Miyamae Yusaku 宮前友策

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MIYAMAE Yusaku 宮前友策

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Researcher Number	30610240
Other IDs
Affiliation (Current)	2022: 筑波大学, 生命環境系, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 筑波大学, 生命環境系, 准教授 2016 – 2018: 筑波大学, 生命環境系, 准教授 2014 – 2017: 京都大学, 生命科学研究科, 助教 2012: 京都大学, 大学院・生命科学研究科, 助教 2011 – 2012: 京都大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Bioorganic chemistry / Biomolecular chemistry / Chemical biology / Complex systems / Basic Section 37030:Chemical biology-related Except Principal Investigator Food science / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator PPARγ / オートファジー / テトランドリン / 共有結合性アゴニスト / 脂肪蓄積 / リポファジー / 肝星細胞 / 脂肪滴蓄積 / Thymelaea hirsuta / daphnolon … More / 脂肪滴 / perilipin / 肝線維化 / 標的分子 / 共有結合型リガンド / 化合物スクリーニング / フラグメント分子 / 抗炎症活性 / タンパク質安定性制御 / デグロン / 脱ユビキチン化酵素 / ユビキチン / 生体直交型反応 / 細胞内合成 / オプトケミカルツール … More Except Principal Investigator 亜鉛欠乏 / トランスポーター / Zip4 / 大豆抽出物 / ソヤサポニンBb / 高齢者 / 亜鉛要求性酵素 / 栄養改善 / ZIP4 / ZNT1 / マーカー酵素 / 亜鉛トランスポーター / 亜鉛吸収促進因子 / 認知機能改善 / 食素材由来化合物 / アルツハイマー型認知症 / イメージングMS / ADモデルマウス Less

多元的評価法を用いた認知機能改善に関わる食素材由来化合物の機能解明
- Principal Investigator
  
  繁森英幸
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  University of Tsukuba
脱ユビキチン化酵素の切断機構を活用した細胞内タンパク質発現制御法の開発Principal Investigator
- Principal Investigator
  
  宮前友策
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
PPARγリガンドの細胞内合成を光で制御するオプトケミカルツールの開発Principal Investigator
- Principal Investigator
  
  宮前友策
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Design, synthesis, and mechanism elucidation of novel covalent PPARgamma agonists that mimic the endogenous ligandsPrincipal Investigator
- Principal Investigator
  
  MIYAMAE Yusaku
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Tsukuba
Studies on a feed for improving zinc nutrition by the use of zinc transporters
- Principal Investigator
  
  Kambe Taiho
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Analysis of mechanism by which tetrandrine modulates lipid degradation via blockade of autophagyPrincipal Investigator
- Principal Investigator
  
  MIYAMAE Yusaku
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioorganic chemistry
  Biomolecular chemistry
- Research Institution
  University of Tsukuba
  Kyoto University
Study on natural bioactive substance that modulate autophagyPrincipal Investigator
- Principal Investigator
  
  MIYAMAE Yusaku
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University

All 2021 2020 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] カフェオイルキナ酸は神経細胞保護作用を持つ2012
- Author(s)
  韓〓奎、宮前友策、繁森英幸、礒田博子
- Data Source
  KAKENHI-PROJECT-23880015
[Journal Article] A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form2020
- Author(s)
  Miyamae Yusaku、Chen Ling-chun、Utsugi Yuki、Farrants Helen、Wandless Thomas J.
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27
- DOI
  10.1016/j.chembiol.2020.09.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05742, KAKENHI-PROJECT-17K13264
[Journal Article] The isoflavone fraction from soybean presents mRNA maturation inhibition activity.2017
- Author(s)
  Kurata M, Murata Y, Momma K, Fouad Ali Mursi I, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, Masuda S
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 81 Pages: 551-554
- DOI
  10.1080/09168451.2016.1249451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-17K19232
[Journal Article] 核内受容体PPARγのユニークな特性と新奇リガンド開発への新展開2016
- Author(s)
  宮前友策、永尾雅哉
- Journal Title
  
  化学と生物
  
  Volume: 54 Pages: 791-793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870309
[Journal Article] Structure-Activity Relationship of Phenylpropanoid Glycosides on the Inhibition of Amyloid β2016
- Author(s)
  Kidachi, E.; Kurisu, M.; Miyamae, Y.; Hanaki, M.; Murakami, K.; Irie, K.; Shigemori, H.
- Journal Title
  
  Heterocycles
  
  Volume: 92 Pages: 1976-1982
- DOI
  10.3987/com-16-13533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870309
[Journal Article] Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line.2016
- Author(s)
  Miyamae Y, Nishito Y, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, Nagao M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 477 Pages: 40-46
- DOI
  10.1016/j.bbrc.2016.06.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-26430140
[Journal Article] The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.2016
- Author(s)
  Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T
- Journal Title
  
  Biochemical Journal
  
  Volume: 473 Pages: 2611-21
- DOI
  10.1042/bcj20160324
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-26292053, KAKENHI-PROJECT-15K14919, KAKENHI-PROJECT-26850037, KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-16K09764
[Journal Article] Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting.2015
- Author(s)
  2)Hashimoto, A., Ohkura, K., Takahashi, M., Kizu, K., Narita, H., Enomoto, S., Miyamae, Y., Masuda, S., Nagao, M., Irie, K., Ohigashi, H., Andrews, G. K., Kambe, T.
- Journal Title
  
  Biochem J
  
  Volume: 472 Pages: 183-193
- DOI
  10.1042/bj20150862
- NAID
  120006305978
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870309, KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-14J06743, KAKENHI-PROJECT-26660086
[Journal Article] Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy.2015
- Author(s)
  Ohtera, A., Miyamae, Y.*, Yoshida, K., Maejima, K., Akita, T., Kakizuka, A., Irie, K., Masuda, S., Kambe, T., Nagao, M.
- Journal Title
  
  ACS Chem Biol.
  
  Volume: 10 Pages: 2794-2804
- DOI
  10.1021/acschembio.5b00628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870309, KAKENHI-PUBLICLY-15H01181
[Journal Article] Promoting effects on hepatocyte growth factor production of daphnane diterpenoids from Daphne odora2013
- Author(s)
  Nakasone, R.; Kurisu, M.; Onodera, M.; Miyamae, Y.; Matsuura, D.; Kanatani, H.; Yano, S.; Shigemori, H
- Journal Title
  
  Heterocycles
  
  Volume: (in press) Pages: 1087-1092
- DOI
  10.3987/com-13-12687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015, KAKENHI-PROJECT-24580156
[Journal Article] カフェオイルキナ酸は神経細胞保護作用をもつ2012
- Author(s)
  韓〓奎、宮前友策、繁森英幸、礒田博子
- Journal Title
  
  化学と生物
  
  Volume: 50 Pages: 77-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015
[Journal Article] Establishment of a Monitoring System to Detect Inhibition of mRNA Processing2012
- Author(s)
  Fujita, K.; Okamura, M.; Nishimoto, S.; Kurihara, T.; Momma, K.; Miyamae, Y.; Kambe, T.; Nagao, M.; Narita, H.; Masuda, S
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 76 Issue: 6 Pages: 1248-1251
- DOI
  10.1271/bbb.120226
- NAID
  10030818658
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015
[Journal Article] Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of 42-residue amyloid βprotein2012
- Author(s)
  Miyamae, Y.; Kurisu, M.; Murakami, K.; Han, J.; Isoda, H.; Irie, K.; Shigemori, H
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Pages: 5844-5849
- DOI
  10.1016/j.bmc.2012.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 生体直交型反応を示す官能基を付加した PPARγ リガンドの合成と活性評価2021
- Author(s)
  安彩伽、大前勇馬、有本光江、加香孝一郎、礒田博子、深水昭吉、繁森英幸、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] 共有結合型PPARγリガンドとその類縁化合物に拠る抗炎症活性の検証2021
- Author(s)
  大前勇馬、礒田博子、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] 共有結合型PPARγリガンドとその類縁化合物に拠る抗炎症活性の検証2021
- Author(s)
  大前勇馬、礒田博子、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] 生体直交型反応を示す官能基を付加した PPARγ リガンドの合成と活性評価2021
- Author(s)
  安彩伽、大前勇馬、有本光江、加香孝一郎、礒田博子、深水昭吉、繁森英幸、宮前友策
- Organizer
  日本農芸化学会2021年大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Effect of a covalent PPARγ agonist on inflammatory pathway2020
- Author(s)
  Yuma Omae, Hiroko Isoda, Yusaku Miyamae
- Organizer
  JAACT2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Effect of a covalent PPARγ agonist on inflammatory pathway2020
- Author(s)
  Yuma Omae, Hiroko Isoda, Yusaku Miyamae
- Organizer
  JAACT2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05742
[Presentation] Biological evaluation of cinnamate-GW9662 hybrid compounds as a novel class of covalent PPARγ agonist2018
- Author(s)
  Yuki Utsugi, Hirona Kobuchi, Yukio Kawamura, Ahmed Salahelden Aboelhamd Atito, Masaya Nagao, Hiroko Isoda, Yusaku Miyamae
- Organizer
  JAACT2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] 新規共有結合性PPARγアゴニストの構造活性相関及び推定結合様式の解析2018
- Author(s)
  宇津木優樹、小渕裕菜、河村幸雄、Ahmed Salahelden Aboelhamd Atito, 永尾雅哉、礒田博子、宮前友策
- Organizer
  日本農芸化学会関東支部大会2018年度大会
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy2018
- Author(s)
  Yusaku Miyamae, Anna Ohtera, Kotaro Yoshida, Kazuhiro Maejima, Toru Akita, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao
- Organizer
  JAACT2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13264
[Presentation] オートファジー阻害剤テトランドリンの新規作用機序2015
- Author(s)
  ○宮前友策、西藤有希奈、仲井奈緒美、増田誠司、神戸大朋、永尾雅哉
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26870309
[Presentation] リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製2015
- Author(s)
  ○宮前友策、大寺杏奈、吉田光多郎、前嶋一宏、秋田徹、垣塚彰、入江一浩、増田誠司、神戸大朋、永尾雅哉
- Organizer
  第10回日本ケミカルバイオロジー学会
- Place of Presentation
  東北大学
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26870309
[Presentation] ヤセウツボ(Orobanche miner)由来化合物のアミロイドβ凝集阻害活性に関する研究2012
- Author(s)
  栗栖真奈美、宮前友策、村上一馬、Han Junkyu、礒田博子、入江一浩、繁森英幸
- Organizer
  日本農芸化学会2012 年度大会
- Place of Presentation
  京都女子大学(京都府)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御2012
- Author(s)
  宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、入江一浩、永尾雅哉
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御2012
- Author(s)
  宮前友策
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  京都大学百周年記念ホール
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御2012
- Author(s)
  宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、増田誠司、入江一浩、永尾雅哉
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都大学(京都府)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御2012
- Author(s)
  宮前友策、仲井奈緒美、翁長彰子、韓〓奎、礒田博子、芦田久、神戸大朋、入江一浩、永尾雅哉
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学(京都府)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] バンウコンからのPPARγアンタゴニスト変換活性物質の探索2012
- Author(s)
  宮前友策、吉田光多郎、大寺杏奈、仲井奈緒美、王健一、秋田徹、前嶋一宏、森直樹、入江一浩、神戸大朋、増田誠司、永尾雅哉
- Organizer
  新規素材探索研究会
- Place of Presentation
  新横浜フジビューホテル(神奈川県)
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構2011
- Author(s)
  宮前友策、栗栖真奈美、村上一馬、入江一浩、Han Junkyu、礒田博子、繁森英幸
- Organizer
  第53回天然有機化合物討論会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-23880015
[Presentation] Cooperative activation of PPARgamma by combination of irreversible antagonist and partial agonists: implication for novel activation mechanism based on covalent modification
- Author(s)
  Yusaku Miyamae, Anna Ohtera, Kotaro Yoshida, Toru Akita, Kazuhiro Maejima, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao
- Organizer
  International Chemical Biology Society, 3rd annual meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-11-17 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26870309
[Presentation] 肝線維化抑制物質テトランドリンによるオートファジー経路制御機構の解明
- Author(s)
  西藤有希奈、宮前友策、仲井奈緒美、Han Junkyu、礒田博子、増田誠司、神戸大朋、永尾雅哉
- Organizer
  第９回日本ケミカルバイオロジー学会
- Place of Presentation
  大阪大学
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26870309

1. Kambe Taiho (90303875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 繁森英幸 (70202108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 平修 (30416672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 落石知世 (30356729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGUMO Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. FUKUNAKA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 増田誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 藤原崇志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyamae Yusaku 宮前 友策

MIYAMAE Yusaku 宮前 友策

Research Projects

Research Products

Co-Researchers

多元的評価法を用いた認知機能改善に関わる食素材由来化合物の機能解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脱ユビキチン化酵素の切断機構を活用した細胞内タンパク質発現制御法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PPARγリガンドの細胞内合成を光で制御するオプトケミカルツールの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design, synthesis, and mechanism elucidation of novel covalent PPARgamma agonists that mimic the endogenous ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on a feed for improving zinc nutrition by the use of zinc transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanism by which tetrandrine modulates lipid degradation via blockade of autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on natural bioactive substance that modulate autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] カフェオイルキナ酸は神経細胞保護作用を持つ2012

Author(s)

Data Source

[Journal Article] A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The isoflavone fraction from soybean presents mRNA maturation inhibition activity.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 核内受容体PPARγのユニークな特性と新奇リガンド開発への新展開2016

Author(s)

Journal Title

Data Source

[Journal Article] Structure-Activity Relationship of Phenylpropanoid Glycosides on the Inhibition of Amyloid β2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting.2015

Miyamae Yusaku 宮前友策

MIYAMAE Yusaku 宮前友策