IMAIZUMI Akira 今泉晃

Researcher Number	30624051
Affiliation (based on the past Project Information) *help	2015 – 2020: 九州大学, 医学研究院, 共同研究員 2014: 九州大学, 大学院医学研究院, 共同研究員 2012 – 2014: 九州大学, 医学(系)研究科(研究院), 共同研究員
Review Section/Research Field	Principal Investigator Digestive surgery Except Principal Investigator General surgery / Basic Section 55020:Digestive surgery-related / Digestive surgery / Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 膵癌幹細胞 / STAT1 / Shh / CD24 / Hedgehogシグナル / 増殖 / 浸潤 / 腫瘍形成能 / 腫瘍形成 / 膵癌 / 幹細胞 … More Except Principal Investigator … More 増殖能 / 新規治療法開発 / 活性化リンパ球 / 膵癌 / 悪性形質誘導 / 浸潤能 / 腫瘍形成能 / Hedgehogシグナル / 抗腫瘍効果 / 運動能 / 細胞障害活性 / バイオマーカー / 治療効果予測 / 免疫療法 / リンパ球 / 癌浸潤リンパ球 / 予後予測因子 / random migration / FTYP / 癌細胞障害活性 / 治療効果 / 患者予後 / がん / リアルタイム評価システム / 定量的評価 / 抗腫瘍活性 / 樹状細胞 / ベッドサイド / リンパ球運動能 / 細胞傷害活性 / リンパ球増殖能 / 癌免疫療法 / ランダムマイグレーション / 免疫細胞療法 / TrkB / BDNF / 治療法開発 / 治療標的分子 / TrkB/BDNFシグナル / 膵癌悪性形質 / 膵癌悪性化 / ＴｒｋＢ / ＢＤＮＦ / 膵癌治療 / 診断補助因子 / GLI2 / 胆嚢癌 / 増殖 / 浸潤 / 抗癌剤感受性 / Gli2 / 転写因子 / Gli1 / スキルス胃癌 / 免疫治療 / 癌線維化 / 抗PD-1抗体 / 免疫チェックポイント / ヘッジホッグ阻害剤 / リンパ球組織浸潤 / 細胞傷害性リンパ球 / 線維化 / hedgehog阻害剤 / 免疫監視機構 / リンパ球浸潤 / 免疫チェックポイント阻害剤 / 免疫監視機構構築 / RBPJ / Notchシグナル / 肺NET / SCLC / MAML3 / 小細胞肺癌 Less

Development of new therapeutical strategy for gallbladder cancer targeting Gli2 signaling pathway
- Principal Investigator
  
  YAMASAKI Akio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of therapy for inhibition of fibrosis of schirrhous type gastric cancer using Hh inhibitor aiming establishment of immunosurveilance
- Principal Investigator
  
  NAGAI Shuntaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of new therapeutical strategy for lung NET by inhibiting Hh/Notch signaling targeting RBPJ
- Principal Investigator
  
  MORISAKI Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
Development of therapeutic strategy of pancreatic cancer by inhibition of both STAT1/Shh signaling pathways targeting pancreatic cancer stem cellPrincipal Investigator
- Principal Investigator
  
  今泉晃
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Analysis of TrkB/BDNF signaling for development of a new therapeutic strategy for pancreatic cancer
- Principal Investigator
  
  Yanai Kosuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Analysis of the mechanism of augmentation of random migration in lymphocytes and verification of the significance as a biomarker predicting therapeutic effect of immunotherapy
- Principal Investigator
  
  Morisaki Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyushu University
The development of the system estimating realtime antitumor activity of activated T lymphocytes in cancer immunotherapy
- Principal Investigator
  
  MORISAKI Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyushu University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer2021
- Author(s)
  Ichimiya Shu、Onishi Hideya、Nagao Shinjiro、Koga Satoko、Sakihama Kukiko、Nakayama Kazunori、Fujimura Akiko、Oyama Yasuhiro、Imaizumi Akira、Oda Yoshinao、Nakamura Masafumi
- Journal Title
  
  Oncol Rep
  
  Volume: 45 Pages: 997-1010
- DOI
  10.3892/or.2021.7947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09047, KAKENHI-PROJECT-19K09124, KAKENHI-PROJECT-19K22662, KAKENHI-PROJECT-18K08620, KAKENHI-PROJECT-18K08682, KAKENHI-PROJECT-18K08788
[Journal Article] Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy2020
- Author(s)
  Oyama Y, Onishi H, Koga S, Murahashi M, Ichimiya S, Nakayama K, Fujimura A, Kawamoto M, Imaizumi A, Umebayashi M, Ohuchida K, Morisaki T, Nakamura M
- Journal Title
  
  J Immunother.
  
  Volume: In press Pages: 121-133
- DOI
  10.1097/cji.0000000000000305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09047, KAKENHI-PROJECT-19K09124, KAKENHI-PROJECT-19K22662, KAKENHI-PROJECT-17K09464, KAKENHI-PROJECT-18K08620, KAKENHI-PROJECT-18K08682, KAKENHI-PROJECT-18K08788
[Journal Article] PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor.2019
- Author(s)
  Fujimura A, Nakayama K, Imaizumi A, Kawamoto M, Oyama Y, Ichimiya S, Umebayashi M, Koya N, Morisaki T, Nakagawa T, Onishi H
- Journal Title
  
  J Immunother
  
  Volume: 68(10) Pages: 1649-60
- DOI
  10.1007/s00262-019-02403-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08682, KAKENHI-PROJECT-19K09047, KAKENHI-PROJECT-19K09124, KAKENHI-PROJECT-19K22662, KAKENHI-PROJECT-17H04283
[Journal Article] RBPJ and MAML3: Potential therapeutic targets for small cell lung cancer2018
- Author(s)
  Onishi H, Ichimiya S, Yanai K, Umebayashi M, Nakamura K, Yamasaki A, Imaizumi A, Nagai S, Murahashi M, Ogata H, Morisaki T
- Journal Title
  
  Anticancer Res.
  
  Volume: 38(5) Pages: 4543-4547
- DOI
  10.21873/anticanres.12758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10792, KAKENHI-PROJECT-18K08620, KAKENHI-PROJECT-18K08788, KAKENHI-PROJECT-17H04283, KAKENHI-PROJECT-16K10603, KAKENHI-PROJECT-17K09464
[Journal Article] Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer.2017
- Author(s)
  Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Pages: 36211-36224
- DOI
  10.18632/oncotarget.16063
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08309, KAKENHI-PROJECT-16K10603, KAKENHI-PROJECT-17K10792, KAKENHI-PLANNED-26111009
[Journal Article] Hedgehog inhibition upregulates TRK expression to antagonize tumor suppression in small cell lung cancer cells.2017
- Author(s)
  Onishi H, Nakamura K, Nagai S, Yanai K, Yamasaki A, Kawamoto M, Imaizumi A, Morisaki T
- Journal Title
  
  Anticancer Res
  
  Volume: 37(9) Pages: 4987-4992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10603
[Journal Article] Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes.2016
- Author(s)
  Onishi H, Fujimura A, Oyama Y,Yamasaki A, Imaizumi A, Kawamoto M, Katano M, Umebayashi M, Morisaki T
- Journal Title
  
  Cellular Immunology
  
  Volume: 310 Pages: 199-204
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10055
[Journal Article] Sugar-carrying Polystyrenes Facilitate Harvesting of APCs from MLRs: Possible Application of Sugar-carrying Polystyrenes to Immunotherapy.2016
- Author(s)
  Imaizumi A, Onishi H, Yamasaki A, Kawamoto M, Morisaki T, Goto M, Iwama M, Akaike T, Hasumi K.
- Journal Title
  
  Anticancer Research
  
  Volume: 36(2) Pages: 673-676
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10055
[Presentation] Patched 1-interacting peptide represses fibrosis in pancreatic cancer to augment the effectiveness of immunotherapy2020
- Author(s)
  村橋睦了, 大山康博 , 大西秀哉 , 草森　浩輔 , 西川　元也 , 古賀智子 , 一宮脩 , 中山和典, 藤村晶子 , 川元真 , 今泉晃 , 梅林雅代, 大内田研宙 , 森崎隆, 中村雅史
- Organizer
  第18回日本臨床腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K08788
[Presentation] Patched 1-interacting peptide represses fibrosis in pancreatic cancer to augment the effectiveness of immunotherapy2020
- Author(s)
  村橋睦了, 大山康博 , 大西秀哉 , 草森　浩輔 , 西川　元也 , 古賀智子 , 一宮脩 , 中山和典, 藤村晶子 , 川元真 , 今泉晃 , 梅林雅代, 大内田研宙 , 森崎隆, 中村雅史
- Organizer
  第18回日本臨床腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K08682
[Presentation] Patched 1-interacting peptide represses fibrosis in pancreatic cancer to augment the effectiveness of immunotherapy2020
- Author(s)
  村橋睦了, 大山康博 , 大西秀哉 , 草森　浩輔 , 西川　元也 , 古賀智子 , 一宮脩 , 中山和典, 藤村晶子 , 川元真 , 今泉晃 , 梅林雅代, 大内田研宙 , 森崎隆, 中村雅史
- Organizer
  第18回日本臨床腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K08620
[Presentation] 新規免疫治療開発のためのリンパ球のPTPN3発現制御機構の解析2019
- Author(s)
  中山和典、大西秀哉、一宮　脩、大山康博、藤村晶子、川元　真、今泉　晃、中村雅史
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08682
[Presentation] 胆嚢癌における非古典的Hedgehog(Hh)シグナル経路：GLI2-Hhシグナル経路を標的とした治療法開発2019
- Author(s)
  一宮　脩、大西秀哉、松下章次郎、中山和典、大山康博、藤村晶子、今泉　晃、中村雅史
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08620
[Presentation] 胆嚢癌における非古典的Hedgehog(Hh)シグナル経路：GLI2-Hhシグナル経路を標的とした治療法開発2019
- Author(s)
  一宮　脩、大西秀哉、松下章次郎、中山和典、大山康博、藤村晶子、今泉　晃、中村雅史
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08788
[Presentation] 低酸素環境に焦点をおいた膵癌病態解析と新規治療法開発への応用2018
- Author(s)
  大西秀哉、山崎章生、川元　真、今泉　晃、中山和典、大山康博、藤村晶子、中村雅史
- Organizer
  第39回　日本癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-17K10698
[Presentation] 小細胞肺癌におけるRBPJおよびMAML3の生物学的意義解析2018
- Author(s)
  大西秀哉、山崎章生、川元　真、今泉　晃、大山康博、藤村晶子、中山和典、今泉　晃
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K10698
[Presentation] 小細胞肺癌におけるRBPJおよびMAML3の生物学的意義解析2018
- Author(s)
  大西秀哉、山崎章生、川元　真、今泉　晃、大山康博、藤村晶子、中山和典、今泉　晃
- Organizer
  第27回　日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-18K08788
[Presentation] 胆嚢癌における非古典的Hedgehog(Hh)シグナル経路：GLI2-Hhシグナル経路の生物学的意義の解析2018
- Author(s)
  一宮　脩、大西秀哉、松下章次郎、中山和典、大山康博、藤村晶子、今泉　晃、中村雅史
- Organizer
  第31回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-17K10698
[Presentation] PTPN3を標的とした新規免疫治療の開発：リンパ球におけるCD3-PTPN3活性化経路解析2018
- Author(s)
  中山和典、大西秀哉、一宮　脩、大山康博、藤村晶子、川元　真、今泉　晃、中村雅史
- Organizer
  第31回　日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-18K08682
[Presentation] 胆嚢癌における非古典的Hedgehog(Hh)シグナル経路：GLI2-Hhシグナル経路の生物学的意義の解析2018
- Author(s)
  一宮　脩、大西秀哉、松下章次郎、中山和典、大山康博、藤村晶子、今泉　晃、中村雅史
- Organizer
  第31回　日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-18K08620
[Presentation] Hedgehogシグナルを標的とした癌幹細胞制御療法の可能性2017
- Author(s)
  中山和典、大西秀哉、大山康弘、藤村晶子、川元　真、今泉　晃、巣山久実、中村雅史
- Organizer
  第３０回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-17K10698
[Presentation] TrkB/BDNF signaling promotes EMT mediated invasiveness and is a potential therapeutic target for gallbladder cancer2016
- Author(s)
  M. Kawamoto, H. Onishi, K. Ozono, A. Yamasaki, A. Imaizumi, M. Nakamura;
- Organizer
  ESMO2016
- Place of Presentation
  Copenhagen （Denmark）
- Year and Date
  2016-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] 神経栄養因子受容体TrkB/脳由来神経栄養因子BDNFシグナル経路の胆嚢癌における生物学的意義の解析2016
- Author(s)
  川元　真、大西　秀哉、大山　康博、藤村　晶子、山崎　章生、今泉　晃、中村　雅史
- Organizer
  第２９回　日本バイオセラピィ学会学術集会総会
- Place of Presentation
  久留米シティプラザ（福岡県・久留米市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] 神経栄養因子受容体TrkB/脳由来神経栄養因子BDNFシグナル経路の膵臓癌における生物学的意義の解析2016
- Author(s)
  大山　康博、大西　秀哉、今泉　晃、山崎　章生、川元　真、藤村　晶子
- Organizer
  第２９回　日本バイオセラピィ学会学術集会総会
- Place of Presentation
  久留米シティプラザ（福岡県・久留米市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] 低酸素環境下、活性化リンパ球および樹状細胞におけるHedgehogシグナルの生物学的役割の解析2016
- Author(s)
  大西　秀哉、藤村　晶子、大山　康博、川元　真、山崎　章生、今泉　晃、中村　雅史、森崎　隆
- Organizer
  第２９回　日本バイオセラピィ学会学術集会総会
- Place of Presentation
  久留米シティプラザ（福岡県・久留米市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K10055

1. ONISHI Hideya (30553276)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. NAGAI Shuntaro (90755240)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. YAMASAKI Akio (80404440)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. MORISAKI Takashi (90291517)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. 三好圭 (70755272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KATANO Mitsuo (10145203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Yanai Kosuke (10621055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 久保真 (60403961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中村勝也 (60585743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 中野賢二 (00315061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. MUTSUNORI Iga

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 中村雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 住本英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鎌倉幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMAIZUMI Akira 今泉 晃

Research Projects

Research Products

Co-Researchers

Development of new therapeutical strategy for gallbladder cancer targeting Gli2 signaling pathway

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapy for inhibition of fibrosis of schirrhous type gastric cancer using Hh inhibitor aiming establishment of immunosurveilance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutical strategy for lung NET by inhibiting Hh/Notch signaling targeting RBPJ

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic strategy of pancreatic cancer by inhibition of both STAT1/Shh signaling pathways targeting pancreatic cancer stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of TrkB/BDNF signaling for development of a new therapeutic strategy for pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism of augmentation of random migration in lymphocytes and verification of the significance as a biomarker predicting therapeutic effect of immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of the system estimating realtime antitumor activity of activated T lymphocytes in cancer immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RBPJ and MAML3: Potential therapeutic targets for small cell lung cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hedgehog inhibition upregulates TRK expression to antagonize tumor suppression in small cell lung cancer cells.2017

Author(s)

Journal Title

Data Source

[Journal Article] Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes.2016

Author(s)

Journal Title

Data Source

[Journal Article] Sugar-carrying Polystyrenes Facilitate Harvesting of APCs from MLRs: Possible Application of Sugar-carrying Polystyrenes to Immunotherapy.2016

IMAIZUMI Akira 今泉晃