OSHIMA NAOHIRO 大嶋直浩

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OSHIMA Naohiro 大嶋直浩

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Researcher Number	30757133
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生活衛生化学部, 主任研究官
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立医薬品食品衛生研究所, 生活衛生化学部, 主任研究官 2020 – 2021: 国立医薬品食品衛生研究所, 生活衛生化学部, 研究員 2018 – 2019: 東京理科大学, 薬学部薬学科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator バイカリン / 副作用 / オウゴン / 小柴胡湯 / 肝機能障害 / 副作用の制御 / 副作用制御 / バイカレイン / 生薬 / 抽出量変化 … More / フラボノイド / 生薬間相互作用 / 間質性肺炎 / 生薬の組み合わせ / 肝細胞毒性 / トランスポーター / 含有量 / 改善策 Less

Strategy to control the side effects of Scutellaria Root and their applicationsPrincipal Investigator
- Principal Investigator
  
  大嶋直浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  National Institute of Health Sciences
Combination study of the optimal crude drugs to prevent interstitial pneumonia with Scutellaria Root-containing Kampo formulaePrincipal Investigator
- Principal Investigator
  
  OSHIMA Naohiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  National Institute of Health Sciences
  Tokyo University of Science

All 2024 2021 2020 2018

All Journal Article Presentation

[Journal Article] Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content2024
- Author(s)
  1.Naohiro Oshima,* Kosuke Kusamori, Ryo Takasaki, Moe Takeda, Yuri Katsurada, Takumi Nose, Kazuki Okoshi, Makiya Nishikawa,* Noriyasu Hada
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: ー Issue: 4 Pages: 978-984
- DOI
  10.1007/s11418-024-01814-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06676
[Journal Article] Synergistic effect of baicalein, wogonin and oroxylin A mixture; multistep inhibition of the NF-kV signaling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids2018
- Author(s)
  T. Shimizu, N. Shibuya, Y. Narukawa, N. Oshima, N. Hada and F. Kiuchi.
- Journal Title
  
  J. Nat. Med.
  
  Volume: 72 Issue: 1 Pages: 181-191
- DOI
  10.1007/s11418-017-1129-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08347, KAKENHI-PROJECT-18K14937
[Journal Article] Quantitative analysis of anti-inflammatory activity of orengedokuto Ⅱ: Berberine is responsible for inhibition of NO production2018
- Author(s)
  Naohiro Oshima, Tomofumi Shimizu, Yuji Narukawa, Noriyasu Hada, and Fumiyuki Kiuchi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 72(3) Issue: 3 Pages: 706-714
- DOI
  10.1007/s11418-018-1209-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08347, KAKENHI-PROJECT-18K06721, KAKENHI-PROJECT-18K14937
[Presentation] 生薬の配合によるオウゴン由来フラボノイドの抽出量の変化2021
- Author(s)
  熊谷朝日、大嶋直浩、羽田紀康
- Organizer
  日本薬学会141回年会
- Data Source
  KAKENHI-PROJECT-18K14937
[Presentation] 生薬の配合によるオウゴン由来フラボノイドの抽出量変化(3)2021
- Author(s)
  武田萌、大嶋直浩、羽田紀康
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-18K14937
[Presentation] 生薬の配合によるオウゴン由来フラボノイドの抽出量変化2020
- Author(s)
  武田萌、大嶋直浩、羽田紀康
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-18K14937

1. 西川元也 (40273437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 羽田紀康 (70296531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

OSHIMA NAOHIRO 大嶋 直浩

OSHIMA Naohiro 大嶋 直浩

Research Projects

Research Products

Co-Researchers

Strategy to control the side effects of Scutellaria Root and their applicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combination study of the optimal crude drugs to prevent interstitial pneumonia with Scutellaria Root-containing Kampo formulaePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synergistic effect of baicalein, wogonin and oroxylin A mixture; multistep inhibition of the NF-kV signaling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative analysis of anti-inflammatory activity of orengedokuto Ⅱ: Berberine is responsible for inhibition of NO production2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 生薬の配合によるオウゴン由来フラボノイドの抽出量の変化2021

Author(s)

Organizer

Data Source

[Presentation] 生薬の配合によるオウゴン由来フラボノイドの抽出量変化(3)2021

Author(s)

Organizer

Data Source

[Presentation] 生薬の配合によるオウゴン由来フラボノイドの抽出量変化2020

Author(s)

Organizer

Data Source

OSHIMA NAOHIRO 大嶋直浩

OSHIMA Naohiro 大嶋直浩