Nakashima Makoto 中島誠

Researcher Number	30733232
Other IDs
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 聖マリアンナ医科大学, 医学研究科, 助教 2022: 東京大学, 大学院新領域創成科学研究科, 特任助教 2019 – 2020: 東京大学, 大学院新領域創成科学研究科, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator CD30 / CD30 signaling / HTLV-1 / ATL / Lymphomagenesis / TNFR superfamily / エピジェネティクス / スーパーエンハンサー / Reactive oxygen species / Double strand breaks … More / Chromosomal instability / DNA double-strand breaks / ROS / ゲノム不安定性 / Genomic instability / CD30L / 成人T細胞白血病 / Chromosome instability / 染色体不安定性 / CD30シグナル … More Except Principal Investigator 補体活性化経路 / 自己抗体 / 空間遺伝子発現解析 / ヒトT細胞白血病ウイルス1型（HTLV-1） / HTLV-1関連脊髄症（HAM） Less

HAM脊髄の空間トランスクリプトーム解析による新規神経障害機構の解明と制御法開発
- Principal Investigator
  
  山野嘉久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  St. Marianna University School of Medicine
スーパーエンハンサー領域のゲノムループ構造形成によるCD30過剰発現機構の解析Principal Investigator
- Principal Investigator
  
  中島誠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  St. Marianna University School of Medicine
Analysis of genomic instability through ROS-DSB by CD30 signaling in ATL progressionPrincipal Investigator
- Principal Investigator
  
  Nakashima Makoto
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  St. Marianna University School of Medicine
  The University of Tokyo
Analysis of ATL progression by CD30 signaling and its biomarkersPrincipal Investigator
- Principal Investigator
  
  Nakashima Makoto
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Transmission of Human T-Cell Leukemia Virus Type 1 From Mother to Child and Adult T-Cell Leukemia/Lymphoma2024
- Author(s)
  Itabashi Kazuo、Miyazawa Tokuo、Nakashima Makoto、Makiyama Junya、Uchimaru Kaoru
- Journal Title
  
  Comprehensive Hematology and Stem Cell Research
  
  Volume: Online First Pages: 330-359
- DOI
  10.1016/b978-0-443-15717-2.00051-2
- ISBN
  9780443157189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15420
[Journal Article] Mechanisms of action and resistance in histone methylation-targeted therapy.2024
- Author(s)
  Yamagishi M, Kuze Y, Kobayashi S, Nakashima M, Morishima S, Kawamata T, Makiyama J, Suzuki K, Seki M, Abe K, Imamura K, Watanabe E, Tsuchiya K, Yasumatsu I, Takayama G, Hizukuri Y, Ito K, Taira Y, Nannya Y, Tojo A, Watanabe T, Tsutsumi S, Suzuki Y, Uchimaru K.
- Journal Title
  
  Nature
  
  Volume: 627 Issue: 8002 Pages: 221-228
- DOI
  10.1038/s41586-024-07103-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08386, KAKENHI-PROJECT-22K15420, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K24248
[Journal Article] CD30 nduces Reed‐Sternberg cell‐like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines2023
- Author(s)
  Watanabe Mariko、Hatsuse Hiromi、Nagao Kazuaki、Nakashima Makoto、Uchimaru Kaoru、Otsu Makoto、Miyazaki Koji、Horie Ryouichi
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 8 Pages: 3433-3445
- DOI
  10.1111/cas.15874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06429, KAKENHI-PROJECT-22K15420
[Journal Article] CD30 Expression and Its Functions during the Disease Progression of Adult T-Cell Leukemia/Lymphoma2023
- Author(s)
  Nakashima Makoto、Uchimaru Kaoru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 10 Pages: 8731-8731
- DOI
  10.3390/ijms24108731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15420
[Journal Article] The oncogenic driving force of CD30 signaling‐induced chromosomal instability in adult T‐cell leukemia/lymphoma2023
- Author(s)
  Makoto Nakashima、Atae Utsunomiya、Toshiki Watanabe、Ryouichi Horie、Kaoru Uchimaru
- Journal Title
  
  Cancer Science
  
  Volume: 114(4) Issue: 4 Pages: 1556-1568
- DOI
  10.1111/cas.15706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22K15420, KAKENHI-PROJECT-22H04923
[Journal Article] Differentiation of Hodgkin lymphoma cells by reactive oxygen species and regulation by heme oxygenase‐1 through HIF‐1α2021
- Author(s)
  Nakashima Makoto、Watanabe Mariko、Nakano Kazumi、Uchimaru Kaoru、Horie Ryouichi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 6 Pages: 2542-2555
- DOI
  10.1111/cas.14890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-19K07442, KAKENHI-PROJECT-20K07379
[Journal Article] Successful clinical sequencing by molecular tumor board in an elderly patient with refractory Sezary syndrome2020
- Author(s)
  Hijikata K, Yokoyama K (co-1st and co-corresponding author), Yokoyama N, Matsubara Y, Shimizu E, Nakashima M, Yamagishi M, Ota Y, Lim L, Yamaguchi R, Ito M, Tanaka Y, Denda T, Tani K, Yotsuyanagi H, Imoto S, Miyano S, Uchimaru K, Tojo A.
- Journal Title
  
  JCO Precis Oncol
  
  Volume: 4 Issue: 4 Pages: 534-560
- DOI
  10.1200/po.19.00254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-17H01547, KAKENHI-PROJECT-18H03329, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580
[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020
- Author(s)
  Saito M, Hasegawa H, Yamauchi S, Nakagawa S, Sasaki D, Nao N, Tanio M, Wada Y, Matsudaira T, Momose H, Kuramitsu M, Yamagishi M, Nakashima M, Nakahata S, Iha H, Ogata M, Imaizumi Y, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 3 Pages: 300-306
- DOI
  10.1007/s12185-020-02935-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08868, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020
- Author(s)
  Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M,, Seiichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
- Journal Title
  
  Blood adv
  
  Volume: 4 Issue: 9 Pages: 1845-1858
- DOI
  10.1182/bloodadvances.2019001139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-19H02853, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-19K16580
[Presentation] HTLV-1関連脊髄症におけるウイルス感染細胞に起因した神経障害機構の解析2023
- Author(s)
  新谷奈津美, 山岸誠, 清原和裕, 浅原尚美, 中島誠, 荒谷聡子, 八木下尚子, 内丸薫, 佐藤知雄, 山野嘉久.
- Organizer
  第27回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] HTLV-1 関連脊髄症に対する MEK 阻害剤の有用性に関する非臨床データ2023
- Author(s)
  鷹尾直誠, 永井香帆, 中島誠, 新谷奈津美, 久世裕太, 鈴木穣, 内丸薫, 山岸誠, 山野嘉久.
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] HLA-A24 拘束性の異なる Tax エピトープを認識する特異的 TCR の解析2023
- Author(s)
  菅田謙治, ジェックヤンタン, 高鳥光徳, ベラルホサイン, サムイルラジブ, オムニアレダ, 徳永雅仁, 野村隼也, 増田曜章, 中島誠, 佐藤知雄, 植田光晴, 宇都宮與, 山野嘉久, 佐藤賢文.
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] オミックス解析によるHTLV-1関連脊髄症に対する新規原因候補遺伝子の探索とMEK阻害剤の有用性に関する非臨床データ2023
- Author(s)
  鷹尾直誠, 永井香帆, 中島誠, 新谷奈津美, 久世裕太, 鈴木穣, 内丸薫, 山岸誠, 山野嘉久.
- Organizer
  第27回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] 統合オミックス解析による HTLV-1 関連脊髄症の新規炎症誘導因子の探索2023
- Author(s)
  中島誠, 永井香帆, 鷹尾直誠, 新谷奈津美, 久世裕太, 鈴木穣, 内丸薫, 山岸誠, 山野嘉久.
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] HTLV-1感染細胞に起因したHAMの神経障害機構2023
- Author(s)
  新谷奈津美, 山岸誠, 清原和裕, 浅原尚美, 中島誠, 荒谷聡子, 八木下尚子, 内丸薫, 佐藤知雄, 山野嘉久.
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] HAM患者脳脊髄液のシングルセル解析2023
- Author(s)
  佐藤賢文, 菅田謙治, ベンジー　タン　ジェック　ヤン, 中島誠, 佐藤知雄, 山野嘉久.
- Organizer
  第27回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] Membrane CD30とSoluble CD30の二重解析によるCD30発現評価法の検討2022
- Author(s)
  中島誠、川俣豊隆、南谷泰仁、宇都宮與、渡邉俊樹、内丸薫
- Organizer
  第8回日本HTLV-1学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] NEDD8 activating enzyme is a novel therapeutic target for HTLV-1-related diseases2022
- Author(s)
  池辺詠美、松岡佐保子、中島誠、村岡弘美、吉村千穂子、山岸誠、内丸薫、伊波英克、浜口功
- Organizer
  第84回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] The oncogenic driving force of CD30 signaling-induced chromosomal instability in disease progression of adult T-cell leukemia/lymphoma2022
- Author(s)
  Makoto Nakashima, Atae Utsunomiya, Toshiki Watanabe, Ryouichi Horie, Kaoru Uchimaru
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] ATL における CD30 発現機構の解析2022
- Author(s)
  瀬賀亜里沙、中島誠、山岸誠、水池潤、宇都宮與、渡邉俊樹、内丸薫
- Organizer
  第8回日本HTLV-1学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15420
[Presentation] CD30シグナルによるATL病態進展機序の解析2020
- Author(s)
  中島誠
- Organizer
  コホート・生体試料支援プラットフォーム（CoBiA）令和2年度若手支援研究成果発表会
- Data Source
  KAKENHI-PROJECT-19K16580
[Presentation] CD30シグナルによるATL病態進展機序の解析2020
- Author(s)
  中島　誠
- Organizer
  新学術領域研究「学術研究支援基盤形成」コホート・生体試料支援プラットフォーム令和元年度若手支援研究成果発表会
- Data Source
  KAKENHI-PROJECT-19K16580
[Presentation] Differentiation of Hodgkin lymphoma cells by reactive oxygen species and its regulation by heme oxigenase-1 through HIF-1α2020
- Author(s)
  Makoto Nakashima, Mariko Watanabe, Kazumi Nakano, Kaoru Uchimaru, Ryouichi Horie
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16580
[Presentation] Differentiation of HL cells by ROS and its regulation by heme oxygenase-1 through HIF-1α2020
- Author(s)
  中島　誠
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16580

1. 山野嘉久 (80445882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HORIE Ryouichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 横山和明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山岸誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 今泉芳孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 浜口功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakashima Makoto 中島 誠

Research Projects

Research Products

Co-Researchers

HAM脊髄の空間トランスクリプトーム解析による新規神経障害機構の解明と制御法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

スーパーエンハンサー領域のゲノムループ構造形成によるCD30過剰発現機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of genomic instability through ROS-DSB by CD30 signaling in ATL progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of ATL progression by CD30 signaling and its biomarkersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Transmission of Human T-Cell Leukemia Virus Type 1 From Mother to Child and Adult T-Cell Leukemia/Lymphoma2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Mechanisms of action and resistance in histone methylation-targeted therapy.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD30 nduces Reed‐Sternberg cell‐like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD30 Expression and Its Functions during the Disease Progression of Adult T-Cell Leukemia/Lymphoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The oncogenic driving force of CD30 signaling‐induced chromosomal instability in adult T‐cell leukemia/lymphoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differentiation of Hodgkin lymphoma cells by reactive oxygen species and regulation by heme oxygenase‐1 through HIF‐1α2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful clinical sequencing by molecular tumor board in an elderly patient with refractory Sezary syndrome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] HTLV-1関連脊髄症におけるウイルス感染細胞に起因した神経障害機構の解析2023

Author(s)

Organizer

Data Source

[Presentation] HTLV-1 関連脊髄症に対する MEK 阻害剤の有用性に関する非臨床データ2023

Author(s)

Nakashima Makoto 中島誠