Ishizawa Michiyasu 石澤通康

… Alternative Names

ISHIZAWA Michiyasu 石澤通康

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Researcher Number	30646542
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 日本大学, 医学部, 助教 2018 – 2019: 日本大学, 医学部, 助教 2014 – 2017: 日本大学, 医学部, 助手 2012: 日本大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 腸内細菌 / 肥満 / 核内受容体 / 胆汁酸 / ビタミンD Except Principal Investigator クッパ－細胞 / NK細胞 / NKT細胞 / マクロファージ / インターロイキン6 … More / ビタミンD受容体 / 自然免疫 / クッパ-細胞 / 急性肝障害 / ビタミンD誘導体 / サイトカイン / 胆汁酸 / 肝臓 / 肝障害 / ビリルビン / リトコール酸 / ノックアウトマウス / 炎症 / 胆汁鬱滞 Less

食事由来成分のビタミンD受容体を介した腸機能恒常性における新機能の解明Principal Investigator
- Principal Investigator
  
  石澤通康
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nihon University
Roles of vitamin D receptor in the gut microbiota and bile acid metabolism in diet-induced obesity mice.Principal Investigator
- Principal Investigator
  
  ISHIZAWA Michiyasu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
The relationship between vitamin D signaling and bile acid metabolism in obesity mice.Principal Investigator
- Principal Investigator
  
  ISHIZAWA Michiyasu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Lithocholic acid is a vitamin D receptor ligand that acts preferentially in the ileum2018
- Author(s)
  Michiyasu Ishizawa, Daisuke Akagi, and Makoto Makishima
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 7 Pages: 1975-1975
- DOI
  10.3390/ijms19071975
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08632, KAKENHI-PROJECT-16K19062
[Journal Article] Synthesis, Biological Activities and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds2015
- Author(s)
  Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mourino, Hiroaki Tokiwa, Makoto Makishima, and Sachiko Yamada
- Journal Title
  
  J.Med.Chem.
  
  Volume: 58 (24) Issue: 24 Pages: 9510-9521
- DOI
  10.1021/acs.jmedchem.5b00792
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-25460394
[Journal Article] Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor2014
- Author(s)
  Takeru Kudo, Michiyasu, Ishizawa, Kazuki Maekawa, Makoto Nakabayashi, Yusuke Watarai, Hikaru Uchida, Hiroaki Tokiwa, Teikichi Ikura, Nobutoshi Ito, Makoto Makishima, Sachiko Yamada,
- Journal Title
  
  J. Med. Chem.
  
  Volume: 57(10) Issue: 10 Pages: 4073-4087
- DOI
  10.1021/jm401989c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-25460394
[Journal Article] Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice.2012
- Author(s)
  Ishizawa M, Ogura M, Kato S, and Makishima M.
- Journal Title
  
  PLoS ONE
  
  Volume: 7(12) Issue: 12 Pages: e51664-e51664
- DOI
  10.1371/journal.pone.0051664
- NAID
  110009807289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] p38 MAPK and GADD45 enhance vitamin D signaling on TRPV6 mRNA induction in intestinal cells2019
- Author(s)
  Michiyasu Ishizawa, Makoto Makishima
- Organizer
  The 22nd Vitamin D Work shop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] アダマンチル基及びアルキル基を付加した新規ビタミンD誘導体の細胞選択的活性2019
- Author(s)
  石澤通康、前川和樹、常盤広明、Antonio Mourino、風間智彦、松本太郎、槇島誠、山田幸子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] ビタミンD受容体リガンドによる腸管部位選択的標的遺伝子調節2019
- Author(s)
  石澤通康、槇島誠
- Organizer
  日本ビタミン学会　第７１回大会
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] 食事性肥満における胆汁酸組成変動とビタミンD受容体の関与2017
- Author(s)
  石澤通康、槇島誠
- Organizer
  第３９回　胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] Lithocholic acid selectively induces ileal CYP24A1 mRNA via Vitamin D receptor.2017
- Author(s)
  Michiyasu Ishizawa, Makoto Makishima
- Organizer
  Keystone Symposia, Bile Acid Receptors as Signal Integrators in Liver and Metabolism.
- Place of Presentation
  Monterey, U.S.A
- Year and Date
  2017-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] ビタミンD受容体の糞中胆汁酸代謝への関与2017
- Author(s)
  石澤通康、槇島誠
- Organizer
  日本レチノイド研究会第28回学術集会
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] 食事性肥満における胆汁酸組成変動とビタミンD受容体の関与2016
- Author(s)
  石澤通康、槇島誠
- Organizer
  第38回胆汁酸研究会
- Place of Presentation
  久留米シティプラザ, 福岡
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-16K19062
[Presentation] 共役三重結合とアダマンチル基を導入したビタミンD誘導体の生物活性及びユニークな受容体結合様式2015
- Author(s)
  石澤通康、渡會友祐、伊倉貞吉、Flavia C. M. Zacconi、Antonio Mourino、常盤広明、伊藤暢聡、山田幸子、槇島誠
- Organizer
  第1回Neo Vitamin D Workshop学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] ビタミンDと消化管2015
- Author(s)
  槇島誠、石澤通康、西田滋
- Organizer
  第1回Neo Vitamin D Workshop学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 細胞選択的及び遺伝子選択的活性を有するビタミンD誘導体の生物活性評価2014
- Author(s)
  石澤通康、高野真史、橘髙敦史、坂根里枝、須原義智、山田幸子、槇島誠
- Organizer
  第344回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京農業大学（東京都世田谷区）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 共役diyneとアダマンチル基を側鎖に有する19-ノルビタミンD誘導体の立体選択的合成と生物活性評価2013
- Author(s)
  渡會友祐、前川和樹、石澤通康、宇野茂之、Antonio Mourino、槇島誠、常盤広明、山田幸子
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島県）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 新規VDRパーシャルアゴニストの立体選択的合成、X線結晶構造解析、および生物活性2013
- Author(s)
  前川和樹、工藤健、渡會友祐、石澤通康、内田光、中林誠、伊藤暢聡、常盤広明、槇島誠、山田幸子
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島県）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] リトコール酸による腸管部位選択的なビタミンD受容体標的遺伝子転写誘導.2012
- Author(s)
  石澤通康、宇野茂之、槇島誠.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡(福岡県)
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] リトコール酸は腸管部位選択的にビタミンD受容体標的遺伝子の転写を誘導する.2012
- Author(s)
  石澤通康、宇野茂之、槇島誠
- Organizer
  第34回胆汁酸研究会
- Place of Presentation
  サンプラーザシーズンズ(愛知県)
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 胆汁鬱滞モデルマウスにおけるビタミンD受容体の機能解析2012
- Author(s)
  石澤通康、小倉道一、加藤茂明、槇島誠
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  長良国際会議場(岐阜県)
- Year and Date
  2012-06-23
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 胆汁鬱滞モデルマウスにおけるビタミンD受容体の機能解析2012
- Author(s)
  石澤　通康
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  長良国際会議場（岐阜県）
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] リトコール酸による腸管部位選択的なビタミンD受容体標的遺伝子転写誘導2012
- Author(s)
  石澤　通康
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 胆汁鬱滞モデルマウスにおけるビタミンD受容体の役割2011
- Author(s)
  石澤通康、小倉道一、槇島誠
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪ガーデンパレス(大阪府)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 胆汁鬱滞モデルマウスにおけるビタミンD受容体の役割2011
- Author(s)
  石澤通康
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] ビタミンD受容体欠損マウスにおける胆汁鬱滞モデルの解析2011
- Author(s)
  石澤通康、小倉道一、槇島誠、加藤茂明.
- Organizer
  第333回脂溶性ビタミン総合研究委員会
- Place of Presentation
  兵衛向陽閣(兵庫県)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] ビタミンD受容体欠損マウスにおける胆汁鬱滞モデルの解析2011
- Author(s)
  石澤通康
- Organizer
  第333回脂溶性ビタミン総合研究委員会
- Place of Presentation
  神戸
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] ビタミンD受容体欠損マウスにおける胆汁酸代謝
- Author(s)
  西田滋、石澤通康、槇島誠
- Organizer
  第35回胆汁酸研究会
- Place of Presentation
  北海道医療大学札幌サテライトキャンパス（北海道）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] リトコール酸は腸管部位選択的にビタミンD受容体標的遺伝子の転写を誘導する
- Author(s)
  石澤　通康
- Organizer
  第34回胆汁酸研究会
- Place of Presentation
  サンプラザシーズンズ（愛知県）
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] AF2構造修飾型の新規VDR選択的モジュレーターの合成と生物活性
- Author(s)
  石澤通康、渡會友祐、前川和樹、工藤健、内田光、伊藤暢聡、常盤広明、山田幸子、槇島誠
- Organizer
  第8回日本大学先端バイオフォーラム
- Place of Presentation
  日本大学会館（東京都）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] VDRパーシャルアゴニスト活性を示す新規ビタミンD誘導体の合成・生物活性
- Author(s)
  渡會友祐、前川和樹、石澤通康、内田光、Flavia Zacconi、宇野茂之、常盤広明、Antonio Mourino、槇島誠、山田幸子
- Organizer
  日本レチノイド研究会第24回学術集会
- Place of Presentation
  星薬科大学百年記念館（東京都）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] ビタミンD受容体パーシャルアゴニストの開発と組織選択的機能発現の可能性
- Author(s)
  石澤通康、前川和樹、工藤健、中林誠、内田光、伊藤暢聡、常盤広明、山田幸子、槇島誠
- Organizer
  第524回日大医学会例会
- Place of Presentation
  日本大学医学部（東京都）
- Data Source
  KAKENHI-PROJECT-25460394

1. MAKISHIMA Makoto (70346146)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. UMEDA Kaori (10445744)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SEKI Shuji (80531392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NISHIDA Shigeru (90211458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SAKURAI Kenichi (20366602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HONDA Akira (10468639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMADA Sachiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. UMEDA Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 常盤広明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ishizawa Michiyasu 石澤 通康

ISHIZAWA Michiyasu 石澤 通康

Research Projects

Research Products

Co-Researchers

食事由来成分のビタミンD受容体を介した腸機能恒常性における新機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of vitamin D receptor in the gut microbiota and bile acid metabolism in diet-induced obesity mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The relationship between vitamin D signaling and bile acid metabolism in obesity mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lithocholic acid is a vitamin D receptor ligand that acts preferentially in the ileum2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis, Biological Activities and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice.2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] p38 MAPK and GADD45 enhance vitamin D signaling on TRPV6 mRNA induction in intestinal cells2019

Author(s)

Organizer

Data Source

[Presentation] アダマンチル基及びアルキル基を付加した新規ビタミンD誘導体の細胞選択的活性2019

Author(s)

Organizer

Data Source

[Presentation] ビタミンD受容体リガンドによる腸管部位選択的標的遺伝子調節2019

Author(s)

Organizer

Data Source

[Presentation] 食事性肥満における胆汁酸組成変動とビタミンD受容体の関与2017

Author(s)

Organizer

Data Source

[Presentation] Lithocholic acid selectively induces ileal CYP24A1 mRNA via Vitamin D receptor.2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ビタミンD受容体の糞中胆汁酸代謝への関与2017

Author(s)

Ishizawa Michiyasu 石澤通康

ISHIZAWA Michiyasu 石澤通康