Saito Ryo 齋藤僚

Researcher Number	30732846
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 一般財団法人脳神経疾患研究所, 先端医療研究センター, 研究員 2016 – 2017: 立命館大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy
Keywords	Principal Investigator 神経薬理学 / 小胞体ストレス / 神経変性疾患 / 神経分化 / ライソゾーム病 / 疾患特異的iPS細胞 / オートファジー / 神経科学 / 薬理学 / PI3K/Akt … More / エピジェネティクス / シグナル伝達 / MAPK / 神経突起伸長 Less

疾患特異的iPS細胞を用いた神経成熟異常における小胞体ストレスの寄与解析Principal Investigator
- Principal Investigator
  
  齋藤僚
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Molecular pharmacological analysis of endoplasmic reticulum stress-induced inhibition of neuronal migration and neurite outgrowth.Principal Investigator
- Principal Investigator
  
  Saito Ryo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
  Ritsumeikan University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Abnormal DNA methylation in pluripotent stem cells from a patient with Prader-Willi syndrome results in neuronal differentiation defects2021
- Author(s)
  Soeda Shuhei、Saito Ryo、Fujii Ai、Tojo Shusei、Tokumura Yuka、Taniura Hideo
- Journal Title
  
  Stem Cell Research
  
  Volume: 53 Pages: 102351-102351
- DOI
  10.1016/j.scr.2021.102351
- Data Source
  KAKENHI-PROJECT-19K16382
[Journal Article] Different Effects of Endoplasmic Reticulum Stress Inducers on Lysophosphatidic Acid-induced A431 Cell Dispersal2020
- Author(s)
  Saito Ryo、Eto Yoshikatsu、Fujita Norihisa
- Journal Title
  
  BPB Reports
  
  Volume: 3 Issue: 6 Pages: 179-184
- DOI
  10.1248/bpbreports.3.6_179
- NAID
  130007944878
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16382
[Journal Article] Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death2019
- Author(s)
  Seisuke Mimori, Koichi Kawada, Ryo Saito, Masato Takahashi, Kenta Mizoi, Yasunobu Okuma, Masakiyo Hosokawa, Tetsuto Kanzaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Issue: 4 Pages: 623-628
- DOI
  10.1016/j.bbrc.2019.07.074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K20157, KAKENHI-PROJECT-16K18889
[Journal Article] Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner.2019
- Author(s)
  Tanaka K, Mizuno K, Natsume C, Takanishi M, Shimada Y, Saito R, Fujita N, Fujita T.
- Journal Title
  
  Int. J. Dermatol. & Clin. Res.
  
  Volume: 5(1) Pages: 006-011
- DOI
  10.17352/2455-8605.000031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18889
[Journal Article] Neuronal differentiation defects in induced pluripotent stem cells derived from a Prader-Willi syndrome patient.2019
- Author(s)
  Soeda S, Saito R, Fujita N, Fukuta K, Taniura H.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 703 Pages: 162-167
- DOI
  10.1016/j.neulet.2019.03.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18889
[Journal Article] Regulation of neural differentiation and synaptogenic factors by silencing of ubiquitin ligase Dorfin.2017
- Author(s)
  Kawada K., Saito R., Mimori S., Okuma Y and Nomura Y.
- Journal Title
  
  Global Drugs & Therap.
  
  Volume: 2 (5) Issue: 5 Pages: 1-6
- DOI
  10.15761/gdt.1000s1002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18889, KAKENHI-PROJECT-15K18879
[Presentation] Neuropathological analysis of Niemann-Pick disease type C using patient-derived iPSCs2021
- Author(s)
  Saito R., Miyajima T., Wu Chen, M. Arif Hossain, Munakata M., Suzuki K., Iwamoto T., Era T., Eto Y.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] Studies of Plasma Biomarkers by Tandem MS toward to evaluated the efficacy of AAV gene therapy for NPC disease.2020
- Author(s)
  Wu Chen, Iwamoto T. Saito R., M. Arif Hossain, Suzuki K., Eto Y.
- Organizer
  2020年度AMED遺伝子治療合同班会議
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] DNA methylation study of GLA gene and its association with autophagy and clinical severity of heterozygous Fabry disease females.2020
- Author(s)
  M. Arif Hossain, Wu Chen, Yanagisawa H., Miyajima T., Saito R., Akiyama K., Eto Y.
- Organizer
  WORLDSymposium 16th Annual Research Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] インドール-3-プロピオン酸（IPA）神経変性疾患モデル培養細胞に対する神経細胞死抑制効果2020
- Author(s)
  三森盛亮, 川田浩一, 齋藤僚, 高橋正人, 溝井健太, 大熊康修, 細川正清, 神崎哲人.
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] Development of neuropathological model using Niemann-Pick type C patient-derived iPSCs.2020
- Author(s)
  Saito R., Miyajima T., Wu Chen, M. Arif Hossain, Itagaki R., Akiyama K., Iwamoto T., Eto Y.
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] Development of neuropathological model using Niemann-Pick type C patients derived iPSCs.2020
- Author(s)
  Saito R., Miyajima T., Wu Chen, M. Arif Hossain, Itagaki R., Akiyama K., Iwamoto T., Eto Y.
- Organizer
  WORLDSymposium 16th Annual Research Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] An update on biomarkers of 7-ketocholesterol, lyso-sphingomyelin, bile acid-408 and glucosyl-sphingosine for Niemann-Pick disease type C.2020
- Author(s)
  Wu Chen, Iwamoto T. M. Arif Hossain, Akiyama K. Igarashi J., Miyajima T., Saito R., Eto Y.
- Organizer
  WORLDSymposium 16th Annual Research Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] CRISPR/Cas9システムによるアンジオテンシンII受容体ノックアウト細胞の樹立と評価2020
- Author(s)
  池尻朱里, 小島美駒, 齋藤僚, 平大樹, 上島智, 蓮元憲祐, 岡野友信, 角本幹夫.
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] Development of neuropathological analysis model using iPSC-derived neural cells from Niemann-Pick type C patients.2019
- Author(s)
  Saito R., Miyajima T., Wu Chen, M. Arif Hossain, Itagaki R., Akiyama K., Iwamoto T., Eto Y.
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] CRISPR/Cas9システムを用いたアンジオテンシンII受容体ノックアウト細胞の構築2019
- Author(s)
  小島美駒, 石戸恵理, 齋藤僚, 平大樹, 上島智, 藤田隆司, 岡野友信, 角本幹夫.
- Organizer
  医療薬学フォーラム2019 第27回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] Generation of iPS Cells derived from Skin Fibroblasts of Patients with Fabry disease using RNA-reprogramming.2019
- Author(s)
  Miyajima T., Yanagisawa H., Saito R., M. Arif Hossain, Wu Chen, Iwamoto T., Eto Y.
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] Prader-Willi症候群由来iPS細胞の神経幹細胞、ニューロン分化能の欠損2019
- Author(s)
  添田修平, 齋藤僚, 藤田典久, 谷浦秀夫.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] 神経セロイドリポフスチン症1・2型; PPT1およびTPP1の酵素特性と金属イオンによって及ぼされる影響の検討2019
- Author(s)
  Itagaki R., Endo M., M. Arif Hossain, Akiyama K., Miyajima T., Wu Chen, Iwamoto T., Saito R., Igarashi J., Eto Y.
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] DNA methylation study of GLA gene and its association with autophagy and clinical severity of heterozygous Fabry females.2019
- Author(s)
  M. Arif Hossain, Wu Chen, Yanagisawa H., Miyajima T., Saito R., Akiyama K., Eto Y.
- Organizer
  日本人類遺伝学会第64回大会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] Combination of lysosphingomyelin, 7-ketocholesterol and bile acid W-408 for diagnosis of Niemann Pick disease type C by MS/MS.2019
- Author(s)
  Wu Chen, Iwamoto T. Akiyama K. Miyajima T., Igarashi J., M. Arif Hossain, Saito R., Eto Y.
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] Future clinical and biochemical predictions of Fabry disease in females by methylation studies of the GLA gene.2019
- Author(s)
  M. Arif Hossain, Wu Chen, Yanagisawa H., Miyajima T., Akiyama K., Saito R., Eto Y.
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-19K16382
[Presentation] LPA誘導性A431細胞分散に対する小胞体ストレス誘導試薬の効果2018
- Author(s)
  齋藤僚，西田佳世，水本由衣，藤田典久．
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] The differential effects of ER stress inducers on LPA-induced A431 cell dispersion2018
- Author(s)
  Saito R., Nishida K., Mizumoto Y., Fujita N.
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] Prader-Willi症候群由来iPS細胞の神経幹細胞分化の欠陥2018
- Author(s)
  添田修平, 齋藤僚, 福田勝一朗, 谷浦秀夫.
- Organizer
  第4回稀少疾患セミナー
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] Tunicamycin-induced endoplasmic reticulum stress inhibits neuronal cell motility2017
- Author(s)
  齋藤僚、嶋路大輝、菊池俊、豊田航平、田中秀和、藤田典久
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県・長崎市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] An endoplasmic reticulum-associated degradation (ERAD)-related factor SEL1L contribute to neuronal cell fate decision2017
- Author(s)
  Saito R., Kawada K., Okuma Y., Fujita N., Nomura Y.
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] ヒトiPS細胞における視床下部神経幹細胞への分化誘導法の検討2017
- Author(s)
  齋藤僚，添田修平，谷浦秀夫，藤田典久．
- Organizer
  第3回希少疾患セミナー
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] 小胞体ストレスによるectodermal-neural cortex 1の発現抑制を介した神経突起伸長の阻害2017
- Author(s)
  菊地俊，嶋路大輝，齋藤僚，藤田典久．
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2017
- Data Source
  KAKENHI-PROJECT-16K18889
[Presentation] ツニカマイシン誘導性小胞体ストレスによる神経細胞動態の抑制2016
- Author(s)
  齋藤僚、嶋路大輝、豊田航平、田中秀和、藤田典久
- Organizer
  第2回希少疾患研究会
- Place of Presentation
  立命館大学びわこ・くさつキャンパス（滋賀県・草津市）
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-16K18889

1. MIMORI Eisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Ryo 齋藤 僚

Research Projects

Research Products

Co-Researchers

疾患特異的iPS細胞を用いた神経成熟異常における小胞体ストレスの寄与解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular pharmacological analysis of endoplasmic reticulum stress-induced inhibition of neuronal migration and neurite outgrowth.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Abnormal DNA methylation in pluripotent stem cells from a patient with Prader-Willi syndrome results in neuronal differentiation defects2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different Effects of Endoplasmic Reticulum Stress Inducers on Lysophosphatidic Acid-induced A431 Cell Dispersal2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuronal differentiation defects in induced pluripotent stem cells derived from a Prader-Willi syndrome patient.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of neural differentiation and synaptogenic factors by silencing of ubiquitin ligase Dorfin.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Neuropathological analysis of Niemann-Pick disease type C using patient-derived iPSCs2021

Author(s)

Organizer

Data Source

[Presentation] Studies of Plasma Biomarkers by Tandem MS toward to evaluated the efficacy of AAV gene therapy for NPC disease.2020

Author(s)

Organizer

Data Source

[Presentation] DNA methylation study of GLA gene and its association with autophagy and clinical severity of heterozygous Fabry disease females.2020

Author(s)

Organizer

Data Source

[Presentation] インドール-3-プロピオン酸（IPA）神経変性疾患モデル培養細胞に対する神経細胞死抑制効果2020

Author(s)

Organizer

Data Source

[Presentation] Development of neuropathological model using Niemann-Pick type C patient-derived iPSCs.2020

Author(s)

Organizer

Data Source

[Presentation] Development of neuropathological model using Niemann-Pick type C patients derived iPSCs.2020

Author(s)

Organizer

Data Source

[Presentation] An update on biomarkers of 7-ketocholesterol, lyso-sphingomyelin, bile acid-408 and glucosyl-sphingosine for Niemann-Pick disease type C.2020

Author(s)

Organizer

Data Source

[Presentation] CRISPR/Cas9システムによるアンジオテンシンII受容体ノックアウト細胞の樹立と評価2020

Author(s)

Organizer

Saito Ryo 齋藤僚