani, H.; Yano, S.; Shigemori, H
    • Journal Title

      Heterocycles

      Volume: (in press) Issue: 5 Pages: 1087-1092

    • DOI

      10.3987/com-13-12687

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23880015, KAKENHI-PROJECT-24580156
  • [Journal Article] カフェオイルキナ酸は神経細胞保護作用をもつ2012

    • Author(s)
      韓〓奎、宮前友策、繁森英幸、礒田博子
    • Journal Title

      化学と生物

      Volume: 50 Pages: 77-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Journal Article] Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of 42-residue amyloid βprotein2012

    • Author(s)
      Miyamae, Y.; Kurisu, M.; Murakami, K.; Han, J.; Isoda, H.; Irie, K.; Shigemori, H
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 20 Issue: 19 Pages: 5844-5849

    • DOI

      10.1016/j.bmc.2012.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Journal Article] Establishment of a Monitoring System to Detect Inhibition of mRNA Processing2012

    • Author(s)
      Fujita, K.; Okamura, M.; Nishimoto, S.; Kurihara, T.; Momma, K.; Miyamae, Y.; Kambe, T.; Nagao, M.; Narita, H.; Masuda, S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 6 Pages: 1248-1251

    • DOI

      10.1271/bbb.120226

    • NAID

      10030818658

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] Effect of Cyanidin 3-Glucoside on the Production of Hepatocyte Growth Factor in Normal Human Dermal Fibroblasts2022

    • Author(s)
      Annisa Krama, Natsu Tokura, Hiroko Isoda, Hideyuki Shigemori, Yusaku Miyamae
    • Organizer
      日本農芸化学会2022年度大会
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Presentation] リガンド結合ポケットの特性を利用したフラグメント分子スクリーニングと核内受容体リガンドの創製2022

    • Author(s)
      宮前友策
    • Organizer
      日本薬学会第142年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Presentation] Analysis of subcellular localization of tetrandrine that modulates autophagy-lysosome pathway2022

    • Author(s)
      ZHE YANG, Tomoki Takahashi, Tatsuya Yamamoto, Hiroko Isoda, Hideyuki Shigemori, Yusaku Miyamae
    • Organizer
      日本農芸化学会2022年度大会
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Presentation] 生体直交型反応を示す官能基を付加した PPARγ リガンドの合成と活性評価2021

    • Author(s)
      安彩伽、大前勇馬、有本光江、加香 孝一郎、礒田博子、深水昭吉、繁森英幸、宮前友策
    • Organizer
      日本農芸化学会2021年大会
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Presentation] 共有結合型PPARγリガンドとその類縁化合物に拠る抗炎症活性の検証2021

    • Author(s)
      大前勇馬、礒田博子、宮前友策
    • Organizer
      日本農芸化学会2021年大会
    • Data Source
      KAKENHI-PROJECT-17K13264
  • [Presentation] 共有結合型PPARγリガンドとその類縁化合物に拠る抗炎症活性の検証2021

    • Author(s)
      大前勇馬、礒田博子、宮前友策
    • Organizer
      日本農芸化学会2021年大会
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Presentation] 生体直交型反応を示す官能基を付加した PPARγ リガンドの合成と活性評価2021

    • Author(s)
      安彩伽、大前勇馬、有本光江、加香 孝一郎、礒田博子、深水昭吉、繁森英幸、宮前友策
    • Organizer
      日本農芸化学会2021年大会
    • Data Source
      KAKENHI-PROJECT-17K13264
  • [Presentation] Effect of a covalent PPARγ agonist on inflammatory pathway2020

    • Author(s)
      Yuma Omae, Hiroko Isoda, Yusaku Miyamae
    • Organizer
      JAACT2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13264
  • [Presentation] Effect of a covalent PPARγ agonist on inflammatory pathway2020

    • Author(s)
      Yuma Omae, Hiroko Isoda, Yusaku Miyamae
    • Organizer
      JAACT2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05742
  • [Presentation] Biological evaluation of cinnamate-GW9662 hybrid compounds as a novel class of covalent PPARγ agonist2018

    • Author(s)
      Yuki Utsugi, Hirona Kobuchi, Yukio Kawamura, Ahmed Salahelden Aboelhamd Atito, Masaya Nagao, Hiroko Isoda, Yusaku Miyamae
    • Organizer
      JAACT2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13264
  • [Presentation] 新規共有結合性PPARγアゴニストの構造活性相関及び推定結合様式の解析2018

    • Author(s)
      宇津木優樹、小渕裕菜、河村幸雄、Ahmed Salahelden Aboelhamd Atito, 永尾雅哉、礒田博子、宮前友策
    • Organizer
      日本農芸化学会関東支部大会2018年度大会
    • Data Source
      KAKENHI-PROJECT-17K13264
  • [Presentation] Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy2018

    • Author(s)
      Yusaku Miyamae, Anna Ohtera, Kotaro Yoshida, Kazuhiro Maejima, Toru Akita, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao
    • Organizer
      JAACT2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13264
  • [Presentation] オートファジー阻害剤テトランドリンの新規作用機序2015

    • Author(s)
      ○宮前友策、西藤有希奈、仲井奈緒美、増田誠司、神戸大朋、永尾雅哉
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール
    • Year and Date
      2015-09-09
    • Data Source
      KAKENHI-PROJECT-26870309
  • [Presentation] リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製2015

    • Author(s)
      ○宮前友策、大寺杏奈、吉田光多郎、前嶋一宏、秋田徹、垣塚彰、入江一浩、増田誠司、神戸大朋、永尾雅哉
    • Organizer
      第10回日本ケミカルバイオロジー学会
    • Place of Presentation
      東北大学
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26870309
  • [Presentation] ヤセウツボ(Orobanche miner)由来化合物のアミロイドβ凝集阻害活性に関する研究2012

    • Author(s)
      栗栖真奈美、宮前友策、村上一馬 、Han Junkyu、礒田博子、入江一浩、繁森英幸
    • Organizer
      日本農芸化学会2012 年度大会
    • Place of Presentation
      京都女子大学(京都府)
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御2012

    • Author(s)
      宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、入江一浩、永尾雅哉
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御2012

    • Author(s)
      宮前友策
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      京都大学百周年記念ホール
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御2012

    • Author(s)
      宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、増田誠司、入江一浩、永尾雅哉
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学(京都府)
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御2012

    • Author(s)
      宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、入江一浩、永尾雅哉
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都府)
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] バンウコンからのPPARγアンタゴニスト変換活性物質の探索2012

    • Author(s)
      宮前友策、吉田光多郎、大寺杏奈、仲井奈緒美、王健一、秋田徹、前嶋一宏、森直樹、入江一浩、神戸大朋、増田誠司、永尾雅哉
    • Organizer
      新規素材探索研究会
    • Place of Presentation
      新横浜フジビューホテル(神奈川県)
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構2011

    • Author(s)
      宮前友策、栗栖真奈美、村上一馬、入江一浩、Han Junkyu、礒田博子、繁森英幸
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2011-09-27
    • Data Source
      KAKENHI-PROJECT-23880015
  • [Presentation] Cooperative activation of PPARgamma by combination of irreversible antagonist and partial agonists: implication for novel activation mechanism based on covalent modification

    • Author(s)
      Yusaku Miyamae, Anna Ohtera, Kotaro Yoshida, Toru Akita, Kazuhiro Maejima, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao
    • Organizer
      International Chemical Biology Society, 3rd annual meeting
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2014-11-17 – 2014-11-19
    • Data Source
      KAKENHI-PROJECT-26870309
  • [Presentation] 肝線維化抑制物質テトランドリンによるオートファジー経路制御機構の解明

    • Author(s)
      西藤有希奈、宮前友策、仲井奈緒美、Han Junkyu、礒田博子、増田誠司、神戸大朋、永尾雅哉
    • Organizer
      第9回日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪大学
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-26870309
  • 1.  Kambe Taiho (90303875)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  繁森 英幸 (70202108)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  落石 知世 (30356729)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  平 修 (30416672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  増田 誠司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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