Niwa Shinsuke 丹羽伸介

Researcher Number	30714985
Other IDs
Affiliation (Current)	2026: 東北大学, 学際科学フロンティア研究所, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 東北大学, 学際科学フロンティア研究所, 准教授 2015 – 2018: 東北大学, 学際科学フロンティア研究所, 助教 2016: 東北大学, 学内共同利用施設等, 助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Morphology/Structure / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Transformative Research Areas, Section (III) / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Biology of Cells to Organisms, and related fields / Cell biology Except Principal Investigator Mathematical Sciences in Search of New Cooperation / Complex systems / General anatomy (including histology/embryology)
Keywords	Principal Investigator キネシン / 軸索輸送 / シナプス小胞 / KIF1A / 線虫 / UNC-104 / 微小管 / ダイニン / シナプス / arl-8 … More / ARL-8 / ARL8B / ARL8A / 神経 / IFT / 神経科学 / クリプトスポリジウム / KIF5A / ALS / 神経疾患 / KAND / intraflagellar transport / ダイニン2 / 繊毛 / クラミドモナス / 繊毛内輸送 / 逆行性輸送 / ダイナクチン / サプレッサー / ARL8 / egl-5 / JIP1 / unc-16 / JIP3 / BORC / 痙性対麻痺 / 疾患 / kinesin / 遺伝性痙性対麻痺 / モーター / 速度 / キリン / 細胞骨格 / 細胞・組織 / 細胞生物学 … More Except Principal Investigator 分子モーター / 揺らぎの定理 / １分子計測 / 生物物理 / 医療 / 非平衡統計力学 / イメージング / 機械学習 / ビジュアルサーボ / 行動モデリング / システム同定 / バイオロギング / 群行動解析 / 行動計測 / 生態学 / ロボティクス / 制御工学 / ログボット / ゆらぎ / キネシン / 分子進化 / 軸索輸送 Less

原虫クリプトスポリジウムの微小管研究への挑戦Principal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Tohoku University
The molecular mechanism of retrograde axonal transportPrincipal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tohoku University
軸索輸送モーターKIF5Aによる長距離輸送機構と疾患のクロススケール解析Principal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tohoku University
In vitro reconstitution of intraflagellar transport by cytoplasmic dynein-2Principal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
The molecular mechanism of KIF1A Associated Neurological DisordersPrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tohoku University
シナプスのスクラップ&ビルドを抑制する新規ARL8サプレッサー遺伝子群の同定Principal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Is giraffe kinesin faster than human kinesin?Principal Investigator
- Principal Investigator
  
  NIWA SHINSUKE
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biology of Cells to Organisms, and related fields
- Research Institution
  Tohoku University
Misregulation of KIF1A in motor neuron diseasePrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tohoku University
The molecular mechanism that regulates axonal transport of synaptic vesicle precursorsPrincipal Investigator
- Principal Investigator
  
  NIWA SHINSUKE
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tohoku University
Why are there more than 40 kinesins in our genome?
- Principal Investigator
  
  Yasushi Okada
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  The University of Tokyo
System Identification of Bio-Navigation and Development of Innovative Logging Device
- Principal Investigator
  
  Hashimoto Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Molecular mechanisms that regulates the localization of organellesPrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems
- Principal Investigator
  
  Hayashi Kumiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Mathematical Sciences in Search of New Cooperation
- Research Institution
  Tohoku University

All 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Biased movement of monomeric kinesin-3 KLP-6 explained by a symmetric Brownian ratchet model2025
- Author(s)
  Kita Tomoki、Sasaki Kazuo、Niwa Shinsuke
- Journal Title
  
  Biophysical Journal
  
  Volume: 124 Issue: 1 Pages: 205-214
- DOI
  10.1016/j.bpj.2024.11.3312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27165, KAKENHI-PROJECT-23KJ0168
[Journal Article] Modular photostable fluorescent DNA blocks dissect the effects of pathogenic mutant kinesin on collective transport2025
- Author(s)
  Kita Tomoki、Sugie Ryota、Suzuki Yuki、Niwa Shinsuke
- Journal Title
  
  Cell Reports Physical Science
  
  Volume: 6 Issue: 2 Pages: 102440-102440
- DOI
  10.1016/j.xcrp.2025.102440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04416, KAKENHI-PROJECT-23K24937, KAKENHI-PROJECT-23K27165, KAKENHI-PROJECT-23K17860, KAKENHI-PROJECT-23KJ0168
[Journal Article] The FHA domain is essential for autoinhibition of KIF1A/UNC-104 proteins2024
- Author(s)
  Niwa Shinsuke、Watanabe Taisei、Chiba Kyoko
- Journal Title
  
  Journal of Cell Science
  
  Volume: 137 Issue: 19
- DOI
  10.1242/jcs.262017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27165
[Journal Article] An Arabidopsis Kinesin-14D motor is associated with midzone microtubules for spindle morphogenesis2024
- Author(s)
  Guo Xiaojiang、Huang Calvin H.、Akagi Takashi、Niwa Shinsuke、McKenney Richard J.、Wang Ji-Rui、Lee Yuh-Ru Julie、Liu Bo
- Journal Title
  
  Current Biology
  
  Volume: 34 Issue: 16 Pages: 3747-3762.e6
- DOI
  10.1016/j.cub.2024.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27165
[Journal Article] Kinesin-like motor protein KIF23 maintains neural stem?and progenitor cell pools in the developing cortex2024
- Author(s)
  Naher Sharmin、Iemura Kenji、Miyashita Satoshi、Hoshino Mikio、Tanaka Kozo、Niwa Shinsuke、Tsai Jin-Wu、Kikkawa Takako、Osumi Noriko
- Journal Title
  
  The EMBO Journal
  
  Volume: 44 Issue: 2 Pages: 331-355
- DOI
  10.1038/s44318-024-00327-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23877, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-23K27165, KAKENHI-PROJECT-24K02203, KAKENHI-PROJECT-23K06297, KAKENHI-PROJECT-23K14295
[Journal Article] Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis2024
- Author(s)
  Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 86 Pages: 102301-102301
- DOI
  10.1016/j.ceb.2023.102301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-23K27165
[Journal Article] Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-32024
- Author(s)
  Kita Tomoki、Chiba Kyoko、Wang Jiye、Nakagawa Atsushi、Niwa Shinsuke
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.89040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PROJECT-23K27165
[Journal Article] Total Internal Reflection Fluorescence (TIRF) Single-Molecule Assay to Analyze the Motility of Kinesin2024
- Author(s)
  Kita Tomoki、Niwa Shinsuke
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 14 Issue: 1361
- DOI
  10.21769/bioprotoc.5135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27165, KAKENHI-PROJECT-23KJ0168
[Journal Article] Extreme-value analysis of intracellular cargo transport by motor proteins2024
- Author(s)
  Naoi Takuma、Kagawa Yuki、Nagino Kimiko、Niwa Shinsuke、Hayashi Kumiko
- Journal Title
  
  Communications Physics
  
  Volume: 7 Issue: 1 Pages: 50-50
- DOI
  10.1038/s42005-024-01538-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18679, KAKENHI-PROJECT-23K27165
[Journal Article] Characterizing human KIF1Bβ motor activity by single-molecule motility assays and <i>Caenorhabditis elegans</i> genetics2024
- Author(s)
  Iguchi Rei、Kita Tomoki、Watanabe Taisei、Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Journal of Cell Science
  
  Volume: 137 Issue: 19
- DOI
  10.1242/jcs.261783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27165, KAKENHI-PROJECT-23KJ0168
[Journal Article] Modeling the motion of disease-associated KIF1A heterodimers2023
- Author(s)
  Kita Tomoki、Sasaki Kazuo、Niwa Shinsuke
- Journal Title
  
  Biophysical Journal
  
  Volume: 122 Issue: 22 Pages: 4348-4359
- DOI
  10.1016/j.bpj.2023.10.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ0168, KAKENHI-PROJECT-23K27165
[Journal Article] Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder2023
- Author(s)
  Chiba Kyoko、Kita Tomoki、Anazawa Yuzu、Niwa Shinsuke
- Journal Title
  
  Journal of Cell Science
  
  Volume: 136 Issue: 5
- DOI
  10.1242/jcs.260742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621, KAKENHI-PROJECT-23K27165
[Journal Article] Generation of recombinant and chickenized scFv versions of an anti‐kinesin monoclonal antibody H22023
- Author(s)
  Niwa Shinsuke、Chiba Kyoko
- Journal Title
  
  Cytoskeleton
  
  Volume: - Issue: 9-10 Pages: 356-366
- DOI
  10.1002/cm.21756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K20621, KAKENHI-PROJECT-22K15053, KAKENHI-PROJECT-23K27165
[Journal Article] Analyzing the Impact of Gene Mutations on Axonal Transport in Caenorhabditis Elegans2022
- Author(s)
  Anazawa Yuzu、Niwa Shinsuke
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: - Pages: 465-479
- DOI
  10.1007/978-1-0716-1990-2_25
- ISBN
  9781071619896, 9781071619902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03247
[Journal Article] De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors2022
- Author(s)
  Anazawa Yuzu、Kita Tomoki、Iguchi Rei、Hayashi Kumiko、Niwa Shinsuke
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 32
- DOI
  10.1073/pnas.2113795119
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247
[Journal Article] CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation2022
- Author(s)
  Imasaki T et al.,
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.77365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06809, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K19352, KAKENHI-PROJECT-23K24057, KAKENHI-PLANNED-21H05254
[Journal Article] Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity2022
- Author(s)
  Chiba Kyoko、Ori-McKenney Kassandra M.、Niwa Shinsuke、McKenney Richard J.
- Journal Title
  
  Cell Reports
  
  Volume: 39 Issue: 9 Pages: 110900-110900
- DOI
  10.1016/j.celrep.2022.110900
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 ?tubulin complex2022
- Author(s)
  Taguchi S et al.,
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.77877
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06809, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K19352, KAKENHI-PROJECT-23K24057, KAKENHI-PLANNED-21H05254
[Journal Article] An ALS‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022
- Author(s)
  Nakano Juri、Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 6 Pages: 421-435
- DOI
  10.1111/gtc.12936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] Dynein intermediate chains DYCI‐1 and WDR‐60 have specific functions in Caenorhabditis elegans2022
- Author(s)
  Higashida Maki、Niwa Shinsuke
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 2 Pages: 97-110
- DOI
  10.1111/gtc.12996
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247
[Journal Article] Effects of dynein inhibitor on the number of motor proteins transporting synaptic cargos2021
- Author(s)
  Hayashi Kumiko、Miyamoto Miki G.、Niwa Shinsuke
- Journal Title
  
  Biophysical Journal
  
  Volume: - Issue: 9 Pages: 1605-1614
- DOI
  10.1016/j.bpj.2021.02.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-20H03247
[Journal Article] Reconstitution of Kinesin-1 Activation2021
- Author(s)
  Chiba Kyoko、Ori-McKenney Kassandra M.、Niwa Shinsuke、McKenney Richard J.
- Journal Title
  
  Biorxiv
  
  Volume: -
- DOI
  10.1101/2021.03.12.434960
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Journal Article] A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health2021
- Author(s)
  Lam Aileen J.、Rao Lu、Anazawa Yuzu、Okada Kyoko、Chiba Kyoko、Dacy Mariah、Niwa Shinsuke、Gennerich Arne、Nowakowski Dan W.、McKenney Richard J.
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 18
- DOI
  10.1126/sciadv.abf1002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03247
[Journal Article] Neural and behavioral control in Caenorhabditis elegans by a yellow-light?activatable caged compound2021
- Author(s)
  Takahashi Hironori、Kamiya Mako、Kawatani Minoru、Umezawa Keitaro、Ukita Yoshiaki、Niwa Shinsuke、Oda Toshiyuki、Urano Yasuteru
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 6
- DOI
  10.1073/pnas.2009634118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PLANNED-20H05724, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-19K16291, KAKENHI-PROJECT-21H02654
[Journal Article] What is the temperature of a cell?2020
- Author(s)
  Hayashi Kumiko、Hasegawa Shin、Niwa Shinsuke
- Journal Title
  
  Europhysics News
  
  Volume: 51 Issue: 5 Pages: 48-50
- DOI
  10.1051/epn/2020510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03247
[Journal Article] A Combinatorial MAP Code Dictates Polarized Microtubule Transport2020
- Author(s)
  Monroy Brigette Y.、Tan Tracy C.、Oclaman Janah May、Han Jisoo S.、Sim? Sergi、Niwa Shinsuke、Nowakowski Dan W.、McKenney Richard J.、Ori-McKenney Kassandra M.
- Journal Title
  
  Developmental Cell
  
  Volume: 53 Issue: 1 Pages: 60-72.e4
- DOI
  10.1016/j.devcel.2020.01.029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19373, KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-20H03247
[Journal Article] Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis2019
- Author(s)
  Shao Zhenhua、Niwa Shinsuke、Higashitani Atsushi、Daigaku Yasukazu
- Journal Title
  
  DNA Repair
  
  Volume: 82 Pages: 102688-102688
- DOI
  10.1016/j.dnarep.2019.102688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17H05010
[Journal Article] Physical parameters describing neuronal cargo transport by kinesin UNC-1042019
- Author(s)
  Hayashi Kumiko、Matsumoto Shiori、Miyamoto Miki G.、Niwa Shinsuke
- Journal Title
  
  Biophysical Reviews
  
  Volume: 11 Issue: 3 Pages: 471-482
- DOI
  10.1007/s12551-019-00548-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H03659, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373
[Journal Article] Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia2019
- Author(s)
  Gabrych Dominik R.、Lau Victor Z.、Niwa Shinsuke、Silverman Michael A.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 13
- DOI
  10.3389/fncel.2019.00419
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373, KAKENHI-PROJECT-17KK0139
[Journal Article] Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba Kyoko、Takahashi Hironori、Chen Min、Obinata Hiroyuki、Arai Shogo、Hashimoto Koichi、Oda Toshiyuki、McKenney Richard J.、Niwa Shinsuke
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 37 Pages: 18429-18434
- DOI
  10.1073/pnas.1905690116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-16K21735, KAKENHI-ORGANIZER-16H06535, KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373, KAKENHI-PROJECT-17KK0139, KAKENHI-PLANNED-16H06536
[Journal Article] Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging2019
- Author(s)
  Yanagi Shota、Sugai Tomoya、Noguchi Takuma、Kawakami Masato、Sasaki Makoto、Niwa Shinsuke、Sugimoto Asako、Fuwa Haruhiko
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 28 Pages: 6771-6776
- DOI
  10.1039/c9ob01276a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K01941
[Journal Article] Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-82018
- Author(s)
  Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki and Shinsuke Niwa
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 20 Issue: 5 Pages: 3403-3410
- DOI
  10.1039/c7cp05890j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26310204, KAKENHI-PUBLICLY-16H00819, KAKENHI-PROJECT-17H03659, KAKENHI-PROJECT-17H05010
[Journal Article] A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability2018
- Author(s)
  Chia Poh Hui、Zhong Franklin Lei、Niwa Shinsuke、Bonnard Carine、Utami Kagistia Hana、Zeng Ruizhu、Lee Hane、Eskin Ascia、Nelson Stanley F、Xie William H、Al-Tawalbeh Samah、El-Khateeb Mohammad、Shboul Mohammad、Pouladi Mahmoud A、Al-Raqad Mohammed、Reversade Bruno
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.32451
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06536, KAKENHI-PROJECT-17H05010
[Journal Article] KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth2018
- Author(s)
  Xu Fang、Takahashi Hironori、Tanaka Yosuke、Ichinose Sotaro、Niwa Shinsuke、Wicklund Matthew P.、Hirokawa Nobutaka
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Issue: 10 Pages: 3480-3496
- DOI
  10.1083/jcb.201801085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-16H06372
[Journal Article] Streptothricin acetyl transferase 2 (Sat2): A dominant selection marker for Caenorhabditis elegans genome editing2018
- Author(s)
  Obinata Hiroyuki、Sugimoto Asako、Niwa Shinsuke
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 5 Pages: e0197128-e0197128
- DOI
  10.1371/journal.pone.0197128
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06536, KAKENHI-PROJECT-17H05010
[Journal Article] Structural basis for CRMP2-induced axonal microtubule formation2017
- Author(s)
  Niwa Shinsuke、Nakamura Fumio、Tomabechi Yuri、Aoki Mari、Shigematsu Hideki、Matsumoto Takashi、Yamagata Atsushi、Fukai Shuya、Hirokawa Nobutaka、Goshima Yoshio、Shirouzu Mikako、Nitta Ryo
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 10681-10681
- DOI
  10.1038/s41598-017-11031-4
- NAID
  120006373796
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07062, KAKENHI-PUBLICLY-17H05897, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-15K08168
[Journal Article] BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-82017
- Author(s)
  Niwa Shinsuke、Tao Li、Lu Sharon Y.、Liew Gerald M.、Feng Wei、Nachury Maxence V.、Shen Kang
- Journal Title
  
  Current Biology
  
  Volume: 27 Issue: 17 Pages: 2569-2578.e4
- DOI
  10.1016/j.cub.2017.07.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Immobilization of <em>Caenorhabditis elegans</em> to Analyze Intracellular Transport in Neurons2017
- Author(s)
  Niwa Shinsuke
- Journal Title
  
  Journal of Visualized Experiment
  
  Volume: - Issue: 128
- DOI
  10.3791/56690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Autoinhibition of a neuronal kinesin UNC-104/KIF1A regulates the size and density of synapses.2016
- Author(s)
  Niwa S., Lipton DM., Morikawa M., Zhao C., Hirokawa N., Lu H., and Shen K.
- Journal Title
  
  Cell Reports
  
  Volume: 16 Issue: 8 Pages: 2129-2141
- DOI
  10.1016/j.celrep.2016.07.043
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06372, KAKENHI-PROJECT-15H06033
[Journal Article] The molecular motor KIF1A transports the TrkA neurotrophin receptor and is essential for sensory neuron survival and function.2016
- Author(s)
  Tanaka, Y., S. Niwa, M. Dong, A. Farkhondeh, L. Wang, R. Zhou, and N. Hirokawa.
- Journal Title
  
  Neuron
  
  Volume: 90 Issue: 6 Pages: 1215-1229
- DOI
  10.1016/j.neuron.2016.05.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H06372, KAKENHI-PROJECT-15H06033
[Journal Article] Nephronophthisis-related gene ift-139 is required for the ciliogenesis in Caenorhabditis elegans.2016
- Author(s)
  Niwa Shinsuke
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 31544-31544
- DOI
  10.1038/srep31544
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H06033
[Presentation] C. elegansの遺伝学によるミトコンドリアの形態形成機構とミトコンドリア病の解析2024
- Author(s)
  丹羽伸介
- Organizer
  NEURO 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] 単量体キネシンは存在するのか？2024
- Author(s)
  丹羽伸介
- Organizer
  分子モーター討論会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Activation of Monomeric Kinesins2024
- Author(s)
  丹羽伸介
- Organizer
  Gordon Research Conference "Molecular motors"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] 神経細胞の軸索輸送と分子モータータンパク質2024
- Author(s)
  丹羽伸介
- Organizer
  丹羽伸介
- Invited
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Overactivation of the Axonal Transport in Neurodegenerative Disorders2024
- Author(s)
  Shinsuke Niwa
- Organizer
  EMBO | The Company of Biologists Workshop “Axonal Degeneration and Regeneration”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Investigating the pathogenesis of KIF1A Associated Neurological Disorder (KAND) and identifying therapeutic targets using C.elegans nerve cells.2024
- Author(s)
  穴澤ゆず, 丹羽伸介
- Organizer
  Cell Bio 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] クロモキネシンKidはホモ二量体を形成し、微小管に沿ってprocessiveに運動する2024
- Author(s)
  古崎夏希, 丹羽伸介, 北智輝, 千葉杏子
- Organizer
  第76回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Activation of Monomeric Kinesins2024
- Author(s)
  Shinsuke Niwa
- Organizer
  EMBO/EMBL meeting "Microtubules"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] In silico isolation, In vitro analysis and in vivo validation of suppressors for KIF1A associated neurological disorder2024
- Author(s)
  Shinsuke Niwa
- Organizer
  Cell Bio 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Investigating the pathogenesis of KIF1A Associated Neurological Disorder (KAND) and identifying therapeutic targets using C.elegans nerve cells2024
- Author(s)
  穴澤ゆず, 丹羽伸介
- Organizer
  EMBO | The Company of Biologists Workshop “Axonal Degeneration and Regeneration”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Increased and Decreased axonal transport of synaptic precursors is associated with neurological disorders2023
- Author(s)
  Shinsuke Niwa
- Organizer
  Tohoku Neurotech Symposium 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Modeling motion of heterodimeric motors uncovers head-to-head coordination in KIF1A dimer2023
- Author(s)
  Tomoki Kita,Shinsuke Niwa,Kazuo Sasaki
- Organizer
  第49回内藤コンファレンス微小管・分子モーター研究の最前線
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] KIF5A遺伝子の変異がALSを引き起こすメカニズム2023
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03247
[Presentation] The FHA domain is essential for the autoinhibition of KIF1A2023
- Author(s)
  Kyoko Chiba,Shinsuke Niwa
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Activation of KIF1A/UNC-104 motor and its involvement in synaptogenesis and neurological disorders2023
- Author(s)
  Shinsuke Niwa
- Organizer
  Cytoskeleton in Neuron and Glia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] The FHA domain is essential for the autoinhibition of KIF1A2023
- Author(s)
  Kyoko Chiba, Shinsuke Niwa
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans2023
- Author(s)
  東田真季,丹羽伸介
- Organizer
  2023年線虫の未来を作る会
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Elucidation of KIF1A Associated Neurological Disorder(KAND) pathogenesis and the search for therapeutic target using C. elegans nerves2023
- Author(s)
  Yuzu Anazawa,Shinsuke Niwa
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Activation of KIF1A/UNC-104 motor and its involvement in synaptogenesis and neurological disorders2023
- Author(s)
  Shinsuke Niwa
- Organizer
  Cytoskeleton in Neuron and Glia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] Modeling the motion of heterodimeric motors uncovers head-head coordination in a KIF1A dimer2023
- Author(s)
  Tomoki Kita,Kazuo Sasaki,Shinsuke Niwa
- Organizer
  日本生物物理学会大会
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Increased and Decreased axonal transport of synaptic precursors is associated with neurological disorders2023
- Author(s)
  Shinsuke Niwa
- Organizer
  Tohoku Neurotech Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] Activation of KIF1A/UNC-104 motor and its involvement in neurological disorders2023
- Author(s)
  丹羽伸介
- Organizer
  第49回内藤コンファレンス微小管・分子モーター研究の最前線
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] KIF5A遺伝子の変異がALSを起こすメカニズム2023
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] KIF1A and KIF1Bbeta form a heterodimer2023
- Author(s)
  Kyoko Chiba,Shinsuke Niwa
- Organizer
  第49回内藤コンファレンス微小管・分子モーター研究の最前線
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] Elucidation of KIF1A Associated Neurological Disorder(KAND) pathogenesis and the search for therapeutic target using C. elegans nerves2023
- Author(s)
  Yuzu Anazawa, Shinsuke Niwa
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05523
[Presentation] De novo mutations in KIF1A-associated neuronal disorder dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors2023
- Author(s)
  穴澤ゆず、丹羽伸介
- Organizer
  第49回内藤コンファレンス微小管・分子モーター研究の最前線
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27165
[Presentation] 線虫遺伝学と1分子計測の融合アプローチによるオルガネラ局在機構の研究2021
- Author(s)
  丹羽伸介
- Organizer
  第４４回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-20H03247
[Presentation] De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.2021
- Author(s)
  Yuzu Anazawa, Kita Tomoki, Hayashi Kumiko, Niwa Shinsuke
- Organizer
  Cell BIo virtual 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03247
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  北京大学生物科学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  北京大学生物科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  清華大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  丹羽伸介
- Organizer
  第４２回神経科学学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S
- Organizer
  分子生物学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  清華大学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  丹羽伸介
- Organizer
  神経科学学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S
- Organizer
  分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor.2018
- Author(s)
  Kyoko Chiba, Richard McKenney, Shinsuke Niwa
- Organizer
  ASCB annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] Disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor.2018
- Author(s)
  Kyoko Chiba, Richard McKenney, Shinsuke Niwa
- Organizer
  EMBL symposium, Microtubule
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-82018
- Author(s)
  Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki and Shinsuke Niwa
- Organizer
  62nd Annual meeting of the Biophysical Society
- Data Source
  KAKENHI-PROJECT-26310204
[Presentation] Motor disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor2018
- Author(s)
  Kyoko Chiba, Richard J. McKenney, Shinsuke Niwa
- Organizer
  EMBL Symposium "Microtubule: From Atoms to Complex Systems"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Motor disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor2018
- Author(s)
  Kyoko Chiba, Richard J. McKenney, Shinsuke Niwa
- Organizer
  American Society for Cell Biology (ASCB)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] 線虫遺伝学を用いた分子モーター研究2017
- Author(s)
  丹羽伸介
- Organizer
  第69回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] 線虫遺伝学を用いた軸索輸送の解析2017
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Place of Presentation
  長崎大学医学部（長崎県長崎市）
- Year and Date
  2017-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H06033
[Presentation] A small GTPase ARL-8 regulates synapse formation by unlocking the autoinhibition of the axonal transport kinesin unc-1042015
- Author(s)
  Kang Shen and Shinsuke Niwa
- Organizer
  ASCB2015
- Place of Presentation
  San Diego
- Year and Date
  2015-12-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06033

1. Yasushi Okada (50272430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 池田一穂 (20642565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Hashimoto Koichi (80228410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Hayashi Kumiko (00585979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 木村暁 (10365447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 神原丈敏 (40451637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中井淳一 (80237198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鏡慎吾 (90361542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 荒井翔悟 (80587874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山口明彦 (10625031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小田賢幸 (20569090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 村越ふみ (20759906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANAKA Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. Goshima Yoshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 広川信隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 大学保一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 今崎剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 田中耕三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 千葉杏子

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
20. 中村史雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 高橋晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 鈴木勇輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niwa Shinsuke 丹羽 伸介

Research Projects

Research Products

Co-Researchers

原虫クリプトスポリジウムの微小管研究への挑戦Principal Investigator

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The molecular mechanism of retrograde axonal transportPrincipal Investigator

Principal Investigator

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軸索輸送モーターKIF5Aによる長距離輸送機構と疾患のクロススケール解析Principal Investigator

Principal Investigator

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In vitro reconstitution of intraflagellar transport by cytoplasmic dynein-2Principal Investigator

Principal Investigator

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The molecular mechanism of KIF1A Associated Neurological DisordersPrincipal Investigator

Principal Investigator

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シナプスのスクラップ&ビルドを抑制する新規ARL8サプレッサー遺伝子群の同定Principal Investigator

Principal Investigator

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Is giraffe kinesin faster than human kinesin?Principal Investigator

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Misregulation of KIF1A in motor neuron diseasePrincipal Investigator

Principal Investigator

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The molecular mechanism that regulates axonal transport of synaptic vesicle precursorsPrincipal Investigator

Principal Investigator

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Why are there more than 40 kinesins in our genome?

Principal Investigator

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System Identification of Bio-Navigation and Development of Innovative Logging Device

Principal Investigator

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Molecular mechanisms that regulates the localization of organellesPrincipal Investigator

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Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems

Principal Investigator

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Niwa Shinsuke 丹羽伸介