KAWANO Toshiaki 川野利明

Researcher Number	30633424
Other IDs
Affiliation (Current)	2022: 大分大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2013 – 2021: 大分大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator インフルエンザウイルス / アジュバント / 鼻腔投与 / 遺伝子改変マウス / SOCS遺伝子 / アレルギー性鼻炎 / 中耳炎 / SOCS / 鼻腔投与ワクチン / 免疫誘導 … More / ワクチン / 複数アジュバント / Th1, Th2 / インフルエンザ / ウイルス / 粘膜ワクチン … More Except Principal Investigator インフルエンザ菌 / 粘膜免疫 / 慢性中耳炎 / 制御性T細胞 / 鼻粘膜 / 上気道 / CD25 / CD2５ / 中耳炎 / 免疫寛容 / B細胞 / 脾臓 / Bリンパ球 / 頸部リンパ節 / 制御性T細胞細胞 / ヘルパーT細胞 / サイトカイン / アジュバント / 自然リンパ球２ / 自然リンパ球 / コレラトキシン / グループ２自然リンパ球 / 免疫 / PDL-1 / 免疫老化 / 上気道粘膜 / 免疫チェックポイント Less

M2タンパクと複合アジュバントを用いた新たなインフルエンザウイルスワクチン戦略Principal Investigator
- Principal Investigator
  
  川野利明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Oita University
Activation of upper respiratory mucosal immune response by immune checkpoint inhibitors
- Principal Investigator
  
  鈴木正志
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Oita University
Effect of Mucosal immune responses on innate lymphoid cells 2 in mucosal and lymphoid tissues.
- Principal Investigator
  
  Suzuki Masashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita University
Evaluation of new adjuvants coadministered with nasal recombinant hemagglutinin influenza vaccinePrincipal Investigator
- Principal Investigator
  
  Kawano Toshiaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita University
Analysis of mucosal tolerance by regulatory T cell in chronic otitis media
- Principal Investigator
  
  Hirano Takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita University
Effect of anti-CD25 monoclonal antibody on chronic otitis media in mice model
- Principal Investigator
  
  Hirano Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita University
Analysis of the immune system of middle ear and nose in suppressor of cytokine signaling (SOCS)- 1 knockout mouse with allergic rhinitis.Principal Investigator
- Principal Investigator
  
  KAWANO Toshiaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita University

All 2019 2018 2017 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] アレルギーの臨床2014
- Author(s)
  中島　重徳、川野利明　他
- Total Pages
  100
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-25861571
[Journal Article] Interaction between regulatory T cells and antibody producing B cells for the immune responses at the upper respiratory mucosae against nontypeable Haemophilus influenza-in vitro assay model-2019
- Author(s)
  Hirano T., Kadowaki Y., Matsunaga T., Yoshinaga K., Kawano T., Moriyama M., Suzuki M.
- Journal Title
  
  Annals of Otology, Rhinology and Laryngology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11187
[Journal Article] Monophosphoryl lipid A enhances nontypeable Haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization2017
- Author(s)
  Taro Iwasaki, Takashi Hirano, Satoru Kodama, Yoshinori Kadowaki, Munehito Moriyama, Toshiaki Kawano, Masashi Suzuki
- Journal Title
  
  International Journal of Pediatric Otorhinolaryngology
  
  Volume: 97 Pages: 5-12
- DOI
  10.1016/j.ijporl.2017.03.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K11187
[Journal Article] Accumulation of regulatory T cells and chronic inflammation in the middle ear in a mouse model of chronic otitis media with effusion induced by combined Eustachian tube blockage and nontypeable Haemophilus influenzae infection2015
- Author(s)
  1. Hirano T, Kodama S, Kawano T, Suzuki M.
- Journal Title
  
  Infection and Immunity
  
  Volume: 84 Pages: 356-364
- DOI
  10.1128/iai.01128-15
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462584, KAKENHI-PROJECT-25462648
[Journal Article] Analysis of dynamics of Th17 cells in chronic middle ear inflammation induced by nontypeable Heamophilus influenzae2014
- Author(s)
  Hirano. T, Kodama. S, Kawano.T, Moriyama. M, Suzuki. M
- Journal Title
  
  Monduzzi Editore International Proceedings Division
  
  Volume: 1 Pages: 17-19
- Data Source
  KAKENHI-PROJECT-25861571
[Journal Article] Analysis of the mucosal immune system of middle ear and nose in suppressor of cytokine signaling (SOCS)-1 knockout mouse model with allergic rhinitis2014
- Author(s)
  Kawano. T, Hirano. T, Kadowaki. Y, Moriyama. M, Iwasaki, T, Noguchi. K, Kobayashi. T, Suzuki. M
- Journal Title
  
  Monduzzi Editore International Proceedings Division
  
  Volume: 1 Pages: 21-24
- Data Source
  KAKENHI-PROJECT-25861571
[Journal Article] Triggering receptor expressed on myeloid cells (TREM)-1 expression on polymorphonuclear neutrophils enhanced the bacterial clearance from the nose in synergy with TLR42014
- Author(s)
  Moriyama. M, Hirano. T, Kodama. S, Kawano.T, Suzuki. M
- Journal Title
  
  Monduzzi Editore International Proceedings Division
  
  Volume: 1 Pages: 25-26
- Data Source
  KAKENHI-PROJECT-25861571
[Presentation] 粘膜アジュバント経鼻投与による自然リンパ球への影響2019
- Author(s)
  平野隆、川野利明、松永崇志、吉永和弘、鈴木正志
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K11333
[Presentation] Effect of Mucosal adjuvant on innate lymphoid cells 2 in mucosal and lymphoid tissues.2019
- Author(s)
  Kazuhiro Yoshinaga, Takashi Hirano, Toshiaki Kawano, Takayuki Matsunaga, Masashi Suzuki
- Organizer
  20th International Symposium on Recent Advances in Otits Media
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11333
[Presentation] インフルエンザウイルスワクチンによる扁桃細胞増殖能の免疫学的検討2019
- Author(s)
  川野利明、平野隆、合原良亮、馬渕英彰、伊東和恵、立山香織、鈴木正志
- Organizer
  日本耳鼻咽喉科・免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 複数アジュバントが鼻腔投与型インフルエンザウイルスワクチンに与える影響2019
- Author(s)
  川野利明、平野隆、赤嶺苑佳、立山香織、鈴木正志
- Organizer
  日本鼻科学会
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 粘膜アジュバント経鼻投与による自然リンパ球への影響2019
- Author(s)
  平野　隆、川野利明、松永崇志、吉永和弘、鈴木正志
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K11333
[Presentation] T and B cell development after intramuscular vaccination with recombinant HA and boosting with multiple intra-nasal adjuvants2019
- Author(s)
  Kaori Shinomura, Toshiaki Kawano, Yumi Kizu (Tokumaru), Takashi Hirano, Hideaki Mabuchi, Ryosuke Gobaru, Takayuki Matsunaga, Kazuhiro Yoshinaga, Kaori Tateyama, Masashi Suzuki
- Organizer
  38th American Society for Virology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] Cross-protective immune responses against lethal heterologous influenza virus after vaccination of mice with recombinant H1N1 and H3N22019
- Author(s)
  Yumi Kizu (Tokumaru), Toshiaki Kawano, Kaori Shinomura, Takashi Hirano, Hideaki Mabuchi, Ryosuke Gobaru, Takayuki Matsunaga, Kazuhiro Yoshinaga, Kaori Tateyama, Masashi Suzuki
- Organizer
  38th American Society for Virology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] Cytokine and proliferative responses of human tonsil-derived leukocytes to in vitro stimulation after three years of annual parenteral influenza virus vaccination2019
- Author(s)
  Toshiaki Kawano, Takashi Hirano, Yumi Kizu, Kaori Shinomura, Hideaki Mabuchi, Ryosuke Gobaru, Kaori Tateyama, Masashi Suzuki
- Organizer
  38th American Society for Virology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 筋肉内rHAワクチン投与後の鼻腔内アジュバントによる免疫応答の検討2019
- Author(s)
  篠村夏織、川野利明、木津有美、平野隆、松永崇志、吉永和弘、立山香織、鈴木正志
- Organizer
  日本耳鼻咽喉科感染症学会
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 鼻腔投与型インフルエンザウイルスワクチンにおける付加アジュバントによる免疫細胞応答2018
- Author(s)
  川野利明、平野隆、馬渕英彰、合原良亮、鈴木正志
- Organizer
  日本耳鼻咽喉科学会総会
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] Comparison of human tonsil or serum immune cell response after 3 years seasonal parenteral influenza virus vaccination2018
- Author(s)
  Ryosuke Gobaru, Toshiaki Kawano, Takashi Hirano, Hideaki Mabuchi, Kazue Ito, Takayuki Matsunaga, Masashi Suzuki
- Organizer
  American Society for Virology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 経鼻粘膜免疫後の頸部リンパ節に対する制御性T細胞が与える影響2018
- Author(s)
  平野　隆，川野利明，松永崇志，門脇嘉宣、児玉　悟、鈴木正志
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-16K11187
[Presentation] 経鼻粘膜免疫後の頸部リンパ節に対する制御性T細胞が与える影響2018
- Author(s)
  平野　隆、川野利明、松永崇志、門脇嘉宣、児玉　悟、鈴木正志
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-16K11187
[Presentation] The expression of T and B cell activation markers following nasal adjuvant for influenza vaccine2018
- Author(s)
  Toshiaki Kawano, Takashi Hirano, Hideaki Mabuchi, Kazue Ito, Ryosuke Gobaru, Takayuki Matsunaga, Masashi Suzuki
- Organizer
  American Society for Virology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] Analysis of immunogenesity of multiple adjuvants coadministered with nasal recombinant hemagglutinin influenza vaccine2018
- Author(s)
  Hideaki Mabuchi, Toshiaki Kawano, Takashi Hirano, Kazue Ito, Ryosuke Gobaru, Takayuki Matsunaga, Masashi Suzuki
- Organizer
  American Society for Virology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 鼻腔投与型インフルエンザウイルスワクチンにおけるアジュバントの免疫応答2017
- Author(s)
  川野利明、平野隆、馬渕英彰、松永崇志、鈴木正志
- Organizer
  日本耳鼻咽喉科、鼻科学会
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] Analysis of follicular helper T cells in mice following nasal adjuvanted recombinant HA vaccination after influenza virus infection2017
- Author(s)
  Toshiaki Kawano, Takashi Hirano, Hideaki Mabuchi, Masashi Suzuki
- Organizer
  36th Annual Meeting of the American Society for Virology Madison, Wisconsin, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] Effect of multiple adjuvants coadministered with nasal recombinant hemagglutinin influenza (H1N1) vaccine on T cells in mice2017
- Author(s)
  Hideaki Mabuchi, Toshiaki Kawano, Takashi Hirano, Masashi Suzuki
- Organizer
  36th Annual Meeting of the American Society for Virology Madison, Wisconsin, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11361
[Presentation] 慢性中耳炎における制御性T細胞免疫寛容機序に対するin vitroでの解析2017
- Author(s)
  平野　隆、川野利明、松永崇志、門脇嘉宣、児玉　悟、鈴木正志
- Organizer
  日本耳科学会
- Data Source
  KAKENHI-PROJECT-16K11187
[Presentation] Effect of anti-CD25 monoclonal antibody on chronic otitis media in mice model2015
- Author(s)
  Takashi Hirano, Satoru Kodama, Munehito Moriyama, Tarou Iwasaki, Yoshinori Kadowaki, Toshiaki Kawano, Masashi Suzuki
- Organizer
  18th International Symposium on Recent Advances in Otitis Media
- Place of Presentation
  Gayload National Resort and Convention Center, Maryland, USA
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462648
[Presentation] Analysis of the mucosal immune system of middle ear and nose in Suppressor of cytokine signaling (SOCS)-1 knockout mouse model with allergic rhinitis2013
- Author(s)
  Kawano. T, Hirano T, Kadowaki Y, Moriyama M, Iwasaki T, Noguchi K, Kobayashi T, Suzuki M
- Organizer
  Extraordinary International Meeting on Recent Advances in Otitis Media
- Place of Presentation
  Clarion Hotel Sign, Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-25861571
[Presentation] Analysis of dynamics of Th17 cells in chronic middle ear inflammation induced by nontypeable Haemophilus influenzae2013
- Author(s)
  Takashi Hirano, Satoru Kodama, Toshiaki Kawano, Munehito Moriyama, Masashi Suzuki
- Organizer
  7th Extraordinary International Symposium on Recent Advances in Otitis Media
- Place of Presentation
  Clarion Hotel Sign, Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-25462648
[Presentation] Neutrophils with triggering receptor expressed on myeloid cells (TREM)-1 expression enhance bacterial clearance from the nose in C3H/HeN mice more than in C3H/HeJ mice.2013
- Author(s)
  Takashi Hirano, Munehito Moriyama, Toshiaki Kawano, Yoshinori Kadowaki, Taro Iwasaki, Satoru Kodama, Masashi Suzuki
- Organizer
  7th International Symposium on Recent Advances in rhino sinusitis and nasal polyposis
- Place of Presentation
  Kunibiki Messe, Simane, Japan
- Data Source
  KAKENHI-PROJECT-25462648
[Presentation] Evaluation of the Immunogenicity and Safety of an MF59-like Adjuvanted H5N1 Vaccine in Mice Using Systems Biology Approach
- Author(s)
  Yanhong Zhu, Toshiaki Kawano, Yangqing Zhao, Anding Zhang, Zhiping Ye, Kinnera Chada, Hong Yang, Steven Anderson, Hang Xie
- Organizer
  33rd Annual Meeting of the American Society for Virology
- Place of Presentation
  Colorado State University, Fort Collins, USA
- Year and Date
  2014-06-21 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-25861571
[Presentation] Impact of avian influenza infections on pregnant mice
- Author(s)
  Anding Zhang, Yangqing Zhao, Yanhong Zhu, Toshiaki Kawano, Zhiping Ye, Hang Xie
- Organizer
  33rd Annual Meeting of the American Society for Virology
- Place of Presentation
  Colorado State University, Fort Collins, USA
- Year and Date
  2014-06-21 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-25861571
[Presentation] Effects of an MF59-like adjuvant on T cell development and migration in mice following vaccination with H5N1 monovalent
- Author(s)
  Toshiaki Kawano, Yanhong Zhu, Yangqing Zhao, Anding Zhang, Zhiping Ye, Kinnera Chada, Hong Yang, Steven Anderson, Hang Xie
- Organizer
  33rd Annual Meeting of the American Society for Virology
- Place of Presentation
  Colorado State University, Fort Collins, USA
- Year and Date
  2014-06-21 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-25861571

1. SUZUKI MASASHI (60211314)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. Hirano Takashi (20305056)

# of Collaborated Projects: 6 results

# of Collaborated Products: 25 results
3. 門脇嘉宣 (10706980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 児玉悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWANO Toshiaki 川野 利明

Research Projects

Research Products

Co-Researchers

M2タンパクと複合アジュバントを用いた新たなインフルエンザウイルスワクチン戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation of upper respiratory mucosal immune response by immune checkpoint inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of Mucosal immune responses on innate lymphoid cells 2 in mucosal and lymphoid tissues.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of new adjuvants coadministered with nasal recombinant hemagglutinin influenza vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mucosal tolerance by regulatory T cell in chronic otitis media

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of anti-CD25 monoclonal antibody on chronic otitis media in mice model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the immune system of middle ear and nose in suppressor of cytokine signaling (SOCS)- 1 knockout mouse with allergic rhinitis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] アレルギーの臨床2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Interaction between regulatory T cells and antibody producing B cells for the immune responses at the upper respiratory mucosae against nontypeable Haemophilus influenza-in vitro assay model-2019

Author(s)

Journal Title

Data Source

[Journal Article] Monophosphoryl lipid A enhances nontypeable Haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of regulatory T cells and chronic inflammation in the middle ear in a mouse model of chronic otitis media with effusion induced by combined Eustachian tube blockage and nontypeable Haemophilus influenzae infection2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of dynamics of Th17 cells in chronic middle ear inflammation induced by nontypeable Heamophilus influenzae2014

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of the mucosal immune system of middle ear and nose in suppressor of cytokine signaling (SOCS)-1 knockout mouse model with allergic rhinitis2014

Author(s)

Journal Title

Data Source

[Journal Article] Triggering receptor expressed on myeloid cells (TREM)-1 expression on polymorphonuclear neutrophils enhanced the bacterial clearance from the nose in synergy with TLR42014

Author(s)

Journal Title

Data Source

[Presentation] 粘膜アジュバント経鼻投与による自然リンパ球への影響2019

Author(s)

Organizer

KAWANO Toshiaki 川野利明