Higuchi Takashi 樋口貴士

Researcher Number	30617626
Affiliation (Current)	2026: 独立行政法人国立病院機構東京病院(臨床研究部), 臨床研究部, 研究員 2026: 東京医科大学, 医学部, その他
Affiliation (based on the past Project Information) *help	2022 – 2025: 独立行政法人国立病院機構東京病院(臨床研究部), 臨床研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator エクソーム解析 / レアバリアント / 肺疾患 / 関節リウマチ / リウマチ性多発筋痛症 / 遺伝子解析 / 病因・病態

エクソーム解析による関節リウマチ関連間質性肺病変のレアバリアント探索Principal Investigator
- Principal Investigator
  
  樋口貴士
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo National Hospital (Clinical research)
Detection of rare variants in the pathogenesis of polymyalgia rheumatica with whole exome sequencing.Principal Investigator
- Principal Investigator
  
  Higuchi Takashi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo National Hospital (Clinical research)

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Helicobacter pylori Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease2024
- Author(s)
 Oka Shomi、Higuchi Takashi、Furukawa Hiroshi、Shimada Kota、Okamoto Akira、Fujimori Misuzu、Hashimoto Atsushi、Komiya Akiko、Saisho Koichiro、Yoshikawa Norie、Katayama Masao、Matsui Toshihiro、Fukui Naoshi、Migita Kiyoshi、Tohma Shigeto
- Journal Title
 
 Biomarker Insights
 
 Volume: 19 Pages: 1-7
- DOI
 10.1177/11772719241297171
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K16756, KAKENHI-PROJECT-23K06879, KAKENHI-PROJECT-24K10589
[Journal Article] Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease2024
- Author(s)
  Oka Shomi、Higuchi Takashi、Furukawa Hiroshi、Shimada Kota、Okamoto Akira、Fujimori Misuzu、Hashimoto Atsushi、Komiya Akiko、Saisho Koichiro、Yoshikawa Norie、Katayama Masao、Matsui Toshihiro、Fukui Naoshi、Migita Kiyoshi、Tohma Shigeto
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 13 Issue: 22 Pages: 6761-6761
- DOI
  10.3390/jcm13226761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756, KAKENHI-PROJECT-23K06879, KAKENHI-PROJECT-24K10589
[Journal Article] Association of rare single-nucleotide variant MUC5B rs35705950 with interstitial lung disease in Japanese rheumatoid arthritis2024
- Author(s)
 Higuchi Takashi、Oka Shomi、Shimada Kota、Tsunoda Shinichiro、Ito Satoshi、Okamoto Akira、Fujimori Misuzu、Nakamura Tadashi、Katayama Masao、Suzuki Michita、Saisho Koichiro、Shinohara Satoshi、Matsui Toshihiro、Migita Kiyoshi、Nagaoka Shouhei、Tohma Shigeto、Furukawa Hiroshi
- Journal Title
 
 Rheumatology
 
 Volume: -- Issue: SI Pages: SI55-SI62
- DOI
 10.1093/rheumatology/keae422
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K16756, KAKENHI-PROJECT-23K06879
[Journal Article] The contributions of deleterious rare alleles in NLRP12 and inflammasome-related genes to polymyalgia rheumatica2024
- Author(s)
  Higuchi Takashi、Oka Shomi、Furukawa Hiroshi、Tohma Shigeto
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 490-490
- DOI
  10.1038/s41598-024-51320-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Antibodies against serum anti-melanoma differentia-tion-associated gene 5 in rheumatoid arthritis patients with chronic lung diseases.2023
- Author(s)
  Oka S, Higuchi T, Furukawa H, Shimada K, Okamoto A, Hashimoto A, Komiya A, Saisho K, Yoshikawa N, Katayama M, Matsui T, Fukui N, Migita K, Tohma S
- Journal Title
  
  Medicina (Kaunas, Lithuania)
  
  Volume: 59 Issue: 2 Pages: 363-363
- DOI
  10.3390/medicina59020363
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09321, KAKENHI-PROJECT-22K09344, KAKENHI-PROJECT-22K16756, KAKENHI-PROJECT-20K09447, KAKENHI-PROJECT-20K09470
[Journal Article] Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients2023
- Author(s)
  Higuchi Takashi、Oka Shomi、Furukawa Hiroshi、Shimada Kota、Tsunoda Shinichiro、Ito Satoshi、Okamoto Akira、Fujimori Misuzu、Nakamura Tadashi、Katayama Masao、Saisho Koichiro、Shinohara Satoshi、Matsui Toshihiro、Migita Kiyoshi、Nagaoka Shouhei、Tohma Shigeto
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 11 Pages: 2084-2084
- DOI
  10.3390/genes14112084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Associations of HLA Polymorphisms with Chronic Kidney Disease in Japanese Rheumatoid Arthritis Patients2023
- Author(s)
  Higuchi Takashi、Oka Shomi、Furukawa Hiroshi、Shimada Kota、Hashimoto Atsushi、Komiya Akiko、Matsui Toshihiro、Fukui Naoshi、Tohma Shigeto
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 7 Pages: 1470-1470
- DOI
  10.3390/genes14071470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Association of aFAM13Avariant with interstitial lung disease in Japanese rheumatoid arthritis2023
- Author(s)
 Higuchi Takashi、Oka Shomi、Furukawa Hiroshi、Shimada Kota、Tsunoda Shinichiro、Ito Satoshi、Okamoto Akira、Katayama Masao、Saisho Koichiro、Shinohara Satoshi、Matsui Toshihiro、Migita Kiyoshi、Nagaoka Shouhei、Tohma Shigeto
- Journal Title
 
 RMD Open
 
 Volume: 9 Issue: 1 Pages: e002828-e002828
- DOI
 10.1136/rmdopen-2022-002828
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K16756
[Journal Article] Associations of HLA Polymorphisms with Anti-SARS-CoV-2 Spike and Neutralizing Antibody Titers in Japanese Rheumatoid Arthritis Patients Vaccinated with BNT162b22023
- Author(s)
  Higuchi Takashi、Oka Shomi、Furukawa Hiroshi、Tohma Shigeto
- Journal Title
  
  Vaccines
  
  Volume: 11 Issue: 2 Pages: 404-404
- DOI
  10.3390/vaccines11020404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Anti-SARS-CoV-2 Spike Antibody Titers and Neutralizing Antibodies in Vaccinated Rheumatoid Arthritis Patients2022
- Author(s)
  Furukawa Hiroshi、Oka Shomi、Higuchi Takashi、Nakama Moriyuki、Nagai Nobuhiro、Tohma Shigeto
- Journal Title
  
  Vaccines
  
  Volume: 10 Issue: 8 Pages: 1365-1365
- DOI
  10.3390/vaccines10081365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Detection of Anti-SARS-CoV-2 Nucleocapsid and Spike Antibodies in Patients with Coronavirus Disease 2019 in Japan2022
- Author(s)
  Furukawa Hiroshi、Oka Shomi、Higuchi Takashi、Yamaguchi Miho、Uchiyama Shota、Koiwa Tomohiro、Nakama Moriyuki、Minegishi Masaaki、Nagai Hideaki、Tohma Shigeto
- Journal Title
  
  Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
  
  Volume: 16
- DOI
  10.1177/11795484221075492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Predisposition of HLA-DRB1*04:01/*15 heterozygous genotypes to Japanese mixed connective tissue disease.2022
- Author(s)
  Oka S, Higuchi T, Furukawa H, Shimada K, Hashimoto A, Komiya A, Matsui T, Fukui N, Suematsu E, Ohno S, Kono H, Katayama M, Nagaoka S, Migita K, Tohma S.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 9916-9916
- DOI
  10.1038/s41598-022-14116-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09344, KAKENHI-PROJECT-22K16756, KAKENHI-PROJECT-20K09447, KAKENHI-PROJECT-20K09470
[Journal Article] Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese2022
- Author(s)
  Midorikawa Rie、Nakama Moriyuki、Furukawa Hiroshi、Oka Shomi、Higuchi Takashi、Nagai Hideaki、Nagai Nobuhiro、Tohma Shigeto
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 5 Pages: 965-965
- DOI
  10.3390/v14050965
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16756
[Journal Article] Lack of Association of rs12702634 in RPA3-UMAD1 With Interstitial Lung Diseases in Japanese Rheumatoid Arthritis Patients2022
- Author(s)
 Higuchi Takashi、Oka Shomi、Furukawa Hiroshi、Shimada Kota、Tohma Shigeto
- Journal Title
 
 Biomarker Insights
 
 Volume: 17
- DOI
 10.1177/11772719221091758
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K16756
[Presentation] rs35705950 MUC5Bと関節リウマチ関連間質性肺病変との関連2024
- Author(s)
  樋口貴士、岡笑美、島田浩太、角田慎一郎、伊藤聡、岡本享、藤森美鈴、中村正、片山雅夫、鈴木道太、税所幸一郎、篠原聡、松井利浩、右田清志、長岡章平、當間重人、古川宏
- Organizer
  第78回国立病院総合医学会
- Data Source
  KAKENHI-PROJECT-22K16756
[Presentation] リウマチ性多発筋痛症におけるインフラマソーム関連遺伝子のレアバリアント解析2024
- Author(s)
  樋口貴士、岡笑美、古川宏、當間重人
- Organizer
  第68回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K16756
[Presentation] 日本人リウマチ患者における慢性腎不全の発症とHLAの関係2023
- Author(s)
  樋口　貴士、岡　笑美、古川　宏、石井　知子、松永　恒明、島田　浩太、橋本　篤、小宮　明子、松井　利浩、楊川　堯基、石津　隆、福井　尚志、當間　重人
- Organizer
  第53回日本腎臓学会東部学術大会
- Data Source
  KAKENHI-PROJECT-22K16756
[Presentation] rs2736100 TERTと関節リウマチに伴う気道病変との関連2023
- Author(s)
  樋口　貴士、岡　笑美、古川　宏、島田　浩太、角田　慎一郎、伊藤　聡、岡本　享、藤森　美鈴、中村　正、片山　雅夫、税所　幸一郎、篠原　聡、松井　利浩、右田　清志、長岡　章平、當間　重人
- Organizer
  第77回国立病院総合医学会
- Data Source
  KAKENHI-PROJECT-22K16756
[Presentation] rs2609255 FAM13Aと関節リウマチ関連間質性肺病変との関連2023
- Author(s)
  樋口　貴士、岡　笑美、古川　宏、島田　浩太、角田　慎一郎、伊藤　聡、片山　雅夫、税所　幸一郎、篠原　聡、松井　利浩、右田　清志、長岡　章平、當間　重人
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K16756
[Presentation] 関節リウマチに伴う間質性肺病変とRPA3-UMAD1 rs12702634の関連2022
- Author(s)
  樋口　貴士、岡　笑美、古川　宏、島田　浩太、當間　重人
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K16756
[Presentation] リウマチ性多発筋痛症のUBA1遺伝子解析2022
- Author(s)
  樋口貴士、野木真、岡笑美、古川宏、島田浩太、橋本篤、小宮明子、松井利浩、東孝典、杉山隆夫、平野史倫、岡本亨、寶來吉朗、片山雅夫、右田清志、當間重人
- Organizer
  第76回国立病院総合医学会
- Data Source
  KAKENHI-PROJECT-22K16756

1. 福井尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Higuchi Takashi 樋口 貴士

Research Projects

Research Products

Co-Researchers

エクソーム解析による関節リウマチ関連間質性肺病変のレアバリアント探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection of rare variants in the pathogenesis of polymyalgia rheumatica with whole exome sequencing.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] <i>Helicobacter pylori</i> Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of rare single-nucleotide variant <i>MUC5B</i> rs35705950 with interstitial lung disease in Japanese rheumatoid arthritis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The contributions of deleterious rare alleles in NLRP12 and inflammasome-related genes to polymyalgia rheumatica2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibodies against serum anti-melanoma differentia-tion-associated gene 5 in rheumatoid arthritis patients with chronic lung diseases.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Associations of HLA Polymorphisms with Chronic Kidney Disease in Japanese Rheumatoid Arthritis Patients2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of a<i>FAM13A</i>variant with interstitial lung disease in Japanese rheumatoid arthritis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Associations of HLA Polymorphisms with Anti-SARS-CoV-2 Spike and Neutralizing Antibody Titers in Japanese Rheumatoid Arthritis Patients Vaccinated with BNT162b22023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-SARS-CoV-2 Spike Antibody Titers and Neutralizing Antibodies in Vaccinated Rheumatoid Arthritis Patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of Anti-SARS-CoV-2 Nucleocapsid and Spike Antibodies in Patients with Coronavirus Disease 2019 in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predisposition of HLA-DRB1*04:01/*15 heterozygous genotypes to Japanese mixed connective tissue disease.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese2022

Author(s)

Journal Title

DOI

Higuchi Takashi 樋口貴士

[Journal Article] Predisposition of HLA-DRB104:01/15 heterozygous genotypes to Japanese mixed connective tissue disease.2022