Hosogane Masaki 細金正樹

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HOSOGANE Masaki 細金正樹

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Researcher Number	30734347
Other IDs	https://orcid.org/0000-0001-5784-304X
Affiliation (Current)	2026: 獨協医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 医学系研究科, 助教 2016: 東北大学, 医学系研究科, 助手 2014 – 2016: 東北大学, 医学(系)研究科(研究院), 助手 2014 – 2015: 東北大学, 大学院医学系研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / 0701:Biology at molecular to cellular levels, and related fields / Genome biology Except Principal Investigator Molecular biology / Basic Section 50010:Tumor biology-related / Basic Section 43050:Genome biology-related / Tumor biology / General physiology / General medical chemistry
Keywords	Principal Investigator 翻訳制御 / リボソーム / tRNA / 小胞体 / タンパク質翻訳 / スプライシングバリアント / 転写制御 / 翻訳制御因子 / 翻訳 / ポリコーム … More / CRISPR/Cas9 / エンハンサー / ヒストン修飾 / 転写 / エピジェネティクス … More Except Principal Investigator エピゲノム / 乳癌細胞株 / 糖鎖 / 腫瘍環境 / splicing / Fibulin 2 / 膵臓癌 / 細胞増殖 / 抗癌剤 / SETD5 / MLL2 / 転写制御 / エピゲム / Cdt1 / ES細胞 / 細胞周期 / Geminin / 腫瘍形成能 / 超並列シークエンス解析 / CRISPR/Cas9システム / ゲノム編集 / スクリーニング / shRNA / サイレンシング / RAS / エピジェネティクス / 転写 / 免疫不全マウス / 次世代シークエンサー / CRISPR/Cas9 / 腫瘍形成 / インスリン分泌細胞 / Bリンパ球 / リンパ球 / ChIPシークエンス / Ｂリンパ球 / ヒストン修飾 / 生体分子 / 細胞・組織 / 蛋白質 / 上皮間葉移行 (EMT) / シグナル伝達 / タンパク質分解 / 上皮間葉移行 / 発生・分化 Less

Regulation of tumor progression by selective splicing of Fibulin 2 in the tumor environment
- Principal Investigator
  
  中山啓子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Alternative splicing plays a role in the cellular localization of translation regulatorsPrincipal Investigator
- Principal Investigator
  
  Masaki Hosogane
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tohoku University
Function of SETD5 in pancreatic cancer
- Principal Investigator
  
  Nakayama Keiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Tohoku University
Protein translation regulated by ribosome heterogeneityPrincipal Investigator
- Principal Investigator
  
  Hosogane Masaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
Verification of genomic diversity required for tumorigenesis
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
Genome wide analysis of epigenetic regulation of enhancer activity via H3K27 modificationsPrincipal Investigator
- Principal Investigator
  
  HOSOGANE Masaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Tohoku University
Verification of genomic diversity required for tumorigenesis
- Principal Investigator
  
  NAKAYAMA KEIKO
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Elucidation of transcriptional regulation by histone modification pattern
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Molecular mechanism of oncogenic RAS-induced gene silencing
- Principal Investigator
  
  Funayama Ryo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Regulation of celullar differentiation by degradation of core promoter recognition complex
- Principal Investigator
  
  NAKAGAWA TADASHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones2022
- Author(s)
  Nakagawa T, Morohoshi A, Nagasawa Y, Nakagawa M, Hosogane M, Noda Y, Hosoi T, Nakayama K.
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 12 Pages: 110541-110541
- DOI
  10.1016/j.celrep.2022.110541
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07837, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-18KK0463, KAKENHI-PROJECT-21H02458
[Journal Article] Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells.2017
- Author(s)
  Hosogane, M., Bosu, L., Fukumoto, E., Yamada, H., Sato, S., Nakayama, K.
- Journal Title
  
  Genes Cells
  
  Volume: 印刷中 Issue: 4 Pages: 360-375
- DOI
  10.1111/gtc.12482
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-26293433, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-15K18453
[Journal Article] Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body.2016
- Author(s)
  Hosogane, M., Funayama, R., Shirota, M., Nakayama, K.
- Journal Title
  
  Cell Rep.
  
  Volume: 16 Issue: 3 Pages: 696-706
- DOI
  10.1016/j.celrep.2016.06.034
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-15K18453
[Presentation] EEF1A1 and EEF1A2 complement each other in regulating protein synthesis and cell cycle in breast cancer cells.2024
- Author(s)
  Mohamad Jamous, Masaki Hosogane, Xiaoxin Huang, Atsushi Hatano, Masaki Matsumoto and Keiko Nakayama.
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] Cellular localization of multi-tRNA synthetase complex is regulated by ER protein Kinectin 1 in a variant-specific manner.2024
- Author(s)
  Masaki Hosogane, Sue Yi Siao, Atsushi Hatano, Masaki Matsumoto, Keiko Nakayama.
- Organizer
  29th tRNA conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] Cellular localization of multi-tRNA synthetase complex is regulated by ER protein Kinectin 1 in a variant-specific manner.2024
- Author(s)
  Masaki Hosogane, Sue Yi Siao, Atsushi Hatano, Masaki Matsumoto, Keiko Nakayama.
- Organizer
  Ribosome meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] ER protein Kinectin 1 regulates cellular localization of multi-tRNA synthetase complex in a variant-specific manner.2024
- Author(s)
  Masaki Hosogane, Sue Yi Siao, Atsushi Hatano, Masaki Matsumoto, Keiko Nakayama.
- Organizer
  第25回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] 大腸がん組織におけるfibulin 2の選択的スプライシングは転移促進性の細胞外マトリクスをつくる.2024
- Author(s)
  舟山亮, Wei-Chen Kao, Yujue Wang, 遠山慎吾, 細金正樹, 松本雅記, 中山敬一, 中山啓子.
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-24K02300
[Presentation] ER membrane protein Kinectin 1 binds to multi-tRNA synthetase complex in a variant-specific manner2023
- Author(s)
  Sue Yi Siao, Masaki Hosogane, Atsushi Hatano, Masaki Matsumoto, and Keiko Nakayama
- Organizer
  第46回日本分子生物学会年会(2023)
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] EEF1A1 and EEF1A2 complement each other in regulating protein synthesis and cell cycle in breast cancer cells2023
- Author(s)
  Mohamad Jamous, Masaki Hosogane, and Keiko Nakayama
- Organizer
  第46回日本分子生物学会年会(2023)
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] Exploring the specific functions of mouse Eef1d variants2022
- Author(s)
  Xiaoxin Huang, Masaki Hosogane, Atsushi Hatano, Masaki Matsumoto, Keiko Nakayama
- Organizer
  第４５回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06198
[Presentation] Analysis of translational regulator EEF1A isoform in cancer cells2021
- Author(s)
  築地巧人、細金正樹、中山啓子
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K22616
[Presentation] H3K27ヒストン修飾によるエンハンサー制御のゲノムワイド解析2016
- Author(s)
  細金正樹、中山啓子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26293059
[Presentation] H3K27ヒストン修飾によるエンハンサー制御のゲノムワイド解析2016
- Author(s)
  細金正樹、中山啓子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K14664
[Presentation] Reactivation of cell proliferation by continuous TGF-β　treatment2016
- Author(s)
  Tadashi Nakagawa, Masaki Hosogane, Ryo Funayama, Keiko Nakayama
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18453
[Presentation] Reactivation of cell proliferation by continuous TGF-β　treatment.2016
- Author(s)
  Tadashi Nakagawa, Masaki Hosogane, Ryo Funayama, Keiko Nakayama.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293059
[Presentation] H3K27ヒストン修飾によるエンハンサー制御のゲノムワイド解析2016
- Author(s)
  細金正樹、中山啓子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K18453
[Presentation] Reactivation of cell proliferation by continuous TGF-β　treatment.2016
- Author(s)
  Tadashi Nakagawa, Masaki Hosogane, Ryo Funayama, Keiko Nakayama.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K14664
[Presentation] TGF-β刺激によるTFIID構成因子TAF7の分解とその役割の解明. 第38回日本分子生物学会年会.2015
- Author(s)
  中川直, 細金正樹, 舟山亮, 中山啓子.
- Organizer
  第38回日本分子生物学会年会.
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830064
[Presentation] がん原遺伝子RASによる遺伝子サイレンシングの分子機構の解析2015
- Author(s)
  舟山亮、細金正樹、長嶋剛史、中山啓子
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15024
[Presentation] がん原遺伝子RASによる遺伝子サイレンシングの分子機構の解析2015
- Author(s)
  舟山亮、細金正樹、長嶋剛史、中山啓子.
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18453
[Presentation] TGF-β刺激によるTFIID構成因子TAF7の分解とその役割の解明2015
- Author(s)
  中川直、細金正樹、舟山亮、中山啓子
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18453
[Presentation] TGF-β刺激によるTFIID構成因子TAF7の分解とその役割の解明2015
- Author(s)
  中川直、細金正樹、舟山亮、中山啓子
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293059
[Presentation] がん原遺伝子RASによる遺伝子サイレンシングの分子機構の解析.2015
- Author(s)
  舟山亮, 細金正樹, 長嶋剛史, 中山啓子.
- Organizer
  第38回日本分子生物学会年会.
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830064
[Presentation] TGF-β刺激によるTFIID構成因子TAF7の分解とその役割の解明2015
- Author(s)
  中川直、細金正樹、舟山亮、中山啓子
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15024
[Presentation] がん原遺伝子RASによる遺伝子サイレンシングの分子機構の解析2015
- Author(s)
  舟山亮、細金正樹、長嶋剛史、中山啓子
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293059
[Presentation] H3K27me3修飾パターン形成過程の時系列解析.2014
- Author(s)
  細金正樹, 舟山亮, 城田松之,中山啓子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26830064
[Presentation] H3K27me3修飾パターン形成過程の時系列解析2014
- Author(s)
  細金正樹, 舟山亮, 城田松之 & 中山啓子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26293059
[Presentation] マウスES細胞におけるgemininの細胞周期と分化に対する制御.2014
- Author(s)
  福本恵美子, Kundu, Lena Rani, 佐藤聡一郎, 細金正樹 & 中山啓子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26293059

1. FUNAYAMA Ryo (20452295)

# of Collaborated Projects: 7 results

# of Collaborated Products: 14 results
2. NAKAYAMA Keiko (60294972)

# of Collaborated Projects: 7 results

# of Collaborated Products: 20 results
3. NAKAGAWA TADASHI (30707013)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. SHIROTA Matuyuki (00549462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAGASHIMA Takeshi (80443000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Hosogane Masaki 細金 正樹

HOSOGANE Masaki 細金 正樹

Research Projects

Research Products

Co-Researchers

Regulation of tumor progression by selective splicing of Fibulin 2 in the tumor environment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Alternative splicing plays a role in the cellular localization of translation regulatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function of SETD5 in pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Protein translation regulated by ribosome heterogeneityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Verification of genomic diversity required for tumorigenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome wide analysis of epigenetic regulation of enhancer activity via H3K27 modificationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Verification of genomic diversity required for tumorigenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of transcriptional regulation by histone modification pattern

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of oncogenic RAS-induced gene silencing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of celullar differentiation by degradation of core promoter recognition complex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body.2016

Author(s)

Journal Title

DOI

Data Source

Hosogane Masaki 細金正樹

HOSOGANE Masaki 細金正樹

[Presentation] Reactivation of cell proliferation by continuous TGF-β　treatment2016

[Presentation] Reactivation of cell proliferation by continuous TGF-β　treatment.2016

[Presentation] Reactivation of cell proliferation by continuous TGF-β　treatment.2016