Ohe Tomoyuki 大江知之

… Alternative Names

OOE Tomoyuki 大江知之

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Researcher Number	30624283
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 教授
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 薬学部(芝共立), 教授 2023: 慶應義塾大学, 薬学部(芝共立), 教授 2016 – 2022: 慶應義塾大学, 薬学部(芝共立), 准教授 2016: 慶應義塾大学, 薬学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Medium-sized Section 28:Nano/micro science and related fields / Medical pharmacy Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 48040:Medical biochemistry-related / Tumor diagnostics
Keywords	Principal Investigator COVID-19 / SARS-CoV-2 / フラーレン / 肝毒性 / 創薬化学 / ラベタロール / 反応性代謝 / リモナバン / ネビラピン / ジクロフェナク … More / ベンズブロマロン / トラッピング剤 / 反応性代謝物 / 代謝活性化 / 薬物代謝 … More Except Principal Investigator 胆道・膵臓がん / 膵臓がん / 胆道がん / 抗真菌薬 / オルガノイド / 化合物 / p62 / プローブ / 低分子化合物 / オートファジープローブ / Keap1 / LC3 / Nrf2 / 選択的オートファジー / オートファジー / 幹細胞 / 癌 / 個別化治療 / エピゲノム / マイクロRNA / オルガノイド培養 / がん幹細胞 Less

細胞内移行型反応性代謝物トラッピング剤の開発Principal Investigator
- Principal Investigator
  
  大江知之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Keio University
新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製Principal Investigator
- Principal Investigator
  
  大江知之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Keio University
Discovery of novel therapeutic agents for biliary tract and pancreatic cancer based on antifungal agents
- Principal Investigator
  
  Yoshimasa Saito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Monitoring autophagy dynamics in vivo using innovative tools
- Principal Investigator
  
  Komatsu Masaaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Juntendo University
  Niigata University
Strategic drug design to avoid metabolic activation of hapatotoxic drugsPrincipal Investigator
- Principal Investigator
  
  Ohe Tomoyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Keio University
Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cells
- Principal Investigator
  
  Saito Yoshimasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] Fullerene derivatives as antiviral and anticancer agents, in Handbook of Fullerene Science and Technology2021
- Author(s)
  Ohe, T., Mashino, T.
- Total Pages
  850
- Publisher
  Springer
- ISBN
  9789811689932
- Data Source
  KAKENHI-PROJECT-21K18881
[Journal Article] Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease2023
- Author(s)
  Daiki Katagishi, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino, Tomoyuki Ohe
- Journal Title
  
  Bioorg Med Chem Lett .
  
  Volume: 80 Pages: 129121-129121
- DOI
  10.1016/j.bmcl.2022.129121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18881
[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021
- Author(s)
  Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41467-020-20185-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-19K16344, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-16H06276
[Journal Article] Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line2020
- Author(s)
  Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino
- Journal Title
  
  Free Radical Research
  
  Volume: Mar 30 Issue: 11-12 Pages: 1-13
- DOI
  10.1080/10715762.2020.1732955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16322, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K19417
[Journal Article] Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.2018
- Author(s)
  Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 28 Issue: 23-24 Pages: 3708-3711
- DOI
  10.1016/j.bmcl.2018.10.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08200, KAKENHI-PROJECT-16K08379
[Journal Article] Strategic Drug Design to Avoid the Metabolic Activation of Hepatotoxic Drugs2017
- Author(s)
  大江知之, 高橋恭子, 中村成夫, 増野匡彦
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 3 Pages: 249-255
- DOI
  10.1248/yakushi.16-00230-1
- NAID
  130005396870
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-03-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] COVID-19治療薬としてのフラーレン誘導体の開発2023
- Author(s)
  片岸大紀、安田大輔、高橋恭子、中村成夫、増野匡彦、熊谷直哉、大江知之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K18881
[Presentation] マロン酸型フラーレン誘導体はSARS-CoV-2メインプロテアーゼを強く阻害する2022
- Author(s)
  片岸大紀、岩﨑彩希子、安田大輔、高橋恭子、中村成夫、増野匡彦、熊谷直哉、大江知之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K18881
[Presentation] Stereoselective synthesis and evaluation of fullerene derivatives as antiviral drugs2021
- Author(s)
  Katagishi D., Takahashi K., Nakamura S., Mashino T., Ohe T.
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18881
[Presentation] ハードな反応性代謝物を捕捉する新規蛍光標識化トラッピング剤の創製2019
- Author(s)
  長邑花、柴崎智香子、髙橋恭子、中村成夫、大江知之、増野匡彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] フッ素導入により反応性代謝物の生成を回避した改良型Diclofenac類縁体の創製2019
- Author(s)
  小川真依、山田晶子、安田大輔、高橋恭子、中村成夫、大江知之、増野匡彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ハード及びソフトな反応性代謝物を捕捉する新規蛍光標識トラッピング剤の創製2019
- Author(s)
  柴崎智香子、髙橋恭子、中村成夫、大江知之、増野匡彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] グルクロン酸抱合経由の代謝活性化を回避したジクロフェナク類縁体の創製2018
- Author(s)
  山田晶子, 大江知之, 小川真依, 高橋恭子, 中村成夫, 増野匡彦
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] Synthesis and biological evaluation of novel nevirapine analogs designed to avoid metabolic activation2018
- Author(s)
  Yasuhiro Tateishi, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs2017
- Author(s)
  大江知之
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ADMET研究と創薬化学を融合した新しいアカデミア創薬2017
- Author(s)
  大江知之
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] 代謝活性化を回避した新規ベンズブロマロン類縁体の合成およびその毒性評価2017
- Author(s)
  梅沢隆太郎, 北川原弓奈, 高橋恭子, 中村成夫, 阿部晃子, 関根修一, 伊藤晃成, 大江知之, 増野匡彦
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ネビラピンA環及びB環の変換により代謝活性化を回避した新規誘導体の合成2017
- Author(s)
  立石泰寛, 藤澤眞太郎, 高橋恭子, 中村成夫, 大江知之, 増野匡彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08379

1. Saito Yoshimasa (90360114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SATO Toshiro (70365245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KANAI Yae (00260315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Komatsu Masaaki (90356254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安西尚彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 曽友深

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 安田大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohe Tomoyuki 大江 知之

OOE Tomoyuki 大江 知之

Research Projects

Research Products

Co-Researchers

細胞内移行型反応性代謝物トラッピング剤の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of novel therapeutic agents for biliary tract and pancreatic cancer based on antifungal agents

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Monitoring autophagy dynamics in vivo using innovative tools

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategic drug design to avoid metabolic activation of hapatotoxic drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Fullerene derivatives as antiviral and anticancer agents, in Handbook of Fullerene Science and Technology2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strategic Drug Design to Avoid the Metabolic Activation of Hepatotoxic Drugs2017

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Presentation] COVID-19治療薬としてのフラーレン誘導体の開発2023

Author(s)

Organizer

Data Source

Ohe Tomoyuki 大江知之

OOE Tomoyuki 大江知之