Sakoda Yukimi 佐古田幸美

… Alternative Names

SAKODA Yukimi 佐古田幸美

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Researcher Number	30629754
Other IDs
Affiliation (Current)	2025: 山口大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2025: 山口大学, 大学院医学系研究科, 准教授 2017: 山口大学, 大学院医学系研究科, 講師 2016: 山口大学, 医学(系)研究科(研究院), 講師 2015: 山口大学, 大学院医学系研究科, 助教 2012 – 2015: 山口大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Tumor therapeutics / Immunology Except Principal Investigator Tumor therapeutics / Medium-sized Section 50:Oncology and related fields / Ophthalmology
Keywords	Principal Investigator キメラ抗原受容体 / 固形がん / 免疫チェックポイント分子 / CAR-NK細胞療法 / がん免疫 / シグナル伝達 / 癌 / 免疫学 / がん傷害活性 / 免疫チェックポイント … More / 免疫抑制シグナル / 免疫療法 / 共シグナル / 免疫 … More Except Principal Investigator がん免疫療法 / 免疫細胞療法 / 遺伝子改変技術 / がん免疫 / 機能的分化 / メモリー細胞 / エフェクター細胞 / T細胞サブセット / エピトープスプレッディング / 新規CAR-T細胞療法 / 免疫学 / 癌 / チトクロームP450 / チトクロームP / オメガ3脂肪酸 / ぶどう膜炎 / 加齢黄斑変性症 / 眼炎症 / 抗体医療 / ADCC活性 / NK細胞 / 抗体療法 / 遺伝子改変Ｔ細胞 / CAR-T細胞 Less

Effector機能とStem cell memory機能を併せ持つユニークなT細胞subsetの特性解析研究
- Principal Investigator
  
  玉田耕治
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Yamaguchi University
Development of next-generation CAR-NK cell immunotherapy against solid tumorsPrincipal Investigator
- Principal Investigator
  
  佐古田幸美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Yamaguchi University
Mechanistic analysis of novel CAR-T cell therapy against solid tumors
- Principal Investigator
  
  玉田耕治
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Yamaguchi University
Next generation CAR-T cell therapy for malignant melanomaPrincipal Investigator
- Principal Investigator
  
  SAKODA YUKIMI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Yamaguchi University
Cancer immunology research to enhance therapeutic effects of immune checkpoint blockade
- Principal Investigator
  
  TAMADA Koji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
Engineering CAR T cells for improved function against solid tumorsPrincipal Investigator
- Principal Investigator
  
  SAKODA Yukimi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
Elucidation of a destruction mechanism and development of new treatment on intraocular chronic inflammatory diseases with CYP metabolites
- Principal Investigator
  
  YANAI Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Yamaguchi University
Novel caner immunotherapy using gene-modification of Fc receptors
- Principal Investigator
  
  TAMADA Koji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
Development of novel CAR-T cell therapy against cancer
- Principal Investigator
  
  TAMADA Koji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
Development of new engineered CAR-T cells with the ability to block immune checkpoint pathwaysPrincipal Investigator
- Principal Investigator
  
  SAKODA Yukimi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
HVEMを標的とした自己免疫疾患に対する新規治療法の開発Principal Investigator
- Principal Investigator
  
  佐古田幸美
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Yamaguchi University

All 2022 2021 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] キメラ抗原受容体発現Ｔ細胞(CAR-T)療法2017
- Author(s)
  佐古田幸美、玉田耕治
- Total Pages
  350
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-16K07176
[Book] がん抗原の新しい概念2017
- Author(s)
  佐古田幸美、玉田耕治
- Total Pages
  94
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-16K07176
[Book] Adaptive immune resistance2017
- Author(s)
  佐古田幸美
- Total Pages
  94
- Publisher
  ライフメディコム
- Data Source
  KAKENHI-PROJECT-16K07176
[Journal Article] Novel technologies for improving the safety and efficacy of CAR-T cell therapy2022
- Author(s)
  Ohta K, Sakoda Y, Tamada K
- Journal Title
  
  Int J Hematol
  
  Volume: - Issue: 5 Pages: 647-651
- DOI
  10.1007/s12185-022-03478-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04808
[Journal Article] Enhanced Antitumor Responses of Tumor Antigen-Specific TCR T Cells Genetically Engineered to Produce IL7 and CCL192021
- Author(s)
  Tokunaga Yoshihiro、Sasaki Takahiro、Goto Shunsuke、Adachi Keishi、Sakoda Yukimi、Tamada Koji
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 21 Issue: 1 Pages: 138-148
- DOI
  10.1158/1535-7163.mct-21-0400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04808
[Journal Article] Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models2021
- Author(s)
  Goto Shunsuke、Sakoda Yukimi、Adachi Keishi、Sekido Yoshitaka、Yano Seiji、Eto Masatoshi、Tamada Koji
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 70 Issue: 9 Pages: 2503-2515
- DOI
  10.1007/s00262-021-02853-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07625, KAKENHI-PROJECT-19H03527
[Journal Article] Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells2019
- Author(s)
  Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K
- Journal Title
  
  Cancer Sci
  
  Volume: 110(10) Issue: 10 Pages: 3079-3088
- DOI
  10.1111/cas.14169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08646, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-16H02474
[Journal Article] 腫瘍免疫研究の最前線「免疫チェックポイント阻害薬」2019
- Author(s)
  中島正夫、佐古田幸美、玉田耕治
- Journal Title
  
  大腸がんperspective
  
  Volume: Vol4(2) Pages: 20-25
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment.2019
- Author(s)
  Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
- Journal Title
  
  Cancer Immunology and Immunotheraoy
  
  Volume: 68 Issue: 2 Pages: 201-211
- DOI
  10.1007/s00262-018-2263-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10603, KAKENHI-PROJECT-16H02474, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-16K15623
[Journal Article] IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.2018
- Author(s)
  1.Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada
- Journal Title
  
  Nature Biotechnology
  
  Volume: 36(4) Issue: 4 Pages: 346-351
- DOI
  10.1038/nbt.4086
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02474, KAKENHI-PROJECT-26830107, KAKENHI-PROJECT-16H05420
[Journal Article] 固形がんに対するCAR-T細胞療法の研究と開発の現状2017
- Author(s)
  佐古田幸美、玉田耕治
- Journal Title
  
  血液フロンティア
  
  Volume: 27(7) Pages: 59-68
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] がん免疫療法の変遷2017
- Author(s)
  佐古田幸美、玉田耕治
- Journal Title
  
  呼吸器内科
  
  Volume: 32(6) Pages: 521-525
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion.2016
- Author(s)
  Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107(4) Issue: 4 Pages: 398-406
- DOI
  10.1111/cas.12861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640104, KAKENHI-PROJECT-25290057, KAKENHI-PROJECT-16H02474
[Journal Article] 造血器腫瘍に対するPD-L1/PD-1免疫チェックポイント阻害療法の進展2016
- Author(s)
  奥山奈美子、佐古田幸美、玉田耕治
- Journal Title
  
  血液内科
  
  Volume: Vol.72 No.5 Pages: 703-708
- NAID
  40020870195
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses.2016
- Author(s)
  Sakoda Y, Nagai T, Murata S, Mizuno Y, Kurosawa H, Shoda H, Morishige N, Yanai R, Sonoda KH, Tamada K.
- Journal Title
  
  J Immunol.
  
  Volume: 196(7) Issue: 7 Pages: 2947-54
- DOI
  10.4049/jimmunol.1501742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640104, KAKENHI-PROJECT-25290057, KAKENHI-PROJECT-16H02474, KAKENHI-PROJECT-15K10869
[Journal Article] がん抗原の新しい概念2016
- Author(s)
  佐古田幸美、玉田耕治
- Journal Title
  
  臨床泌尿器科
  
  Volume: Vol.71(1) Pages: 24-29
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function．2015
- Author(s)
  Shoda H，Yanai R，Yoshimura T，Nagai T，Kimura K，Sobrin L，Connor KM，Sakoda Y, Tamada K，Ikeda T，Sonoda KH
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 9 Pages: e0138241-e0138241
- DOI
  10.1371/journal.pone.0138241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462663, KAKENHI-PROJECT-26640104, KAKENHI-PROJECT-25290057
[Journal Article] Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function．2015
- Author(s)
  Shoda H，Yanai R，Yoshimura T，Nagai T，Kimura K，Sobrin L，Connor KM，Sakoda Y, Tamada K，Ikeda T，Sonoda KH
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10869
[Journal Article] Vγ2Vδ2 T cell Costimulation Increases NK cell Killing of Monocyte-derived Dendritic Cells. Immunology.2015
- Author(s)
  Cairo C, Surendran N, Harris KM, Mazan-Mamczarz K, Sakoda Y, Diaz-Mendez F, Tamada K, Gartenhaus RB, Mann DL, Pauza CD.
- Journal Title
  
  Immunoogy
  
  Volume: 144 Issue: 3 Pages: 422-430
- DOI
  10.1111/imm.12386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290057
[Journal Article] 複数のがん標的分子を認識する次世代型CAR-T細胞の研究と開発2014
- Author(s)
  佐古田幸美、玉田耕治
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290057
[Journal Article] T複数のがん標的分子を認識する次世代型CAR-T細胞の研究と開発2014
- Author(s)
  佐古田幸美、玉田耕治
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 651-656
- Data Source
  KAKENHI-PROJECT-25290057
[Presentation] 実験的自己免疫性ぶどう膜炎誘導におけるHVEM共シグナルの免疫学的制御2016
- Author(s)
  柳井　亮二，佐古田　幸美，永井　智彦，庄田　裕美，森重　直行，園田　康平，玉田　耕治
- Organizer
  第50回日本眼炎症学会
- Place of Presentation
  東京都（東京国際フォーラム）
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K10869
[Presentation] ω-3脂肪酸の眼炎症抑制機序におけるマクロファージの関与の検討2016
- Author(s)
  内　翔平，柳井　亮二，陳　上，庄田　裕美，永井　智彦，佐古田　幸美，玉田　耕治，園田　康平
- Organizer
  第50回日本眼炎症学会
- Place of Presentation
  東京都（東京国際フォーラム）
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K10869
[Presentation] ω-3脂肪酸による実験的自己免疫性ぶどう膜炎に対する炎症抑制効果2015
- Author(s)
  庄田　裕美，柳井　亮二，木村　和博，吉村　武，Connor Kip，玉田　耕治，佐古田　幸美，池田　恒彦，園田　康平
- Organizer
  第49回日本眼炎症学会
- Place of Presentation
  大阪府（コンベンションセンター）
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-15K10869
[Presentation] Omega-3 fatty acids suppress Experimental Autoimmune Uveitis by inhibiting Th1/Th17 cells．2015
- Author(s)
  Shoda H，Yanai R，Yoshimura T，Nagai T，Kimura K，Sobrin L，Kip M Connor，Sakoda Y，Tamada K，Ikeda T，Sonoda KH
- Organizer
  13th Congress of the International Ocular Inflammation Society
- Place of Presentation
  USA（San Francisco）
- Year and Date
  2015-09-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10869

1. TAMADA Koji (00615841)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
2. 城崎幸介 (80721323)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OKA Masaaki (70144946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YANAI Ryoji (10346554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 園田康平 (10294943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 折田朋子 (50467792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木村和博 (60335255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 寺西慎一郎 (90649360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 安達圭志 (40598611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. OJIMA Toshiyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 永野浩昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 山上裕機

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakoda Yukimi 佐古田 幸美

SAKODA Yukimi 佐古田 幸美

Research Projects

Research Products

Co-Researchers

Effector機能とStem cell memory機能を併せ持つユニークなT細胞subsetの特性解析研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next-generation CAR-NK cell immunotherapy against solid tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic analysis of novel CAR-T cell therapy against solid tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Next generation CAR-T cell therapy for malignant melanomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cancer immunology research to enhance therapeutic effects of immune checkpoint blockade

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Engineering CAR T cells for improved function against solid tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a destruction mechanism and development of new treatment on intraocular chronic inflammatory diseases with CYP metabolites

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel caner immunotherapy using gene-modification of Fc receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel CAR-T cell therapy against cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new engineered CAR-T cells with the ability to block immune checkpoint pathwaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HVEMを標的とした自己免疫疾患に対する新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] キメラ抗原受容体発現Ｔ細胞(CAR-T)療法2017

Author(s)

Total Pages

Publisher

Data Source

[Book] がん抗原の新しい概念2017

Author(s)

Total Pages

Publisher

Sakoda Yukimi 佐古田幸美

SAKODA Yukimi 佐古田幸美