Matsuda Shinji 松田真司

… Alternative Names

MATSUDA Shinji 松田真司

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Researcher Number	30611321
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(歯), 講師
Affiliation (based on the past Project Information) *help	2025: 広島大学, 医系科学研究科(歯), 講師 2022 – 2023: 広島大学, 医系科学研究科(歯), 助教 2016 – 2021: 広島大学, 病院(歯), 病院助教 2013 – 2015: 広島大学, 大学病院, 病院助教 2014: 広島大学, 病院(歯), 病院助教 2014: 広島大学, 病院, 病院助教 2012: 広島大学, 病院(歯), 病院助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology / Periodontal dentistry Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology / Periodontal dentistry
Keywords	Principal Investigator 薬物性歯肉増殖症 / NR4A1 / 歯周炎 / 創薬研究 / DELスクリーニング / 創薬スクリーニング / Nr4a1 / ブチリデンフタリド / 歯学 / 歯肉増殖症 … More / メカニズム / 動物モデル / マウスモデル / シクロスポリン / アポトーシス / 歯肉上皮細胞 / 歯周組織再生 / BDNF … More Except Principal Investigator 侵襲性歯周炎 / iPS細胞 / MMD2 / 線維化 / インテグリン / 特発性歯肉線維腫症 / 薬物性歯肉増殖症 / IL-6 / SAA / CRP / 血清アミロイド　A / グリチルリチン / 歯周炎 / マウス / 血糖値 / RAGE / HMGB1 / サイトカイン / Porphyromonas gulae / 糖尿病 / 歯周病 / アポトーシスシグナル / TGF-betaレセプター / smad2リン酸化 / 歯肉上皮細胞 / 歯周病原細菌 / ERK / smad2 / IL-8 / イルソグラジンマレイン酸 / アポトーシス / 歯肉上皮 / 歯周病予防 Less

Search for novel specific molecular targets for aggressive periodontitis patients with MMD2 mutations
- Principal Investigator
  
  水野智仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
DNA-Encoded Libraryを活用したNR4A1を標的とする新規歯周炎治療薬の創薬研究Principal Investigator
- Principal Investigator
  
  松田真司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
侵襲性歯周炎の新規責任遺伝子の同定と病態解析
- Principal Investigator
  
  水野智仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
インテグリンを標的とした薬物性歯肉増殖症の新規治療法の開発
- Principal Investigator
  
  岡信愛
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
To identify novel therapy drug of Drug induced gingival overgrowth targeting NR4A1 by drug screeningPrincipal Investigator
- Principal Investigator
  
  Shinji Matsuda
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Research to develop new therapy targeting NR4A1 for drug-induced gingival overgrowthPrincipal Investigator
- Principal Investigator
  
  Matsuda Shinji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
Regulation of gingival epithelial cell's function suppresses systemic infection of periodontal pathogen.
- Principal Investigator
  
  Tsuyoshi Fujita
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
Elucidating the mechanism of drug-indcued gingival overgrowth using disease modelPrincipal Investigator
- Principal Investigator
  
  Matsuda Shinji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
The regulatory mechanism of function on gingival epithelium by irsogladine maleate
- Principal Investigator
  
  FUJITA TSUYOSHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University
Elucidation of the mechanism of BDNF-induced suppression of gingival epithelium invasion in the process of periodontal tissue regenerationPrincipal Investigator
- Principal Investigator
  
  MATSUDA Shinji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University

All 2021 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] The role of nuclear receptor 4A1 (NR4A1) in drug‐induced gingival overgrowth2021
- Author(s)
  Hatano Saki、Matsuda Shinji、Okanobu Ai、Furutama Daisuke、Memida Takumi、Kajiya Mikihito、Ouhara Kazuhisa、Fujita Tsuyoshi、Mizuno Noriyoshi、Kurihara Hidemi
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 7
- DOI
  10.1096/fj.202100032r
- Data Source
  KAKENHI-PROJECT-19K10130
[Journal Article] Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth?a cross-sectional study in a Japanese population2019
- Author(s)
  Matsuda Shinji、Okanobu Ai、Hatano Saki、Kajiya Mikihito、Sasaki Shinya、Hamamoto Yuta、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Clinical Oral Investigations
  
  Volume: - Issue: 11 Pages: 4099-4105
- DOI
  10.1007/s00784-019-02846-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11830
[Journal Article] Regulation of defensive function on gingival epithelial cells can prevent periodontal disease2018
- Author(s)
  Fujita　T., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Takemura T., Akutagawa K., Takeda K., Mizuno N., Kurihara H.
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 印刷中 Issue: 2 Pages: 66-75
- DOI
  10.1016/j.jdsr.2017.11.003
- NAID
  50013109052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-18K09599
[Journal Article] A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation.2017
- Author(s)
  Okanobu A, Matsuda S, Kajiya M, Fujita T, Kittaka M, Shiba H, Kurihara H
- Journal Title
  
  Journal of Immunological Methods
  
  Volume: 印刷中 Pages: 31-36
- DOI
  10.1016/j.jim.2017.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11830
[Journal Article] Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alfa2016
- Author(s)
  Miyagawa T., Fujita T., Yumoto H., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Shiba H., Matsuo T., Kurihara H.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 62 Pages: 64-69
- DOI
  10.1016/j.archoralbio.2015.11.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-15K15766
[Journal Article] Houttunia Cordata suppressed the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells.2015
- Author(s)
  Kabir MA., Fujita T., Ouhara K., Kajiya M., Matsuda S., Shiba H., Kurihara H.
- Journal Title
  
  Journal of Dental Sciences
  
  Volume: 10 Pages: 88-94
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24593123
[Journal Article] Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1β and tumor necrosis factor-α2015
- Author(s)
  Matsuda S, Fujita T, Kajiya M, Kashiwai K, Takeda K, Shiba H, Kurihara H.
- Journal Title
  
  Journal of periodontal research
  
  Volume: 50(4) Issue: 4 Pages: 444-451
- DOI
  10.1111/jre.12226
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26861815
[Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.2014
- Author(s)
  Kajiya M, Takeshita K, Kittaka M, Matsuda S, Ouhara K, Takeda K, Takata T, Kitagawa M, Fujita T, Shiba H, Kurihara H
- Journal Title
  
  International Immunopharmacology
  
  Volume: 19 Pages: 245-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792330
[Journal Article] Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells.2014
- Author(s)
  Imai H., Fujita T., Kajiya M., Ouhara K., Miyagawa T., Matsuda S., Shiba H., Kurihara H.
- Journal Title
  
  Celler Immunology
  
  Volume: 290 Issue: 2 Pages: 201-208
- DOI
  10.1016/j.cellimm.2014.07.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24593123, KAKENHI-PROJECT-25862051
[Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade2014
- Author(s)
  Kajiya M, Takeshita K, Kittaka M, Matsuda S, Ouhara K, Takeda K, Takata T, Kitagawa M, Fujita T, Shiba H, Kurihara H
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 19(2) Pages: 245-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792330
[Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans.2013
- Author(s)
  Miyagawa T, Fujita T, Ouhara K, Matsuda S, Kajiya M, Hayashida K, Imai H, Yoshimoto T, Iwata T, Shiba H, Abiko Y, Kurihara H.
- Journal Title
  
  International Immunopharmacology
  
  Volume: 15 Pages: 340-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792330
[Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans2013
- Author(s)
  Miyagawa T, Fujita T, Ouhara K, Matsuda S, Kajiya M, Hayashida K, Imai H, Yoshimoto T, Iwata T, Shiba H, Abiko Y, Kurihara H
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 15(2) Pages: 340-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792330
[Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans.2013
- Author(s)
  Miyagawa T
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 15 Issue: 2 Pages: 340-347
- DOI
  10.1016/j.intimp.2012.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390497, KAKENHI-PROJECT-22792085, KAKENHI-PROJECT-24593123, KAKENHI-PROJECT-24792330
[Presentation] 薬物性歯肉増殖症におけるNR4A1 の役割2018
- Author(s)
  畑野　紗希，松田　真司，岡信　愛，加治屋　幹人，古玉　大祐，應原　一久，水野　智仁，
- Organizer
  第60回春季歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-16K11830
[Presentation] 絹糸結紮による実験的歯周炎マウスモデルにおける接合上皮の経時的変化について2017
- Author(s)
  竹村　翼，藤田　剛，松田真司，加治屋幹人，内田雄士，芥川桂一，應原一久，武田克浩，水野智仁，栗原英見
- Organizer
  第60回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-15K11389
[Presentation] 糖尿病マウスにおいて誘発された歯周炎に対するGlycyrrhizinの抗炎症作用の評価2017
- Author(s)
  芥川桂一, 藤田剛, 竹村翼, 應原一久, 加冶屋幹人, 松田真司, 水野智仁, 栗原英見
- Organizer
  第38回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-15K11389
[Presentation] 歯周炎を誘発した糖尿病モデルマウスに対するGlycyrrhizinの作用について2017
- Author(s)
  芥川桂一, 藤田剛, 竹村翼, 應原一久, 加冶屋幹人, 松田真司, 田利美沙子, 水野智仁,　栗原英見
- Organizer
  日本歯周病学会60周年記念京都大会
- Data Source
  KAKENHI-PROJECT-15K11389
[Presentation] NR4A1を標的とした薬物性歯肉増殖症の新規治療法の開発2016
- Author(s)
  松田　真司、岡信愛、加治屋幹人、藤田　剛、栗原英見
- Organizer
  第32回歯科医学を中心とした総合的な研究を推進する集い
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16K11830
[Presentation] NR4A1に着目した薬物性歯肉増殖症のメカニズム解明の研究2016
- Author(s)
  岡信　愛、松田真司、加治屋幹人、藤田　剛、栗原英見
- Organizer
  第59回秋季歯周病学会学術大会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-16K11830
[Presentation] Elucidation of the role of NR4A1 in drug induced gingival overgrowth2016
- Author(s)
  岡信　愛、松田真司、加治屋幹人、藤田　剛、栗原英見
- Organizer
  第49回広島大学歯学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-16K11830
[Presentation] Porphyromonas gulae 感染糖尿病モデルマウスの歯周炎病態の評価2016
- Author(s)
  芥川桂一，藤田剛，内田雄士，竹村翼，應原一久，加冶屋幹人，松田真司，水野智仁，栗原英見
- Organizer
  第 59 回春季日本歯周病学会学術大会
- Place of Presentation
  鹿児島
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K11389
[Presentation] NR4A1に着目した薬物性歯肉増殖症のメカニズム解明の研究2016
- Author(s)
  岡信　愛、松田真司、加治屋幹人、藤田　剛、栗原英見
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-16K11830
[Presentation] Development of Calcineurin Inhibitor Induced Gingival Hyperplasia Mice Model2015
- Author(s)
  岡信　愛、松田真司, 加治屋幹人, 水野智仁, 藤田　剛, 栗原英見
- Organizer
  第6回広島カンファレンス
- Place of Presentation
  広島市
- Year and Date
  2015-10-23
- Data Source
  KAKENHI-PROJECT-26861815
[Presentation] カルシニューリン阻害薬誘導性歯肉増殖症の病態解明2015
- Author(s)
  岡信　愛、松田真司, 加治屋幹人, 内田雄士, 水野智仁, 藤田　剛, 栗原英見
- Organizer
  第58回秋季日本歯周病学会学術大会
- Place of Presentation
  浜松市
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26861815
[Presentation] 疾患モデルマウスを用いた薬物性歯肉増殖症の病態解明2015
- Author(s)
  岡信　愛、松田真司, 藤田　剛, 加治屋幹人, 内田雄士, 栗原英見
- Organizer
  第99回広島大学歯学会
- Place of Presentation
  広島市
- Year and Date
  2015-11-08
- Data Source
  KAKENHI-PROJECT-26861815
[Presentation] カルシニューリン阻害剤に誘導される歯肉増殖症の病態解明2015
- Author(s)
  岡信　愛、松田真司, 加治屋幹人, 水野智仁, 藤田　剛, 栗原英見
- Organizer
  日本歯科保存学会　2015年度春季学術大会（第142回）
- Place of Presentation
  北九州市
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-26861815
[Presentation] 脳由来神経栄養因子はヒト歯肉上皮細胞のアポトーシスカスケードを活性化する2013
- Author(s)
  柏井桂, 加治屋幹人, 藤田剛, 松田真司, 武田克浩, 柴秀樹, 栗原英見
- Organizer
  日本歯科保存学会 2013年度秋季学術大会(第139回)
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-24792330
[Presentation] Aggregatibacter actynomycetemcomitansのouter membrane protein-29はヒト歯肉上皮細胞においてsmad2を介してアポトーシスシグナルを誘導し，E-cadherinの発現を減少させる2012
- Author(s)
  吉本哲也，藤田　剛，應原一久，内田雄士，松田真司，宮川剛史，今井遥香，柴　秀樹，河口浩之，栗原英見
- Organizer
  平成24年度春季学術大会（第136回）
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24593123
[Presentation] 脳由来神経栄養因子のヒト歯肉上皮細胞に与える影響2012
- Author(s)
  柏井桂, 加治屋幹人, 藤田剛, 松田真司, 武田克浩, 柴秀樹, 栗原英見
- Organizer
  第137回日本歯科保存学会学術大会(秋季)
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24792330
[Presentation] The effect of BDNF on human gingival epithelial cells2012
- Author(s)
  K.Kashiwai, S.Matsuda, T.Fujita, M.Kajiya, K.Takeda, H.Shiba, H.Kurihara
- Organizer
  The American Academy of Periodontology
- Place of Presentation
  ロサンゼルス, アメリカ
- Data Source
  KAKENHI-PROJECT-24792330

1. FUJITA TSUYOSHI (80379883)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. 水野智仁 (60325181)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 加治屋幹人 (00633041)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. 應原一久 (80550425)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. 吉本哲也 (60758209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 岡信愛 (00806581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横崎恭之 (80210607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIYAGAWA TSUYOSHI

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. IMAI HARUKA

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AKUTAGAWA KEIICHI

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. TAKEMURA TASUKU

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

Matsuda Shinji 松田 真司

MATSUDA Shinji 松田 真司

Research Projects

Research Products

Co-Researchers

Search for novel specific molecular targets for aggressive periodontitis patients with MMD2 mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA-Encoded Libraryを活用したNR4A1を標的とする新規歯周炎治療薬の創薬研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

侵襲性歯周炎の新規責任遺伝子の同定と病態解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インテグリンを標的とした薬物性歯肉増殖症の新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To identify novel therapy drug of Drug induced gingival overgrowth targeting NR4A1 by drug screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research to develop new therapy targeting NR4A1 for drug-induced gingival overgrowthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of gingival epithelial cell's function suppresses systemic infection of periodontal pathogen.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the mechanism of drug-indcued gingival overgrowth using disease modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulatory mechanism of function on gingival epithelium by irsogladine maleate

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of BDNF-induced suppression of gingival epithelium invasion in the process of periodontal tissue regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The role of nuclear receptor 4A1 (NR4A1) in drug‐induced gingival overgrowth2021

Author(s)

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[Journal Article] Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth?a cross-sectional study in a Japanese population2019

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[Journal Article] Regulation of defensive function on gingival epithelial cells can prevent periodontal disease2018

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Matsuda Shinji 松田真司

MATSUDA Shinji 松田真司