Ohe Tomoyuki 大江知之

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OOE Tomoyuki 大江知之

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Researcher Number	30624283
Other IDs
Affiliation (Current)	2022: 慶應義塾大学, 薬学部(芝共立), 准教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 慶應義塾大学, 薬学部(芝共立), 准教授 2016: 慶應義塾大学, 薬学部, 准教授
Review Section/Research Field	Principal Investigator Medical pharmacy / Medium-sized Section 28:Nano/micro science and related fields Except Principal Investigator Tumor diagnostics / Basic Section 48040:Medical biochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 薬物代謝 / 代謝活性化 / 反応性代謝物 / トラッピング剤 / ベンズブロマロン / ジクロフェナク / ネビラピン / リモナバン / 反応性代謝 / ラベタロール … More / 創薬化学 / 肝毒性 / フラーレン / SARS-CoV-2 / COVID-19 … More Except Principal Investigator 胆道・膵臓がん / 胆道がん / 膵臓がん / がん幹細胞 / オルガノイド培養 / マイクロRNA / エピゲノム / 個別化治療 / 癌 / 幹細胞 / オートファジー / 選択的オートファジー / Nrf2 / LC3 / Keap1 / オートファジープローブ / 低分子化合物 / プローブ / p62 / 化合物 / 抗真菌薬 / オルガノイド Less

新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製Principal Investigator
- Principal Investigator
  
  大江知之
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Keio University
抗真菌薬を基盤とした胆道・膵臓がんに対する新規治療薬の創製
- Principal Investigator
  
  齋藤義正
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Monitoring autophagy dynamics in vivo using innovative tools
- Principal Investigator
  
  Komatsu Masaaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Juntendo University
  Niigata University
Strategic drug design to avoid metabolic activation of hapatotoxic drugsPrincipal Investigator
- Principal Investigator
  
  Ohe Tomoyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Keio University
Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cells
- Principal Investigator
  
  Saito Yoshimasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Keio University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021
- Author(s)
  Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
- Journal Title
  
  Nat Commun.
  
  Volume: 12 Pages: 1-16
- DOI
  10.1038/s41467-020-20185-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-19K16344, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20H03415
[Journal Article] Inhibitors of the protein?protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line2020
- Author(s)
  Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino
- Journal Title
  
  Free Radical Research
  
  Volume: Mar 30 Pages: 1-13
- DOI
  10.1080/10715762.2020.1732955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16322, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-18H02611
[Journal Article] Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.2018
- Author(s)
  Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 28 Pages: 3708-3711
- DOI
  10.1016/j.bmcl.2018.10.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08200, KAKENHI-PROJECT-16K08379
[Journal Article] Strategic Drug Design to Avoid the Metabolic Activation of Hepatotoxic Drugs2017
- Author(s)
  大江知之, 高橋恭子, 中村成夫, 増野匡彦
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 3 Pages: 249-255
- DOI
  10.1248/yakushi.16-00230-1
- NAID
  130005396870
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ハードな反応性代謝物を捕捉する新規蛍光標識化トラッピング剤の創製2019
- Author(s)
  長邑花、柴崎智香子、髙橋恭子、中村成夫、大江知之、増野匡彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] フッ素導入により反応性代謝物の生成を回避した改良型Diclofenac類縁体の創製2019
- Author(s)
  小川真依、山田晶子、安田大輔、高橋恭子、中村成夫、大江知之、増野匡彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ハード及びソフトな反応性代謝物を捕捉する新規蛍光標識トラッピング剤の創製2019
- Author(s)
  柴崎智香子、髙橋恭子、中村成夫、大江知之、増野匡彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] グルクロン酸抱合経由の代謝活性化を回避したジクロフェナク類縁体の創製2018
- Author(s)
  山田晶子, 大江知之, 小川真依, 高橋恭子, 中村成夫, 増野匡彦
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] Synthesis and biological evaluation of novel nevirapine analogs designed to avoid metabolic activation2018
- Author(s)
  Yasuhiro Tateishi, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs2017
- Author(s)
  大江知之
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ADMET研究と創薬化学を融合した新しいアカデミア創薬2017
- Author(s)
  大江知之
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] 代謝活性化を回避した新規ベンズブロマロン類縁体の合成およびその毒性評価2017
- Author(s)
  梅沢隆太郎, 北川原弓奈, 高橋恭子, 中村成夫, 阿部晃子, 関根修一, 伊藤晃成, 大江知之, 増野匡彦
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08379
[Presentation] ネビラピンA環及びB環の変換により代謝活性化を回避した新規誘導体の合成2017
- Author(s)
  立石泰寛, 藤澤眞太郎, 高橋恭子, 中村成夫, 大江知之, 増野匡彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08379

1. Saito Yoshimasa (90360114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SATO Toshiro (70365245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KANAI Yae (00260315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Komatsu Masaaki (90356254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. ICHIMURA Yoshinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. NODA Nobuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SUGIURA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 安西尚彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 曽友深

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 蔭山俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 能代大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 崎村建司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 和栗聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田村直輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 安田大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohe Tomoyuki 大江 知之

OOE Tomoyuki 大江 知之

Research Projects

Research Products

Co-Researchers

新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗真菌薬を基盤とした胆道・膵臓がんに対する新規治療薬の創製

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Monitoring autophagy dynamics in vivo using innovative tools

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategic drug design to avoid metabolic activation of hapatotoxic drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibitors of the protein?protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strategic Drug Design to Avoid the Metabolic Activation of Hepatotoxic Drugs2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] ハードな反応性代謝物を捕捉する新規蛍光標識化トラッピング剤の創製2019

Author(s)

Organizer

Data Source

[Presentation] フッ素導入により反応性代謝物の生成を回避した改良型Diclofenac類縁体の創製2019

Author(s)

Organizer

Data Source

[Presentation] ハード及びソフトな反応性代謝物を捕捉する新規蛍光標識トラッピング剤の創製2019

Author(s)

Organizer

Data Source

[Presentation] グルクロン酸抱合経由の代謝活性化を回避したジクロフェナク類縁体の創製2018

Author(s)

Organizer

Data Source

[Presentation] Synthesis and biological evaluation of novel nevirapine analogs designed to avoid metabolic activation2018

Author(s)

Organizer

Data Source

[Presentation] Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs2017

Author(s)

Ohe Tomoyuki 大江知之

OOE Tomoyuki 大江知之