Kobayashi Yoshihisa 小林祥久

… Alternative Names

小林祥久コバヤシヨシヒサ

KOBAYASHI Yoshihisa 小林祥久

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Researcher Number	30734628
Other IDs
Affiliation (Current)	2022: 国立研究開発法人国立がん研究センター, 研究所, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2017: 近畿大学, 医学部, 助教 2014 – 2017: 近畿大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Respiratory surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 肺癌 / EGFR / 薬剤耐性 / すりガラス様陰影 / ground glass nodule / ground glass opacity / CT / GGN / スリガラス陰影 / 癌遺伝子 … More / 腺癌 / チロシンキナーゼ阻害剤 / アファチニブ / ダコミチニブ / L792F / 分子標的治療 / 耐性機序 / 遺伝子増幅 / MET … More Except Principal Investigator 肺癌 / KRAS / 浸潤性粘液性癌 / 喫煙 / RNAseq / 腺癌 / 非小細胞肺癌 / 浸潤性粘液腺癌 / 遺伝子増幅 / アイソフォーム / 肺腺癌 / KRAS変異 / 上皮内腺癌 / 分子病理 Less

薬剤耐性としての遺伝子増幅の機序解明と臨床応用Principal Investigator
- Principal Investigator
  
  小林祥久
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
KRAS mutations in lung cancer
- Principal Investigator
  
  谷田部恭
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Cancer Center Japan
EGFR mutant lung cancer and second generation tyrosine kinase inhibitor: acquired resistance and personalized medicinePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Yoshihisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kindai University
Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growthPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Yoshihisa
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Respiratory surgery
- Research Institution
  Kinki University

All 2021 2020 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] 肺癌診療Q&A 第3版一つ上を行く診療の実践 (分担執筆 P42-46, P326-329)2017
- Author(s)
  小林祥久、光冨徹哉
- Total Pages
  521
- Publisher
  中外医学社
- ISBN
  9784498131002
- Data Source
  KAKENHI-PROJECT-16K19989
[Journal Article] MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples2021
- Author(s)
  Ikegami M, Kohsaka S, Hirose T, Ueno T, Inoue S, Konomata N, Yamauchi H, Mori T, Sekine S, Inamoto Y, Yatabe Y, Kobayashi H, Tanaka S, Mano H.
- Journal Title
  
  Commun Biol. Commun Biol.
  
  Volume: 4 Pages: 1396-1396
- DOI
  10.1038/s42003-021-02930-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07708, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20K09453, KAKENHI-PROJECT-21K12117
[Journal Article] An Alert to Possible False Positives With a Commercial Assay for MET Exon 14 Skipping2021
- Author(s)
  Teishikata Takashi、Shiraishi Kouya、Shinno Yuki、Kobayashi Yoshihisa、Kashima Jumpei、Ishiyama Takako、Yoshida Tatsuya、Mori Taisuke、Yatabe Yasushi
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 16 Pages: 2133-2138
- DOI
  10.1016/j.jtho.2021.07.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-20H03695, KAKENHI-PROJECT-21K19492
[Journal Article] Full-coverage TP53 deep sequencing of recurrent head and neck squamous cell carcinoma facilitates prognostic assessment after recurrence2021
- Author(s)
  Kobayashi K, Yoshimoto S, Ando M, Matsumoto F, Murakami N, Omura G, Honma Y, Matsumoto Y, Ikeda A, Sakai A, Eguchi K, Ito A, Eigitsu R, Yatabe Y, Mori T.
- Journal Title
  
  Oral Oncology
  
  Volume: 113 Pages: 105091-105091
- DOI
  10.1016/j.oraloncology.2020.105091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09923, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-18K09339
[Journal Article] Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph+ B cells but not bone marrow stem/progenitors2020
- Author(s)
  Daiki Karigane, Hidenori Kasahara, ... , Keiyo Takubo.
- Journal Title
  
  Leukemia & Lymphoma
  
  Volume: 62 Pages: 679-687
- DOI
  10.1080/10428194.2020.1837366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-19J00502, KAKENHI-PROJECT-19K17847
[Journal Article] Distal‐type bronchiolar adenoma of the lung expressing p16 INK4a ? morphologic, immunohistochemical, ultrastructural and genomic analysis ? report of a case and review of the literature2020
- Author(s)
  Tachibana Mitsuhiro、Saito Masao、Kobayashi Jun、Isono Tadahiro、Yatabe Yasushi、Tsutsumi Yutaka
- Journal Title
  
  Pathology International
  
  Volume: 70 Pages: 179-185
- DOI
  10.1111/pin.12904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03461
[Journal Article] Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan2020
- Author(s)
  Tachibana M、M Saito、J Kobayashi、T Isono、Y Yatabe and Y Tsutsumi
- Journal Title
  
  Translational Oncology
  
  Volume: 13 Pages: 100786-100786
- DOI
  10.1016/j.tranon.2020.100786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03461
[Journal Article] EGFR T790M and C797S mutations as mechanisms of acquired resistance to dacomitinib2018
- Author(s)
  Kobayashi Y, Fujino T, Nishino M, Koga T, Chiba M, Sesumi Y, Ohara S, Shimoji M, Tomizawa K, Takemoto T, Mitsudomi T
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: ePub中
- DOI
  10.1016/j.jtho.2018.01.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05433, KAKENHI-PROJECT-16K19989
[Journal Article] Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer2017
- Author(s)
  Kobayashi, Y. Azuma, K. Nagai, H. Kim, Y. H. Togashi, Y. Sesumi, Y. Chiba, M. Shimoji, M. Sato, K. Tomizawa, K. Takemoto, T. Nishio, K. Mitsudomi, T.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 16 Pages: 357-364
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K19989
[Journal Article] ALK遺伝子転座陽性例への薬物療法-治療開始からラストラインまで2017
- Author(s)
  小林祥久、光冨徹哉
- Journal Title
  
  臨床腫瘍プラクティス
  
  Volume: 13 Pages: 16-20
- Data Source
  KAKENHI-PROJECT-16K19989
[Journal Article] Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy2016
- Author(s)
  Kobayashi, Y. Mitsudomi, T.
- Journal Title
  
  Cancer Science
  
  Volume: 107 Pages: 1179-1186
- DOI
  10.1111/cas.12996
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K19989
[Journal Article] EGFR-TKI耐性とその克服2015
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  臨床と研究
  
  Volume: 92 Pages: 892-895
- Data Source
  KAKENHI-PROJECT-26893310
[Journal Article] Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth2015
- Author(s)
  Kobayashi Y, Mitsudomi T, Sakao Y, Yatabe Y
- Journal Title
  
  Ann Oncol. 2015;26:156-61.
  
  Volume: 26 Pages: 156-161
- DOI
  10.1093/annonc/mdu505
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893310, KAKENHI-PROJECT-25293090
[Journal Article] EGFR遺伝子変異と阻害薬: さらなる個別化治療への展望2015
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  最新医学
  
  Volume: 70 Pages: 2461-2468
- Data Source
  KAKENHI-PROJECT-26893310
[Journal Article] EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third-Generation TKIs2015
- Author(s)
  Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Park J, Kondo C, Shimoji M, Sato K, Suda K, Tomizawa K, Takemoto T, Hida T, Nishio K, and Mitsudomi T
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 21 Pages: 5405-13
- DOI
  10.1158/1078-0432.ccr-15-1046
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893310, KAKENHI-PROJECT-25293090
[Journal Article] 海外における標準治療にかかわる大規模無作為化比較試験の意味と問題点(IPASS，OPTIMAL，EURTAC，LUX-lung 3).2014
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  オンコロジークリニカルガイド肺癌化学療法
  
  Volume: なし Pages: 279-288
- Data Source
  KAKENHI-PROJECT-26893310
[Journal Article] EGFR変異と特異的阻害剤2014
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  Pharma Medica
  
  Volume: 32 Pages: 15-19
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] Application of CRISPR-Cas9 to the study of resistant mechanisms to EGFR inhibitors2021
- Author(s)
  小林祥久
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15581
[Presentation] Molecular targeted therapy for EGFR mutant lung cancer: mutation-specific drug selection.2017
- Author(s)
  Kobayashi Y
- Organizer
  The Satelite Symposium of Biological Session of Japan Nucleic Acid Therapeutics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19989
[Presentation] Mechanisms of acquired resistance to dacomitinib in cell models2017
- Author(s)
  Kobayashi Y, Fujino T, Nishino M, Ohara S, Sesumi Y, Chiba M, Shimoji M, Tomizawa K, Takemoto T, Mitsudomi T
- Organizer
  World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19989
[Presentation] アファチニブ獲得耐性機序としてのEGFR二次変異T790M、L792F、C797Sの特徴2016
- Author(s)
  小林祥久、東公一、永井宏樹、金永学、冨樫庸介、瀬角裕一、西野将矢、西平守道、佐藤克明、千葉眞人、下治正樹、富沢健二、武本智樹、西尾和人、光冨徹哉
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡市)
- Year and Date
  2016-12-20
- Data Source
  KAKENHI-PROJECT-16K19989
[Presentation] EGFR T790M, L792F, and C797S mutations as mechanisms of acquired resistance to afatinib2016
- Author(s)
  Kobayashi, Y. Azuma, K. Nagai, H. Kim, Y. H. Togashi, Y. Sesumi, Y. Chiba, M. Shimoji, M. Sato, K. Tomizawa, K. Takemoto, T. Nishio, K. Mitsudomi, T.
- Organizer
  17th World Conference on Lung Cancer
- Place of Presentation
  ウィーン (オーストリア)
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19989
[Presentation] EGFR exon 18 mutations in lung cancer: molecular predictors of sensitivity to afatinib or neratinib but not to other EGFR-TKIs2015
- Author(s)
  Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Park J, Kondo C, Shimoji M, Sato K, Suda K, Tomizawa K, Takemoto T, Hida T, Nishio K, and Mitsudomi T
- Organizer
  16th World Conference on Lung Cancer
- Place of Presentation
  アメリカ合衆国、デンバー
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] EGFR遺伝子変異の種類による治療の最適化と外科切除の役割2015
- Author(s)
  小林祥久、光冨徹哉
- Organizer
  第68 回日本胸部外科学会定期学術集会
- Place of Presentation
  神戸ポートピアホテル、神戸
- Year and Date
  2015-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] 肺腺癌のdriver mutationと画像所見: GGNのユニークな遺伝子的特徴2015
- Author(s)
  小林祥久、光冨徹哉
- Organizer
  第56 回日本肺癌学会学術集会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] スリガラス様陰影 (GGO)を呈する肺腺癌の遺伝子的特徴; 増大するGGOと変化しないGGOの違い.2014
- Author(s)
  小林祥久，光冨徹哉，坂尾幸則，谷田部恭
- Organizer
  第9回肺癌分子病態研究会
- Place of Presentation
  東京 (TKP東京駅前カンファレンスセンター)
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] すりガラス陰影 (GGO)を呈する肺腺癌の遺伝子的特徴：増大する病変と変化しない病変の違い.
- Author(s)
  小林祥久，光冨徹哉，水野鉄也，黒田浩章，坂倉範昭，下治正樹，水内寛，佐藤克明，須田健一，富沢健二，武本智樹，岩崎拓也，阪口全宏，坂尾幸則，谷田部恭
- Organizer
  第55回日本肺癌学会総会
- Place of Presentation
  京都 (国立京都国際会館)
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] 肺腺癌のCT画像と遺伝子的特徴
- Author(s)
  小林祥久
- Organizer
  第56回日本肺癌学会総会
- Place of Presentation
  横浜 (パシフィコ横浜)
- Year and Date
  2015-11-26 – 2015-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-26893310

1. 谷田部恭 (90280809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 加島淳平 (80893883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 藤田史郎 (60612140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 真砂勝泰 (80338160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KOBAYASHI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. MITSUDOMI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KOGA Takamasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. FUJINO Toshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. NISHINO Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 井上聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 高阪真路

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 森泰昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 坂尾幸則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小林央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 白石航也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 吉本世一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 小林謙也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 安藤瑞生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小村豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 樋田豊明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Yoshihisa 小林 祥久

小林 祥久 コバヤシ ヨシヒサ

KOBAYASHI Yoshihisa 小林 祥久

Research Projects

Research Products

Co-Researchers

薬剤耐性としての遺伝子増幅の機序解明と臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

KRAS mutations in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

EGFR mutant lung cancer and second generation tyrosine kinase inhibitor: acquired resistance and personalized medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肺癌診療Q&A 第3版 一つ上を行く診療の実践 (分担執筆 P42-46, P326-329)2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Alert to Possible False Positives With a Commercial Assay for MET Exon 14 Skipping2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Full-coverage TP53 deep sequencing of recurrent head and neck squamous cell carcinoma facilitates prognostic assessment after recurrence2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph+ B cells but not bone marrow stem/progenitors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distal‐type bronchiolar adenoma of the lung expressing p16 INK4a ? morphologic, immunohistochemical, ultrastructural and genomic analysis ? report of a case and review of the literature2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGFR T790M and C797S mutations as mechanisms of acquired resistance to dacomitinib2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer2017

Author(s)

Journal Title

Data Source

[Journal Article] ALK遺伝子転座陽性例への薬物療法-治療開始からラストラインまで2017

Author(s)

Journal Title

Data Source

[Journal Article] Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy2016

Kobayashi Yoshihisa 小林祥久

小林祥久コバヤシヨシヒサ

KOBAYASHI Yoshihisa 小林祥久

[Book] 肺癌診療Q&A 第3版一つ上を行く診療の実践 (分担執筆 P42-46, P326-329)2017