Toyokawa Gouji 豊川剛二

… Alternative Names

Researcher Number	30627261
Affiliation (Current)	2020: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科医師 2020: 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 呼吸器腫瘍科医師
Affiliation (based on the past Project Information) *help	2018 – 2019: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科医師 2018: 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 呼吸器腫瘍科医師 2017: 九州大学, 大学病院, 助教 2016: 九州大学, 医学研究院, 助教 2015 – 2016: 九州大学, 医学研究員, 助教 2015: 九州大学, 医学(系)研究科(研究院), 助教 2014: 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他
Review Section/Research Field	Principal Investigator Tumor therapeutics / Tumor biology Except Principal Investigator Respiratory surgery / Digestive surgery / Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 肺癌 / 非小細胞肺癌 / ALK融合遺伝子 / ALK阻害剤 / 耐性機序 / 次世代ALK阻害剤 / 耐性獲得機序 / PD-L1 / EZH2 / 肺腺癌 / 手術 / 免疫学 … More Except Principal Investigator … More

免疫抑制性酵素IDOに着目した悪性胸膜中皮腫に対する新規免疫療法の開発Ongoing
- Principal Investigator
  
  田川哲三
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
慢性炎症・線維化に着目した肺癌悪性度獲得メカニズムの解明と新規治療への応用Ongoing
- Principal Investigator
  
  庄司文裕
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  National Hospital Organization, Kyushu Medical Center (Clinical Institute)
  Kyushu University
ヒストンメチル化によるPD-L1発現調節の分子機序解明Principal InvestigatorOngoing
- Principal Investigator
  
  豊川剛二
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Hospital Organization, Kyushu Medical Center (Clinical Institute)
  Kyushu University
Comprehensive analysis of resistance mechanism against ALK inhibitors and treatment strategy against such resistance mechanismPrincipal Investigator
- Principal Investigator
  
  TOYOKAWA Gouji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyushu University
がん幹細胞化に関与するSphere形成メカニズムを標的とした革新的治療開発Ongoing
- Principal Investigator
  
  前原喜彦
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Digestive surgery
- Research Institution
  Fukuoka Dental College
  Kyushu University
Clinicopathological analysis of expression of immune checkpoint molecules in patient with resected lung cancer
- Principal Investigator
  
  Mitsuhiro Takenoyama
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  National Hospital Organization, Kyushu Cancer Center

All 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas2019
- Author(s)
  Toyokawa G, Takada K, Tagawa T, Hamamoto R, Yamada Y, Shimokawa M, Oda Y, Maehara Y
- Journal Title
  
  The Annals of Thoracic Surgery
  
  Volume: １０７ Pages: 393-400
- DOI
  10.1016/j.athoracsur.2018.08.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14994, KAKENHI-PROJECT-17K15645, KAKENHI-PUBLICLY-18H04908
[Journal Article] W‘ALK’ Into the Next Stage.2017
- Author(s)
  Toyokawa G, Seto T, Takenoyama M, Ichinose Y.
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 18 Pages: 122-126
- DOI
  10.1016/j.cllc.2016.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18452
[Journal Article] Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer2016
- Author(s)
  Takenaka T, Inamasu E, Yoshida T, Toyokawa G, Nosaki K, Hirai F, Yamaguchi M, Seto T, Takenoyama M, Ichinose Y
- Journal Title
  
  Surg Today
  
  Volume: 46 Pages: 430-436
- DOI
  10.1007/s00595-015-1200-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462144
[Journal Article] Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma2016
- Author(s)
  Ohba T, Toyokawa G, Osoegawa A, Hirai F, Yamaguchi M, Taguchi K, Seto T, Takenoyama M,
- Journal Title
  
  Surg Today
  
  Volume: 46 Pages: 1091-1098
- DOI
  10.1007/s00595-015-1295-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462144
[Journal Article] Insights into brain metastasis in patients with ALK+ lung cancer: is the brain truly a sanctuary?2015
- Author(s)
  Toyokawa G, Seto T, Takenoyama M, Ichinose Y.
- Journal Title
  
  Cancer Metastasis Rev
  
  Volume: 34 Pages: 797-805
- DOI
  10.1007/s10555-015-9592-y
- Data Source
  KAKENHI-PROJECT-15K18452
[Journal Article] Identification of a Novel ALK G1123S Mutation in a Patient with ALK-rearranged Non-small-cell Lung Cancer Exhibiting Resistance to Ceritinib.2015
- Author(s)
  Toyokawa G, Inamasu E, Shimamatsu S, Yoshida T, Nosaki K, Hirai F, Yamaguchi M, Seto T, Takenoyama M, Ichinose Y.
- Journal Title
  
  J Thorac Oncol
  
  Volume: 10
- DOI
  10.1097/jto.0000000000000509
- Data Source
  KAKENHI-PROJECT-15K18452
[Journal Article] Updated Evidence on the Mechanisms of Resistance to ALK Inhibitors and Strategies to Overcome Such Resistance: Clinical and Preclinical Data.2015
- Author(s)
  Toyokawa G, Seto T.
- Journal Title
  
  Oncol Res Treat
  
  Volume: 38 Pages: 291-8
- DOI
  10.1159/000430852
- Data Source
  KAKENHI-PROJECT-15K18452
[Journal Article] Experience with erlotinib in lung adenocarcinoma harboring a coexisting KIF5B-RET fusion gene and EGFR mutation: report of a rare case2014
- Author(s)
  Hirai F, Takenoyama M, Taguchi K, Toyozawa R, Inamasu E, Toyokawa G, Yoshida T, Shiraishi Y, Takenaka T, Yamaguchi M, Ushijima C, Seto T, Takeo S, Ichinose Y
- Journal Title
  
  J Thorac Oncol
  
  Volume: 9(5)
- DOI
  10.1097/jto.0000000000000097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462144
[Journal Article] Secondary Mutations at I1171 in the ALK Gene Confer Resistance to Both Crizotinib and Alectinib2014
- Author(s)
  Toyokawa G, Hirai F, Inamasu E, Yoshida T, Nosaki K, Takenaka T, Yamaguchi M, Seto T,
- Journal Title
  
  J Thorac Oncol
  
  Volume: 9(12)
- DOI
  10.1097/jto.0000000000000358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462144
[Journal Article] Impact of the epidermal growth factor receptor mutation status on the post-recurrence survival of patients with surgically resected non-small-cell lung cancerdagger2014
- Author(s)
  Takenaka T, Takenoyama M, Yamaguchi M, Toyozawa R, Inamasu E, Kojo M, Toyokawa G, Yoshida T, Shiraishi Y, Morodomi Y, Hirai F, Taguchi K, Shimokawa M, Seto T, Ichinose Y
- Journal Title
  
  Eur J Cardiothorac Surg
  
  Volume: 47(3) Pages: 550-555
- DOI
  10.1093/ejcts/ezu227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462144
[Presentation] A positive correlation between EZH2 and PD-L1 expression in resected lung adenocarcinomas2018
- Author(s)
  Gouji Toyokawa, Kazuki Takada, Yuichi Yamada, Tetsuzo Tagawa, Fumihiro Shoji, Koji Yamazaki, Sadanori Takeo, Yoshinao Oda
- Organizer
  European Society of Medical Oncology, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14994
[Presentation] 肺腺癌切除例におけるヒストンメチル化酵素EZH2とPD-L1との関連の検討2018
- Author(s)
  豊川剛二
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K14994
[Presentation] 肺腺癌切除例におけるヒストンメチル化酵素EZH2とPD-L1との関連の検討2018
- Author(s)
  豊川剛二、田川哲三、髙田和樹、木下郁彦、上妻由佳、松原太一、原武直紀、髙森信吉、赤嶺貴紀、平井文彦、前原喜彦
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K14994
[Presentation] Treatment Strategy for Patients with the Acquired Resistance against ALK Inhibitors2016
- Author(s)
  Gouji Toyokawa
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-15K18452
[Presentation] Pulmonary resection and reconstruction after induction chemoradiotherapy for locally advanced non-small cell lung cancer.2016
- Author(s)
  OkamotoT, Shoji F, Morodomi Y, Toyokawa G, Suzuki Y, Fujishita T, Katsura M, Takada K, Akamine T, Takamori S, Maehara Y.
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H05792
[Presentation] I期非小細胞肺癌におけるsarcopeniaの意義と免疫栄養・炎症関連指数との関連性の検討2016
- Author(s)
  庄司　文裕、松原　太一、上妻　由佳、原武　直紀、赤嶺　貴紀、高森　信吉、桂　　正和、高田　和樹、豊川　剛二、岡本　龍郎、前原　喜彦
- Organizer
  第54回日本癌治療学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-15H05792
[Presentation] Pure GGOを呈する肺癌切除例におけるEGFRとALKの解析2015
- Author(s)
  豊川剛二, 島松晋一郎, 吉田月久, 野崎要, 平井文彦, 山口正史, 田口健一, 瀬戸貴司, 竹之山光広, 一瀬幸人
- Organizer
  第32回日本呼吸器外科学会
- Place of Presentation
  高松市
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-15K18452
[Presentation] ALK阻害剤に対する耐性獲得と克服の治療戦略2015
- Author(s)
  豊川剛二
- Organizer
  第56回日本肺癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K18452
[Presentation] 75 歳以上高齢者非小細胞肺癌術後再発症例の治療成績
- Author(s)
  竹中朋祐、稲益英子、吉田月久、豊川剛二、野崎要、平井文彦、山口正史、瀬戸貴司、竹之山　光広、一瀬幸人
- Organizer
  第31回日本呼吸器外科学会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26462144
[Presentation] 遺伝子変異検索を目的とした手術の検討
- Author(s)
  稲益英子、吉田月久、豊川剛二、野崎要、竹中朋祐、平井文彦、山口正史、瀬戸貴司、竹之山光広、一瀬幸人
- Organizer
  第31回日本呼吸器外科学会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26462144
[Presentation] 胸腔鏡下肺部分切除によりc kit 遺伝子変異が確認された胸腺癌の一例
- Author(s)
  稲益英子、豊澤亮、豊川剛二、白石祥理、竹中朋祐、平井文彦、山口正史、瀬戸貴司、竹之山光広、一瀬幸人
- Organizer
  第37回日本呼吸器内視鏡学会
- Place of Presentation
  京都
- Year and Date
  2014-04-14 – 2014-04-15
- Data Source
  KAKENHI-PROJECT-26462144
[Presentation] ALK阻害剤に対する耐性獲得症例の検討
- Author(s)
  豊川剛二、稲益栄子、吉田月久、野崎要、竹中朋祐、平井文彦、山口正史、瀬戸貴司、竹之山光広、一瀬幸人
- Organizer
  第55回日本肺癌学会総会
- Place of Presentation
  京都
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26462144

1. 岡本龍郎 (80568626)

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2. 田川哲三 (90419557)

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Toyokawa Gouji 豊川 剛二

TOYOKAWA Gouji 豊川 剛二

Research Projects

Research Products

Co-Researchers

免疫抑制性酵素IDOに着目した悪性胸膜中皮腫に対する新規免疫療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

慢性炎症・線維化に着目した肺癌悪性度獲得メカニズムの解明と新規治療への応用Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒストンメチル化によるPD-L1発現調節の分子機序解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of resistance mechanism against ALK inhibitors and treatment strategy against such resistance mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん幹細胞化に関与するSphere形成メカニズムを標的とした革新的治療開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinicopathological analysis of expression of immune checkpoint molecules in patient with resected lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] W‘ALK’ Into the Next Stage.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insights into brain metastasis in patients with ALK+ lung cancer: is the brain truly a sanctuary?2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a Novel ALK G1123S Mutation in a Patient with ALK-rearranged Non-small-cell Lung Cancer Exhibiting Resistance to Ceritinib.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Updated Evidence on the Mechanisms of Resistance to ALK Inhibitors and Strategies to Overcome Such Resistance: Clinical and Preclinical Data.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Experience with erlotinib in lung adenocarcinoma harboring a coexisting KIF5B-RET fusion gene and EGFR mutation: report of a rare case2014

Author(s)

Journal Title

DOI

Toyokawa Gouji 豊川剛二

TOYOKAWA Gouji 豊川剛二