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Mohri Kohta  毛利 浩太

ORCIDConnect your ORCID iD *help
Researcher Number 30723697
Affiliation (Current) 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
Affiliation (based on the past Project Information) *help 2018 – 2021: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
2016 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員
2014 – 2016: 摂南大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Physical pharmacy
Except Principal Investigator
Physical pharmacy
Keywords
Principal Investigator
DDS / 核酸 / ナノ粒子 / CpGモチーフ / DNA assembly / dendritic structure / CpG motif / macrophage / innate immunity / 核酸ナノ構造体 … More / DNAアッセンブリ / 抗体 / がん診断 / がん免疫療法 / アップコンバージョン / 無機ナノ粒子 / 光線力学療法 … More
Except Principal Investigator
ワクチン / 粘膜免疫 / インフルエンザウイルス / 膜透過ペプチド / オリゴアルギニン固定化高分子 / 膜透過ペプチド固定化ヒアルロン酸 / 感染実験 Less
  • Research Projects

    (4 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (11 People)
  •  アップコンバージョンナノ粒子を基盤とした光線力学療法用製剤の開発Principal Investigator

    • Principal Investigator
      毛利 浩太
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  核酸ナノ構造体を基盤とした機能性抗体創出システムの開発とがん診断・治療への応用Principal Investigator

    • Principal Investigator
      毛利 浩太
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Mucosal vaccines using oligoarginine-linked polymers that overcome gene diversities of viruses

    • Principal Investigator
      SAKUMA SHINJI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  Development of polypodna based dendritic nano-sized DDSPrincipal Investigator

    • Principal Investigator
      Mohri Kohta
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University

All 2020 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells2020

    • Author(s)
      Mohri Kohta、Hayashi Emi、Nishino Manato、Matsushita Nao、Tanishita Sohei、Nishikawa Makiya、Sakuma Shinji
    • Journal Title

      Journal of Drug Targeting

      Volume: 29 Pages: 217-224

    • DOI

      10.1080/1061186x.2020.1830407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15294
  • [Journal Article] Optimal arrangement of four short DNA strands for delivery of immunostimulatory nucleic acids to immune cells.2015

    • Author(s)
      Shozo Ohtsuki, Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu Kadowaki, Yoshinobu Takakura, Makiya Nishikawa.
    • Journal Title

      Nucleic Acid Theraputics

      Volume: 25 Pages: 245-253

    • DOI

      10.1089/nat.2014.0524

    • NAID

      120005690147

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860021, KAKENHI-PROJECT-15H03837, KAKENHI-PROJECT-26620133, KAKENHI-PROJECT-26293008, KAKENHI-PLANNED-24104002
  • [Journal Article] Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells.2015

    • Author(s)
      Kohta Mohri, Eri Kusuki, Shozo Ohtsuki, Natsuki Takahashi, Masayuki Endo, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
    • Journal Title

      Biomacromolecules

      Volume: 16 Pages: 1095-1101

    • DOI

      10.1021/bm501731f

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860021, KAKENHI-PROJECT-15H03837, KAKENHI-PROJECT-26620133, KAKENHI-PROJECT-26293008, KAKENHI-PLANNED-24104002
  • [Presentation] Kissing-loop相互作用を介して多足型DNA構造体を連結したDNAハイドロゲルの開発2017

    • Author(s)
      野々村茉緒,毛利浩太,西川元也,佐久間信至
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] ヒアルロン酸を支持体とするオクタアルギニン固定化高分子の粘膜投与型ワクチンの抗原キャリアとしての有用性評価2017

    • Author(s)
      谷下宗平、八木晴也、毛利浩太、熊谷光倫、宮田康平、落合恭平、日渡謙一郎、滋野浩一、飛田悦男、宇都倫史、馬場昌範、佐久間信至
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-16K08210
  • [Presentation] A potential of L-octaarginine-linked hyaluronic acid as an adjuvant for mucosal vaccination2017

    • Author(s)
      Sohei Tanishita, Haruya Yagi, Kohta Mohri, Hironori Kumagai, Kohei Miyata, Kyohei Ochiai, Ken-ichiro Hiwatari, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
    • Organizer
      44th Annual Meeting & Exposition of the Controlled release Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08210
  • [Presentation] グアニンを豊富に含むオリゴヌクレオチドを付与した多足型DNA構造体のがん細胞指向性の評価2017

    • Author(s)
      松下奈央,毛利浩太,林英美,西野真名仁,西川元也,佐久間信至
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] Polypodna構造によるCpG DNAの免疫活性増強メカニズムの解明2016

    • Author(s)
      永田健吾,毛利浩太,外山詩栞,高橋有己,高倉喜信,西川元也,佐久間信至
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] がん指向性の向上を目的としたguanine-richオリゴヌクレオチドを付与した多足型DNA構造体の開発.第32回日本DDS学会学術集会2016

    • Author(s)
      林英美,毛利浩太,西川元也,西野真名仁,谷下宗平,佐久間信至
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2016-07-01
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] 粘膜投与型ワクチンの抗原キャリアとしてのD-オクタアルギニン固定化高分子による免疫活性増強機構の解明2016

    • Author(s)
      遠藤力斗、毛利浩太、宮田康平、江河智美、落合恭平、日渡謙一郎、椿和文、飛田悦男、佐久間信至
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-16K08210
  • [Presentation] Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by Formation of Polypod-like Structure.2015

    • Author(s)
      Kohta Mohri, Makiya Nishikawa, Shiori Toyama, Kengo Nagata, Yuki Takahashi, Yoshinobu Takakura, Shinji Sakuma.
    • Organizer
      The 42nd Annual Meeting & Exposition of the Controlled Release Society,
    • Place of Presentation
      Edinburgh International Conference Centre (Edinburgh, Scotland)
    • Year and Date
      2015-07-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] がん指向性DNA構造体の開発を目的としたG-rich DNAアプタマーの基礎検討.2015

    • Author(s)
      谷下宗平,林英美,毛利浩太,西川元也,佐久間信至.
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] 多足型構造体によるCpG DNAの免疫活性増強メカニズムの解析.2015

    • Author(s)
      外山詩栞,永田健悟,毛利浩太,西川元也,高橋有己,高倉喜信,佐久間信至.
    • Organizer
      第65回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学(大阪)
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] 免疫刺激性CpG DNAデリバリーのための自己組織型DNAデンドリマーの開発2015

    • Author(s)
      毛利浩太
    • Organizer
      日本薬剤学会英語セミナー
    • Place of Presentation
      慶応義塾大学薬学部芝共立キャンパス(東京)
    • Year and Date
      2015-03-13
    • Data Source
      KAKENHI-PROJECT-26860021
  • [Presentation] Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by Formation of Polypod-like Structure

    • Author(s)
      Kohta Mohri, Makiya Nishikawa, Shiori Toyama, Kengo Nagata, Yuki Takahashi, Yoshinobu Takakura, Shinji Sakuma.
    • Organizer
      The 42nd Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Edinburgh International Conference Centre (Edinburgh, Scotland)
    • Year and Date
      2015-07-26 – 2015-07-29
    • Data Source
      KAKENHI-PROJECT-26860021
  • 1.  SAKUMA SHINJI (80388644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  馬場 昌範 (70181039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  鵜川 真実 (50735511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  川上 茂 (20322307)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  向井 英史 (60570885)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIYATA kohei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  OCHIAI kyohei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  遠藤 政幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  西川 元也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  高倉 喜信
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  高橋 有己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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