Moriya Shota 森谷昇太

… Alternative Names

森谷昇太モリヤショウタ

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Researcher Number	30634935
Other IDs
Affiliation (Current)	2022: 東京医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2022: 東京医科大学, 医学部, 助教 2015 – 2020: 東京医科大学, 医学部, 助教 2013 – 2014: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Applied pharmacology / Basic Section 47040:Pharmacology-related Except Principal Investigator Otorhinolaryngology / Applied pharmacology
Keywords	Principal Investigator プロテアソーム / オートファジー / ボルテゾミブ / 多発性骨髄腫 / マクロライド / 小胞体ストレス / クラリスロマイシン / 骨髄腫 / 微小環境 / アグリソーム … More / ミエローマ / CHOP / ベルケイド / bortezomib / リソソーム / 共培養 … More Except Principal Investigator 頭頸部癌 / マクロライド抗菌薬 / オートファジー / アミノ酸 / 小胞体ストレス / EGFR-TKI / 頭頸部腫瘍 / アポトーシス / ネクロプトーシス / がん / マクロライド抗生剤 / 分子標的薬 / マクロライド系抗菌薬 / アミノ酸トランスポーター / ＥＧＦＲ　ＴＫＩ / 薬物治療学 / 分子標的治療 Less

骨髄腫の薬剤耐性におけるオートファジーネットワークの解明と、阻害による耐性化克服Principal Investigator
- Principal Investigator
  
  森谷昇太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
骨髄腫に治療抵抗をもたらす微小環境オートファジーの解明と、その阻害に基づく新治療Principal Investigator
- Principal Investigator
  
  森谷昇太
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
Elucidation of autophagy inhibition mechanism by macrolide antibiotics and therapeutic application to multiple myeloma.Principal Investigator
- Principal Investigator
  
  Moriya Shota
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Medical University
Establishment of novel "amino acid starvation induction therapy" using macrolide antibiotics for head and neck cancer
- Principal Investigator
  
  Hirasawa Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
  Applied pharmacology
- Research Institution
  Tokyo Medical University
Development of intracellular proteolytic pathways targeted therapies for the treatment of multiple myelomaPrincipal Investigator
- Principal Investigator
  
  Moriya Shota
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Medical University

All 2021 2020 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells2021
- Author(s)
  Mierxiati Saimi, Shota Moriya, Zhong-Lian Li , Hidenobu Miyaso, Kenta Nagahori, Shinichi Kawata, Takuya Omotehara, Yuki Ogawa, Hirotsugu Hino, Keisuke Miyazawa, Kou Sakabe, Masahiro Itoh
- Journal Title
  
  Tokai J Exp Clin Med.
  
  Volume: Apr 20;46(1) Pages: 7-16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07107
[Journal Article] Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization?associated cell death2020
- Author(s)
  Takeda Atsuo、Takano Naoharu、Kokuba Hiroko、Hino Hirotsugu、Moriya Shota、Abe Akihisa、Hiramoto Masaki、Tsukahara Kiyoaki、Miyazawa Keisuke
- Journal Title
  
  International Journal of Oncology
  
  Volume: 57 Pages: 1280-1292
- DOI
  10.3892/ijo.2020.5138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-18K06901
[Journal Article] Comparison of Autophagy Inducibility in Various Tyrosine Kinase Inhibitors and Their Enhanced Cytotoxicity via Inhibition of Autophagy in Cancer Cells in Combined Treatment With Azithromycin2020
- Author(s)
  Tanaka Hideki、Hino Hirotsugu、Moriya Shota、Kazama Hiromi、Miyazaki Masaya、Takano Naoharu、Hiramoto Masaki、Tsukahara Kiyoaki、Miyazawa Keisuke
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 22 Pages: 100750-100750
- DOI
  10.1016/j.bbrep.2020.100750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-20K08970
[Journal Article] Abemaciclib Induces Atypical Cell Death in Cancer Cells Characterized by Formation of Cytoplasmic Vacuoles Derived From Lysosomes2020
- Author(s)
  Hino Hirotsugu, Iriyama Noriyoshi, Kokuba Hiroko, Kazama Hiromi, Moriya Shota, Takano Naoharu, Hiramoto Masaki, Aizawa Shin, Miyazawa Keisuke
- Journal Title
  
  Cancer Sci.
  
  Volume: － Pages: 2132-2145
- DOI
  10.1111/cas.14419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-18K06846, KAKENHI-PROJECT-18K06901
[Journal Article] Vitamin K2 Induces Non-Apoptotic Cell Death Along With Autophagosome Formation in Breast Cancer Cell Lines2020
- Author(s)
  Miyazawa Shinsuke、Moriya Shota、Kokuba Hiroko、Hino Hirotsugu、Takano Naoharu、Miyazawa Keisuke
- Journal Title
  
  Breast Cancer
  
  Volume: 27 Pages: 225-235
- DOI
  10.1007/s12282-019-01012-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771
[Journal Article] Fingolimod sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest2019
- Author(s)
  Ohta　K, Ohkuma T, Lorenzo AD, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K.
- Journal Title
  
  Oncology Reports
  
  Volume: - Pages: 231-242
- DOI
  10.3892/or.2019.7140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-19K07107
[Journal Article] Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis2018
- Author(s)
  Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi　H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 52 Pages: 1165-1177
- DOI
  10.3892/ijo.2018.4282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-17K15031
[Journal Article] The　cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent　cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells.2018
- Author(s)
  Iriyama Noriyoshi、Hino Hirotsugu、Moriya Shota、Hiramoto Masaki、Hatta Yoshihiro、Takei Masami、Miyazawa Keisuke
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: Sep 18: Pages: 1-12
- DOI
  10.1080/10428194.2017.1376741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-17K08771
[Journal Article] Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis2017
- Author(s)
  Yamane M, Moriya S, Kokuba H.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: in Press
- DOI
  10.1016/j.bbrep.2017.02.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19187
[Journal Article] Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos2016
- Author(s)
  Ogawa H, Takyu R, Morimoto H, Toei S, Sakon H, Goto S, Moriya S, Kono T.
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 62 Issue: 1 Pages: 51-58
- DOI
  10.1262/jrd.2015-097
- NAID
  130005126319
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450470, KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-15H02472, KAKENHI-PROJECT-16K19187
[Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines2016
- Author(s)
  Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Omura S, Handa H, Itoi T, Miyazawa K.
- Journal Title
  
  Int. J. Clin. Oncol.
  
  Volume: 48 Pages: 1848-1858
- DOI
  10.3892/ijo.2015.3237
- NAID
  120005845877
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-26460478, KAKENHI-PLANNED-23102002, KAKENHI-PUBLICLY-26102737, KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388
[Journal Article] Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone.2016
- Author(s)
  Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M.
- Journal Title
  
  Sci Reｐ.
  
  Volume: 18 Pages: 35599-35599
- DOI
  10.1038/srep35599
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K08937, KAKENHI-PROJECT-16K09219, KAKENHI-PROJECT-26460809, KAKENHI-PROJECT-16K19187
[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  Miyahara K, Kazama H, Kokuba H, Komatsu S, Hirota A, Takemura J, Hirasawa K,Moriya S, Abe A, Hiramoto M, Ishikawa T, Miyazawa K.
- Journal Title
  
  Int J Oncol
  
  Volume: 49 Pages: 1848-1858
- DOI
  10.3892/ijo.2016.3673
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387
[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, Abe A, Inazu　M, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Pages: 1848-1858
- DOI
  10.1371/journal.pone.0164529
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387, KAKENHI-PROJECT-16K21388
[Journal Article] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.2015
- Author(s)
  Sugita S, Ito K, Yamashiro Y, Moriya S, Che XF, Yokoyama T, Hiramoto M, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Apr 7 Pages: 28-34
- DOI
  10.1016/j.bbrc.2015.03.162
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972
[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015
- Author(s)
  Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K
- Journal Title
  
  Int J Oncol
  
  Volume: Feb;46(2) Pages: 474-486
- DOI
  10.3892/ijo.2014.2773
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26430170, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972
[Journal Article] 2-Aminophenoxazine-3-one-induced apoptosis via generation of reactive oxygen species followed by c-jun N-terminal kinase activation in the human glioblastoma cell line LN229.2013
- Author(s)
  Che XF, Moriya S, Zheng CL, Abe A, Tomoda A, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume: Nov;43(5) Pages: 1456-66
- DOI
  10.3892/ijo.2013.2088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860398
[Journal Article] Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.2013
- Author(s)
  Komatsu S, Moriya S, Che XF, Yokoyama T, Kohno N, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Jul 19;437(1) Pages: 41-7
- DOI
  10.1016/j.bbrc.2013.06.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860398
[Journal Article] Macrolide antibiotics block autophagy flux and sensitize tobortezomib via endoplasmic reticulum stress-mediated CHOP induction in myelomacells.2013
- Author(s)
  Moriya S, Che XF, Komatsu S, Abe A,Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K
- Journal Title
  
  Int J Oncol.
  
  Volume: 42 Pages: 1541-1550
- DOI
  10.3892/ijo.2013.1870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590248, KAKENHI-PROJECT-22591050, KAKENHI-PROJECT-25860398
[Presentation] 細胞質・核内に局在のエストロゲンリセプタ―αによる子宮内膜癌細胞の増殖と遊走の制御機構2021
- Author(s)
  Mierxiati Saimi, Shota Moriya, Zhong-Lian Li, Hidenobu Miyaso, Kenta Nagahori, Shinichi Kawata, Takuya Omotehara1, Yuki Ogawa1, Hirotsugu Hino, Keisuke Miyazawa, Kou Sakabe, Masahiro Itoh
- Organizer
  第126回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] ClarithromycinのNOXAのオートファジー分解阻害による骨髄腫のストローマ接着によるbortezomib耐性化の克服2020
- Author(s)
  森谷昇太、風間宏美、日野浩嗣、高野直治、平本正樹、相澤信、宮澤啓介
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] ERストレスはruxolitinibの変異CALR導入細胞増殖抑制効果を増強する2020
- Author(s)
  Mitsuru Moriyama，Daigo Akahan，Shota Moriya，Arisa Yamada，Misa Imai，Marito Araki，Norio Komatsu，Keisuke Miyazawa，Akihiko Gotoh
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] CDK4/6阻害剤abemaciclibはリソソーム機能障害を介した空胞形成を伴う新規細胞死を誘導する2020
- Author(s)
  日野浩嗣、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] 頭頸部扁平上皮癌細胞株に対するHDAC6阻害剤とプロテアソーム阻害剤との相乗的殺細胞効果と非アポトーシス誘導の分子メカニズムの検討2020
- Author(s)
  服部和裕 , 塚原清彰 , 高野直治 , 風間宏美 , 森谷昇太 , 宮澤啓介
- Organizer
  第185回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] DNA-damaging drugs in combination with a macrolide antibiotic enhance cytotoxicity for nonsmall cell lung cancer cells2020
- Author(s)
  鳥山和俊 , 阿部信二 , 高野直治 , 風間宏美 , 森谷昇太 , 宮澤啓介
- Organizer
  第185回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] CDK4/6阻害薬abemaciclibはリソソームの酸性化、膨化による空胞形成を伴った新規細胞死を誘導する2019
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、相澤信、宮澤啓介
- Organizer
  第125回日本解剖学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] イソリキリチゲニンはプロテアソーム系を阻害することによりERストレスを誘導し、ヒトメラノーマ細胞に非アポトーシス性細胞死を誘導する2019
- Author(s)
  阿部晃久、森谷昇太、山田博之
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] Combied treatment with bortezomib plus clarithromycin overcomes stromal cell-mediated drug resistance in myeloma cells via ER-stress and NOXA induction.2019
- Author(s)
  森谷昇太、風間宏美、高野直治、平本正樹、宮澤啓介
- Organizer
  第184回　東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells by quantitative autophagy flux monitoring system.2019
- Author(s)
  田中英基、日野浩嗣、森谷昇太、風間宏美、高野直治、平本正樹、塚原清彰、宮澤啓介
- Organizer
  第183回　東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] CDK4/6阻害薬abemaciclibによるリソソーム由来の空胞形成を伴った新規細胞死誘導2019
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] Lysosome-targeted atypical cell-death with vacuolar formation by CDK4/6 inhibitor abemaciclib2019
- Author(s)
  Hirotsugu Hino, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07107
[Presentation] 東京医科大学・生化学分野の取り組み-オートファジーの制御法の確立と臨床応用に向けて-2018
- Author(s)
  宮澤啓介, 森谷昇太, 風間宏美, 山田裕美子, 徳久真弓, 廣田綾子, 日野浩嗣, 高野直治, 阿部晃久, 平本正樹
- Organizer
  第181回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] CDK4/6阻害薬abemaciclibのリソソームを標的とした細胞死誘導効果2018
- Author(s)
  日野浩嗣, 入山規良, 國場寛子, 風間宏美, 森谷昇太, 高野直治, 平本正樹, 宮澤啓介
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] CDK4/6阻害薬アベマシクリブはリソソーム機能阻害に起因する空胞形成を伴った細胞死を誘導する2018
- Author(s)
  日野浩嗣, 入山規良, 國場寛子, 風間宏美, 森谷昇太, 高野直治, 平本正樹, 宮澤啓介
- Organizer
  第182回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] CDK4/6阻害剤abemaciclibはリソソーム由来の空胞形成を伴った細胞死を誘導する2018
- Author(s)
  日野浩嗣, 入山規良, 國場寛子, 風間宏美, 森谷昇太, 高野直治, 平本正樹, 宮澤啓介
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] プロトンポンプ阻害薬とマクロライド系抗生剤との併用による殺細胞効果の増強2018
- Author(s)
  武田淳雄, 高野直治, 森谷昇太, 風間宏美, 日野浩嗣, 山田裕美子, 阿部晃久, 平本正樹, 宮澤啓介,　塚原清彰
- Organizer
  第182回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Amino acid-starving culture condition enhances gefitinib-induced cytotoxicity via necroptosis-like cell death in EGFR-expressing cancer cells2017
- Author(s)
  Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
- Organizer
  第179回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] CDK4/6阻害剤abemaciclibはmethuosis様の細胞死を誘導する2017
- Author(s)
  日野浩嗣，入山規良，國場寛子，風間宏美，森谷昇太，高野直治，平本正樹，宮澤啓介
- Organizer
  第40回日本分子生物学会年会第90回日本生化学会大会合同開催
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Amino acid-starving culture condition enhances gefitinib-induced cytotoxicity via necroptosis-like cell death in EGFR-expressing cancer cells2017
- Author(s)
  Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
- Organizer
  第180回東京医科大学医学会総会医学会奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity and overcome stromal cell-mediated drug resistance in myeloma cells2017
- Author(s)
  森谷昇太，風間宏美，平本正樹，半田宏，宮澤啓介
- Organizer
  第179回東京医科大学医学会総会医学会奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] ハルミンはヒトメラノーマ細胞G361において抗アポトーシスタンパク質であるサバイビンとMcl-1のユビキチン-プロテアソーム系による分解を促進しアポトーシスを誘導する2017
- Author(s)
  阿部晃久，森谷昇太，平本正樹，風間宏美，山田博之
- Organizer
  第40回日本分子生物学会年会第90回日本生化学会大会合同開催
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] アミノ酸飢餓条件下におけるEGFR発現癌細胞に対するゲフィチニブのネクロプトーシス様細胞死を介した殺細胞増強効果2017
- Author(s)
  齊藤雄，森谷昇太，風間宏美，平澤一浩，宮原か奈，高野直治，平本正樹，塚原清彰，宮澤啓介
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] 多発性硬化症治療薬FTY720の抗腫瘍効果の検討2017
- Author(s)
  太田行紀，大熊尭，Alberto L，平本正樹，日野浩嗣，風間宏美，森谷昇太，高野直治，宮澤啓介
- Organizer
  第180回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] マクロライド抗生剤は骨髄腫細胞株のストローマ細胞接着依存性プロテアソーム阻害剤耐性を克服し、殺細胞作用を増強する2017
- Author(s)
  森谷昇太，風間宏美，平本正樹，宮澤啓介
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] CDK4/6阻害剤アベマシクリブによる非アポトーシス/非ネクロプトーシス細胞死を介した抗腫瘍効果の検討2017
- Author(s)
  日野浩嗣，風間宏美，森谷昇太，高野直治，平本正樹，國場寛子，宮澤啓介
- Organizer
  第180回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] ハルミンはヒトメラノーマ細胞G361において抗アポトーシスタンパク質であるサバイビンとMcl-1のユビキチン-プロテアソーム系による分解を促進しアポトーシスを誘導する2017
- Author(s)
  阿部晃久，森谷昇太，平本正樹，風間宏美，宮澤啓介
- Organizer
  第180回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity and overcome stromal cell-mediated drug resistance in myeloma cells.2016
- Author(s)
  森谷昇太, 風間宏美, 平本正樹, 半田宏, 宮澤啓介
- Organizer
  第178回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity in myeloma cells co-cultured with stroma layer2016
- Author(s)
  森谷昇太, 風間宏美, 平本正樹, 相澤信, 砂塚敏明, 半田宏, 宮澤啓介
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.2016
- Author(s)
  平澤一浩，森谷昇太，宮原か奈，風間宏美，廣田綾子，武村淳，阿部晃久，稲津正人，平本正樹，塚原清彰，宮澤啓介
- Organizer
  第177回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] リソソーム膜にパルミトイルセラミド・チャンネルが形成できるか2016
- Author(s)
  山根基輝，森谷昇太，國場寛子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮崎県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition2016
- Author(s)
  Kazuhiro Hirasawa、Shota Moriya、Kana Miyahara、Hiromi Kazama、Ayako Hirota、Jun Yoshida、Akihisa Abe、Masato Inazu、Masaki Hiramoto、Kiyoaki Tsukahara、Keisuke Miyazawa
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K21387
[Presentation] 光反応性クロスリンカーと磁性ナノビーズを用いた分子的探索の試み2016
- Author(s)
  平本正樹，武村淳，風間宏美，森谷昇太，廣田綾子，日野浩嗣，高野直治，阿部晃久，宮澤啓介
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮崎県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] トリプルネガティブ乳がん細胞におけるハルミンの抗腫瘍作用について2016
- Author(s)
  阿部晃久，山田博之，森谷昇太
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮崎県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] ビノレルビンは乳癌細胞株においてアグリソーム形成を阻害することによりボルテゾミブ誘導性の細胞毒性を増強する2016
- Author(s)
  宮原か奈, 森谷昇太, 小松誠一郎, 平澤一浩, 阿部晃久, 平本正樹, 石川孝, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] アミノ酸飢餓状態下で、マクロライド系抗菌薬はオートファジー阻害により頭頸部癌細胞株の細胞死を誘導する2016
- Author(s)
  平澤一浩, 森谷昇太, 宮原か奈, 平本正樹, 塚原清彰, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  宮原か奈，風間宏美，國場寛子，小松誠一郎，廣田綾子，武村淳，平澤一浩，森谷昇太，阿部晃久，平本正樹，石川考，宮澤啓介
- Organizer
  第177回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.2016
- Author(s)
  平澤一浩，森谷昇太，宮原か奈，風間宏美，廣田綾子，武村淳，阿部晃久，稲津正人，平本正樹，塚原清彰，宮澤啓介
- Organizer
  第178回東京医科大学医学会総会東京医科大学医学会奨励賞受賞講演
- Place of Presentation
  東京医科大学病院（東京都新宿区）
- Invited
- Data Source
  KAKENHI-PROJECT-16K19187
[Presentation] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells2015
- Author(s)
  伊藤謙太郎，杉田翔平，山城優太朗，森谷昇太，車暁芳，平本正樹，横山智央，宮澤啓介
- Organizer
  第17５回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] クラリスロマイシン併用によるゲフィチニブ誘導性オートファジーを標的とした肺癌細胞株の殺細胞効果の増強2015
- Author(s)
  森谷昇太，車暁芳，横山智央，平本正樹，宮澤啓介
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015
- Author(s)
  森谷昇太，小松誠一郎，山﨑佳穗，河合優佑，國場寛子，車暁芳，稲津正人，後藤明彦，平本正樹，半田宏，宮澤啓介
- Organizer
  第17５回東京医科大学医学会総会　（医学会奨励賞受賞講演）
- Place of Presentation
  東京医科大学病院
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Macrolides Sensitize EGFR-TKI-Induced Non-Apoptotic Cell Death via Blocking Autophagy Flux in Pancreatic Cancer Cell Lines2015
- Author(s)
  向井俊太郎，森谷昇太，平本正樹，風間宏美，國場寛子，横山智央，半田宏，糸井隆夫，宮澤啓介
- Organizer
  第176回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting intracellular proteolytic pathways with bortezomib, clarithromycin, and HDAC6 inhibitor enhances ER-stress mediated cell death in myeloma cells2013
- Author(s)
  森谷昇太，小松誠一郎，山﨑佳穗，車暁芳，宮澤啓介
- Organizer
  第86回　日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting intracellular proteolytic systems enhances ER-stress mediated myel oma cell death.2013
- Author(s)
  森谷昇太，小松誠一郎，山﨑佳穗，車暁芳，宮澤啓介
- Organizer
  第75回　日本血液学会学術集会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Concomitant Targeting Intracellular Proteolytic Pathways Enhances ER-stress Mediated Cell Death in Breast Cancer Cells2013
- Author(s)
  小松誠一郎，森谷昇太，車暁芳，河野範男，宮澤啓介
- Organizer
  第７２回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Simultaneous targeting aggresome, proteasome, and autophagy potentiates ER-stress mediated cell death in myeloma cells
- Author(s)
  森谷昇太，小松誠一郎，車暁芳，後藤明彦，宮澤啓介
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Targeting aggresome formation enhances ER-stress mediated cell death in myeloma cells.
- Author(s)
  森谷昇太，小松誠一郎，車暁芳，山﨑佳穗，國場寛子，廣田綾子，稲津正人，後藤明彦，宮澤啓介
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] Survivin を標的とする合成ペプチドによる成人T 細胞白血病細胞（ATL）に対する新規治療法の開発
- Author(s)
  車暁芳，森谷昇太，宮澤啓介
- Organizer
  第171 回　東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Data Source
  KAKENHI-PROJECT-25860398
[Presentation] DNAメチル化阻害剤による白血病細胞のオートファジーと小胞体ストレス誘導に関する検討
- Author(s)
  宮下竜伊，石川和宏，森谷昇太，宮澤啓介
- Organizer
  第171 回　東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Data Source
  KAKENHI-PROJECT-25860398

1. Hirasawa Kazuhiro (90772161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. MIYAZAWA Keisuke (50209897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. KONO Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SUGAWARA Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. HIRAI Shuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TERAYAMA Hayato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. NAITO Munekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. CHE Xiao-fang

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 平本正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results
10. 小川英彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 半田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 風間宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
13. 高野直治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 相沢信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 曲寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 伊藤正裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 畑山直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 坂部貢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 小松則夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 稲津正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小松誠一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 後藤明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Moriya Shota 森谷 昇太

森谷 昇太 モリヤ ショウタ

Research Projects

Research Products

Co-Researchers

骨髄腫の薬剤耐性におけるオートファジーネットワークの解明と、阻害による耐性化克服Principal Investigator

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骨髄腫に治療抵抗をもたらす微小環境オートファジーの解明と、その阻害に基づく新治療Principal Investigator

Principal Investigator

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Elucidation of autophagy inhibition mechanism by macrolide antibiotics and therapeutic application to multiple myeloma.Principal Investigator

Principal Investigator

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Research Institution

Establishment of novel "amino acid starvation induction therapy" using macrolide antibiotics for head and neck cancer

Principal Investigator

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Research Institution

Development of intracellular proteolytic pathways targeted therapies for the treatment of multiple myelomaPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Cytonuclear Estrogen Receptor Alpha Regulates Proliferation and Migration of Endometrial Carcinoma Cells2021

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[Journal Article] Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization?associated cell death2020

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DOI

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[Journal Article] Comparison of Autophagy Inducibility in Various Tyrosine Kinase Inhibitors and Their Enhanced Cytotoxicity via Inhibition of Autophagy in Cancer Cells in Combined Treatment With Azithromycin2020

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DOI

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[Journal Article] Abemaciclib Induces Atypical Cell Death in Cancer Cells Characterized by Formation of Cytoplasmic Vacuoles Derived From Lysosomes2020

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DOI

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[Journal Article] Vitamin K2 Induces Non-Apoptotic Cell Death Along With Autophagosome Formation in Breast Cancer Cell Lines2020

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DOI

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[Journal Article] Fingolimod sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest2019

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[Journal Article] Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis2018

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[Journal Article] The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells.2018

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[Journal Article] Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis2017

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[Journal Article] Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos2016

Moriya Shota 森谷昇太

森谷昇太モリヤショウタ

[Journal Article] The　cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent　cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells.2018