• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Ohe Tomoyuki  大江 知之

ORCIDConnect your ORCID iD *help
… Alternative Names

OOE Tomoyuki  大江 知之

Less
Researcher Number 30624283
Other IDs
Affiliation (Current) 2022: 慶應義塾大学, 薬学部(芝共立), 准教授
Affiliation (based on the past Project Information) *help 2016 – 2022: 慶應義塾大学, 薬学部(芝共立), 准教授
2016: 慶應義塾大学, 薬学部, 准教授
Review Section/Research Field
Principal Investigator
Medical pharmacy / Medium-sized Section 28:Nano/micro science and related fields
Except Principal Investigator
Tumor diagnostics / Basic Section 48040:Medical biochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
薬物代謝 / 代謝活性化 / 反応性代謝物 / トラッピング剤 / ベンズブロマロン / ジクロフェナク / ネビラピン / リモナバン / 反応性代謝 / ラベタロール … More / 創薬化学 / 肝毒性 / フラーレン / SARS-CoV-2 / COVID-19 … More
Except Principal Investigator
胆道・膵臓がん / 胆道がん / 膵臓がん / がん幹細胞 / オルガノイド培養 / マイクロRNA / エピゲノム / 個別化治療 / 癌 / 幹細胞 / オートファジー / 選択的オートファジー / Nrf2 / LC3 / Keap1 / オートファジープローブ / 低分子化合物 / プローブ / p62 / 化合物 / 抗真菌薬 / オルガノイド Less
  • Research Projects

    (5 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (17 People)
  •  新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製Principal Investigator

    • Principal Investigator
      大江 知之
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 28:Nano/micro science and related fields
    • Research Institution
      Keio University
  •  抗真菌薬を基盤とした胆道・膵臓がんに対する新規治療薬の創製

    • Principal Investigator
      齋藤 義正
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Keio University
  •  Monitoring autophagy dynamics in vivo using innovative tools

    • Principal Investigator
      Komatsu Masaaki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Juntendo University
      Niigata University
  •  Strategic drug design to avoid metabolic activation of hapatotoxic drugsPrincipal Investigator

    • Principal Investigator
      Ohe Tomoyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Keio University
  •  Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cells

    • Principal Investigator
      Saito Yoshimasa
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor diagnostics
    • Research Institution
      Keio University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

    • Author(s)
      Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
    • Journal Title

      Nat Commun.

      Volume: 12 Pages: 1-16

    • DOI

      10.1038/s41467-020-20185-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-19K16344, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20H03415
  • [Journal Article] Inhibitors of the protein?protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line2020

    • Author(s)
      Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino
    • Journal Title

      Free Radical Research

      Volume: Mar 30 Pages: 1-13

    • DOI

      10.1080/10715762.2020.1732955

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16322, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-18H02611
  • [Journal Article] Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.2018

    • Author(s)
      Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 28 Pages: 3708-3711

    • DOI

      10.1016/j.bmcl.2018.10.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08200, KAKENHI-PROJECT-16K08379
  • [Journal Article] Strategic Drug Design to Avoid the Metabolic Activation of Hepatotoxic Drugs2017

    • Author(s)
      大江 知之, 高橋 恭子, 中村 成夫, 増野 匡彦
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 3 Pages: 249-255

    • DOI

      10.1248/yakushi.16-00230-1

    • NAID

      130005396870

    • ISSN
      0031-6903, 1347-5231
    • Language
      Japanese
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] ハードな反応性代謝物を捕捉する新規蛍光標識化トラッピング剤の創製2019

    • Author(s)
      長邑花、柴崎智香子、髙橋恭子、中村成夫、大江知之、増野匡彦
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] フッ素導入により反応性代謝物の生成を回避した改良型Diclofenac類縁体の創製2019

    • Author(s)
      小川 真依、山田晶子、安田大輔、高橋恭子、中村成夫、大江知之、増野匡彦
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] ハード及びソフトな反応性代謝物を捕捉する新規蛍光標識トラッピング剤の創製2019

    • Author(s)
      柴崎智香子、髙橋恭子、中村成夫、大江知之、増野匡彦
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] グルクロン酸抱合経由の代謝活性化を回避したジクロフェナク類縁体の創製2018

    • Author(s)
      山田 晶子, 大江 知之, 小川 真依, 高橋 恭子, 中村 成夫, 増野 匡彦
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] Synthesis and biological evaluation of novel nevirapine analogs designed to avoid metabolic activation2018

    • Author(s)
      Yasuhiro Tateishi, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino
    • Organizer
      2018 International Meeting on 22nd MDO and 33rd JSSX
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs2017

    • Author(s)
      大江 知之
    • Organizer
      日本薬物動態学会第32回年会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] ADMET研究と創薬化学を融合した新しいアカデミア創薬2017

    • Author(s)
      大江 知之
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] 代謝活性化を回避した新規ベンズブロマロン類縁体の合成およびその毒性評価2017

    • Author(s)
      梅沢 隆太郎, 北川原 弓奈, 高橋 恭子, 中村 成夫, 阿部 晃子, 関根 修一, 伊藤 晃成, 大江 知之, 増野 匡彦
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-16K08379
  • [Presentation] ネビラピンA環及びB環の変換により代謝活性化を回避した新規誘導体の合成2017

    • Author(s)
      立石 泰寛, 藤澤 眞太郎, 高橋 恭子, 中村 成夫, 大江 知之, 増野 匡彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K08379
  • 1.  Saito Yoshimasa (90360114)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  SATO Toshiro (70365245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  KANAI Yae (00260315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  Komatsu Masaaki (90356254)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  ICHIMURA Yoshinobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  NODA Nobuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  SUGIURA Yuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  安西 尚彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  曽 友深
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  蔭山 俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  能代 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  本橋 ほづみ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  崎村 建司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  和栗 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  田村 直輝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  安田 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  山本 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to connect your ORCID iD to this researcher?
* This action can be performed only by the researcher themselves.

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi