Lee h 李賢哲

… Alternative Names

LEE Hyeon-Cheol 李賢哲

Less

Researcher Number	30758321
Other IDs
Affiliation (Current)	2022: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2016 – 2022: 順天堂大学, 医学部, 助教 2015: 順天堂大学, 医学(系)研究科(研究院), ポスドク
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Biological pharmacy Except Principal Investigator Basic Section 55020:Digestive surgery-related / Gastroenterology / Biological Sciences / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 後期エンドソーム / BMP / DHA / ドコサヘキサエン酸 / PUFA / リン脂質 / 脂質 / DPAn-6 / DPA / 脂肪酸組成 / 高度不飽和脂肪酸 … More Except Principal Investigator … More 非アルコール性脂肪肝炎 / 脂肪毒性 / 酸化ストレス / 極長鎖脂肪酸 / 消化器癌 / ペルオキシソーム / ジェントロジー / サルコペニア / リピドミクス / ヘパトカイン / 脂質代謝 / 肝線維化 / 非アルコール脂肪肝炎 / ユビキチン化 / ジエントロジー / ジェロントロジー / 脂質 / 老化 / 筋肝連関 / 胃癌 / 大腸癌 / 副腎白質ジストロフィー / AOM/DSS / 脂肪酸合成酵素 / ガスダミンD / 癌治療、予防 / マルチモードオートファジー / オートファジー / マクロオートファジー / 選択的オートファジー / UFM1システム / p62 / 液―液相分離 / KEAP1 / ユビキチン / 液ー液相分離 / 液－液相分離 / NCoR1 / 脂肪酸不飽和化酵素 / PTEN / 肝癌 / 自然免疫 / アミノ酸 / 肝がん / 脂質合成 / 抗酸化物質 / 脂肪酸代謝 / アルコール性肝障害 / 脂肪酸伸長酵素 / パーキンソン病 / 慢性虫垂炎 / αシニクレイン / ASシード / 虫垂炎 / αシヌクレイン / 脂肪酸合成蛋白 Less

極長鎖脂肪酸をターゲットとした新規抗癌治療戦略
- Principal Investigator
  
  折田創
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Juntendo University
ドコサヘキサエン酸選択的細胞内輸送経路の生理的意義の解明Principal Investigator
- Principal Investigator
  
  李賢哲
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
Mechanism elucidation for influences of the Parkinson disease after appendectomy
- Principal Investigator
  
  福永哲
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Juntendo University
Mechanism of enhanced hepatotoxicity through fatty acid metabolic imbalance in the progression of fatty liver disease
- Principal Investigator
  
  今一義
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Juntendo University
Anticancer treatment targeted fot VLCFA
- Principal Investigator
  
  Orita Hajime
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Juntendo University
Selective autophagy-mediated cellular regulations
- Principal Investigator
  
  小松雅明
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Elucidation of physiological roles of fatty acyl species of late endosome-specific phospholipid BMPPrincipal Investigator
- Principal Investigator
  
  LEE-OKADA Hyeon-Cheol
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
The impact of lipid composition alteration via beta-oxidation failure on the pathophysiological linkage between nonalcoholic steatohepatitis and sarcopenia
- Principal Investigator
  
  Kon Kazuyoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
Functional analysis of docosahexaenoic acids in late-endosome specific phospholipid BMPPrincipal Investigator
- Principal Investigator
  
  LEE Hyeon-Cheol
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Juntendo University

All 2021 2020 2019 2018 2016

All Journal Article Presentation

[Journal Article] Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice2021
- Author(s)
  Y. Hayashi, HC. Lee-Okada, E. Nakamura, N. Tada, T. Yokomizo, Y. Fujiwara, I. Ichi
- Journal Title
  
  FEBES Letters
  
  Volume: Accepted Pages: 1920-1932
- DOI
  10.1002/1873-3468.14134
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K02383, KAKENHI-PROJECT-21H04798, KAKENHI-PROJECT-18K02252, KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-21K08565, KAKENHI-PROJECT-19KK0199
[Journal Article] Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids2021
- Author(s)
  Lee-Okada Hyeon-Cheol、Hama Kotaro、Yokoyama Kazuaki、Yokomizo Takehiko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Pages: 389-397
- DOI
  10.1093/jb/mvab054
- NAID
  40022721885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04798, KAKENHI-PROJECT-19K11777, KAKENHI-PROJECT-20K08218, KAKENHI-PROJECT-21K08565, KAKENHI-PROJECT-19KK0199
[Journal Article] Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability2020
- Author(s)
  Gemma Aragones, Kalavathi Dasuri, Opeoluwa Olukorede, Sarah G Francisco, Carol Renneburg, et al.
- Journal Title
  
  Aging Cell
  
  Volume: 19
- DOI
  10.1111/acel.13257
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06549, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611
[Journal Article] A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy2020
- Author(s)
  Cabrera-Serrano Macarena、Coote David Joseph、Azmanov Dimitar、Goullee Hayley、Andersen Erik、McLean Catriona、Davis Mark、Ishimura Ryosuke、Stark Zornitza、Vallat Jean-Michel、Komatsu Masaaki、Kornberg Andrew、Ryan Monique、Laing Nigel G、Ravenscroft Gina
- Journal Title
  
  J Med Genet.
  
  Volume: - Pages: 835-842
- DOI
  10.1136/jmedgenet-2019-106496
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K15061, KAKENHI-PROJECT-20K16161
[Journal Article] Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice2020
- Author(s)
  Ishizuka Kei、Kon Kazuyoshi、Lee‐Okada Hyeon‐Cheol、Arai Kumiko、Uchiyama Akira、Yamashina Shunhei、Yokomizo Takehiko、Ikejima Kenichi
- Journal Title
  
  journal of gastroenterology and hepatology
  
  Volume: In press Pages: 1437-1448
- DOI
  10.1111/jgh.15006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-17K09440, KAKENHI-PROJECT-20K17032
[Journal Article] Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence2020
- Author(s)
  Kaji S, Irino T, Kusuhara M, Makuuchi R, Yamakawa Y, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Kami K, Ohashi Y, Zhang S, Orita H, Lee-Okada HC, Fukunaga T, Terashima M.
- Journal Title
  
  Gastric Cancer
  
  Volume: - Pages: 874-883
- DOI
  10.1007/s10120-020-01065-5
- NAID
  40022329548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-19K09227, KAKENHI-PROJECT-19KK0199, KAKENHI-PROJECT-18H02627
[Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.2020
- Author(s)
  Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
- Journal Title
  
  Life Sci Alliance.
  
  Volume: 3 Pages: 201900513-201900513
- DOI
  10.26508/lsa.201900513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-16H06276
[Journal Article] Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis2019
- Author(s)
  Lee H. C., Tominaga M., Yasukawa K., Ohba M., Takahashi N., Honda K., Okuno T., Takamori K., Yokomizo T.
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 95 Pages: 130-133
- DOI
  10.1016/j.jdermsci.2019.07.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07357, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-16K08596, KAKENHI-PROJECT-18K16246
[Journal Article] Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses.2019
- Author(s)
  Hirakata T., Lee H. C., Ohba M., Saeki K., Okuno T., Murakami A., Matsuda A., Yokomizo T.
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Pages: 3392-3403
- DOI
  10.1096/fj.201801805r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08596, KAKENHI-PROJECT-18K06923, KAKENHI-PROJECT-18K16246, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-15K08316
[Journal Article] Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation2019
- Author(s)
  Zhang Shun、Kohira Yoshinori、Orita Hajime、Ishimine Momoko、Kobayashi Toshiyuki、Buendia Chua Sharlyn Mae、Nakaoka Hirofumi、Inoue Ituro、Hino Okio、Yokomizo Takehiko、Fukunaga Tetsu、Lee-Okada Hyeon-Cheol
- Journal Title
  
  BPB Reports
  
  Volume: 2 Pages: 130-133
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16246
[Journal Article] 【生理活性脂質とアレルギー炎症】脂肪酸由来の脂質メディエーターによるアレルギー炎症の制御2018
- Author(s)
  平形寿彬、李賢哲、横溝岳彦
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 69 Pages: 569-575
- Data Source
  KAKENHI-PROJECT-18K16246
[Journal Article] Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond2018
- Author(s)
  Shin Myungsun、Ware Timothy B.、Lee Hyeon-Cheol、Hsu Ku-Lung
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1864 Pages: 907-921
- DOI
  10.1016/j.bbalip.2018.08.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16246
[Presentation] 三連四重極型質量分析計を用いた簡便な遊離脂肪酸測定法の開発とその応用2021
- Author(s)
  李賢哲
- Organizer
  第46回日本医用マススペクトル学会
- Data Source
  KAKENHI-PROJECT-21K08565
[Presentation] カルボキシルエステラーゼ2の消化器癌における発現調節機構の解明2020
- Author(s)
  張順、伊志嶺百々子、小平佳典、折田創、小林敏之、樋野興夫、横溝岳彦、福永哲、李賢哲
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K16246
[Presentation] C型肝炎治療薬ソホスブビルのカルボキシルエステラーゼ阻害活性の検討2020
- Author(s)
  李賢哲、伊志嶺百々子、横溝岳彦
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K16246
[Presentation] Age-related enhancement of cellular stresses and lipotoxicity exacerbates dietary steatohepatitis in mice.2019
- Author(s)
  Ishizuka K, Kon K, Lee HC, Arai K, Uchiyama A, Fukuo H, Yamashina S, Yokomizo T, Ikejima K.
- Organizer
  American Association for the Study of Liver Disease (AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09440
[Presentation] 脂肪酸不飽和化酵素FADS2欠損マウスにおける脂質プロファイル異常2019
- Author(s)
  李賢哲、李慶賢、平形寿彬、横溝岳彦
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K16246
[Presentation] 高度不飽和脂肪酸欠乏時における脂質関連遺伝子発現の変動2019
- Author(s)
  李慶賢、李賢哲、横溝岳彦
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K16246
[Presentation] Regulatory mechanism of expression of polyunsaturated fatty acids-related genes2019
- Author(s)
  李慶賢、李賢哲、横溝岳彦
- Organizer
  第60回国際脂質生物科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16246
[Presentation] N-アシルリン脂質代謝酵素ABHD4の生化学的解析および脂質解析2016
- Author(s)
  李賢哲
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H06600

1. Orita Hajime (50465069)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 小林敏之 (40260070)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Kon Kazuyoshi (30398672)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 池嶋健一 (20317382)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 小松雅明 (90356254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 和栗聡 (30244908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 杉浦悠毅 (30590202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 千葉麻子 (40532726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 福永哲 (20245731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 波田野琢 (60338390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. FUJIWARA Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. HAMA Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 奥野利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 横溝岳彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
16. 多田昇弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 横山和明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 石村亮輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 寺島雅典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 楠原正俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 佐伯和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 曽友深

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Lee h 李 賢哲

LEE Hyeon-Cheol 李 賢哲

Research Projects

Research Products

Co-Researchers

極長鎖脂肪酸をターゲットとした新規抗癌治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ドコサヘキサエン酸選択的細胞内輸送経路の生理的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism elucidation for influences of the Parkinson disease after appendectomy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of enhanced hepatotoxicity through fatty acid metabolic imbalance in the progression of fatty liver disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anticancer treatment targeted fot VLCFA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Selective autophagy-mediated cellular regulations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of physiological roles of fatty acyl species of late endosome-specific phospholipid BMPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The impact of lipid composition alteration via beta-oxidation failure on the pathophysiological linkage between nonalcoholic steatohepatitis and sarcopenia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of docosahexaenoic acids in late-endosome specific phospholipid BMPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy2020

Author(s)

Journal Title

DOI

Data Source

Lee h 李賢哲

LEE Hyeon-Cheol 李賢哲

[Journal Article] 【生理活性脂質とアレルギー炎症】脂肪酸由来の脂質メディエーターによるアレルギー炎症の制御2018