Niwa Shinsuke 丹羽伸介

Researcher Number	30714985
Other IDs
Affiliation (Current)	2021: 東北大学, 学際科学フロンティア研究所, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 東北大学, 学際科学フロンティア研究所, 准教授 2015 – 2019: 東北大学, 学際科学フロンティア研究所, 助教 2016: 東北大学, 学内共同利用施設等, 助教
Review Section/Research Field	Principal Investigator Morphology/Structure / Cell biology / Biology of Cells to Organisms, and related fields / Biological Sciences / Basic Section 44010:Cell biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields Except Principal Investigator General anatomy (including histology/embryology) / Complex systems / Mathematical Sciences in Search of New Cooperation
Keywords	Principal Investigator 軸索輸送 / キネシン / KIF1A / 神経科学 / シナプス小胞 / UNC-104 / ARL-8 / 線虫 / arl-8 / 細胞生物学 … More Except Principal Investigator 分子モーター / 軸索輸送 / 分子進化 / キネシン / ゆらぎ / ログボット / バイオロギング / システム同定 / 行動モデリング / ビジュアルサーボ / 機械学習 / イメージング / 非平衡統計力学 / 医療 / 生物物理 / １分子計測 / 揺らぎの定理 Less

The molecular mechanism of KIF1A Associated Neurological DisordersPrincipal InvestigatorOngoing
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tohoku University
In vitro reconstitution of intraflagellar transport by cytoplasmic dynein-2Principal InvestigatorOngoing
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
シナプスのスクラップ&ビルドを抑制する新規ARL8サプレッサー遺伝子群の同定Principal InvestigatorOngoing
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Is giraffe kinesin faster than human kinesin?Principal Investigator
- Principal Investigator
  
  NIWA SHINSUKE
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biology of Cells to Organisms, and related fields
- Research Institution
  Tohoku University
Misregulation of KIF1A in motor neuron diseasePrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tohoku University
The molecular mechanism that regulates axonal transport of synaptic vesicle precursorsPrincipal Investigator
- Principal Investigator
  
  丹羽伸介
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tohoku University
Why are there more than 40 kinesins in our genome?
- Principal Investigator
  
  Yasushi Okada
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  The University of Tokyo
System Identification of Bio-Navigation and Development of Innovative Logging DeviceOngoing
- Principal Investigator
  
  橋本浩一
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Molecular mechanisms that regulates the localization of organellesPrincipal Investigator
- Principal Investigator
  
  Niwa Shinsuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems
- Principal Investigator
  
  Hayashi Kumiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Mathematical Sciences in Search of New Cooperation
- Research Institution
  Tohoku University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] A Combinatorial MAP Code Dictates Polarized Microtubule Transport2020
- Author(s)
  Monroy Brigette Y.、Tan Tracy C.、Oclaman Janah May、Han Jisoo S.、Sim? Sergi、Niwa Shinsuke、Nowakowski Dan W.、McKenney Richard J.、Ori-McKenney Kassandra M.
- Journal Title
  
  Developmental Cell
  
  Volume: 53
- DOI
  10.1016/j.devcel.2020.01.029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19373
[Journal Article] Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis2019
- Author(s)
  Shao Zhenhua、Niwa Shinsuke、Higashitani Atsushi、Daigaku Yasukazu
- Journal Title
  
  DNA Repair
  
  Volume: 82 Pages: 102688-102688
- DOI
  10.1016/j.dnarep.2019.102688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17H05010
[Journal Article] Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging2019
- Author(s)
  Yanagi Shota、Sugai Tomoya、Noguchi Takuma、Kawakami Masato、Sasaki Makoto、Niwa Shinsuke、Sugimoto Asako、Fuwa Haruhiko
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Pages: 6771-6776
- DOI
  10.1039/c9ob01276a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K01941
[Journal Article] Physical parameters describing neuronal cargo transport by kinesin UNC-1042019
- Author(s)
  Hayashi Kumiko、Matsumoto Shiori、Miyamoto Miki G.、Niwa Shinsuke
- Journal Title
  
  Biophysical Review
  
  Volume: 11 Pages: 471-482
- DOI
  10.1007/s12551-019-00548-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H03659, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373
[Journal Article] Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba Kyoko、Takahashi Hironori、Chen Min、Obinata Hiroyuki、Arai Shogo、Hashimoto Koichi、Oda Toshiyuki、McKenney Richard J.、Niwa Shinsuke
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Pages: 18429-18434
- DOI
  10.1073/pnas.1905690116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-16K21735, KAKENHI-ORGANIZER-16H06535, KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373, KAKENHI-PROJECT-17KK0139
[Journal Article] Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia2019
- Author(s)
  Gabrych Dominik R.、Lau Victor Z.、Niwa Shinsuke、Silverman Michael A.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 13
- DOI
  10.3389/fncel.2019.00419
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-17K19373, KAKENHI-PROJECT-17KK0139
[Journal Article] KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth2018
- Author(s)
  Xu Fang、Takahashi Hironori、Tanaka Yosuke、Ichinose Sotaro、Niwa Shinsuke、Wicklund Matthew P.、Hirokawa Nobutaka
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Pages: 3480-3496
- DOI
  10.1083/jcb.201801085
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Streptothricin acetyl transferase 2 (Sat2): A dominant selection marker for Caenorhabditis elegans genome editing2018
- Author(s)
  Obinata Hiroyuki、Sugimoto Asako、Niwa Shinsuke
- Journal Title
  
  PLOS ONE
  
  Volume: 13
- DOI
  10.1371/journal.pone.0197128
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06536, KAKENHI-PROJECT-17H05010
[Journal Article] Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-82018
- Author(s)
  Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki and Shinsuke Niwa
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 20 Pages: 3403-3410
- DOI
  10.1039/c7cp05890j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26310204, KAKENHI-PUBLICLY-16H00819, KAKENHI-PROJECT-17H03659, KAKENHI-PROJECT-17H05010
[Journal Article] A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability2018
- Author(s)
  Chia Poh Hui、Zhong Franklin Lei、Niwa Shinsuke、Bonnard Carine、Utami Kagistia Hana、Zeng Ruizhu、Lee Hane、Eskin Ascia、Nelson Stanley F、Xie William H、Al-Tawalbeh Samah、El-Khateeb Mohammad、Shboul Mohammad、Pouladi Mahmoud A、Al-Raqad Mohammed、Reversade Bruno
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.32451
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06536, KAKENHI-PROJECT-17H05010
[Journal Article] Structural basis for CRMP2-induced axonal microtubule formation2017
- Author(s)
  Niwa Shinsuke、Nakamura Fumio、Tomabechi Yuri、Aoki Mari、Shigematsu Hideki、Matsumoto Takashi、Yamagata Atsushi、Fukai Shuya、Hirokawa Nobutaka、Goshima Yoshio、Shirouzu Mikako、Nitta Ryo
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 10681-10681
- DOI
  10.1038/s41598-017-11031-4
- NAID
  120006373796
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07062, KAKENHI-PUBLICLY-17H05897, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-17H05010, KAKENHI-PROJECT-15K08168
[Journal Article] BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-82017
- Author(s)
  Niwa Shinsuke、Tao Li、Lu Sharon Y.、Liew Gerald M.、Feng Wei、Nachury Maxence V.、Shen Kang
- Journal Title
  
  Current Biology
  
  Volume: 27
- DOI
  10.1016/j.cub.2017.07.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Immobilization of <em>Caenorhabditis elegans</em> to Analyze Intracellular Transport in Neurons2017
- Author(s)
  Niwa Shinsuke
- Journal Title
  
  Journal of Visualized Experiment
  
  Volume: -
- DOI
  10.3791/56690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05010
[Journal Article] Autoinhibition of a neuronal kinesin UNC-104/KIF1A regulates the size and density of synapses.2016
- Author(s)
  Niwa S., Lipton DM., Morikawa M., Zhao C., Hirokawa N., Lu H., and Shen K.
- Journal Title
  
  Cell Reports
  
  Volume: 16 Pages: 2129-2141
- DOI
  10.1016/j.celrep.2016.07.043
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06372, KAKENHI-PROJECT-15H06033
[Journal Article] The molecular motor KIF1A transports the TrkA neurotrophin receptor and is essential for sensory neuron survival and function.2016
- Author(s)
  Tanaka, Y., S. Niwa, M. Dong, A. Farkhondeh, L. Wang, R. Zhou, and N. Hirokawa.
- Journal Title
  
  Neuron
  
  Volume: 90 Pages: 1215-1229
- DOI
  10.1016/j.neuron.2016.05.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H06372, KAKENHI-PROJECT-15H06033
[Journal Article] Nephronophthisis-related gene ift-139 is required for the ciliogenesis in Caenorhabditis elegans.2016
- Author(s)
  Niwa Shinsuke
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 31544-31544
- DOI
  10.1038/srep31544
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H06033
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  清華大学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  北京大学生物科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S
- Organizer
  分子生物学会大会
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  丹羽伸介
- Organizer
  神経科学学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  清華大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  丹羽伸介
- Organizer
  第４２回神経科学学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] The regulation of axonal transport and motor neuron disease2019
- Author(s)
  丹羽伸介
- Organizer
  北京大学生物科学セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] Disease-associated mutations in human KIF1A overactivate motility of KIF1A and anterograde axonal transport of synaptic vesicle precursors2019
- Author(s)
  Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S
- Organizer
  分子生物学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04738
[Presentation] Disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor.2018
- Author(s)
  Kyoko Chiba, Richard McKenney, Shinsuke Niwa
- Organizer
  EMBL symposium, Microtubule
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] Motor disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor2018
- Author(s)
  Kyoko Chiba, Richard J. McKenney, Shinsuke Niwa
- Organizer
  American Society for Cell Biology (ASCB)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] Disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor.2018
- Author(s)
  Kyoko Chiba, Richard McKenney, Shinsuke Niwa
- Organizer
  ASCB annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-82018
- Author(s)
  Kumiko Hayashi, Shin Hasegawa, Takashi Sagawa, Sohei Tasaki and Shinsuke Niwa
- Organizer
  62nd Annual meeting of the Biophysical Society
- Data Source
  KAKENHI-PROJECT-26310204
[Presentation] Motor disease mutations in human KIF1A disrupt autoinhibition of KIF1A motor2018
- Author(s)
  Kyoko Chiba, Richard J. McKenney, Shinsuke Niwa
- Organizer
  EMBL Symposium "Microtubule: From Atoms to Complex Systems"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0139
[Presentation] 線虫遺伝学を用いた分子モーター研究2017
- Author(s)
  丹羽伸介
- Organizer
  第69回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05010
[Presentation] 線虫遺伝学を用いた軸索輸送の解析2017
- Author(s)
  丹羽伸介
- Organizer
  日本解剖学会
- Place of Presentation
  長崎大学医学部（長崎県長崎市）
- Year and Date
  2017-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H06033
[Presentation] A small GTPase ARL-8 regulates synapse formation by unlocking the autoinhibition of the axonal transport kinesin unc-1042015
- Author(s)
  Kang Shen and Shinsuke Niwa
- Organizer
  ASCB2015
- Place of Presentation
  San Diego
- Year and Date
  2015-12-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06033

1. Yasushi Okada (50272430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 池田一穂 (20642565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Hayashi Kumiko (00585979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 木村暁 (10365447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 神原丈敏 (40451637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 橋本浩一 (80228410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 中井淳一 (80237198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鏡慎吾 (90361542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 荒井翔悟 (80587874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山口明彦 (10625031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小田賢幸 (20569090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Goshima Yoshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. NITTA Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. TANAKA Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 中村史雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 山形敦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 広川信隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 大学保一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 不破春彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 高橋晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niwa Shinsuke 丹羽 伸介

Research Projects

Research Products

Co-Researchers

The molecular mechanism of KIF1A Associated Neurological DisordersPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vitro reconstitution of intraflagellar transport by cytoplasmic dynein-2Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シナプスのスクラップ&ビルドを抑制する新規ARL8サプレッサー遺伝子群の同定Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Is giraffe kinesin faster than human kinesin?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Misregulation of KIF1A in motor neuron diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanism that regulates axonal transport of synaptic vesicle precursorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Why are there more than 40 kinesins in our genome?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

System Identification of Bio-Navigation and Development of Innovative Logging DeviceOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms that regulates the localization of organellesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Combinatorial MAP Code Dictates Polarized Microtubule Transport2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physical parameters describing neuronal cargo transport by kinesin UNC-1042019

Niwa Shinsuke 丹羽伸介