Itoh Yukihiro 伊藤幸裕

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ITOH Yukihiro 伊藤幸裕

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Researcher Number	30636402
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 大阪大学, 産業科学研究所, 准教授 2019: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2015 – 2018: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2012 – 2014: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 37030:Chemical biology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Complex systems Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator ケミカルバイオロジー / 分子設計 / 創薬化学 / ドラッグデザイン / 低分子薬物 / 酵素阻害薬 / 化合物探索 / 分解誘導剤 / 非翻訳RNA / 非翻訳TNA … More / プローブ / ユビキチン / 低分子化合物 / 触媒メカニズム / エピジェネティクス … More Except Principal Investigator キメラ分子 / 創薬 / 転写因子 / 分子接着剤 / PROTAC / 歯周組織再生 / がん / エピジェネティクス / 複合体 / in situクリックケミストリー / 阻害薬 / 医薬品 / 標的誘導型合成 Less

Development of chimera molecules targeting epigenetic complexes
- Principal Investigator
  
  鈴木孝禎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Osaka
分子接着剤を用いた超効率的な組織再生誘導
- Principal Investigator
  
  岩山智明
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Osaka University
クリックケミストリーに基づく生物活性化合物創製法の確立Principal Investigator
- Principal Investigator
  
  伊藤幸裕
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Osaka University
Development of innovative drug candidates by target guided synthesis
- Principal Investigator
  
  Suzuki Takayoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of RNA degradation inducers and their application studyPrincipal Investigator
- Principal Investigator
  
  Itoh Yukihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製Principal Investigator
- Principal Investigator
  
  伊藤幸裕
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
  Kyoto Prefectural University of Medicine
Identification of artificial ubiquitin compounds and their application studyPrincipal Investigator
- Principal Investigator
  
  Itoh Yukihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Discovery of ubiquitin-activating enzyme inhibitors designed based on its catalytic mechanismPrincipal Investigator
- Principal Investigator
  
  Itoh Yukihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Discovery of lysine-specific demethylase 1 Inhibitors based on enzymatic mechanismPrincipal Investigator
- Principal Investigator
  
  ITOH Yukihiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells2024
- Author(s)
  Ota Y, Itoh Y, Takada Y, Yamashita Y, Hu C, Horinaka M, Sowa Y, Masuda M, Sakai T, Suzuki T
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 100 Pages: 117632-117632
- DOI
  10.1016/j.bmc.2024.117632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795
[Journal Article] Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning2024
- Author(s)
  Nurani Atika、Yamashita Yasunobu、Taki Yuuki、Takada Yuri、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 173-178
- DOI
  10.1248/cpb.c23-00577
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 12024
- Author(s)
  Takada Yuri、Adachi Kyohei、Fujinaga Yuka、Yamashita Yasunobu、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 155-160
- DOI
  10.1248/cpb.c23-00671
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice2024
- Author(s)
  Li Haiyan、Kawatake-Kuno Ayako、Inaba Hiromichi、Miyake Yuka、Itoh Yukihiro、Ueki Takatoshi、Oishi Naoya、Murai Toshiya、Suzuki Takayoshi、Uchida Shusaku
- Journal Title
  
  Neuron
  
  Volume: 112 Issue: 5 Pages: 00934-0
- DOI
  10.1016/j.neuron.2023.12.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18186, KAKENHI-PROJECT-21K07593, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-23K21413, KAKENHI-PROJECT-23K24789
[Journal Article] Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity2024
- Author(s)
  Terao Mitsuhiro、Yamashita Yasunobu、Takada Yuri、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 98 Pages: 117579-117579
- DOI
  10.1016/j.bmc.2023.117579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18186, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] Discovery of selective histone deacetylase 1 and 2 inhibitors: screening of a focused library constructed by click chemistry, kinetic binding analysis, and biological evaluation2023
- Author(s)
  Itoh Y, Zhan P, Tojo T, Jaikhan P, Ota Y, Suzuki M, Li Y, Hui Z, Moriyama Y, Takada Y, Yamashita Y, Oba M, Uchida S, Masuda M, Ito S, Sowa Y, Sakai T, Suzuki T
- Journal Title
  
  J Med Chem
  
  Volume: 66 Issue: 22 Pages: 15171-15188
- DOI
  10.1021/acs.jmedchem.3c01095
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-20K15959, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-23K23487
[Journal Article] Origin of the kinetic <scp>HDAC2</scp>‐selectivity of an <scp>HDAC</scp> inhibitor2023
- Author(s)
  Mishima Hirokazu、Itoh Yukihiro、Kurohara Takashi、Suzuki Takayoshi、Asada Naoya、Kusakabe Ken‐ichi、Okamoto Yuko
- Journal Title
  
  Journal of Computational Chemistry
  
  Volume: 44 Issue: 18 Pages: 1604-1609
- DOI
  10.1002/jcc.27111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795
[Journal Article] Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)2022
- Author(s)
  Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Chem. Commun.
  
  Volume: 58 Issue: 29 Pages: 5051-5056
- DOI
  10.1039/d2cc00272h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K20719
[Journal Article] A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production2022
- Author(s)
  Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase*, Daisuke Takahashi* (*equal correspondence)
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 9 Pages: 1364-1372
- DOI
  10.1248/bpb.b22-00321
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-21H04795
[Journal Article] Medicinal Chemistry Research on Targeting Epigenetic Complexes2022
- Author(s)
  Yuri Takada, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 7 Pages: 664-675
- DOI
  10.5059/yukigoseikyokaishi.80.664
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-07-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K20719
[Journal Article] Cancer-cell-selective targeting by arylcyclopropylamine-vorinostat conjugates2022
- Author(s)
  Ota Y, Itoh Y, Kurohara T, Singh R, Elboray EE, Hu C, Zamani F, Mukherjee A, Takada Y, Yamashita Y, Morita M, Horinaka M, Sowa Y, Masuda M, Sakai T, Suzuki T
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 10 Pages: 1568-1573
- DOI
  10.1021/acsmedchemlett.2c00126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-20F40107, KAKENHI-PROJECT-21K20719
[Journal Article] Recent progress on small molecules targeting epigenetic complexes2022
- Author(s)
  Itoh Yukihiro、Takada Yuri、Yamashita Yasunobu、Suzuki Takayoshi
- Journal Title
  
  Current Opinion in Chemical Biology
  
  Volume: 67 Pages: 102130-102130
- DOI
  10.1016/j.cbpa.2022.102130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-21K20719
[Journal Article] Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group2021
- Author(s)
  Kurohara Takashi、Tanaka Keita、Takahashi Daisuke、Ueda Satoshi、Yamashita Yasunobu、Takada Yuri、Takeshima Hirokazu、Yu Shengwang、Itoh Yukihiro、Hase Koji、Suzuki Takayoshi
- Journal Title
  
  ChemBioChem
  
  Volume: 22 Issue: 22 Pages: 3158-3163
- DOI
  10.1002/cbic.202100255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K07552
[Journal Article] Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5?C Degraders2021
- Author(s)
  Iida Tetsuya、Itoh Yukihiro、Takahashi Yukari、Yamashita Yasunobu、Kurohara Takashi、Miyake Yuka、Oba Makoto、Suzuki Takayoshi
- Journal Title
  
  ChemMedChem
  
  Volume: - Issue: 10 Pages: 1609-1618
- DOI
  10.1002/cmdc.202000933
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05295, KAKENHI-PROJECT-19H01079
[Journal Article] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach2021
- Author(s)
  Prakash Muthuraj、Itoh Yukihiro、Fujiwara Yoshie、Takahashi Yukari、Takada Yuri、Mellini Paolo、Elboray Elghareeb E.、Terao Mitsuhiro、Yamashita Yasunobu、Yamamoto Chika、Yamaguchi Takao、Kotoku Masayuki、Kitao Yuki、Singh Ritesh、Roy Rohini、Obika Satoshi、Oba Makoto、Wang Dan Ohtan、Suzuki Takayoshi
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15810-15824
- DOI
  10.1021/acs.jmedchem.1c01107
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K21488, KAKENHI-PROJECT-21H02580
[Journal Article] Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches2020
- Author(s)
  Itoh Yukihiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 68 Issue: 1 Pages: 34-45
- DOI
  10.1248/cpb.c19-00741
- NAID
  130007778877
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2020-01-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05295, KAKENHI-PROJECT-17K08367
[Journal Article] Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors2018
- Author(s)
  Itoh Yukihiro、Suzuki Miki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 印刷中 Issue: 16 Pages: 2723-2727
- DOI
  10.1016/j.bmcl.2018.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08367
[Journal Article] Chemical Protein Degradation Approach and its Application to Epigenetic Targets2018
- Author(s)
  Itoh Yukihiro
- Journal Title
  
  The Chemical Record
  
  Volume: 18 Issue: 12 Pages: 1681-1700
- DOI
  10.1002/tcr.201800032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08367
[Journal Article] “Drug” Discovery with the Help of Organic Chemistry2017
- Author(s)
  Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 3 Pages: 283-292
- DOI
  10.1248/yakushi.16-00231-1
- NAID
  130005396859
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-03-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14982, KAKENHI-PROJECT-26870495
[Journal Article] LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates Synthesis2014
- Author(s)
  Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki.
- Journal Title
  
  Computational and Structural Biotechnology Journal
  
  Volume: 9 Issue: 14 Pages: e201402002-e201402002
- DOI
  10.5936/csbj.201402002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890193
[Journal Article] Lysine-Specific Demethylase 1-Selective Inactivators Based on Protein-Targeted Drug Delivery Mechanism2013
- Author(s)
  Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N, Suzuki T
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 52 Issue: 33 Pages: 8620-8624
- DOI
  10.1002/anie.201303999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24790117, KAKENHI-PROJECT-24890193, KAKENHI-PROJECT-221S0001
[Patent] 化合物又はその塩及びその製造方法、化合物又はその塩を含む医薬品組成物及びその製造方法2023
- Inventor(s)
  鈴木孝禎、伊藤幸裕、渡部素生
- Industrial Property Rights Holder
  鈴木孝禎、伊藤幸裕、渡部素生
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-143583
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K23487
[Patent] リシン構造を有するLSD1選択阻害薬2012
- Inventor(s)
  鈴木孝禎、伊藤幸裕、小笠原大介、宮田直樹、水上民夫、佐々木隆造、河原真大
- Industrial Property Rights Holder
  学校法人関西文理総合学園長浜バイオ大学、京都府公立大学法人、公立大学法人名古屋市立大学、国立大学法人京都大学、株式会社フロンティアファーマ
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-260222
- Filing Date
  2012-11-28
- Overseas
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 架橋部位にE3リガンド構造を持つペプチド性PROTACの創製研究2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第40回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] クリックケミストリーを利用したGLS1 PROTACライブラリーの構築2023
- Author(s)
  林海伶、伊藤幸裕、山下泰信、高田悠里、鈴木孝禎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] Discovery of hydrophobic tag-based degraders targeting lysine-specific demethylase 12023
- Author(s)
  Shengwanf Yu, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] HDAC8を標的としたPROTAC化合物による成人T細胞白血病細胞株の細胞死2023
- Author(s)
  西中間翔和、小迫知弘、徳永彩華、加藤奈歩、伊藤幸裕、鈴木孝禎、本田伸一郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] BRD4を標的としたスクアレート型コバレントドラッグの創製研究2023
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] みなさんが知ってる基礎化学を使って創薬化学研究をしています！2023
- Author(s)
  伊藤幸裕
- Organizer
  大阪大学薬学部・特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] タンパク質分解誘導活性を持つペプチド化合物の創製を指向したステープル化2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] E3リガンド構造によるステープル化を基盤としたペプチド性PROTACの創製研究2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] リシン脱メチル化酵素KDM5Cを標的とした分解誘導薬（PROTAC）の創製2023
- Author(s)
  伊藤幸裕、飯田哲也、高橋ゆかり、山下泰信、黒原崇、三宅由花、大庭誠、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第17回年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] 逆電子要請型 Diels-Alder 反応に基づく標的タンパク質分解誘導薬PROTAC の創製研究2023
- Author(s)
  Yu Shengwang、伊藤幸裕、山下泰信、高田悠里、鈴木孝禎
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] 二核ビスマス錯体(III)錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-20K21488
[Presentation] 創薬研究に応用できる化学的思考2022
- Author(s)
  伊藤幸裕
- Organizer
  創薬等先端技術支援基盤プラットホーム（BINDS）第３回合成勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] 二核ビスマス錯体型 RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K21488
[Presentation] 「化学的」発想に基づく生物活性化合物の創製2022
- Author(s)
  伊藤幸裕
- Organizer
  生体機能関連化学部会若手の会第33回サマースクール
- Invited
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] RNA創薬を志向した金属錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K21488
[Presentation] Proteolysis targeting chimeras (PROTACs) targeting epigenetic enzymes2022
- Author(s)
  Yukihiro Itoh
- Organizer
  International Congress on Pure & Applied Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] 低分子創薬の発展を目指して2022
- Author(s)
  伊藤幸裕
- Organizer
  第26回ケムステVシンポ「創薬モダリティ座談会」
- Invited
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] 創薬を志向したキメラ分子の創製研究2022
- Author(s)
  伊藤幸裕
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] HDAC8阻害薬の同定、構造最適化およびPROTACへの応用2022
- Author(s)
  伊藤幸裕、太田庸介Jiranan Chotitumnavee、武藤伸輔、宮田直樹、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-23K23487
[Presentation] RNA創薬を志向した金属錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４２年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04795
[Presentation] エピジェネティクス関連酵素に対する分解誘導薬の創製2021
- Author(s)
  伊藤幸裕、飯田哲也、Chotitumnavee Jiranan、高橋ゆかり、山下泰信、黒原崇、三宅由花、大庭誠、鈴木孝禎
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21H04795
[Presentation] タンパク質分解を誘導する低分子化合物の創製2021
- Author(s)
  伊藤幸裕
- Organizer
  産研テクノサロン
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05295
[Presentation] Induced-fit 型 HDAC 酵素阻害薬の同定とそのアロステリック作用の解析2021
- Author(s)
  伊藤幸裕、展鵬、東條敏史、鈴木美紀、李頴、内田周作、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-21H04795
[Presentation] 合理的な分子設計と独特な創薬方法論が導くリシン修飾酵素制御化合物の創製2019
- Author(s)
  伊藤幸裕
- Organizer
  日本薬学会　第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08367
[Presentation] 新規ユビキチン活性化酵素阻害薬の創製2018
- Author(s)
  伊藤幸裕、鈴木美紀
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08367
[Presentation] リシン修飾酵素を制御する低分子化合物の修飾酵素を制御する低分子化合物の修飾酵素を制御する低分子化合物の創製～化学的発想を活かした創薬～2018
- Author(s)
  伊藤幸裕
- Organizer
  第４回近畿薬学シンポジウム：化学系の若い力
- Invited
- Data Source
  KAKENHI-PROJECT-17K08367
[Presentation] 低分子化合物を用いたタンパク質化学修飾制御の分子技術2017
- Author(s)
  伊藤幸裕
- Organizer
  日本化学会　第97春季年会
- Place of Presentation
  横浜
- Year and Date
  2017-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-26870495
[Presentation] 有機化学の力を借りた「薬」創り2016
- Author(s)
  伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26870495
[Presentation] PCPA－リシン誘導体ハイブリット型LSD1不活性化薬の立体化学－活性相関研究2014
- Author(s)
  伊藤幸裕、小笠原大介、太田庸介、水上民夫、鈴木孝禎
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] PCPA-リシン誘導体ハイブリット型LSD1不活性化薬の立体化学-活性相関研究2014
- Author(s)
  伊藤幸裕、小笠原大介、太田庸介、水上民夫、鈴木孝禎
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を運ぶ低分子化合物2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 標的酵素へのドラッグデリバリーを目指したLSD1不活性化薬の創製2013
- Author(s)
  小笠原大介、伊藤幸裕、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1 に阻害薬を届ける低分子化合物の創製2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を届ける小分子2013
- Author(s)
  伊藤幸裕、宮田直樹、鈴木孝禎
- Organizer
  第13回第日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Year and Date
  2013-06-12
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1 へ阻害薬を届ける小分子2013
- Author(s)
  伊藤幸裕、宮田直樹、鈴木孝禎
- Organizer
  第13回第日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Invited
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] Design and Synthesis of LSD1 inactivators Based on Enzyme-targeted Drug Delivery Mechanism2013
- Author(s)
  Yukihiro Itoh
- Organizer
  2nd Annual Conference ICBS2013
- Place of Presentation
  Kyoto
- Year and Date
  2013-10-07
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 標的酵素への直接的ドラッグデリバリーに基づいたLSD1選択的不活性化薬の創製2013
- Author(s)
  小笠原大介、伊藤幸裕、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会第8回年会
- Place of Presentation
  東京
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を届ける小分子2013
- Author(s)
  伊藤幸裕
- Organizer
  第13回日本蛋白質科学会
- Place of Presentation
  鳥取
- Invited
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] 標的酵素への直接的ドラッグデリバリーに基づいたLSD1 選択的不活性化薬の創製2013
- Author(s)
  小笠原大介、伊藤幸裕、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1に阻害薬を届ける低分子化合物の創製2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2013-11-05
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] Design and Synthesis of LSD1 inactivators Based on Enzyme-targeted Drug Delivery Mechanism.2013
- Author(s)
  Yukihiro Itoh
- Organizer
  2nd Annual Conference ICBS2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24890193
[Presentation] ヒストン脱メチル化酵素LSD1へ阻害薬を運ぶ低分子化合物2013
- Author(s)
  伊藤幸裕、小笠原大介、三野光識、中川秀彦、杉野典子、河原真大、高折晃史、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Year and Date
  2013-11-21
- Data Source
  KAKENHI-PROJECT-24890193

1. Suzuki Takayoshi (90372838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. 山下泰信 (10873408)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 高田悠里 (20902357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 岩山智明 (80757865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 村上伸也 (70239490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山下元三 (90524984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HORINAKA Mano

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. HASEGAWA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 酒井敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Itoh Yukihiro 伊藤 幸裕

ITOH Yukihiro 伊藤 幸裕

Research Projects

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Development of chimera molecules targeting epigenetic complexes

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分子接着剤を用いた超効率的な組織再生誘導

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クリックケミストリーに基づく生物活性化合物創製法の確立Principal Investigator

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Development of innovative drug candidates by target guided synthesis

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Development of RNA degradation inducers and their application studyPrincipal Investigator

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ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製Principal Investigator

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Identification of artificial ubiquitin compounds and their application studyPrincipal Investigator

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Discovery of ubiquitin-activating enzyme inhibitors designed based on its catalytic mechanismPrincipal Investigator

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Discovery of lysine-specific demethylase 1 Inhibitors based on enzymatic mechanismPrincipal Investigator

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[Journal Article] Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells2024

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[Journal Article] Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning2024

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[Journal Article] A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 12024

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Itoh Yukihiro 伊藤幸裕

ITOH Yukihiro 伊藤幸裕