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Itoh Yukihiro  伊藤 幸裕

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ITOH Yukihiro  伊藤 幸裕

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Researcher Number 30636402
Other IDs
Affiliation (Current) 2022: 大阪大学, 産業科学研究所, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 大阪大学, 産業科学研究所, 准教授
2019: 京都府立医科大学, 医学(系)研究科(研究院), 准教授
2015 – 2018: 京都府立医科大学, 医学(系)研究科(研究院), 講師
2012 – 2014: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Drug development chemistry / Chemical pharmacy / Complex systems / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 37030:Chemical biology-related
Except Principal Investigator
Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords
Principal Investigator
ケミカルバイオロジー / 創薬化学 / 分子設計 / ドラッグデザイン / 低分子薬物 / エピジェネティクス / 触媒メカニズム / 低分子化合物 / ユビキチン / プローブ … More / 非翻訳RNA / 分解誘導剤 / 化合物探索 / 酵素阻害薬 … More
Except Principal Investigator
標的誘導型合成 / 医薬品 / 阻害薬 / in situクリックケミストリー / 創薬 Less
  • Research Projects

    (7 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (12 People)
  •  クリックケミストリーに基づく生物活性化合物創製法の確立Principal Investigator

    • Principal Investigator
      伊藤 幸裕
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Osaka University
  •  Development of innovative drug candidates by target guided synthesis

    • Principal Investigator
      鈴木 孝禎
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Osaka University
  •  RNA分解誘導化合物の開発とその薬学的応用Principal Investigator

    • Principal Investigator
      伊藤 幸裕
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Osaka University
  •  ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製Principal Investigator

    • Principal Investigator
      伊藤 幸裕
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Osaka University
      Kyoto Prefectural University of Medicine
  •  Identification of artificial ubiquitin compounds and their application studyPrincipal Investigator

    • Principal Investigator
      Itoh Yukihiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Discovery of ubiquitin-activating enzyme inhibitors designed based on its catalytic mechanismPrincipal Investigator

    • Principal Investigator
      Itoh Yukihiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
      Drug development chemistry
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Discovery of lysine-specific demethylase 1 Inhibitors based on enzymatic mechanismPrincipal Investigator

    • Principal Investigator
      ITOH Yukihiro
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2021 2020 2019 2018 2017 2016 2014 2013 2012

All Journal Article Presentation Patent

  • [Journal Article] Design, synthesis, and biological evaluation of lysine demethylase 5C degraders2021

    • Author(s)
      Iida Tetsuya、Itoh Yukihiro、Takahashi Yukari、Yamashita Yasunobu、Kurohara Takashi、Miyake Yuka、Oba Makoto、Suzuki Takayoshi
    • Journal Title

      ChemMedChem

      Volume: -

    • DOI

      10.1002/cmdc.202000933

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-19H05295, KAKENHI-PROJECT-19H01079
  • [Journal Article] Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches2020

    • Author(s)
      Itoh Yukihiro
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 68 Issue: 1 Pages: 34-45

    • DOI

      10.1248/cpb.c19-00741

    • NAID

      130007778877

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-19H05295, KAKENHI-PROJECT-17K08367
  • [Journal Article] Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors2018

    • Author(s)
      Itoh Yukihiro、Suzuki Miki
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 印刷中

    • DOI

      10.1016/j.bmcl.2018.03.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08367
  • [Journal Article] Chemical Protein Degradation Approach and its Application to Epigenetic Targets2018

    • Author(s)
      Itoh Yukihiro
    • Journal Title

      The Chemical Record

      Volume: 18 Pages: 1681-1700

    • DOI

      10.1002/tcr.201800032

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08367
  • [Journal Article] “Drug” Discovery with the Help of Organic Chemistry2017

    • Author(s)
      Yukihiro Itoh, Takayoshi Suzuki
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 3 Pages: 283-292

    • DOI

      10.1248/yakushi.16-00231-1

    • NAID

      130005396859

    • ISSN
      0031-6903, 1347-5231
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K14982, KAKENHI-PROJECT-26870495
  • [Journal Article] LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates Synthesis2014

    • Author(s)
      Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki.
    • Journal Title

      Computational and Structural Biotechnology Journal

      Volume: 9

    • DOI

      10.5936/csbj.201402002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Journal Article] Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism2013

    • Author(s)
      Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N, Suzuki T
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 52 Pages: 8520-8624

    • DOI

      10.1002/anie.201303999

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24790117, KAKENHI-PROJECT-24890193, KAKENHI-PROJECT-221S0001
  • [Patent] リシン構造を有するLSD1選択阻害薬2012

    • Inventor(s)
      鈴木孝禎、伊藤幸裕、小笠原大介、 宮田直樹、水上民夫、佐々木隆造、河原真大
    • Industrial Property Rights Holder
      学校法人 関西文理総合学園 長浜 バイオ大学、京都府公立大学法人、公立大学法人 名古屋市立大学、国立大学法人 京都大学、株式会社フロンティアファーマ
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-260222
    • Filing Date
      2012-11-28
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] タンパク質分解を誘導する低分子化合物の創製2021

    • Author(s)
      伊藤幸裕
    • Organizer
      産研テクノサロン
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-19H05295
  • [Presentation] 合理的な分子設計と独特な創薬方法論が導くリシン修飾酵素制御化合物の創製2019

    • Author(s)
      伊藤幸裕
    • Organizer
      日本薬学会 第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08367
  • [Presentation] 新規ユビキチン活性化酵素阻害薬の創製2018

    • Author(s)
      伊藤幸裕、鈴木美紀
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08367
  • [Presentation] リシン 修飾酵素を制御する低分子化合物の 修飾酵素を制御する低分子化合物の 修飾酵素を制御する低分子化合物の 創製 ~化学 的発想を活かした創薬~2018

    • Author(s)
      伊藤幸裕
    • Organizer
      第4回近畿薬学シンポジウム:化学系の若い力
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08367
  • [Presentation] 低分子化合物を用いたタンパク質化学修飾制御の分子技術2017

    • Author(s)
      伊藤幸裕
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-03-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870495
  • [Presentation] 有機化学の力を借りた「薬」創り2016

    • Author(s)
      伊藤幸裕、鈴木孝禎
    • Organizer
      日本薬学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870495
  • [Presentation] PCPA-リシン誘導体ハイブリット型LSD1不活性化薬の立体化学-活性相関研究2014

    • Author(s)
      伊藤幸裕、小笠原大介、太田庸介、水上民夫、鈴木孝禎
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] PCPA-リシン誘導体ハイブリット型LSD1不活性化薬の立体化学-活性相関研究2014

    • Author(s)
      伊藤幸裕、小笠原大介、太田庸介、水上民夫、鈴木孝禎
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を運ぶ低分子化合物2013

    • Author(s)
      伊藤幸裕、小笠原大介、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      第31回 メディシナルケミストリーシンポジウム
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] 標的酵素へのドラッグデリバリーを目指したLSD1不活性化薬の創製2013

    • Author(s)
      小笠原大介、伊藤幸裕、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1 に阻害薬を届ける低分子化合物の創製2013

    • Author(s)
      伊藤幸裕、小笠原大介、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      第39回反応と合成の進歩シンポジウム
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を届ける小分子2013

    • Author(s)
      伊藤幸裕、宮田直樹、鈴木孝禎
    • Organizer
      第13回第日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Year and Date
      2013-06-12
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1 へ阻害薬を届ける小分子2013

    • Author(s)
      伊藤幸裕、宮田直樹、鈴木孝禎
    • Organizer
      第13回第日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Invited
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] Design and Synthesis of LSD1 inactivators Based on Enzyme-targeted Drug Delivery Mechanism2013

    • Author(s)
      Yukihiro Itoh
    • Organizer
      2nd Annual Conference ICBS2013
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-10-07
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] 標的酵素への直接的ドラッグデリバリーに基づいたLSD1選択的不活性化薬の創製2013

    • Author(s)
      小笠原大介、伊藤幸裕、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-20
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を届ける小分子2013

    • Author(s)
      伊藤幸裕
    • Organizer
      第13回日本蛋白質科学会
    • Place of Presentation
      鳥取
    • Invited
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] 標的酵素への直接的ドラッグデリバリーに基づいたLSD1 選択的不活性化薬の創製2013

    • Author(s)
      小笠原大介、伊藤幸裕、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] Design and Synthesis of LSD1 inactivators Based on Enzyme-targeted Drug Delivery Mechanism.2013

    • Author(s)
      Yukihiro Itoh
    • Organizer
      2nd Annual Conference ICBS2013
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を運ぶ低分子化合物2013

    • Author(s)
      伊藤幸裕、小笠原大介、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      第31回メディシナルケミストリーシンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2013-11-21
    • Data Source
      KAKENHI-PROJECT-24890193
  • [Presentation] ヒストン脱メチル化酵素LSD1に阻害薬を届ける低分子化合物の創製2013

    • Author(s)
      伊藤幸裕、小笠原大介、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      第39回反応と合成の進歩シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-05
    • Data Source
      KAKENHI-PROJECT-24890193
  • 1.  鈴木 孝禎 (90372838)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  山下 泰信 (10873408)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  高田 悠里 (20902357)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  HASEGAWA Makoto
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  KAKIZAWA Taeko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  MIZUKAMI Tamio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  ITO Hidemi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  SUZUKI Hiromu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  鈴木 登
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  鈴木 貞夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  鈴木 操
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  佐々木 泰史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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