Moriya Shota 森谷昇太

Researcher Number	30634935
Other IDs
Affiliation *help	2015 – 2018 : 東京医科大学, 医学部, 助教 2013 – 2014 : 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Applied pharmacology
Keywords	Principal Investigator 多発性骨髄腫 / マクロライド / ボルテゾミブ / プロテアソーム / 小胞体ストレス / オートファジー / クラリスロマイシン / ミエローマ / CHOP / リソソーム / 微小環境 / アグリソーム / 骨髄腫

マクロライド系抗生剤によるオートファジー阻害機構の解明と多発性骨髄腫治療への応用Principal InvestigatorOngoing
- Principal Investigator
  
  森谷昇太
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Medical University
Development of intracellular proteolytic pathways targeted therapies for the treatment of multiple myelomaPrincipal Investigator
- Principal Investigator
  
  Moriya Shota
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Medical University

All 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis2017
- Author(s)
  Yamane M, Moriya S, Kokuba H.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume : in Press
- DOI
  10.1016/j.bbrep.2017.02.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19187
[Journal Article] Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone.2016
- Author(s)
  Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M.
- Journal Title
  
  Sci Rep 18;6:35599, 2016
  
  Volume : 18 Pages : 35599-35599
- DOI
  10.1038/srep35599
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K08937, KAKENHI-PROJECT-16K09219, KAKENHI-PROJECT-26460809, KAKENHI-PROJECT-16K19187
[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  Miyahara K, Kazama H, Kokuba H, Komatsu S, Hirota A, Takemura J, Hirasawa K,Moriya S, Abe A, Hiramoto M, Ishikawa T, Miyazawa K.
- Journal Title
  
  Int J Oncol
  
  Volume : 49 Pages : 1848-1858
- DOI
  10.3892/ijo.2016.3673
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387
[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, Abe A, Inazu　M, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  International Journal of Oncology
  
  Volume : 11 Pages : 1848-1858
- DOI
  10.1371/journal.pone.0164529
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387, KAKENHI-PROJECT-16K21388
[Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines2016
- Author(s)
  Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Omura S, Handa H, Itoi T, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume : 48 Pages : 45-54
- DOI
  10.3892/ijo.2015.3237
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-26460478, KAKENHI-PUBLICLY-26102737, KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388, KAKENHI-PLANNED-23102002
[Journal Article] Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos2016
- Author(s)
  Ogawa H, Takyu R, Morimoto H, Toei S, Sakon H, Goto S, Moriya S, Kono T.
- Journal Title
  
  J Reprod Dev.
  
  Volume : 62 Pages : 51-8
- DOI
  10.1262/jrd.2015-097
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450470, KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-15H02472, KAKENHI-PROJECT-16K19187
[Journal Article] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.2015
- Author(s)
  Sugita S, Ito K, Yamashiro Y, Moriya S, Che XF, Yokoyama T, Hiramoto M, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : Apr 7 Pages : 28-34
- DOI
  10.1016/j.bbrc.2015.03.162
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972
[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015
- Author(s)
  Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K
- Journal Title
  
  Int J Oncol
  
  Volume : Feb;46(2) Pages : 474-86
- DOI
  10.3892/ijo.2014.2773
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26430170, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972
[Journal Article] Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.2013
- Author(s)
  Komatsu S, Moriya S, Che XF, Yokoyama T, Kohno N, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : Jul 19;437(1) Pages : 41-7
- DOI
  10.1016/j.bbrc.2013.06.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860398
[Journal Article] 2-Aminophenoxazine-3-one-induced apoptosis via generation of reactive oxygen species followed by c-jun N-terminal kinase activation in the human glioblastoma cell line LN229.2013
- Author(s)
  Che XF, Moriya S, Zheng CL, Abe A, Tomoda A, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume : Nov;43(5) Pages : 1456-66
- DOI
  10.3892/ijo.2013.2088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860398
[Journal Article] Macrolide antibiotics block autophagy flux and sensitize tobortezomib via endoplasmic reticulum stress-mediated CHOP induction in myelomacells.2013
- Author(s)
  Moriya S, Che XF, Komatsu S, Abe A,Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K
- Journal Title
  
  Int J Oncol.
  
  Volume : 42 Pages : 1541-1550
- DOI
  10.3892/ijo.2013.1870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590248, KAKENHI-PROJECT-22591050, KAKENHI-PROJECT-25860398
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity and overcome stromal cell-mediated drug resistance in myeloma cells.2016
- Author(s)
  森谷昇太, 風間宏美, 平本正樹, 半田宏, 宮澤啓介
- Organizer
  第178回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.2016
- Author(s)
  平澤一浩，森谷昇太，宮原か奈，風間宏美，廣田綾子，武村淳，阿部晃久，稲津正人，平本正樹，塚原清彰，宮澤啓介
- Organizer
  第177回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  宮原か奈，風間宏美，國場寛子，小松誠一郎，廣田綾子，武村淳，平澤一浩，森谷昇太，阿部晃久，平本正樹，石川考，宮澤啓介
- Organizer
  第177回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] トリプルネガティブ乳がん細胞におけるハルミンの抗腫瘍作用について2016
- Author(s)
  阿部晃久，山田博之，森谷昇太
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮崎県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] リソソーム膜にパルミトイルセラミド・チャンネルが形成できるか2016
- Author(s)
  山根基輝，森谷昇太，國場寛子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮崎県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] アミノ酸飢餓状態下で、マクロライド系抗菌薬はオートファジー阻害により頭頸部癌細胞株の細胞死を誘導する2016
- Author(s)
  平澤一浩, 森谷昇太, 宮原か奈, 平本正樹, 塚原清彰, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] ビノレルビンは乳癌細胞株においてアグリソーム形成を阻害することによりボルテゾミブ誘導性の細胞毒性を増強する2016
- Author(s)
  宮原か奈, 森谷昇太, 小松誠一郎, 平澤一浩, 阿部晃久, 平本正樹, 石川孝, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity in myeloma cells co-cultured with stroma layer2016
- Author(s)
  森谷昇太, 風間宏美, 平本正樹, 相澤信, 砂塚敏明, 半田宏, 宮澤啓介
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.2016
- Author(s)
  平澤一浩，森谷昇太，宮原か奈，風間宏美，廣田綾子，武村淳，阿部晃久，稲津正人，平本正樹，塚原清彰，宮澤啓介
- Organizer
  第178回東京医科大学医学会総会東京医科大学医学会奨励賞受賞講演
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Invited
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] 光反応性クロスリンカーと磁性ナノビーズを用いた分子的探索の試み2016
- Author(s)
  平本正樹，武村淳，風間宏美，森谷昇太，廣田綾子，日野浩嗣，高野直治，阿部晃久，宮澤啓介
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮崎県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolides Sensitize EGFR-TKI-Induced Non-Apoptotic Cell Death via Blocking Autophagy Flux in Pancreatic Cancer Cell Lines2015
- Author(s)
  向井俊太郎，森谷昇太，平本正樹，風間宏美，國場寛子，横山智央，半田宏，糸井隆夫，宮澤啓介
- Organizer
  第176回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015
- Author(s)
  森谷昇太，小松誠一郎，山﨑佳穗，河合優佑，國場寛子，車暁芳，稲津正人，後藤明彦，平本正樹，半田宏，宮澤啓介
- Organizer
  第17５回東京医科大学医学会総会　（医学会奨励賞受賞講演）
- Place of Presentation
  東京医科大学病院
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] クラリスロマイシン併用によるゲフィチニブ誘導性オートファジーを標的とした肺癌細胞株の殺細胞効果の増強2015
- Author(s)
  森谷昇太，車暁芳，横山智央，平本正樹，宮澤啓介
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells2015
- Author(s)
  伊藤謙太郎，杉田翔平，山城優太朗，森谷昇太，車暁芳，平本正樹，横山智央，宮澤啓介
- Organizer
  第17５回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Concomitant Targeting Intracellular Proteolytic Pathways Enhances ER-stress Mediated Cell Death in Breast Cancer Cells2013
- Author(s)
  小松誠一郎，森谷昇太，車暁芳，河野範男，宮澤啓介
- Organizer
  第７２回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting intracellular proteolytic pathways with bortezomib, clarithromycin, and HDAC6 inhibitor enhances ER-stress mediated cell death in myeloma cells2013
- Author(s)
  森谷昇太，小松誠一郎，山﨑佳穗，車暁芳，宮澤啓介
- Organizer
  第86回　日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting intracellular proteolytic systems enhances ER-stress mediated myel oma cell death.2013
- Author(s)
  森谷昇太，小松誠一郎，山﨑佳穗，車暁芳，宮澤啓介
- Organizer
  第75回　日本血液学会学術集会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] DNAメチル化阻害剤による白血病細胞のオートファジーと小胞体ストレス誘導に関する検討
- Author(s)
  宮下竜伊，石川和宏，森谷昇太，宮澤啓介
- Organizer
  第171 回　東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Survivin を標的とする合成ペプチドによる成人T 細胞白血病細胞（ATL）に対する新規治療法の開発
- Author(s)
  車暁芳，森谷昇太，宮澤啓介
- Organizer
  第171 回　東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting aggresome formation enhances ER-stress mediated cell death in myeloma cells.
- Author(s)
  森谷昇太，小松誠一郎，車暁芳，山﨑佳穗，國場寛子，廣田綾子，稲津正人，後藤明彦，宮澤啓介
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Simultaneous targeting aggresome, proteasome, and autophagy potentiates ER-stress mediated cell death in myeloma cells
- Author(s)
  森谷昇太，小松誠一郎，車暁芳，後藤明彦，宮澤啓介
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25860398

1. Komatsu Seiichiro

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
2. INAZU Masato

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
3. HANDA Hiroshi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
4. 宮澤啓介

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# of Collaborated Products : 7results
5. 平本正樹

# of Collaborated Projects : 0results

# of Collaborated Products : 4results
6. 伊藤正裕

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# of Collaborated Products : 1results
7. 曲寧

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8. 畑山直之

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9. 平井宗一

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10. 内藤宗和

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11. 坂部貢

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12. 寺山隼人

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13. 小松則夫

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# of Collaborated Products : 2results
14. 菅原章公

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15. 車暁芳

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16. 後藤明彦

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17. 小川英彦

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18. 河野友宏

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

Moriya Shota 森谷 昇太

Research Projects

Research Products

Co-Researchers

マクロライド系抗生剤によるオートファジー阻害機構の解明と多発性骨髄腫治療への応用Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of intracellular proteolytic pathways targeted therapies for the treatment of multiple myelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2-Aminophenoxazine-3-one-induced apoptosis via generation of reactive oxygen species followed by c-jun N-terminal kinase activation in the human glioblastoma cell line LN229.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrolide antibiotics block autophagy flux and sensitize tobortezomib via endoplasmic reticulum stress-mediated CHOP induction in myelomacells.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Macrolides enhance bortezomib-induced cytotoxicity and overcome stromal cell-mediated drug resistance in myeloma cells.2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.2016

Author(s)

Organizer

Place of Presentation

Moriya Shota 森谷昇太

[Presentation] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015