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Toyokawa Gouji  豊川 剛二

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TOYOKAWA Gouji  豊川 剛二

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Researcher Number 30627261
Affiliation (Current) 2025: 東京大学, 医学部附属病院, 助教
2025: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科医師
Affiliation (based on the past Project Information) *help 2018 – 2022: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科医師
2018 – 2019: 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 呼吸器腫瘍科医師
2017: 九州大学, 大学病院, 助教
2016: 九州大学, 医学研究院, 助教
2015 – 2016: 九州大学, 医学研究員, 助教
2015: 九州大学, 医学(系)研究科(研究院), 助教
2014: 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他
Review Section/Research Field
Principal Investigator
Tumor biology / Tumor therapeutics
Except Principal Investigator
Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Digestive surgery
Keywords
Principal Investigator
肺癌 / 免疫学 / 手術 / 肺腺癌 / 免疫療法 / EZH2 / PD-L1 / 耐性獲得機序 / 次世代ALK阻害剤 / 耐性機序 / ALK阻害剤 / ALK融合遺伝子 / 非小細胞肺癌 … More
Except Principal Investigator
… More 肺癌 / バイオマーカー / 悪性度獲得メカニズム / 宿主内細菌叢 / 気道内細菌叢 / 肺癌悪性度 / 菌種 / 多様性 / 腸内細菌叢 / 口腔内細菌叢 / IDO / 腫瘍浸潤リンパ球 / 免疫療法 / 悪性胸膜中皮腫 / 創薬 / プロテオーム / Sphere / 化合物ライブラリー / 造血幹細胞 / がん幹細胞 / 集学的治療 / Type IVcollagen / plasma fibronectin / 腹膜播種 / sphere / シグナル伝達 / トランスレーショナルリサーチ / 薬剤反応性 / 細胞・組織 / 外科 / 癌 / 抗線維化 / 抗炎症 / 繊維化サイトカイン / 間質性肺炎合併肺癌 / 線維化サイトカイン / 間質性肺炎合併 / 非小細胞肺癌 / 予後 / 悪性度 / 線維化 / 間質性肺炎 / 予後因子 / 悪性度獲得 / 炎症性バイオマーカー / 炎症性サイトカイン / 線維性サイトカイン / driver mutation / PD-1 / 呼吸器悪性腫瘍 / 免疫チェックポイント Less
  • Research Projects

    (7 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (51 People)
  •  The diversity and specific composition of the oral and gut microbiota in lung cancer patients

    • Principal Investigator
      Shoji Fumihiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      National Hospital Organization, Kyushu Cancer Center
      National Hospital Organization, Kyushu Medical Center (Clinical Institute)
  •  Novel immunotherapy targetting immunosuppressive effector IDO1 for malignant pleural mesothelioma

    • Principal Investigator
      TAGAWA Tetsuzo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Kyushu University
  •  The role of inflammation and fibrosis through the malignant process in lung cancer

    • Principal Investigator
      Fumihiro Shoji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      National Hospital Organization, Kyushu Medical Center (Clinical Institute)
      Kyushu University
  •  Elucidation of molecular mechanism of the regulation of PD-L1 expression by histone methylationPrincipal Investigator

    • Principal Investigator
      Toyokawa Gouji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      National Hospital Organization, Kyushu Medical Center (Clinical Institute)
      Kyushu University
  •  Comprehensive analysis of resistance mechanism against ALK inhibitors and treatment strategy against such resistance mechanismPrincipal Investigator

    • Principal Investigator
      TOYOKAWA Gouji
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Kyushu University
  •  Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

    • Principal Investigator
      Maehara Yoshihiko
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Digestive surgery
    • Research Institution
      Fukuoka Dental College
      Kyushu University
  •  Clinicopathological analysis of expression of immune checkpoint molecules in patient with resected lung cancer

    • Principal Investigator
      Mitsuhiro Takenoyama
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      National Hospital Organization, Kyushu Cancer Center

All 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype2020

    • Author(s)
      Kazuki Takada , Gouji Toyokawa , Fumihiko Kinoshita , Tomoko Jogo, Kenichi Kohashi, Sho Wakasu, Yuki Ono, Kensuke Tanaka, Taro Oba, Atsushi Osoegawa, Tetsuzo Tagawa, Koichi Azuma, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Masaki Mori
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 146 Pages: 26392650-26392650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08787
  • [Journal Article] Complete Blood Cell Count-Derived Inflammatory Biomarkers in Early-Stage Non-Small-Cell Lung Cancer2020

    • Author(s)
      Shoji Fumihiro、Kozuma Yuka、Toyokawa Gouji、Yamazaki Koji、Takeo Sadanori
    • Journal Title

      ATCS

      Volume: 26 Issue: 5 Pages: 248-255

    • DOI

      10.5761/atcs.oa.19-00315

    • NAID

      130007928557

    • ISSN
      1341-1098, 2186-1005
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10793
  • [Journal Article] Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients2019

    • Author(s)
      Takamori Shinkichi、Takada Kazuki、Azuma Koichi、Jogo Tomoko、Shimokawa Mototsugu、Toyokawa Gouji、Hirai Fumihiko、Tagawa Tetsuzo、Kawahara Akihiko、Akiba Jun、Okamoto Isamu、Nakanishi Yoichi、Oda Yoshinao、Hoshino Tomoaki、Maehara Yoshihiko
    • Journal Title

      Annals of Surgical Oncology

      Volume: 26 Issue: 6 Pages: 1916-1924

    • DOI

      10.1245/s10434-019-07231-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05792
  • [Journal Article] A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma2019

    • Author(s)
      Matsubara Taichi、Takada Kazuki、Azuma Koichi、Takamori Shinkichi、Toyokawa Gouji、Haro Akira、Osoegawa Atsushi、Tagawa Tetsuzo、Kawahara Akihiko、Akiba Jun、Okamoto Isamu、Nakanishi Yoichi、Oda Yoshinao、Hoshino Tomoaki、Maehara Yoshihiko
    • Journal Title

      Annals of Surgical Oncology

      Volume: 26 Issue: 6 Pages: 1925-1933

    • DOI

      10.1245/s10434-019-07257-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05792
  • [Journal Article] A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas2019

    • Author(s)
      Toyokawa Gouji、Takada Kazuki、Tagawa Tetsuzo、Hamamoto Ryuji、Yamada Yuichi、Shimokawa Mototsugu、Oda Yoshinao、Maehara Yoshihiko
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 107 Issue: 2 Pages: 393-400

    • DOI

      10.1016/j.athoracsur.2018.08.056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15645, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-17K14994
  • [Journal Article] Clinical and Genetic Implications of Mutation Burden in Squamous Cell Carcinoma of the Lung2018

    • Author(s)
      Okamoto Tatsuro、Takada Kazuki、Sato Seijiro、Toyokawa Gouji、Tagawa Tetsuzo、Shoji Fumihiro、Nakanishi Ryota、Oki Eiji、Koike Terumoto、Nagahashi Masayuki、Ichikawa Hiroshi、Shimada Yoshifumi、Watanabe Satoshi、Kikuchi Toshiaki、Akazawa Kouhei、Lyle Stephen、Takabe Kazuaki、Okuda Shujiro、Sugio Kenji
    • Journal Title

      Annals of Surgical Oncology

      Volume: 25 Issue: 6 Pages: 1564-1571

    • DOI

      10.1245/s10434-018-6401-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09168, KAKENHI-PROJECT-15K10235, KAKENHI-PROJECT-15K10263, KAKENHI-PROJECT-15K15316, KAKENHI-PROJECT-15H05792
  • [Journal Article] Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma2018

    • Author(s)
      Kozuma Yuka、Takada Kazuki、Toyokawa Gouji、Kohashi Kenichi、Shimokawa Mototsugu、Hirai Fumihiko、Tagawa Tetsuzo、Okamoto Tatsuro、Oda Yoshinao、Maehara Yoshihiko
    • Journal Title

      European Journal of Cancer

      Volume: 101 Pages: 20-29

    • DOI

      10.1016/j.ejca.2018.06.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08722, KAKENHI-PROJECT-17K11511, KAKENHI-PROJECT-15H05792
  • [Journal Article] Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients2018

    • Author(s)
      Katsura Masakazu、Shoji Fumihiro、Okamoto Tatsuro、Shimamatsu Shinichiro、Hirai Fumihiko、Toyokawa Gouji、Morodomi Yosuke、Tagawa Tetsuzo、Oda Yoshinao、Maehara Yoshihiko
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 1 Pages: 154-165

    • DOI

      10.1111/cas.13422

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05792
  • [Journal Article] W‘ALK’ Into the Next Stage.2017

    • Author(s)
      Toyokawa G, Seto T, Takenoyama M, Ichinose Y.
    • Journal Title

      Clinical Lung Cancer

      Volume: 18 Issue: 2 Pages: 122-126

    • DOI

      10.1016/j.cllc.2016.10.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Journal Article] Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma2016

    • Author(s)
      Ohba T, Toyokawa G, Osoegawa A, Hirai F, Yamaguchi M, Taguchi K, Seto T, Takenoyama M,
    • Journal Title

      Surg Today

      Volume: 46 Issue: 9 Pages: 1091-1098

    • DOI

      10.1007/s00595-015-1295-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Journal Article] Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer2016

    • Author(s)
      Takenaka T, Inamasu E, Yoshida T, Toyokawa G, Nosaki K, Hirai F, Yamaguchi M, Seto T, Takenoyama M, Ichinose Y
    • Journal Title

      Surg Today

      Volume: 46 Issue: 4 Pages: 430-436

    • DOI

      10.1007/s00595-015-1200-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Journal Article] Insights into brain metastasis in patients with ALK+ lung cancer: is the brain truly a sanctuary?2015

    • Author(s)
      Toyokawa G, Seto T, Takenoyama M, Ichinose Y.
    • Journal Title

      Cancer Metastasis Rev

      Volume: 34 Issue: 4 Pages: 797-805

    • DOI

      10.1007/s10555-015-9592-y

    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Journal Article] Identification of a Novel ALK G1123S Mutation in a Patient with ALK-rearranged Non-small-cell Lung Cancer Exhibiting Resistance to Ceritinib.2015

    • Author(s)
      Toyokawa G, Inamasu E, Shimamatsu S, Yoshida T, Nosaki K, Hirai F, Yamaguchi M, Seto T, Takenoyama M, Ichinose Y.
    • Journal Title

      J Thorac Oncol

      Volume: 10 Issue: 7 Pages: e55-e57

    • DOI

      10.1097/jto.0000000000000509

    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Journal Article] Updated Evidence on the Mechanisms of Resistance to ALK Inhibitors and Strategies to Overcome Such Resistance: Clinical and Preclinical Data.2015

    • Author(s)
      Toyokawa G, Seto T.
    • Journal Title

      Oncol Res Treat

      Volume: 38 Issue: 6 Pages: 291-8

    • DOI

      10.1159/000430852

    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Journal Article] Impact of the epidermal growth factor receptor mutation status on the post-recurrence survival of patients with surgically resected non-small-cell lung cancerdagger2014

    • Author(s)
      Takenaka T, Takenoyama M, Yamaguchi M, Toyozawa R, Inamasu E, Kojo M, Toyokawa G, Yoshida T, Shiraishi Y, Morodomi Y, Hirai F, Taguchi K, Shimokawa M, Seto T, Ichinose Y
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 47(3) Issue: 3 Pages: 550-555

    • DOI

      10.1093/ejcts/ezu227

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Journal Article] Secondary Mutations at I1171 in the ALK Gene Confer Resistance to Both Crizotinib and Alectinib2014

    • Author(s)
      Toyokawa G, Hirai F, Inamasu E, Yoshida T, Nosaki K, Takenaka T, Yamaguchi M, Seto T,
    • Journal Title

      J Thorac Oncol

      Volume: 9(12) Issue: 12 Pages: e86-e87

    • DOI

      10.1097/jto.0000000000000358

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Journal Article] Experience with erlotinib in lung adenocarcinoma harboring a coexisting KIF5B-RET fusion gene and EGFR mutation: report of a rare case2014

    • Author(s)
      Hirai F, Takenoyama M, Taguchi K, Toyozawa R, Inamasu E, Toyokawa G, Yoshida T, Shiraishi Y, Takenaka T, Yamaguchi M, Ushijima C, Seto T, Takeo S, Ichinose Y
    • Journal Title

      J Thorac Oncol

      Volume: 9(5) Issue: 5 Pages: e37-e39

    • DOI

      10.1097/jto.0000000000000097

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Presentation] Preoperative complete blood cell count-derived inflammation biomarkers for postoperative recurrence in early-staged non-small cell lung cancer patients2019

    • Author(s)
      Fumihiro Shoji, Yuka Kozuma, Gouji Toyokawa, Koji Yamazaki and Sadanori Takeo
    • Organizer
      2019 World Conference on Lung Cancer
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10793
  • [Presentation] 病理病期IA期非小細胞肺癌における術前炎症性バイオマーカーの意義に関する検討2019

    • Author(s)
      庄司文裕、上妻由佳、豊川剛二、山﨑宏司、竹尾貞徳
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10793
  • [Presentation] 病理病期IA期非小細胞肺癌における術前Systemic immune-inflammation indexの意義2019

    • Author(s)
      庄司文裕、上妻由佳、豊川剛二、山﨑宏司、竹尾貞徳
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K10793
  • [Presentation] 肺腺癌切除例におけるヒストンメチル化酵素EZH2とPD-L1との関連の検討2018

    • Author(s)
      豊川剛二
    • Organizer
      第118回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K14994
  • [Presentation] A positive correlation between EZH2 and PD-L1 expression in resected lung adenocarcinomas2018

    • Author(s)
      Gouji Toyokawa, Kazuki Takada, Yuichi Yamada, Tetsuzo Tagawa, Fumihiro Shoji, Koji Yamazaki, Sadanori Takeo, Yoshinao Oda
    • Organizer
      European Society of Medical Oncology, 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14994
  • [Presentation] 肺腺癌切除例におけるヒストンメチル化酵素EZH2とPD-L1との関連の検討2018

    • Author(s)
      豊川剛二、田川哲三、髙田和樹、木下郁彦、上妻由佳、松原太一、原武直紀、髙森信吉、赤嶺貴紀、平井文彦、前原喜彦
    • Organizer
      第118回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K14994
  • [Presentation] Treatment Strategy for Patients with the Acquired Resistance against ALK Inhibitors2016

    • Author(s)
      Gouji Toyokawa
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-12-19
    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Presentation] Pulmonary resection and reconstruction after induction chemoradiotherapy for locally advanced non-small cell lung cancer.2016

    • Author(s)
      OkamotoT, Shoji F, Morodomi Y, Toyokawa G, Suzuki Y, Fujishita T, Katsura M, Takada K, Akamine T, Takamori S, Maehara Y.
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-15H05792
  • [Presentation] I期非小細胞肺癌におけるsarcopeniaの意義と免疫栄養・炎症関連指数との関連性の検討2016

    • Author(s)
      庄司 文裕、松原 太一、上妻 由佳、原武 直紀、赤嶺 貴紀、高森 信吉、桂  正和、高田 和樹、豊川 剛二、岡本 龍郎、前原 喜彦
    • Organizer
      第54回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-20
    • Data Source
      KAKENHI-PROJECT-15H05792
  • [Presentation] Pure GGOを呈する肺癌切除例におけるEGFRとALKの解析2015

    • Author(s)
      豊川剛二, 島松晋一郎, 吉田月久, 野崎要, 平井文彦, 山口正史, 田口健一, 瀬戸貴司, 竹之山光広, 一瀬幸人
    • Organizer
      第32回日本呼吸器外科学会
    • Place of Presentation
      高松市
    • Year and Date
      2015-05-14
    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Presentation] ALK阻害剤に対する耐性獲得と克服の治療戦略2015

    • Author(s)
      豊川剛二
    • Organizer
      第56回日本肺癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2015-11-26
    • Data Source
      KAKENHI-PROJECT-15K18452
  • [Presentation] 75 歳以上高齢者非小細胞肺癌術後再発症例の治療成績

    • Author(s)
      竹中 朋祐、稲益 英子、吉田 月久、豊川 剛二、野崎 要、平井 文彦、山口 正史、瀬戸 貴司、竹之山 光広、一瀬 幸人
    • Organizer
      第31回日本呼吸器外科学会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Presentation] ALK阻害剤に対する耐性獲得症例の検討

    • Author(s)
      豊川剛二、稲益栄子、吉田月久、野崎要、竹中朋祐、平井文彦、山口正史、瀬戸貴司、竹之山光広、一瀬幸人
    • Organizer
      第55回日本肺癌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-14 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Presentation] 遺伝子変異検索を目的とした手術の検討

    • Author(s)
      稲益 英子、吉田 月久、豊川 剛二、野崎 要、竹中 朋祐、平井 文彦、山口 正史、瀬戸 貴司、竹之山 光広、一瀬 幸人
    • Organizer
      第31回日本呼吸器外科学会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-26462144
  • [Presentation] 胸腔鏡下肺部分切除によりc kit 遺伝子変異が確認された胸腺癌の一例

    • Author(s)
      稲益英子、豊澤亮、豊川剛二、白石祥理、竹中朋祐、平井文彦、山口正史、瀬戸貴司、 竹之山光広、一瀬幸人
    • Organizer
      第37回日本呼吸器内視鏡学会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-14 – 2014-04-15
    • Data Source
      KAKENHI-PROJECT-26462144
  • 1.  Fumihiro Shoji (90444851)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 2.  TAGAWA Tetsuzo (90419557)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  岡本 龍郎 (80568626)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  Mitsuhiro Takenoyama (10309966)
    # of Collaborated Projects: 1 results
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  • 50.  KOHASHI Kenichi
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  • 51.  山田 裕一
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