Mohri Kohta 毛利浩太

Researcher Number	30723697
Affiliation (Current)	2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2021: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2016 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 2014 – 2016: 摂南大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Physical pharmacy Except Principal Investigator Physical pharmacy
Keywords	Principal Investigator DDS / 核酸 / ナノ粒子 / CpGモチーフ / DNA assembly / dendritic structure / CpG motif / macrophage / innate immunity / 核酸ナノ構造体 … More / DNAアッセンブリ / 抗体 / がん診断 / がん免疫療法 / アップコンバージョン / 無機ナノ粒子 / 光線力学療法 … More Except Principal Investigator ワクチン / 粘膜免疫 / インフルエンザウイルス / 膜透過ペプチド / オリゴアルギニン固定化高分子 / 膜透過ペプチド固定化ヒアルロン酸 / 感染実験 Less

アップコンバージョンナノ粒子を基盤とした光線力学療法用製剤の開発Principal Investigator
- Principal Investigator
  
  毛利浩太
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Institute of Physical and Chemical Research
核酸ナノ構造体を基盤とした機能性抗体創出システムの開発とがん診断・治療への応用Principal Investigator
- Principal Investigator
  
  毛利浩太
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Institute of Physical and Chemical Research
Mucosal vaccines using oligoarginine-linked polymers that overcome gene diversities of viruses
- Principal Investigator
  
  SAKUMA SHINJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
Development of polypodna based dendritic nano-sized DDSPrincipal Investigator
- Principal Investigator
  
  Mohri Kohta
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University

All 2020 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells2020
- Author(s)
  Mohri Kohta、Hayashi Emi、Nishino Manato、Matsushita Nao、Tanishita Sohei、Nishikawa Makiya、Sakuma Shinji
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 29 Pages: 217-224
- DOI
  10.1080/1061186x.2020.1830407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15294
[Journal Article] Optimal arrangement of four short DNA strands for delivery of immunostimulatory nucleic acids to immune cells.2015
- Author(s)
  Shozo Ohtsuki, Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu Kadowaki, Yoshinobu Takakura, Makiya Nishikawa.
- Journal Title
  
  Nucleic Acid Theraputics
  
  Volume: 25 Pages: 245-253
- DOI
  10.1089/nat.2014.0524
- NAID
  120005690147
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860021, KAKENHI-PROJECT-15H03837, KAKENHI-PROJECT-26620133, KAKENHI-PROJECT-26293008, KAKENHI-PLANNED-24104002
[Journal Article] Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells.2015
- Author(s)
  Kohta Mohri, Eri Kusuki, Shozo Ohtsuki, Natsuki Takahashi, Masayuki Endo, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
- Journal Title
  
  Biomacromolecules
  
  Volume: 16 Pages: 1095-1101
- DOI
  10.1021/bm501731f
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860021, KAKENHI-PROJECT-15H03837, KAKENHI-PROJECT-26620133, KAKENHI-PROJECT-26293008, KAKENHI-PLANNED-24104002
[Presentation] Kissing-loop相互作用を介して多足型DNA構造体を連結したDNAハイドロゲルの開発2017
- Author(s)
  野々村茉緒，毛利浩太，西川元也，佐久間信至
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] ヒアルロン酸を支持体とするオクタアルギニン固定化高分子の粘膜投与型ワクチンの抗原キャリアとしての有用性評価2017
- Author(s)
  谷下宗平、八木晴也、毛利浩太、熊谷光倫、宮田康平、落合恭平、日渡謙一郎、滋野浩一、飛田悦男、宇都倫史、馬場昌範、佐久間信至
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08210
[Presentation] A potential of L-octaarginine-linked hyaluronic acid as an adjuvant for mucosal vaccination2017
- Author(s)
  Sohei Tanishita, Haruya Yagi, Kohta Mohri, Hironori Kumagai, Kohei Miyata, Kyohei Ochiai, Ken-ichiro Hiwatari, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
- Organizer
  44th Annual Meeting & Exposition of the Controlled release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08210
[Presentation] グアニンを豊富に含むオリゴヌクレオチドを付与した多足型DNA構造体のがん細胞指向性の評価2017
- Author(s)
  松下奈央，毛利浩太，林英美，西野真名仁，西川元也，佐久間信至
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] Polypodna構造によるCpG DNAの免疫活性増強メカニズムの解明2016
- Author(s)
  永田健吾，毛利浩太，外山詩栞，高橋有己，高倉喜信，西川元也，佐久間信至
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  岐阜
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] がん指向性の向上を目的としたguanine-richオリゴヌクレオチドを付与した多足型DNA構造体の開発．第32回日本DDS学会学術集会2016
- Author(s)
  林英美，毛利浩太，西川元也，西野真名仁，谷下宗平，佐久間信至
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] 粘膜投与型ワクチンの抗原キャリアとしてのD-オクタアルギニン固定化高分子による免疫活性増強機構の解明2016
- Author(s)
  遠藤力斗、毛利浩太、宮田康平、江河智美、落合恭平、日渡謙一郎、椿和文、飛田悦男、佐久間信至
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  グランシップ（静岡県静岡市）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16K08210
[Presentation] Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by Formation of Polypod-like Structure.2015
- Author(s)
  Kohta Mohri, Makiya Nishikawa, Shiori Toyama, Kengo Nagata, Yuki Takahashi, Yoshinobu Takakura, Shinji Sakuma.
- Organizer
  The 42nd Annual Meeting & Exposition of the Controlled Release Society,
- Place of Presentation
  Edinburgh International Conference Centre (Edinburgh, Scotland)
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] がん指向性DNA構造体の開発を目的としたG-rich DNAアプタマーの基礎検討．2015
- Author(s)
  谷下宗平，林英美，毛利浩太，西川元也，佐久間信至．
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] 多足型構造体によるCpG DNAの免疫活性増強メカニズムの解析．2015
- Author(s)
  外山詩栞，永田健悟，毛利浩太，西川元也，高橋有己，高倉喜信，佐久間信至．
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学（大阪）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] 免疫刺激性CpG DNAデリバリーのための自己組織型DNAデンドリマーの開発2015
- Author(s)
  毛利浩太
- Organizer
  日本薬剤学会英語セミナー
- Place of Presentation
  慶応義塾大学薬学部芝共立キャンパス（東京）
- Year and Date
  2015-03-13
- Data Source
  KAKENHI-PROJECT-26860021
[Presentation] Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by Formation of Polypod-like Structure
- Author(s)
  Kohta Mohri, Makiya Nishikawa, Shiori Toyama, Kengo Nagata, Yuki Takahashi, Yoshinobu Takakura, Shinji Sakuma.
- Organizer
  The 42nd Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Edinburgh International Conference Centre (Edinburgh, Scotland)
- Year and Date
  2015-07-26 – 2015-07-29
- Data Source
  KAKENHI-PROJECT-26860021

1. SAKUMA SHINJI (80388644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 馬場昌範 (70181039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 鵜川真実 (50735511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 川上茂 (20322307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 向井英史 (60570885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYATA kohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. OCHIAI kyohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 遠藤政幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 西川元也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 高倉喜信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 高橋有己

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Mohri Kohta 毛利 浩太

Research Projects

Research Products

Co-Researchers

アップコンバージョンナノ粒子を基盤とした光線力学療法用製剤の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核酸ナノ構造体を基盤とした機能性抗体創出システムの開発とがん診断・治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mucosal vaccines using oligoarginine-linked polymers that overcome gene diversities of viruses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of polypodna based dendritic nano-sized DDSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimal arrangement of four short DNA strands for delivery of immunostimulatory nucleic acids to immune cells.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Kissing-loop相互作用を介して多足型DNA構造体を連結したDNAハイドロゲルの開発2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ヒアルロン酸を支持体とするオクタアルギニン固定化高分子の粘膜投与型ワクチンの抗原キャリアとしての有用性評価2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A potential of L-octaarginine-linked hyaluronic acid as an adjuvant for mucosal vaccination2017

Author(s)

Organizer

Data Source

[Presentation] グアニンを豊富に含むオリゴヌクレオチドを付与した多足型DNA構造体のがん細胞指向性の評価2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Polypodna構造によるCpG DNAの免疫活性増強メカニズムの解明2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] がん指向性の向上を目的としたguanine-richオリゴヌクレオチドを付与した多足型DNA構造体の開発．第32回日本DDS学会学術集会2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 粘膜投与型ワクチンの抗原キャリアとしてのD-オクタアルギニン固定化高分子による免疫活性増強機構の解明2016

Author(s)

Mohri Kohta 毛利浩太