KOBAYASHI Yoshihisa 小林祥久

Researcher Number	30734628
Other IDs
Affiliation *help	2017 – 2018 : 近畿大学, 医学部, 助教 2014 – 2016 : 近畿大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Respiratory surgery
Keywords	Principal Investigator 肺癌 / EGFR / 癌遺伝子 / スリガラス陰影 / 耐性機序 / アファチニブ / ground glass opacity / 腺癌 / 薬剤耐性 / 分子標的治療 … More

Research Projects
(2results)
Research Products
(16results)

EGFR肺癌と第二世代キナーゼ阻害剤:獲得耐性の網羅的解析と個別化治療の新展開Principal InvestigatorOngoing
- Principal Investigator
  
  小林祥久
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kinki University
Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growthPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Yoshihisa
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Respiratory surgery
- Research Institution
  Kinki University

All 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer2017
- Author(s)
  Kobayashi, Y. Azuma, K. Nagai, H. Kim, Y. H. Togashi, Y. Sesumi, Y. Chiba, M. Shimoji, M. Sato, K. Tomizawa, K. Takemoto, T. Nishio, K. Mitsudomi, T.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume : 16 Pages : 357-364
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K19989
[Journal Article] Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy2016
- Author(s)
  Kobayashi, Y. Mitsudomi, T.
- Journal Title
  
  Cancer Science
  
  Volume : 107 Pages : 1179-1186
- DOI
  10.1111/cas.12996
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K19989
[Journal Article] EGFR-TKI耐性とその克服2015
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  臨床と研究
  
  Volume : 92 Pages : 892-895
- Data Source
  KAKENHI-PROJECT-26893310
[Journal Article] EGFR exon 18 mutations in lung cancer: molecular predictors of augmented sensitivity to afatinib or neratinib as compared with first or third generation TKIs.2015
- Author(s)
  Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Park J, Kondo C, Shimoji M, Sato K, Suda K, Tomizawa K, Takemoto T, Hida T, Nishio K, and Mitsudomi T
- Journal Title
  
  Clinical Cancer Research
  
  Volume : 21 Pages : 5305-5313
- DOI
  10.1158/1078-0432.CCR-15-1046
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893310, KAKENHI-PROJECT-25293090
[Journal Article] EGFR遺伝子変異と阻害薬: さらなる個別化治療への展望2015
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  最新医学
  
  Volume : 70 Pages : 2461-2468
- Data Source
  KAKENHI-PROJECT-26893310
[Journal Article] Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth.2015
- Author(s)
  Kobayashi Y, Mitsudomi T, Sakao Y, Yatabe Y
- Journal Title
  
  Annals of Oncology
  
  Volume : 26 Pages : 156-161
- DOI
  10.1093/annonc/mdu505
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893310, KAKENHI-PROJECT-25293090
[Journal Article] 海外における標準治療にかかわる大規模無作為化比較試験の意味と問題点(IPASS，OPTIMAL，EURTAC，LUX-lung 3).2014
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  オンコロジークリニカルガイド肺癌化学療法
  
  Volume : なし Pages : 279-288
- Data Source
  KAKENHI-PROJECT-26893310
[Journal Article] EGFR変異と特異的阻害剤2014
- Author(s)
  小林祥久, 光冨徹哉
- Journal Title
  
  Pharma Medica
  
  Volume : 32 Pages : 15-19
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] EGFR T790M, L792F, and C797S mutations as mechanisms of acquired resistance to afatinib2016
- Author(s)
  Kobayashi, Y. Azuma, K. Nagai, H. Kim, Y. H. Togashi, Y. Sesumi, Y. Chiba, M. Shimoji, M. Sato, K. Tomizawa, K. Takemoto, T. Nishio, K. Mitsudomi, T.
- Organizer
  17th World Conference on Lung Cancer
- Place of Presentation
  ウィーン (オーストリア)
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19989
[Presentation] アファチニブ獲得耐性機序としてのEGFR二次変異T790M、L792F、C797Sの特徴2016
- Author(s)
  小林祥久、東公一、永井宏樹、金永学、冨樫庸介、瀬角裕一、西野将矢、西平守道、佐藤克明、千葉眞人、下治正樹、富沢健二、武本智樹、西尾和人、光冨徹哉
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡市)
- Year and Date
  2016-12-20
- Data Source
  KAKENHI-PROJECT-16K19989
[Presentation] EGFR exon 18 mutations in lung cancer: molecular predictors of sensitivity to afatinib or neratinib but not to other EGFR-TKIs2015
- Author(s)
  Kobayashi Y, Togashi Y, Yatabe Y, Mizuuchi H, Park J, Kondo C, Shimoji M, Sato K, Suda K, Tomizawa K, Takemoto T, Hida T, Nishio K, and Mitsudomi T
- Organizer
  16th World Conference on Lung Cancer
- Place of Presentation
  アメリカ合衆国、デンバー
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] 肺腺癌のdriver mutationと画像所見: GGNのユニークな遺伝子的特徴2015
- Author(s)
  小林祥久、光冨徹哉
- Organizer
  第56 回日本肺癌学会学術集会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] EGFR遺伝子変異の種類による治療の最適化と外科切除の役割2015
- Author(s)
  小林祥久、光冨徹哉
- Organizer
  第68 回日本胸部外科学会定期学術集会
- Place of Presentation
  神戸ポートピアホテル、神戸
- Year and Date
  2015-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] スリガラス様陰影 (GGO)を呈する肺腺癌の遺伝子的特徴; 増大するGGOと変化しないGGOの違い.2014
- Author(s)
  小林祥久，光冨徹哉，坂尾幸則，谷田部恭
- Organizer
  第9回肺癌分子病態研究会
- Place of Presentation
  東京 (TKP東京駅前カンファレンスセンター)
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] すりガラス陰影 (GGO)を呈する肺腺癌の遺伝子的特徴：増大する病変と変化しない病変の違い.
- Author(s)
  小林祥久，光冨徹哉，水野鉄也，黒田浩章，坂倉範昭，下治正樹，水内寛，佐藤克明，須田健一，富沢健二，武本智樹，岩崎拓也，阪口全宏，坂尾幸則，谷田部恭
- Organizer
  第55回日本肺癌学会総会
- Place of Presentation
  京都 (国立京都国際会館)
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26893310
[Presentation] 肺腺癌のCT画像と遺伝子的特徴
- Author(s)
  小林祥久
- Organizer
  第56回日本肺癌学会総会
- Place of Presentation
  横浜 (パシフィコ横浜)
- Year and Date
  2015-11-26 – 2015-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-26893310

KOBAYASHI Yoshihisa 小林 祥久

Research Projects

Research Products

EGFR肺癌と第二世代キナーゼ阻害剤:獲得耐性の網羅的解析と個別化治療の新展開Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer2017

Author(s)

Journal Title

Data Source

[Journal Article] Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGFR-TKI耐性とその克服2015

Author(s)

Journal Title

Data Source

[Journal Article] EGFR exon 18 mutations in lung cancer: molecular predictors of augmented sensitivity to afatinib or neratinib as compared with first or third generation TKIs.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGFR遺伝子変異と阻害薬: さらなる個別化治療への展望2015

Author(s)

Journal Title

Data Source

[Journal Article] Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 海外における標準治療にかかわる大規模無作為化比較試験の意味と問題点(IPASS，OPTIMAL，EURTAC，LUX-lung 3).2014

Author(s)

Journal Title

Data Source

[Journal Article] EGFR変異と特異的阻害剤2014

Author(s)

Journal Title

Data Source

[Presentation] EGFR T790M, L792F, and C797S mutations as mechanisms of acquired resistance to afatinib2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] アファチニブ獲得耐性機序としてのEGFR二次変異T790M、L792F、C797Sの特徴2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] EGFR exon 18 mutations in lung cancer: molecular predictors of sensitivity to afatinib or neratinib but not to other EGFR-TKIs2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 肺腺癌のdriver mutationと画像所見: GGNのユニークな遺伝子的特徴2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] EGFR遺伝子変異の種類による治療の最適化と外科切除の役割2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

KOBAYASHI Yoshihisa 小林祥久