Mizuguchi Takaaki 水口貴章

… Alternative Names

水口貴章ミズグチタカアキ

MIZUGUCHI Takaaki 水口貴章

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Researcher Number	30732557
Other IDs	https://orcid.org/0000-0002-9073-9591
Affiliation (Current)	2022: 北里大学, 薬学部, 助教 2022: 東京医科歯科大学, 生体材料工学研究所, 助教
Affiliation (based on the past Project Information) *help	2021: 北里大学, 薬学部, 助教 2017: 北里大学, 薬学部, 助教 2014 – 2017: 東京医科歯科大学, 生体材料工学研究所, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator EGFレセプター / 二量体化アーム / 抗がん活性ペプチド / 細胞内薬物送達分子 / 環状ペプチド / 二量化阻害 / 蛍光プローブ / フルオレセイン / フルオレセイン標識 / 細胞内輸送 … More / 抗がん薬リード / 共焦点レーザー顕微鏡 / ＥＧＦレセプター / アラニン置換 / 抗がん薬 / 創薬研究 / 二量化アーム / 環状ぺプチド / 細胞内送達分子 / EGF受容体 / 二量体化阻害 / 細胞内送達 / ドラッグデリバリー / 蛍光イメージング / フローサイトメトリー / 抗がん剤 / 中分子 / 薬学 / 創薬化学 / ケミカルバイオロジー / ペプチド / 有機化学 / オキシトシン / オピオイド受容体 / 鎮痛薬 / ポジティブアロステリック効果 / bitopic化合物 … More Except Principal Investigator EGFレセプター / 二量化阻害 / ループ構造模倣環状ペプチド / レセプター創薬 / スクリーニング / キャピラリー電気泳動 / 質量分析 / ＥＧＦレセプター / 二量化阻害ペプチド / 親和性増強 / 側鎖改変 / 中分子 / ペプチドミメティック / 環状ペプチド / HIV / がん / ステープルペプチド / CXCR4 / GPCR / ヒト免疫不全ウイルス / 医薬品開発 / 中分子創薬 / 二次構造 / 2価型 / 二量体 / 高次構造模倣型 / 2価結合型GPCRリガンド Less

Studies on the development of oxytocin derivatives as novel mu-opioid receptor-mediated analgesicsPrincipal Investigator
- Principal Investigator
  
  水口貴章
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Studies on the development of a new class of anticancer agents based on dimerization arm of the EGF receptorPrincipal Investigator
- Principal Investigator
  
  MIZUGUCHI Takaaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
  Tokyo Medical and Dental University
Development of mid-size drugs based on peptidomimetic
- Principal Investigator
  
  TAMAMURA Hirokazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo Medical and Dental University
Studies on new chemical probes development that assumed dimeric interface of the EGF receptor ectodomain a targetPrincipal Investigator
- Principal Investigator
  
  Mizuguchi Takaaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo Medical and Dental University
Systematic structure optimization of the EGF receptor-inhibiting peptide through use of a screening technology
- Principal Investigator
  
  SAITO Kazuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-haorpin Loop Sequence of Human EGF Receptor2017
- Author(s)
  Kobayashi K, Mizuguchi T, Hattori Y, Ohara N, Ninomiya R, Iida M, Ooe H, Yamazaki Y, Takata M, Tamamura H, Akaji K
- Journal Title
  
  J. Pept. Sci.
  
  Volume: 印刷中 Pages: 581-586
- DOI
  10.1002/psc.3004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18910, KAKENHI-PROJECT-16H05104
[Journal Article] Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.2016
- Author(s)
  Nami Ohashi1, Shigeyoshi Harada, Takaaki Mizuguchi1, Yu Irahara1, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura.
- Journal Title
  
  ChemMedChem
  
  Volume: 19 Pages: 940-6
- DOI
  10.1002/cmdc.201500590
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16K01931, KAKENHI-PROJECT-16K15139
[Journal Article] A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.2016
- Author(s)
  Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 26 Pages: 397-400
- DOI
  10.1016/j.bmcl.2015.11.103
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26105721, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-16K01931
[Journal Article] Functional Evaluation of Fluorescent-Labeled Derivatives of an Inhibitory Peptide against EGF Receptor Dimerization2016
- Author(s)
  Mizuguchi T., Toyama K., Ishida Y., Nomura W., Tamamura H.
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 41-42
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893061
[Journal Article] Studies on a Novel Delivery Peptide Derived from the Dimerization Arm of EGF Receptor2016
- Author(s)
  Toyama K., Mizuguchi T., Ishida Y., Nomura W., Tamamura H.
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 249-250
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893061
[Journal Article] Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands.2016
- Author(s)
  Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Pages: 6967-6973
- DOI
  10.1016/j.bmc.2015.09.040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15J05835, KAKENHI-PROJECT-26670053
[Journal Article] Studies on Identification of Active Sites of an Inhibitory Cyclic Peptide against EGF Receptor Dimerization2015
- Author(s)
  Mizuguchi T, Yamazaki Y, Kobayashi K, Ooe H, Iida M, Ninomiya R, Saito K, Akaji K, Tamamura H.
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 163-164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893061
[Journal Article] Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.2015
- Author(s)
  Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Pages: 4423-4427
- DOI
  10.1016/j.bmc.2015.06.020
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-26670053
[Journal Article] Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.2015
- Author(s)
  Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Pages: 8734-8739
- DOI
  10.1039/c5ob00891c
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-26670053
[Journal Article] Studies on identification of active sites of an inhibitory cyclic peptide against EGF receptor dimerization.2015
- Author(s)
  Takaaki Mizuguchi, Yukako Yamazaki, Kazuya Kobayashi, Honami Ooe, Mika Iida, Ryunosuke Ninomiya, Kazuki Saito, Kenichi Akaji, Hirokazu Tamamura
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 163-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Application of plug-plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin-binding fragments selected from a digested mixture of reduced BSA.2014
- Author(s)
  Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Hiroshi Kataoka, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
- Journal Title
  
  Electrophoresis
  
  Volume: 35 Pages: 846-854
- DOI
  10.1002/elps.201300339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Effect of ring size and side-chain orientation of cyclic peptides for the inhibition of EGF receptor dimerization.2013
- Author(s)
  Takaaki Mizuguchi, Naho Ohara, Mika Iida, Ryunosuke Ninomiya, Shinji Wada, Yoshiaki Kiso, Kazuki Saito, Kenichi Akaji
- Journal Title
  
  Peptide Science
  
  Volume: 2012 Pages: 19-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor.2012
- Author(s)
  Takaaki Mizuguchi, et al.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Pages: 5730-5737
- DOI
  10.1016/j.bmc.2012.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06748, KAKENHI-PROJECT-24590134
[Presentation] Functional Evaluation of Fluorescein-Labeled Peptides Based on the EGF Receptor Dimerization Arm Sequences2016
- Author(s)
  Toyama K, Mizuguchi T, Nomura W, Tamamura H.
- Organizer
  34th European Peptide Symposium 2016 & 8th International Peptide Symposium
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18910
[Presentation] Studies on cyclic peptides for the development of potent dimerization inhibitors against the EGF receptor2016
- Author(s)
  Takaaki Mizuguchi, Kei Toyama, Wataru Nomura, Kenichi Akaji, Hirokazu Tamamura
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Center for Learning and Innovation Takeda Pharmaceutical Company, Ltd.
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] Studies on new intracellular delivery peptides based on the dimerization arm sequence of the EGF receptor2016
- Author(s)
  Kei Toyama, Takaaki Mizuguchi, Yusuke Ishida, Wataru Nomura, and Hirokazu Tamamura
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Center for Learning and Innovation Takeda Pharmaceutical Company, Ltd.
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] EGF受容体の二量体化アームを基盤とした新規細胞内輸送ペプチドに関する研究2016
- Author(s)
  外山桂、水口貴章、野村渉、玉村啓和
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] Development of New Fluorescein-Labeled Peptides with Inhibitory Effect on the EGF Receptor Activation2016
- Author(s)
  Toyama K, Mizuguchi T, Nomura W, Tamamura H.
- Organizer
  The 20th Korean Peptide Protein Society Symposium.
- Place of Presentation
  Yangyang, Korea
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18910
[Presentation] Studies on a Novel Delivery Peptide Derived from the Dimerization Arm of EGF Receptor2015
- Author(s)
  Kei Toyama, Takaaki Mizuguchi, Yusuke Ishida, Wataru Nomura, and Hirokazu Tamamura
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市民会館（平塚）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] Functional Evaluation of Fluorescent-Labeled Derivatives of an Inhibitory Peptide against EGF Receptor Dimerization2015
- Author(s)
  Takaaki Mizuguchi, Kei Toyama, Yusuke Ishida, Wataru Nomura, and Hirokazu Tamamura
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市民会館（平塚）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] 蛍光プローブを用いたEGFレセプター二量体化阻害ペプチドの機能評価2015
- Author(s)
  外山桂、水口貴章、石田有佑、野村渉、玉村啓和
- Organizer
  創薬懇話会2015
- Place of Presentation
  徳島大学（鳴門）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] EGFレセプター二量化阻害ペプチドの蛍光標識体の合成と機能評価2015
- Author(s)
  水口貴章、外山桂、石田有佑、野村渉、玉村啓和
- Organizer
  日本ケミカルバイオロジー学会　第10回年会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] 上皮成長因子受容体の「二量体化アーム」を基盤とした新規抗がん薬開発に向けた環状ペプチドに関する研究2015
- Author(s)
  水口貴章、外山桂、石田有佑、野村渉、玉村啓和
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（幕張）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] EGFレセプター二量化阻害環状ペプチドの活性部位に関する研究2014
- Author(s)
  水口貴章, 山﨑由香子, 小林数也, 大江保奈美, 飯田美佳, 二宮龍之介, 齋藤一樹, 赤路健一, 玉村啓和
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス大塚講堂（徳島県徳島市）
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] 二量体化に着目した新規作用機序のEGFレセプター阻害薬研究2014
- Author(s)
  水口貴章, 二宮龍之介, 飯田美佳, 大江保奈美, 山崎由香子, 小林数也, 齋藤一樹, 赤路健一, 玉村啓和
- Organizer
  創薬懇話会2014
- Place of Presentation
  長良川温泉ホテルパーク（岐阜県岐阜市）
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプター二量化阻害環状ペプチドの活性部位に関する研究
- Author(s)
  水口貴章，他
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス大塚講堂
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] EGFレセプターの二量化阻害を示す環状ペプチドの構造的特徴
- Author(s)
  水口貴章, 大原菜穂, 二宮龍之介, 山崎由香子, 飯田美佳, 大江保奈美, 齋藤一樹, 赤路健一
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害ペプチドをもとにしたアラニン置換ペプチドの細胞増殖抑制効果
- Author(s)
  二宮龍之介, 水口貴章, 大原菜穂, 飯田美佳, 齋藤一樹, 赤路健一
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学浜甲子園キャンパス（西宮市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害に必要な環状ペプチドの環の大きさと側鎖配置の効果
- Author(s)
  水口貴章, 大原菜穂, 飯田美佳, 二宮龍之介, 和田真治, 木曽良明, 齋藤一樹, 赤路健一
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害活性を示す環状ペプチドの環サイズと側鎖配置の評価
- Author(s)
  大原菜穂, 水口貴章, 二宮龍之介, 飯田美佳, 齋藤一樹, 赤路健一
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学浜甲子園キャンパス（西宮市）
- Data Source
  KAKENHI-PROJECT-24590134

1. AKAJI Kenichi (60142296)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. TAMAMURA Hirokazu (80217182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. NOMURA Wataru (80463909)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
4. SAITO Kazuki (10192585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大橋南美 (90707051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. TOYAMA Kei

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. YOSHIMURA Kazuhisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MURAKAMI Tsutomu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. HARADA Shigeyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. NARUMI Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 斎藤一樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results
12. 松下修三

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 三浦智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizuguchi Takaaki 水口 貴章

水口 貴章 ミズグチ タカアキ

MIZUGUCHI Takaaki 水口 貴章

Research Projects

Research Products

Co-Researchers

Studies on the development of oxytocin derivatives as novel mu-opioid receptor-mediated analgesicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the development of a new class of anticancer agents based on dimerization arm of the EGF receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of mid-size drugs based on peptidomimetic

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on new chemical probes development that assumed dimeric interface of the EGF receptor ectodomain a targetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Systematic structure optimization of the EGF receptor-inhibiting peptide through use of a screening technology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-haorpin Loop Sequence of Human EGF Receptor2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional Evaluation of Fluorescent-Labeled Derivatives of an Inhibitory Peptide against EGF Receptor Dimerization2016

Author(s)

Journal Title

Data Source

[Journal Article] Studies on a Novel Delivery Peptide Derived from the Dimerization Arm of EGF Receptor2016

Author(s)

Journal Title

Data Source

[Journal Article] Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Studies on Identification of Active Sites of an Inhibitory Cyclic Peptide against EGF Receptor Dimerization2015

Author(s)

Journal Title

Data Source

[Journal Article] Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Studies on identification of active sites of an inhibitory cyclic peptide against EGF receptor dimerization.2015

Author(s)

Mizuguchi Takaaki 水口貴章

水口貴章ミズグチタカアキ

MIZUGUCHI Takaaki 水口貴章