Tada Mari 他田真理

Researcher Number	30646394
Other IDs
Affiliation (Current)	2025: 新潟大学, 脳研究所, 教授
Affiliation (based on the past Project Information) *help	2025: 新潟大学, 脳研究所, 教授 2019 – 2024: 新潟大学, 脳研究所, 准教授 2013 – 2018: 新潟大学, 脳研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Nerve anatomy/Neuropathology / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator CSF1R / microglia / ミクログリア / アストロサイト / ALSP / astrocyte / leukoencephalopathy / macrophage / 神経病理学 / 認知症 … More / spatial gene expression / snRNA-seq / Neuropathology / Microglia / neuropathology / 白質脳症 / CSF１R / C3d / TGFβ / 認知症疾患 / 神経科学 / white matter / HDLS / 白質 / 遺伝性白質脳症 / マクロファージ / 病理学的解析 / 臨床研究 / 病理学的定量解析 / 臨床病理学的研究 / 認知機能障害 / 神経変性疾患 / 多系統萎縮症 … More Except Principal Investigator 筋萎縮性側索硬化症 / TDP-43 / 神経変性疾患 / 人工知能 / エクソーム解析 / 空間的トランスクリプトーム / シングルセルトランスクリプトーム / ネットワーク / 組織透明化 / 興奮伝播特性 / 分子プロファイル / 神経回路 / 病態形成機序 / 機能脳外科 / てんかん / 病理多型 / テキストマイニング / ALS / 脂質 / 認知症 / 脂質代謝 / ミスセンスバリアント / コモンレアミスセンスバリアント / コモンミスセンスバリアント / レアミスセンスバリアント / バリアント / 感受性遺伝子 / アルツハイマー病 / APOE / 免疫組織化学 / 病型分類 / 進行性核上性麻痺 / タウオリゴマー / ピック病 / オリゴマー / globular glial tauopathy / アストロサイト / タウオパチー / 脳神経疾患 / 神経病理学 Less

ミクログリアによるグリア連関維持機構を解明し、剖検脳から認知症治療介入標的を探るPrincipal Investigator
- Principal Investigator
  
  他田真理
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Niigata University
AIと剖検組織を用いたALSの新規原因遺伝子同定
- Principal Investigator
  
  石原智彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
ひとてんかん原性病態機序を知りこれを制御する
- Principal Investigator
  
  柿田明美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Niigata University
認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫るPrincipal Investigator
- Principal Investigator
  
  他田真理
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Niigata University
Missense rare variant analysis of APOE: Exploring the link between lipid metabolism and Alzheimer's disease
- Principal Investigator
  
  Miyashita Akinori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
Exploring genetic factors that define TDP-43 pathological polymorphisms in ALS.
- Principal Investigator
  
  Ishihara Tomohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
Microglia-astrocyte crosstalk in leukoencephalopathiesPrincipal Investigator
- Principal Investigator
  
  Tada Mari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Microglial involvement in the pathomechanisms of white matter degenerationPrincipal Investigator
- Principal Investigator
  
  Tada Mari
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning
- Principal Investigator
  
  Takahashi Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Globular glial tauopathy: investigation of the pathological features
- Principal Investigator
  
  TOYOSHIMA Yasuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis
- Principal Investigator
  
  TAKAHASHI Hitoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Neuropathological analysis of multiple system atrophy with cognitive impairmentPrincipal Investigator
- Principal Investigator
  
  Tada Mari
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 非腫瘍性疾患病理アトラス　中枢神経2024
- Author(s)
  新井信隆　編集　他田真理
- Total Pages
  291
- Publisher
  文光堂
- ISBN
  9784830604942
- Data Source
  KAKENHI-PROJECT-23K24256
[Book] 非定型パーキンソニズム　基礎と臨床2019
- Author(s)
  他田真理、柿田明美　編集：下畑享良
- Total Pages
  272
- Publisher
  文光堂
- ISBN
  9784830615474
- Data Source
  KAKENHI-PROJECT-19K07972
[Journal Article] Slow disease progression and characteristic TDP-43 inclusions in a patient with familial amyotrophic lateral sclerosis carrying a TARDBP G357S variant2024
- Author(s)
  Sainouchi, M. Oginezawa, S. Tada, M. Ishihara, T. Onodera, O. Kakita, A.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: 50 Issue: 1
- DOI
  10.1111/nan.12966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07272, KAKENHI-PROJECT-23H00434, KAKENHI-PROJECT-23K24256
[Journal Article] Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia2023
- Author(s)
  Zhou Yingyue、Tada Mari、Cai Zhangying、Andhey Prabhakar S.、Swain Amanda、Miller Kelly R.、Gilfillan Susan、Artyomov Maxim N.、Takao Masaki、Kakita Akiyoshi、Colonna Marco
- Journal Title
  
  Nature Immunology
  
  Volume: 24 Issue: 3 Pages: 545-557
- DOI
  10.1038/s41590-022-01403-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24256
[Journal Article] 多発性硬化症2023
- Author(s)
  他田真理
- Journal Title
  
  病理と臨床臨時増刊号　病理診断クイックリファレンス
  
  Volume: 41 Pages: 338-338
- Data Source
  KAKENHI-PROJECT-23K24256
[Journal Article] Alzheimer病2023
- Author(s)
  他田真理
- Journal Title
  
  病理と臨床臨時増刊号　病理診断クイックリファレンス
  
  Volume: 41 Pages: 335-335
- Data Source
  KAKENHI-PROJECT-23K24256
[Journal Article] 脳アミロイド血管症2023
- Author(s)
  他田真理
- Journal Title
  
  病理と臨床臨時増刊号　病理診断クイックリファレンス
  
  Volume: 41 Pages: 337-337
- Data Source
  KAKENHI-PROJECT-23K24256
[Journal Article] Brain TDP‐43 pathology in corticobasal degeneration: Topographical correlation with neuronal loss2022
- Author(s)
  Sainouchi Makoto、Tada Mari、Fitrah Yusran Ady、Hara Norikazu、Tanaka Kou、Idezuka Jiro、Aida Izumi、Nakajima Takashi、Miyashita Akinori、Akazawa Kohei、Ikeuchi Takeshi、Onodera Osamu、Kakita Akiyoshi
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 48 Issue: 3
- DOI
  10.1111/nan.12786
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-21H03537
[Journal Article] ミクログリア関連疾患の病理（HDLS, NHD, ALD）2022
- Author(s)
  他田真理、柿田明美
- Journal Title
  
  脳神経内科
  
  Volume: 97 Pages: 91-100
- Data Source
  KAKENHI-PROJECT-23K24256
[Journal Article] Endogenous human retrovirus-K is not increased in the affected tissues of Japanese ALS patients2022
- Author(s)
  Ishihara Tomohiko、Koyama Akihide、Hatano Yuya、Takeuchi Ryoko、Koike Yuka、Kato Taisuke、Tada Mari、Kakita Akiyoshi、Onodera Osamu
- Journal Title
  
  Neuroscience Research
  
  Volume: 178 Pages: 78-82
- DOI
  10.1016/j.neures.2022.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-21K07272
[Journal Article] SYNE1-ataxia: clinicopathologic features of an autopsied patient with novel compound heterozygous mutations2022
- Author(s)
  Saito Rie、Hara Norikazu、Tada Mari、Wakabayashi Masatoshi、Miyashita Akinori、Nishizawa Masatoyo、Onodera Osamu、Ikeuchi Takeshi、Kakita Akiyoshi
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 82 Issue: 3 Pages: 267-271
- DOI
  10.1093/jnen/nlac120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24256, KAKENHI-PROJECT-21H03537
[Journal Article] Correction to: A novel splicing variant of ANXA11 in a patient with amyotrophic lateral sclerosis: histologic and biochemical features2021
- Author(s)
  Sainouchi Makoto、Hatano Yuya、Tada Mari、Ishihara Tomohiko、Ando Shoichiro、Kato Taisuke、Tokunaga Jun、Ito Gaku、Miyahara Hiroaki、Toyoshima Yasuko、Yokoseki Akio、Ozawa Tetsutaro、Akazawa Kohei、Onodera Osamu、Kakita Akiyoshi
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 9 Issue: 1 Pages: 106-106
- DOI
  10.1186/s40478-021-01217-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972
[Journal Article] Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex2021
- Author(s)
  Koike Yuka、Sugai Akihiro、Hara Norikazu、Ito Junko、Yokoseki Akio、Ishihara Tomohiko、Yamagishi Takuma、Tsuboguchi Shintaro、Tada Mari、Ikeuchi Takeshi、Kakita Akiyoshi、Onodera Osamu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1107-1107
- DOI
  10.1038/s42003-021-02621-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K07880
[Journal Article] Parkinson's disease and parkinsonism: Clinicopathological discrepancies on diagnosis in three patients2021
- Author(s)
  Toyoshima Yasuko、Takahashi Hitoshi、Katada Shinnichi、Kojima Naoyuki、Tada Mari、Tani Takashi、Koike Ryoko、Nozawa Takanori、Aida Izumi、Nakajima Takashi、Onodera Osamu、Kakita Akiyoshi
- Journal Title
  
  Neuropathology
  
  Volume: 41 Issue: 6 Pages: 450-456
- DOI
  10.1111/neup.12777
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K20468, KAKENHI-PROJECT-19H01043
[Journal Article] Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells2021
- Author(s)
  Sasahara Tomoya、Satomura Kaori、Tada Mari、Kakita Akiyoshi、Hoshi Minako
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 9 Pages: 102936-102936
- DOI
  10.1016/j.isci.2021.102936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K16022, KAKENHI-PROJECT-20H03457
[Journal Article] Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.2020
- Author(s)
  Watabe K, Kato Y, Sakuma M, Murata M, Niida-Kawaguchi M, Takemura T, Hanagata N, Tada M, Kakita A, Shibata N.
- Journal Title
  
  Neuropathology
  
  Volume: 40 Issue: 6 Pages: 570-586
- DOI
  10.1111/neup.12694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06507, KAKENHI-PROJECT-19K07972
[Journal Article] Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 32020
- Author(s)
  Prudencio Mercedes、Garcia-Moreno Hector、Jansen-West Karen R.、Tada Mari、Petrucelli Leonard et al.
- Journal Title
  
  Science Translational Medicine
  
  Volume: 12 Issue: 566
- DOI
  10.1126/scitranslmed.abb7086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07972
[Journal Article] Novel CHP1 mutation in autosomal-recessive cerebellar ataxia: autopsy features of two siblings2020
- Author(s)
  Saito Rie、Hara Norikazu、Tada Mari、Honma Yoshiaki、Miyashita Akinori、Onodera Osamu、Ikeuchi Takeshi、Kakita Akiyoshi
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 134-134
- DOI
  10.1186/s40478-020-01008-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K20468
[Journal Article] TDP-43 プロテイノパチー(1) 前頭側頭葉変性症 (FTLD)2019
- Author(s)
  他田真理、柿田明美
- Journal Title
  
  病理と臨床
  
  Volume: 37 Pages: 1131-1137
- Data Source
  KAKENHI-PROJECT-19K07972
[Journal Article] Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions.2019
- Author(s)
  Mori F, Tada M, Kon T, Miki Y, Tanji K, Kurotaki H, Tomiyama M, Ishihara T, Onodera O, Kakita A, Wakabayashi K.
- Journal Title
  
  Acta Neuropatholgica Communications
  
  Volume: 7 Issue: 1 Pages: 165-165
- DOI
  10.1186/s40478-019-0824-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-18H02533, KAKENHI-PROJECT-17K07088, KAKENHI-PROJECT-17K09751
[Journal Article] ミクログリアの組織学的特徴2018
- Author(s)
  他田真理、柿田明美
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 36 Pages: 276-277
- Data Source
  KAKENHI-PROJECT-16K07041
[Journal Article] Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.2016
- Author(s)
  Takeuchi R, Tada M, Shiga A, Toyoshima Y, Konno T, Sato T, Nozaki H, Kato T, Horie M, Shimizu H, Takebayashi H, Onodera O, Nishizawa M, Kakita A, Takahashi H.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 4 Issue: 1 Pages: 61-61
- DOI
  10.1186/s40478-016-0335-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250017, KAKENHI-PLANNED-26117006
[Journal Article] Expression of aquaporin 1 and aquaporin 4 in the temporal neocortex of patients with Parkinson's disease.2016
- Author(s)
  Hoshi A, Tsunoda A, Tada M, Nishizawa M, Ugawa Y, Kakita A.
- Journal Title
  
  Brain Pathol.
  
  Volume: - Issue: 2 Pages: 160-168
- DOI
  10.1111/bpa.12369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430048, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-26461314, KAKENHI-INTERNATIONAL-15K21731
[Journal Article] Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: With Special Reference to Astrocytic Tau Pathology.2016
- Author(s)
  Yokoyama Y, Toyoshima Y, Shiga A, Tada M, Kitamura H, Hasegawa K, Onodera O, Ikeuchi T, Someya T, Nishizawa M, Kakita A, Takahashi H.
- Journal Title
  
  Brain Pathol.
  
  Volume: 26 Issue: 2 Pages: 155-166
- DOI
  10.1111/bpa.12265
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-26250017, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-26640029, KAKENHI-PROJECT-15K09860
[Journal Article] Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids2016
- Author(s)
  Tada M，Konno T，Tada M, Tezuka T, Okazaki K, Arakawa M，Itoh K，Yamamoto T, Yokoo H, Yoshikura N，Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T，Kakita A
- Journal Title
  
  Annals of Neurology
  
  Volume: 80 Issue: 4 Pages: 554-565
- DOI
  10.1002/ana.24754
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01331, KAKENHI-ORGANIZER-25117001, KAKENHI-PROJECT-16K07041
[Journal Article] Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: with Special Reference to Astrocytic Tau Pathology2015
- Author(s)
  Yokoyama Y, Toyoshima Y, Shiga A, Tada M, Kitamura H, Hasegawa K, Onodera O, Ikeuchi T, Someya T, Nishizawa M, Kakita A, Takahashi H
- Journal Title
  
  Brain Pathology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430052
[Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia2015
- Author(s)
  Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
- Journal Title
  
  Brain Pathology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430052
[Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia.2015
- Author(s)
  Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H.
- Journal Title
  
  Brain Pathology
  
  Volume: in press Issue: 1 Pages: 82-94
- DOI
  10.1111/bpa.12262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25830038, KAKENHI-PROJECT-26250017, KAKENHI-PUBLICLY-26117506, KAKENHI-PROJECT-25253065, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-26640029, KAKENHI-PROJECT-15H04839
[Journal Article] Na,K-ATPaseα3 is a death target of alzheimer patient amyloid-β assembly.2015
- Author(s)
  Ohnishi T, ..., Matsui K, ..., Hoshi M （計35名, 記載欄不足）
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Issue: 32 Pages: 4465-4474
- DOI
  10.1073/pnas.1421182112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12765, KAKENHI-PROJECT-15K21099, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26115004, KAKENHI-PUBLICLY-26117501, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-26750365, KAKENHI-PROJECT-25290077, KAKENHI-PROJECT-26293213, KAKENHI-PROJECT-25702054
[Journal Article] Effect of sodium pyruvate on exercise intolerance and muscle weakness due to mitochondrial myopathy: a case report2015
- Author(s)
  黒羽　泰子, 他田　真理, 河内　泉, 西澤　正豊, 松原　奈絵, 小池　亮子
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 55 Issue: 6 Pages: 412-416
- DOI
  10.5692/clinicalneurol.cn-000652
- NAID
  130005083894
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Journal Article] Hereditary diffuse leukoencephalopathy with spheroids (HDLS): a review of the literature on its clinical characteristics and mutations in the colony-stimulating factor-1 receptor gene.2014
- Author(s)
  Konno T, Tada M, Tada M, Nishizawa M, Ikeuchi T.
- Journal Title
  
  Brain Nerve
  
  Volume: 66 Pages: 581-90
- NAID
  40020089061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Journal Article] Pathology and sensitivity of current clinical criteria in corticobasal syndrome.2014
- Author(s)
  Ouchi H, Toyoshima Y, Tada M, Oyake M, Aida I, Tomita I, Satoh A, Tsujihata M, Takahashi H, Nishizawa M, Shimohata T.
- Journal Title
  
  Mov Disord
  
  Volume: 29 Issue: 2 Pages: 238-44
- DOI
  10.1002/mds.25746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Journal Article] C9ORF72 repeat-associated non-ATG-translated polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS2014
- Author(s)
  Konno T　ほか
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: 40 Issue: 6 Pages: 783-788
- DOI
  10.1111/nan.12157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-25670417, KAKENHI-PLANNED-26117005, KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-26250017
[Journal Article] Haploinsufficiency of CSF-1R and clinicopathological characterization in patients with HDLS.2014
- Author(s)
  Konno T, Tada M, Tada M, Koyama A, Nozaki H, Harigaya Y, Nishimiya J, Matsunaga A, Yoshikura N, Ishihara K, Arakawa M, Isami A, Okazaki K, Yokoo H, Ihoh K, Yoneda M, Kawamura M, Inuzuka T, Takahashi H, Nishizawa M, Onodera O, Kakita A, Ikeuchi T
- Journal Title
  
  Neurology
  
  Volume: 82 Issue: 2 Pages: 139-148
- DOI
  10.1212/wnl.0000000000000046
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PUBLICLY-24111517, KAKENHI-PROJECT-25293200, KAKENHI-PROJECT-25430048
[Journal Article] Early clinical features of patients with progressive supranuclear palsy with predominant cerebellar ataxia.2013
- Author(s)
  Kanazawa M, Tada M, Onodera O, Takahashi H, Nishizawa M, Shimohata T.
- Journal Title
  
  Parkinsonism Relat Disord
  
  Volume: 19 Issue: 12 Pages: 1149-51
- DOI
  10.1016/j.parkreldis.2013.07.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Journal Article] Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations.2013
- Author(s)
  Fu YJ, Aida I, Tada M, Tada M, Toyoshima Y, Takeda S, Nakajima T, Naito H, Nishizawa M, Onodera O, Kakita A, Takahashi H.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: epub ahead of print Issue: 5 Pages: 551-563
- DOI
  10.1111/nan.12057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] 認知症のトランスクリプトーム解析：ヒト剖検脳のシングル核解析から見えてくるもの2023
- Author(s)
  宮下哲典、他田真理、原範和、長谷川舞衣、柿田明美、池内健
- Organizer
  第41回（2022年）日本認知症学会学術集会（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-21K07271
[Presentation] Histological and molecular studies of primary microgliopathies using autopsied human brains.2023
- Author(s)
  他田真理
- Organizer
  第64回日本神経病理学会総会学術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24256
[Presentation] 脱髄・白質脳症.2023
- Author(s)
  他田真理
- Organizer
  第17回診断病理サマーフェスト
- Invited
- Data Source
  KAKENHI-PROJECT-23K24256
[Presentation] ヒト剖検脳を用いた一次性ミクログリア病の病態研究.2023
- Author(s)
  他田真理
- Organizer
  第42回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24256
[Presentation] Clinicopathologic features of a patient with ALSP of long disease duration2022
- Author(s)
  Mari Tada, Takanobu Ishiguro, Takuya Konno, Osamu Onodera, Takeshi Ikeuchi, Akiyoshi Kakita
- Organizer
  第63回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-23K24256
[Presentation] Clinicopathologic features of a patient with nemaline myopathy and intellectual disability harboring a ADSSL1 mutation2021
- Author(s)
  他田真理
- Organizer
  第62回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-19K07972
[Presentation] 新規TBK1遺伝子変異を伴う孤発性筋萎縮性側索硬化症の2剖検例の臨床病理学的検討2020
- Author(s)
  他田真理
- Organizer
  第61回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-19K07972
[Presentation] 教育セミナー：脱髄・白質脳症2019
- Author(s)
  他田真理
- Organizer
  第60回日本神経病理学会総会学術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] 遺伝性白質脳症：病理から見た病態形成2019
- Author(s)
  他田真理
- Organizer
  第60回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07972
[Presentation] 脱髄・白質脳症2019
- Author(s)
  他田真理
- Organizer
  第60回日本神経病理学会総会学術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07972
[Presentation] 遺伝性白質脳症：病理から見た病態形成2019
- Author(s)
  他田真理、柿田明美
- Organizer
  第60回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] 神経軸索スフェロイドを伴う遺伝性びまん性白質脳症（HDLS）の臨床と病理2018
- Author(s)
  他田　真理、柿田明美
- Organizer
  第59回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): pathologic features suggestive of microgliopathy2018
- Author(s)
  Mari Tada, Akiyoshi Kakita
- Organizer
  19th International Congress of Neuropathology
- Invited
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] Globular glial tauopathy: characteristic histologic features of an autopsied patient with its type II2017
- Author(s)
  Tanaka H, Toyoshima Y, Tada M, Shimizu H, Miura T, Ikeuchi T, Takahashi H,　Kakita A
- Organizer
  The 10th Congress of Asia Pacific International Academy of Pathology &
- Place of Presentation
  Bali (Indonesia)
- Year and Date
  2017-04-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] 認知症を呈する白質脳症　病理から見た病態形成：グリア細胞の関与2017
- Author(s)
  他田真理、高橋均、柿田明美
- Organizer
  第36回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] Microglial appearance in the white matter in hereditary diffuse leukoencephalopathy with spheroids2016
- Author(s)
  他田真理，今野卓哉，他田正義，岡崎健一，荒川武蔵，伊東恭子，山本徹，横尾英明，吉倉延亮，石原健司，豊島靖子，小野寺理，西澤正豊，高橋均，池内健，柿田明美
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  兵庫県神戸市、神戸国際展示場
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] Immunohistochemical features of GGT revealed using a tau oligomer-specific antibody2016
- Author(s)
  Tanaka H, Toyoshima Y, Tada M, Ikeuchi T, Nishizawa M, Takahashi H, Kakita A
- Organizer
  11th European Congress of Neuropathology
- Place of Presentation
  Bordeaux （France）
- Year and Date
  2016-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] The expression of Human endogenous retrovirus-K in the neuronal tissues of Japanese ALS patients.2016
- Author(s)
  Ishihara T, Koyama A, Kato T, Takeuchi R, Tada M, Kakita A, Onodera O.
- Organizer
  Key stone symposium: Common Mechanisms of Neurodegeneration
- Place of Presentation
  Keystone (Colorado), USA
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250017
[Presentation] Immunohistochemical features of tauopathies revealed usiing a tau oligomer-specific antibody.2016
- Author(s)
  Tanaka H, Toyoshima Y, Tada M, Shimizu H, Shiga A, Ikeuchi T, Takahashi H, Kakita A
- Organizer
  第57回日本神経病理学会総会学術研究会
- Place of Presentation
  ホテルニューキャッスル (青森県・弘前市）
- Year and Date
  2016-06-01
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] Appearance of unique tau-positive astrocytes in the motor cortex in amyotrophic lateral sclerosis.2016
- Author(s)
  竹内亮子, 清水　宏, 他田真理, 豊島靖子, 小野寺　理, 西澤正豊, 高橋　均, 柿田明美.
- Organizer
  第57回日本神経病理学会
- Place of Presentation
  ホテルニューキャッスル（青森県・弘前市）
- Year and Date
  2016-06-01
- Data Source
  KAKENHI-PROJECT-26250017
[Presentation] Microglial appearance in the white matter in hereditary diffuse leukoencephalopathy with spheroids2016
- Author(s)
  他田真理，今野卓哉，他田正義，岡崎健一，荒川武蔵，伊東恭子，山本徹，横尾英明，吉倉延亮，石原健司，豊島靖子，小野寺理，西澤正豊，高橋均，池内健，柿田明美
- Organizer
  第57回日本神経病理学会総会学術研究会
- Place of Presentation
  青森県弘前市、ホテルニューキャッスル
- Year and Date
  2016-06-01
- Data Source
  KAKENHI-PROJECT-16K07041
[Presentation] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia2015
- Author(s)
  Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
- Organizer
  The 26th International Symposium on ALS/MND
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] 常染色体優性遺伝性と考えられ高齢発症の家族性パーキンソン病の１剖検2015
- Author(s)
  他田真理，横関明男，木村正志，池内健，石川厚, 高橋均，柿田明美
- Organizer
  第56回日本神経病理学会総会学術研究会
- Place of Presentation
  九州大学医学部百年講堂 (福岡県福岡市）
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] Tau oligomer accumulation in patients with globular glial tauopathies -type III2015
- Author(s)
  Toyoshima Y, Tanaka H, Takeuchi R, Shimizu H, Tada M, Shiga A, Yokota O, Kuroda S, Ikeuchi T, Kakita A, Takahashi H
- Organizer
  The 26th International Symposium on ALS/MND
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] Globular glial mixed four repeat tau and TDP-43 proteinopathy with motor neuron disease and frontotemporal dementia.2015
- Author(s)
  Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
- Organizer
  26th International Symposium on ALS/MND
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640029
[Presentation] Distinct patterns of neuronal and glial TDP-43 inclusions in motor cortex.2015
- Author(s)
  Takeuchi R, Tada M, Toyohima Y, Shiga A, Sato A, Horie M, Takebayashi H, Onodera O, Nishizawa M, Takahashi H, Kakita A
- Organizer
  第56回日本神経学会
- Place of Presentation
  朱鷺メッセ（新潟県・新潟市）
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-26250017
[Presentation] HDLS患者脳におけるミクログリアの形態学的異常： Microgliopathyとして2015
- Author(s)
  他田真理、高橋　均、柿田明美
- Organizer
  第56回日本神経学会総会学術大会
- Place of Presentation
  新潟朱鷺メッセ(新潟県新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] Distinct patterns of neuronal and glial TDP-43 inclusions in motor cortex.2015
- Author(s)
  Takeuchi R, Tada M, Toyoshima Y, Shiga A, Sato T, Horie M, Takebayashi H, Onodera O, Nishizawa M, Takahashi H, Kakita A
- Organizer
  第56回日本神経学会
- Place of Presentation
  朱鷺メッセ（新潟県・新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26640029
[Presentation] Globular glial tauopathy：蓄積タウの特徴2015
- Author(s)
  豊島靖子、竹内亮子、田中英智、他田真理、清水　宏、池内　健、柿田明美、高橋　均
- Organizer
  第56回日本神経病理学会総会学術研究会
- Place of Presentation
  九州大学医学部百年講堂、福岡
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] Globular glial mixed four repeat tau and TDP-43 proteinopathy with motor neuron disease and frontotemporal dementia.2015
- Author(s)
  Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
- Organizer
  26th International Symposium on ALS/MND
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250017
[Presentation] Globular glial tauopathy (type II) clinically mimicking ALS2015
- Author(s)
  Tanaka H, Toyoshima Y, Miura T, Tada M, Shimizu H, Shiga A, Ikeuchi T, Kakita A, Takahashi H
- Organizer
  The 26th International Symposium on ALS/MND
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430052
[Presentation] 神経軸索スフェロイドを伴う白質脳症HDLS：Microgliaの組織学的解析2013
- Author(s)
  他田真理，今野卓哉，他田正義，岡崎健一，荒川武蔵，横尾英明，伊東恭子，吉倉延亮，豊島靖子，小野寺理，西澤正豊，池内健, 高橋均，柿田明美
- Organizer
  第５４回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] 神経軸索スフェロイドを伴う白質脳症HDLS：Microgliaの組織学的解析2013
- Author(s)
  他田真理，今野卓哉，他田正義，岡崎健一，荒川武蔵，横尾英明，伊東恭子，吉倉延亮，豊島靖子，小野寺理，西澤正豊，池内健, 高橋均，柿田明美
- Organizer
  第５４回日本神経病理学会総会学術研究会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] Clinicopathologic analysis of TDP-43 expression in the cerebral cortex in ALS
- Author(s)
  Takeuchi R, Tada M, Shiga A, Konno T, Toyoshima Y, Onodera O, Nishizawa M, Kakita A, Takahashi H.
- Organizer
  The 66th Annual Meeting of American Academy of Neurology
- Place of Presentation
  Pennsylvania Convention Center, Philadelphia, USA
- Year and Date
  2014-04-27 – 2014-04-29
- Data Source
  KAKENHI-PROJECT-26640029
[Presentation] 神経軸索スフェロイドを伴う白質脳症HDLS：Microgliaの組織学的異常
- Author(s)
  他田真理，今野卓哉，他田正義，岡崎健一，荒川武蔵，横尾英明，山本　徹，伊東恭子，吉倉延亮，豊島靖子，小野寺理，西澤正豊，池内健, 高橋均，柿田明美
- Organizer
  第５５回日本神経病理学会総会学術研究会
- Place of Presentation
  東京都千代田区一ツ橋　学術総合センター
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] 筋萎縮性側索硬化症のTDP-43皮質組織像の多様性：臨床病理および生化学的解析
- Author(s)
  竹内亮子, 他田真理, 志賀　篤, 今野卓哉, 豊島靖子, 小野寺理, 西澤正豊, 柿田明美, 高橋　均
- Organizer
  日本神経病理学会
- Place of Presentation
  学術総合センター、東京
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26640029
[Presentation] Hereditary diffuse leukoencephalopathy with spheroids (HDLS): Histological features of microglia
- Author(s)
  Mari Tada, Takuya Konno，Masayoshi Tada，Ken-ichi Okazaki，Musashi Arakawa，Kyoko Itoh，Toru Yamamoto, Hideaki Yokoo, Nobuaki Yoshikura，Kenji Ishihara, Yasuko Toyoshima, Osamu Onodera, Masatoyo Nishizawa, Takeshi Ikeuchi，Hitoshi Takahashi，Akiyoshi Kakita
- Organizer
  American Academy of Neurology Annual meeting 2014
- Place of Presentation
  Pennsylvania Convention Center in Philadelphia, PA, USA
- Year and Date
  2014-04-26 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-25430048
[Presentation] 神経軸索スフェロイドを伴う白質脳症HDLS：Microgliaの組織学的異常
- Author(s)
  他田真理，今野卓哉，他田正義，岡崎健一，荒川武蔵，横尾英明，山本　徹，伊東恭子，吉倉延亮，豊島靖子，小野寺理，西澤正豊，池内健, 高橋均，柿田明美
- Organizer
  第５５回日本神経学会学術総会
- Place of Presentation
  福岡国際会議場・福岡サンパレス・福岡国際センター
- Year and Date
  2014-05-21 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-25430048

1. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. IKEUCHI Takeshi (20372469)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
3. TAKAHASHI Hitoshi (90206839)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
4. TOYOSHIMA Yasuko (20334675)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
5. 竹林浩秀 (60353439)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. ONODERA Osamu (20303167)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. Ishihara Tomohiko (70612232)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 加藤隆弘 (70546465)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. SHIMOHATA Takayoshi (60361911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. NISHIZAWA Masatoyo (80198457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
11. SAKIMURA Kenji (40162325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Miyashita Akinori (60323995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 清水宏 (40608767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 阿部学 (10334674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 畠野雄也 (10943540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 北浦弘樹 (80401769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田井中一貴 (80506113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 池田昭夫 (90212761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 濱崎英臣 (80843771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Hashimoto Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 渡部和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 村田麻喜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 松井広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tada Mari 他田 真理

Research Projects

Research Products

Co-Researchers

ミクログリアによるグリア連関維持機構を解明し、剖検脳から認知症治療介入標的を探るPrincipal Investigator

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AIと剖検組織を用いたALSの新規原因遺伝子同定

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ひとてんかん原性病態機序を知りこれを制御する

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認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫るPrincipal Investigator

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Missense rare variant analysis of APOE: Exploring the link between lipid metabolism and Alzheimer's disease

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Exploring genetic factors that define TDP-43 pathological polymorphisms in ALS.

Principal Investigator

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Microglia-astrocyte crosstalk in leukoencephalopathiesPrincipal Investigator

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Microglial involvement in the pathomechanisms of white matter degenerationPrincipal Investigator

Principal Investigator

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Research Institution

Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

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Globular glial tauopathy: investigation of the pathological features

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Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis

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Neuropathological analysis of multiple system atrophy with cognitive impairmentPrincipal Investigator

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[Book] 非腫瘍性疾患病理アトラス 中枢神経2024

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Tada Mari 他田真理

[Book] 非腫瘍性疾患病理アトラス　中枢神経2024

[Book] 非定型パーキンソニズム　基礎と臨床2019