Itoh Yukihiro 伊藤幸裕

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ITOH Yukihiro 伊藤幸裕

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Researcher Number	30636402
Other IDs
Affiliation (Current)	2022: 大阪大学, 産業科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 大阪大学, 産業科学研究所, 准教授 2019: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2015 – 2018: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2012 – 2014: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Complex systems / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 37030:Chemical biology-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator ケミカルバイオロジー / 創薬化学 / 分子設計 / ドラッグデザイン / 低分子薬物 / エピジェネティクス / 触媒メカニズム / 低分子化合物 / ユビキチン / プローブ … More / 非翻訳RNA / 分解誘導剤 / 化合物探索 / 酵素阻害薬 … More Except Principal Investigator 標的誘導型合成 / 医薬品 / 阻害薬 / in situクリックケミストリー / 創薬 Less

クリックケミストリーに基づく生物活性化合物創製法の確立Principal Investigator
- Principal Investigator
  
  伊藤幸裕
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Osaka University
Development of innovative drug candidates by target guided synthesis
- Principal Investigator
  
  鈴木孝禎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
RNA分解誘導化合物の開発とその薬学的応用Principal Investigator
- Principal Investigator
  
  伊藤幸裕
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製Principal Investigator
- Principal Investigator
  
  伊藤幸裕
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
  Kyoto Prefectural University of Medicine
Identification of artificial ubiquitin compounds and their application studyPrincipal Investigator
- Principal Investigator
  
  Itoh Yukihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Discovery of ubiquitin-activating enzyme inhibitors designed based on its catalytic mechanismPrincipal Investigator
- Principal Investigator
  
  Itoh Yukihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Discovery of lysine-specific demethylase 1 Inhibitors based on enzymatic mechanismPrincipal Investigator
- Principal Investigator
  
  ITOH Yukihiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine

All 2021 2020 2019 2018 2017 2016 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Design, synthesis, and biological evaluation of lysine demethylase 5C degraders2021
- Author(s)
  Iida Tetsuya、Itoh Yukihiro、Takahashi Yukari、Yamashita Yasunobu、Kurohara Takashi、Miyake Yuka、Oba Makoto、Suzuki Takayoshi
- Journal Title
  
  ChemMedChem
  
  Volume: -
- DOI
  10.1002/cmdc.202000933
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05295, KAKENHI-PROJECT-19H01079
[Journal Article] Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches2020
- Author(s)
  Itoh Yukihiro
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 68 Issue: 1 Pages: 34-45
- DOI
  10.1248/cpb.c19-00741
- NAID
  130007778877
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05295, KAKENHI-PROJECT-17K08367
[Journal Article] Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors2018
- Author(s)
  Itoh Yukihiro、Suzuki Miki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 印刷中
- DOI
  10.1016/j.bmcl.2018.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08367
[Journal Article] Chemical Protein Degradation Approach and its Application to Epigenetic Targets2018
- Author(s)
  Itoh Yukihiro
- Journal Title
  
  The Chemical Record
  
  Volume: 18 Pages: 1681-1700
- DOI
  10.1002/tcr.201800032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08367
[Journal Article] “Drug” Discovery with the Help of Organic Chemistry2017
- Author(s)
  Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 3 Pages: 283-292
- DOI
  10.1248/yakushi.16-00231-1
- NAID
  130005396859
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14982, KAKENHI-PROJECT-26870495
[Journal Article] LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates Synthesis2014
- Author(s)
  Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki.
- Journal Title
  
  Computational and Structural Biotechnology Journal
  
  Volume: 9
- DOI
  10.5936/csbj.201402002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890193
[Journal Article] Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism2013
- Author(s)
  Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N, Suzuki T
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 52 Pages: 8520-8624
- DOI
  10.1002/anie.201303999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24790117, KAKENHI-PROJECT-24890193, KAKENHI-PROJECT-221S0001
[Patent] リシン構造を有するLSD1選択阻害薬2012
- Inventor(s)
  鈴木孝禎、伊藤幸裕、小笠原大介、宮田直樹、水上民夫、佐々木隆造、河原真大
- Industrial Property Rights Holder
  学校法人関西文理総合学園長浜バイオ大学、京都府公立大学法人、公立大学法人名古屋市立大学、国立大学法人京都大学、株式会社フロンティアファーマ
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-260222
- Filing Date
  2012-11-28
- Overseas
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] タンパク質分解を誘導する低分子化合物の創製2021
- Author(s)
  伊藤幸裕
- Organizer
  産研テクノサロン
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05295
[Presentation] 合理的な分子設計と独特な創薬方法論が導くリシン修飾酵素制御化合物の創製2019
- Author(s)
  伊藤幸裕
- Organizer
  日本薬学会　第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08367
[Presentation] 新規ユビキチン活性化酵素阻害薬の創製2018
- Author(s)
  伊藤幸裕、鈴木美紀
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08367
[Presentation] リシン修飾酵素を制御する低分子化合物の修飾酵素を制御する低分子化合物の修飾酵素を制御する低分子化合物の創製～化学的発想を活かした創薬～2018
- Author(s)
  伊藤幸裕
- Organizer
  第４回近畿薬学シンポジウム：化学系の若い力
- Invited
- Data Source
  KAKENHI-PROJECT-17K08367
[Presentation] 低分子化合物を用いたタンパク質化学修飾制御の分子技術2017
- Author(s)
  伊藤幸裕
- Organizer
  日本化学会　第97春季年会
- Place of Presentation
  横浜
- Year and Date
  2017-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-26870495
[Presentation] 有機化学の力を借りた「薬」創り2016
- Author(s)
  伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26870495
[Presentation] PCPA－リシン誘導体ハイブリット型LSD1不活性化薬の立体化学－活性相関研究2014
- Author(s)
  伊藤幸裕、小笠原大介、太田庸介、水上民夫、鈴木孝禎
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] PCPA-リシン誘導体ハイブリット型LSD1不活性化薬の立体化学-活性相関研究2014
- Author(s)
  伊藤幸裕、小笠原大介、太田庸介、水上民夫、鈴木孝禎
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を運ぶ低分子化合物2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 標的酵素へのドラッグデリバリーを目指したLSD1不活性化薬の創製2013
- Author(s)
  小笠原大介、伊藤幸裕、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1 に阻害薬を届ける低分子化合物の創製2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を届ける小分子2013
- Author(s)
  伊藤幸裕、宮田直樹、鈴木孝禎
- Organizer
  第13回第日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Year and Date
  2013-06-12
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1 へ阻害薬を届ける小分子2013
- Author(s)
  伊藤幸裕、宮田直樹、鈴木孝禎
- Organizer
  第13回第日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Invited
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] Design and Synthesis of LSD1 inactivators Based on Enzyme-targeted Drug Delivery Mechanism2013
- Author(s)
  Yukihiro Itoh
- Organizer
  2nd Annual Conference ICBS2013
- Place of Presentation
  Kyoto
- Year and Date
  2013-10-07
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 標的酵素への直接的ドラッグデリバリーに基づいたLSD1選択的不活性化薬の創製2013
- Author(s)
  小笠原大介、伊藤幸裕、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会第8回年会
- Place of Presentation
  東京
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を届ける小分子2013
- Author(s)
  伊藤幸裕
- Organizer
  第13回日本蛋白質科学会
- Place of Presentation
  鳥取
- Invited
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 標的酵素への直接的ドラッグデリバリーに基づいたLSD1 選択的不活性化薬の創製2013
- Author(s)
  小笠原大介、伊藤幸裕、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] Design and Synthesis of LSD1 inactivators Based on Enzyme-targeted Drug Delivery Mechanism.2013
- Author(s)
  Yukihiro Itoh
- Organizer
  2nd Annual Conference ICBS2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を運ぶ低分子化合物2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Year and Date
  2013-11-21
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1に阻害薬を届ける低分子化合物の創製2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2013-11-05
- Data Source
  KAKENHI-PROJECT-24890193

1. 鈴木孝禎 (90372838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 山下泰信 (10873408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高田悠里 (20902357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HASEGAWA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KAKIZAWA Taeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. MIZUKAMI Tamio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. ITO Hidemi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SUZUKI Hiromu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 鈴木登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 鈴木貞夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木操

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐々木泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Itoh Yukihiro 伊藤 幸裕

ITOH Yukihiro 伊藤 幸裕

Research Projects

Research Products

Co-Researchers

クリックケミストリーに基づく生物活性化合物創製法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative drug candidates by target guided synthesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA分解誘導化合物の開発とその薬学的応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of artificial ubiquitin compounds and their application studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of ubiquitin-activating enzyme inhibitors designed based on its catalytic mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of lysine-specific demethylase 1 Inhibitors based on enzymatic mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Design, synthesis, and biological evaluation of lysine demethylase 5C degraders2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical Protein Degradation Approach and its Application to Epigenetic Targets2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] &#x201C;Drug&#x201D; Discovery with the Help of Organic Chemistry2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates Synthesis2014

Author(s)

Itoh Yukihiro 伊藤幸裕

ITOH Yukihiro 伊藤幸裕

[Journal Article] “Drug” Discovery with the Help of Organic Chemistry2017

[Presentation] リシン修飾酵素を制御する低分子化合物の修飾酵素を制御する低分子化合物の修飾酵素を制御する低分子化合物の創製～化学的発想を活かした創薬～2018