Komatsu Naoki 小松直貴

Researcher Number	30737440
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 助教
Affiliation (based on the past Project Information) *help	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 助教 2022 – 2023: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 2019 – 2021: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 基礎科学特別研究員 2018: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 2016 – 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 2014 – 2015: 京都大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Cell biology / Tumor biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator mTOR / 生細胞イメージング / 細胞周期 / 光遺伝学 / シグナル伝達 / 光操作 / 蛍光プローブ / mTORC1 / 細胞増殖 / 細胞恒常性 … More / 活性操作 / FRETプローブ / リボソームプロファイリング / RNA-seq / 遺伝子発現解析 / ライブイメージング / タンパク質ビオチン化 / 1細胞解析 / リボソーム / 蛍光タンパク質 / ビオチン化 / 細胞内シグナル伝達 / 抗癌剤抵抗性 / MEK阻害剤 / 生物画像解析 / 蛍光ライブイメージング / MEK阻害剤抵抗性 / 発現誘導 / BRET … More Except Principal Investigator 固体イメージング / 個体イメージング / 共鳴エネルギー移動 / 固定イメージング / レチノイン酸 / 細胞周期 / 共鳴エネルギ移動 / バイオイメージング Less

Unraveling the mechanism for keeping cellular homeostasis with temporal and specific control of mTORC1 activity.Principal Investigator
- Principal Investigator
  
  小松直貴
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  The University of Tokushima
Unraveling mTORC1 activity dynamics and its information processing in cell proliferationPrincipal Investigator
- Principal Investigator
  
  小松直貴
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Institute of Physical and Chemical Research
Platform for light-inducible, biochemical labeling of ribosomes in living single cells for the novel single-cell analytics based on seamlessly connected live cell imaging and transcriptomicsPrincipal Investigator
- Principal Investigator
  
  Komatsu Naoki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Unraveling the working principle of MEK inhibitor resistance in cancer cells by artificial control of cell growth signal dynamicsPrincipal Investigator
- Principal Investigator
  
  Komatsu Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
The development of fundamental bioimaging technologies for comprehensive understanding
- Principal Investigator
  
  Atsushi Miyawaki
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Quantitative analysis of MEK inhibitor resistance in cancer cells based on reconstitution of cell growth signalingPrincipal Investigator
- Principal Investigator
  
  Komatsu Naoki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2015 Other

All Journal Article Presentation

[Journal Article] Single-Cell Live Imaging2019
- Author(s)
  Toru Hiratsuka and Naoki Komatsu
- Journal Title
  
  Single Cell Methods
  
  Volume: - Pages: 409-421
- DOI
  10.1007/978-1-4939-9240-9_24
- ISBN
  9781493992393, 9781493992409
- Data Source
  KAKENHI-PROJECT-18K19313, KAKENHI-PROJECT-16K21109
[Journal Article] A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging.2018
- Author(s)
  Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 8984-8984
- DOI
  10.1038/s41598-018-27174-x
- NAID
  120006523820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08796, KAKENHI-PUBLICLY-17H05516, KAKENHI-PROJECT-16K21109, KAKENHI-PLANNED-15H05949, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18H02490
[Journal Article] Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle2017
- Author(s)
  Sakaue-Sawano Asako、Yo Masahiro、Komatsu Naoki、Hiratsuka Toru、Kogure Takako、Hoshida Tetsushi、Goshima Naoki、Matsuda Michiyuki、Miyoshi Hiroyuki、Miyawaki Atsushi
- Journal Title
  
  Molecular Cell
  
  Volume: 68 Issue: 3 Pages: 626-640
- DOI
  10.1016/j.molcel.2017.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06900, KAKENHI-PROJECT-16K21109, KAKENHI-PLANNED-15H05948, KAKENHI-PUBLICLY-16H01653, KAKENHI-ORGANIZER-15H05935
[Journal Article] Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Foerster resonance energy transfer2017
- Author(s)
  Takuya Hiratsuka,Takeshi Sano,Hisashi Kato,Naoki Komatsu,Masamichi Imajo,Yuji Kamioka,Kenta Sumiyama,Fumiaki Banno,Toshiyuki Miyata,Michiyuki Matsuda
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 印刷中 Issue: 7 Pages: 1487-1499
- DOI
  10.1111/jth.13723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21109, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K09835, KAKENHI-PROJECT-16K21106
[Journal Article] A FRET Biosensor for ROCK Based on a Consensus Substrate Sequence Identified by KISS Technology2017
- Author(s)
  Chunjie Li, Ayako Imanishi, Naoki Komatsu, Kenta Terai, Mutsuki Amano, Kozo Kaibuchi and Michiyuki Matsuda
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 42 Issue: 1 Pages: 1-13
- DOI
  10.1247/csf.16016
- NAID
  130005308480
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21109, KAKENHI-PROJECT-17H01380
[Journal Article] mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.2015
- Author(s)
  Komatsu N, Fujita Y, Matsuda M, Aoki K
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 45 Pages: 5607-5616
- DOI
  10.1038/onc.2015.16
- NAID
  120005712924
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23701052, KAKENHI-PROJECT-26890015, KAKENHI-PROJECT-26290053
[Journal Article] Ras/Rap2015
- Author(s)
  小松直貴,松田道行
- Journal Title
  
  生体の科学
  
  Volume: 66 Pages: 402-403
- Data Source
  KAKENHI-PROJECT-26890015
[Presentation] Visualization of cell cycle-dependent mTORC1/S6K activation2023
- Author(s)
  小松直貴, 宮脇敦史
- Organizer
  第61回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06230
[Presentation] 細胞周期依存的なmTORC1活性化の可視化2022
- Author(s)
  小松直貴、宮脇敦史
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06230
[Presentation] mTORC1活性動態の細胞周期進行における生物学的意義の解明2021
- Author(s)
  小松直貴
- Organizer
  第73回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-18K19313
[Presentation] 細胞周期依存的なmTORC1活性波の可視化2021
- Author(s)
  小松直貴
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19313
[Presentation] mTORC1活性動態の細胞周期進行における生物学的意義の解明2020
- Author(s)
  小松直貴
- Organizer
  多次元細胞計測ワークショップ
- Data Source
  KAKENHI-PROJECT-18K19313
[Presentation] 癌細胞増殖シグナルのライブイメージング2019
- Author(s)
  小松直貴
- Organizer
  理研シンポジウム「細胞システムの動態と論理XI」
- Invited
- Data Source
  KAKENHI-PROJECT-16K21109
[Presentation] Unraveling mTORC1 activity dynamics and its biological roles in cell cycle progression2019
- Author(s)
  Naoki Komatsu, Sakaue-Sawano Asako, Atsushi Miyawaki
- Organizer
  ASCB|EMBO 2019 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19313
[Presentation] 癌細胞増殖シグナルのライブイメージング2019
- Author(s)
  小松直貴
- Organizer
  理研シンポジウム「細胞システムの動態と論理XI」
- Invited
- Data Source
  KAKENHI-PROJECT-18K19313
[Presentation] Unraveling mTORC1 activity dynamics and its biological roles in cell cycle progression2019
- Author(s)
  Naoki Komatsu, Sakaue-Sawano Asako, Atsushi Miyawaki
- Organizer
  ResonanceBio International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19313
[Presentation] Unraveling mTORC1 activity dynamics and its biological roles in cell cycle progression2019
- Author(s)
  Naoki Komatsu
- Organizer
  Resonance Bio International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05948
[Presentation] KRas変異およびBRaf変異による癌細胞増殖促進はmTORC1活性化に収束する2015
- Author(s)
  小松直貴、松田道行、青木一洋
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀、東京
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-26890015
[Presentation] KRas変異細胞およびBRaf変異細胞におけるMEK阻害剤感受性のFRETイメージングを用いた定量解析
- Author(s)
  小松直貴
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26890015

1. Atsushi Miyawaki (80251445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 牧昌次郎 (20266349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 下薗哲 (40391982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 阪上朝子 (90462689)

# of Collaborated Projects: 1 results

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5. 濱裕 (30261796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AOKI Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. YO Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 三好浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 上岡裕治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Komatsu Naoki 小松 直貴

Research Projects

Research Products

Co-Researchers

Unraveling the mechanism for keeping cellular homeostasis with temporal and specific control of mTORC1 activity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling mTORC1 activity dynamics and its information processing in cell proliferationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Platform for light-inducible, biochemical labeling of ribosomes in living single cells for the novel single-cell analytics based on seamlessly connected live cell imaging and transcriptomicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling the working principle of MEK inhibitor resistance in cancer cells by artificial control of cell growth signal dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of fundamental bioimaging technologies for comprehensive understanding

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Quantitative analysis of MEK inhibitor resistance in cancer cells based on reconstitution of cell growth signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Single-Cell Live Imaging2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Foerster resonance energy transfer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A FRET Biosensor for ROCK Based on a Consensus Substrate Sequence Identified by KISS Technology2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Ras/Rap2015

Author(s)

Journal Title

Data Source

Komatsu Naoki 小松直貴