SAKAVE Jun-ichi 坂部純一

Researcher Number	30631494
Other IDs	https://orcid.org/0000-0002-8237-0472
Affiliation (based on the past Project Information) *help	2013 – 2015: 浜松医科大学, 医学部, 特任助教 2012 – 2015: 浜松医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Dermatology Except Principal Investigator Dermatology
Keywords	Principal Investigator 蛋白発現 / プロセシング / タンパク精製 / フィラグリン / 表皮バリア機能 / 蛋白のプロセシング / C末端領域結合タンパク / C末端領域の機能 Except Principal Investigator アトピー性皮膚炎 / 皮膚バリア … More / フィラグリン / 蛋白 / 細胞・組織 / 発現制御 / 免疫学 / 表皮バリア / 皮膚バリア機能 / 接触性皮膚炎 / 天然保湿因子 / プロフィラグリン / 角化細胞 / カリクレイン / バリア / 角層 / 皮膚生理学 Less

Proteome analysis of stratum corneum from atopic dermatitis patients using non-invasive tape-stripping method.
- Principal Investigator
  
  Tokura Yoshiki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Hamamatsu University School of Medicine
プロフィラグリンのプロセシングにおけるC末領域の機能解析とガレクチン７の共同作用Principal Investigator
- Principal Investigator
  
  坂部純一
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hamamatsu University School of Medicine
Evaluation of percutaneous immune responses and role of natural moisturizing factor in filaggrin monomer transgenic mice
- Principal Investigator
  
  IKEYA Shigeki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hamamatsu University School of Medicine
Significance of kallikrein-5 in the formation of filaggrin monomer
- Principal Investigator
  
  TOKURA Yoshiki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Hamamatsu University School of Medicine
Functional analysis of human profilaggrin C-terminus region: Identification of molecular mechanism in profilaggrin processingPrincipal Investigator
- Principal Investigator
  
  SAKABE Jun-ichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  Hamamatsu University School of Medicine

All 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CCL17 in patients with atopic dermatitis2015
- Author(s)
  Ito T, Tatsuno K, Fujiyama T, Sakabe J, Tokura Y.
- Journal Title
  
  Allergol. Int.
  
  Volume: 64 Issue: 2 Pages: 200-202
- DOI
  10.1016/j.alit.2014.10.008
- NAID
  130005290340
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461689, KAKENHI-PROJECT-26670524
[Journal Article] Leukoderma in patients with atopic dermatitis.2015
- Author(s)
  Kuriyama S, Kasuya A, Fujiyama T, Tatsuno K, Sakabe J, Yamaguchi H, Ito T, Tokura Y
- Journal Title
  
  J Dermatol
  
  Volume: 42 Issue: 2 Pages: 215-218
- DOI
  10.1111/1346-8138.12746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461655, KAKENHI-PROJECT-26670524
[Journal Article] Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.2015
- Author(s)
  Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y:
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 4 Pages: e0125082-e0125082
- DOI
  10.1371/journal.pone.0125082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670524
[Journal Article] Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.2015
- Author(s)
  Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y
- Journal Title
  
  PLoS One
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670524
[Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation2014
- Author(s)
  Nakazawa S, Moriki M, Ikeya S, Sakabe J-I, Tokura Y
- Journal Title
  
  J Dermatol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659525
[Journal Article] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異と手掌皺亢進・尋常性魚鱗癬との関連.2014
- Author(s)
  坂部純一、山口隼人、福家辰樹、池谷茂樹、神谷浩二、龍野一樹、戸倉新樹
- Journal Title
  
  日本小児皮膚科学会雑誌
  
  Volume: 33 Pages: 127-131
- Data Source
  KAKENHI-PROJECT-25860944
[Journal Article] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異と手掌皺亢進・尋常性魚鱗癬との関連2014
- Author(s)
  坂部純一，山口隼人，福家辰樹，池谷茂樹，神谷浩二，龍野一樹，戸倉新樹
- Journal Title
  
  日小皮会誌
  
  Volume: 33 Pages: 27-31
- Data Source
  KAKENHI-PROJECT-26670524
[Journal Article] Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer2014
- Author(s)
  Jun-Ichi Sakabe, Koji Kamiya, Hayato Yamaguchi, Shigeki Ikeya, Takahiro Suzuki, Masahiro Aoshima, Kazuki Tatsuno, Toshiharu Fujiyama, Masako Suzuki, Tsuyoshi Yatagai, Taisuke Ito, Toshiyuki Ojima, Yoshiki Tokura
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 134 Issue: 4 Pages: 957-960
- DOI
  10.1016/j.jaci.2014.07.054
- NAID
  40020962750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860944, KAKENHI-PROJECT-26670524, KAKENHI-PROJECT-26860877
[Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.2013
- Author(s)
  Sakabe J, Yamamoto M, Hirakawa S, Motoyama A, Ohta I, Tatsuno K, Ito T, Kabashima K, Hibino T, Tokura Y
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Pages: 17179-17189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890082
[Journal Article] Second report of FLG R501X mutation in Japanese patients with atopic dermatitis2013
- Author(s)
  Yamaguchi H, Tatsuno K, Sakabe J, Tokura Y.
- Journal Title
  
  J Dermatol
  
  Volume: 40 Pages: 498-499
- Data Source
  KAKENHI-PROJECT-24659525
[Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes2013
- Author(s)
  Sakabe J, Yamamoto M, Hirakawa S, Motoyama A, Ohta I, Tatsuno K, Ito T, Kabashima K, Hibino T, Tokura Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 17179-17189
- Data Source
  KAKENHI-PROJECT-24659525
[Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes2013
- Author(s)
  Sakabe J, Yamamoto M, Hirakawa S, Motoyama A, Ohta I, Tatsuno K, Ito T, Kabashima K, Hibino T, Tokura Y
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 17179-17189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890082
[Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation2013
- Author(s)
  Shinsuke Nakazawa
- Journal Title
  
  Journal of Dermatology
  
  Volume: 41 Issue: 3 Pages: 230-231
- DOI
  10.1111/1346-8138.12339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860944, KAKENHI-PROJECT-26670524
[Journal Article] High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis2013
- Author(s)
  Yamaguchi H, Kabashima-Kubo R, Bito T, Sakabe JI, Shimauchi T, Ito T, Hirakawa S, Hirasawa N, Ogasawara K, Tokura Y.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 72(3) Pages: 240-245
- Data Source
  KAKENHI-PROJECT-24659525
[Journal Article] High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis.2013
- Author(s)
  Yamaguchi H, Kabashima-Kubo R, Bito T, Sakabe JI, Shimauchi T, Ito T, Hirakawa S, Hirasawa N, Ogasawara K, Tokura Y
- Journal Title
  
  J Dermatol Sci
  
  Volume: 73 Issue: 3 Pages: 240-245
- DOI
  10.1016/j.jdermsci.2013.07.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659525, KAKENHI-PROJECT-25293399
[Journal Article] Second report of FLG R501X mutation in Japanese patients with atopic dermatitis.2013
- Author(s)
  Yamaguchi H, Tatsuno K, Sakabe J, Tokura Y
- Journal Title
  
  J Dermatol
  
  Volume: in press Issue: 6 Pages: 498-499
- DOI
  10.1111/1346-8138.12133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659525
[Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency : Possible immunological state of the intrinsic type2012
- Author(s)
  Kabashima-Kubo R, Nakamura M, Sakabe JI, Sugita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 67 Pages: 37-43
- Data Source
  KAKENHI-PROJECT-24659525
[Journal Article] Connexin 26 (GJB2) mutations in keratitis-ichthyosisdeafness (KID) syndrome presenting with squamous cell carcinoma2012
- Author(s)
  Sakabe J-I, Yoshiki R, Sugita K, Haruyama S, Sawada Y, Kabashima R, Bito T, Nakamura M, Tokura Y
- Journal Title
  
  J Dermatol
  
  Volume: (in press) Issue: 9 Pages: 814-815
- DOI
  10.1111/j.1346-8138.2011.01414.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390328, KAKENHI-PROJECT-22659208, KAKENHI-PROJECT-24890082
[Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type2012
- Author(s)
  Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 67 Issue: 1 Pages: 37-43
- DOI
  10.1016/j.jdermsci.2012.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390370, KAKENHI-PROJECT-23591662, KAKENHI-PROJECT-23659546, KAKENHI-PROJECT-23791245, KAKENHI-PROJECT-24390152, KAKENHI-PROJECT-24659525, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-24890082
[Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation
- Author(s)
  Nakazawa S, Moriki M, Ikeya S, Sakabe J-I, Tokura Y.
- Journal Title
  
  J Dermatol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24659525
[Presentation] アトピー性皮膚炎における発汗低下の指標：GCDFP15発現量の利用．2015
- Author(s)
  神谷浩二，坂部純一，山口隼人，鈴木健晋，矢田貝　剛，青島正浩，伊藤泰介，戸倉新樹：
- Organizer
  第265回日本皮膚科学会岡山地方会．
- Place of Presentation
  岡山市
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-26670524
[Presentation] アトピー性皮膚炎における発汗低下の指標と機序：角層中GCDFP15量の利用．2015
- Author(s)
  神谷浩二，坂部純一，山口隼人，鈴木健晋，矢田貝剛，青島正浩，伊藤泰介，戸倉新樹：
- Organizer
  第114回日本皮膚科学会総会．
- Place of Presentation
  横浜市
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-26670524
[Presentation] Gross cystic disease fluid protein 15 as a potential marker for decreased sweating in atopic dermatitis.2015
- Author(s)
  Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y:
- Organizer
  45th Annual Meeting of the European Society for Dermatological Research
- Place of Presentation
  Rotterdam, the Netherlands
- Year and Date
  2015-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670524
[Presentation] アトピー性皮膚炎における発汗低下の指標としての角層GCDFP15．2015
- Author(s)
  神谷浩二，坂部純一，山口隼人，鈴木健晋，矢田貝剛，青島正浩，伊藤泰介，戸倉新樹：
- Organizer
  第2回汗と皮膚疾患の研究会．
- Place of Presentation
  東京
- Year and Date
  2015-08-08
- Data Source
  KAKENHI-PROJECT-26670524
[Presentation] Proteome analysis of stratum corneum from atopic dermatitis patients and GCDFP15 as a typical fruitful indicator for the disease condition.2015
- Author(s)
  Sakabe J, Kamiya K, Tokura Y:
- Organizer
  The 6th Annual Congress of Pan Asian-Pacific Skin Barrier Research Society [PAPSBRS].
- Place of Presentation
  Okayama, Japan
- Year and Date
  2015-12-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670524
[Presentation] Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer.2014
- Author(s)
  Sakabe J, Kamiya K, Tokura Y
- Organizer
  The 39th Annual Meeting of the Japanese Society for Investigative Dermatology.
- Place of Presentation
  Suita, Japan
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-26670524
[Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing2013
- Author(s)
  Sakabe J, Yamamoto M, Motoyama A, Ohta I, Hirakawa S, Hibino T, Tokura Y.
- Organizer
  2013 International Investigative Dermatology Meeting
- Place of Presentation
  Edinburgh, United Kingdom
- Data Source
  KAKENHI-PROJECT-24659525
[Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing.2013
- Author(s)
  Jun-ichi Sakabe, Mami Yamamoto, Akira Motoyama, Isao Ohta, Satoshi Hirakawa, Toshihiko Hibino, Yoshiki Tokura
- Organizer
  International Investigative Dermatology (IID) 2013
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-24890082
[Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing2013
- Author(s)
  Sakabe J, Yamamoto M, Motoyama A, Ohta I, Hirakawa S, Hibino T, Tokura Y
- Organizer
  International Investigative Dermatology
- Place of Presentation
  英国　エディンバラ
- Data Source
  KAKENHI-PROJECT-24659525
[Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing2013
- Author(s)
  Sakabe J, Yamamoto M, Motoyama A, Ohta I, Hirakawa S, Hibino T, Tokura Y
- Organizer
  International Investigative Dermatology (IID) 2013
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-24890082
[Presentation] Mandatory role of kallikrein 5 in profilaggrin maturation and possible association of its impairment with atopic dermatitis.2012
- Author(s)
  Sakabe Jun-ichi
- Organizer
  The 12th Kyungpook-Hamamatsu Joint Medical Symposium Hamamatsu Meeting
- Place of Presentation
  Hamamatsu
- Data Source
  KAKENHI-PROJECT-24890082
[Presentation] Co-localization of kallikrein5 and profilaggrin in keratohyalin granules and reduction of filaggrin monomers by kallikrein5 downmodulation.2012
- Author(s)
  Sakabe Jun-ichi
- Organizer
  The 37th Annual Meeting of the Japan Society for Investigative Dermatology (JSID)
- Place of Presentation
  Naha
- Data Source
  KAKENHI-PROJECT-24890082
[Presentation] Co-localization of kallikrein5 and profilaggrin in keratohyalin granules and reduction of filaggrin monomers by kallikrein5 downmodulation2012
- Author(s)
  Sakabe J, Ohta I, Hirakawa S, Tokura Y.
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Naha, Japan
- Data Source
  KAKENHI-PROJECT-24659525
[Presentation] Co-localization of kallikrein5 and profilaggrin in keratohyalin granules and reduction of filaggrin monomers by kallikrein5 downmodulation.
- Author(s)
  Sakabe J, Ohta I, Hirakawa S, Tokura Y
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology.
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24659525

1. TOKURA Yoshiki (00172156)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
2. HIRAKAWA Satoshi (50419511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. IKEYA Shigeki (40436936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 高橋慶人

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 行卓男

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 糟谷啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中村元信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小笠原康悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAVE Jun-ichi 坂部 純一

Research Projects

Research Products

Co-Researchers

Proteome analysis of stratum corneum from atopic dermatitis patients using non-invasive tape-stripping method.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロフィラグリンのプロセシングにおけるC末領域の機能解析とガレクチン７の共同作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of percutaneous immune responses and role of natural moisturizing factor in filaggrin monomer transgenic mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of kallikrein-5 in the formation of filaggrin monomer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of human profilaggrin C-terminus region: Identification of molecular mechanism in profilaggrin processingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CCL17 in patients with atopic dermatitis2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Leukoderma in patients with atopic dermatitis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.2015

Author(s)

Journal Title

Data Source

[Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation2014

Author(s)

Journal Title

Data Source

[Journal Article] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異と手掌皺亢進・尋常性魚鱗癬との関連.2014

Author(s)

Journal Title

Data Source

[Journal Article] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異と手掌皺亢進・尋常性魚鱗癬との関連2014

Author(s)

Journal Title

Data Source

[Journal Article] Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.2013

Author(s)

Journal Title

Data Source

[Journal Article] Second report of FLG R501X mutation in Japanese patients with atopic dermatitis2013

Author(s)

SAKAVE Jun-ichi 坂部純一