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Lee h  李 賢哲

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… Alternative Names

LEE Hyeon-Cheol  李 賢哲

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Researcher Number 30758321
Other IDs
Affiliation (Current) 2022: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2016 – 2022: 順天堂大学, 医学部, 助教
2015: 順天堂大学, 医学(系)研究科(研究院), ポスドク
Review Section/Research Field
Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related / Biological pharmacy
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Gastroenterology / Biological Sciences / Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
後期エンドソーム / BMP / DHA / ドコサヘキサエン酸 / PUFA / リン脂質 / 脂質 / DPAn-6 / DPA / 脂肪酸組成 / 高度不飽和脂肪酸 … More
Except Principal Investigator
… More 非アルコール性脂肪肝炎 / 脂肪毒性 / 酸化ストレス / 極長鎖脂肪酸 / 消化器癌 / ペルオキシソーム / ジェントロジー / サルコペニア / リピドミクス / ヘパトカイン / 脂質代謝 / 肝線維化 / 非アルコール脂肪肝炎 / ユビキチン化 / ジエントロジー / ジェロントロジー / 脂質 / 老化 / 筋肝連関 / 胃癌 / 大腸癌 / 副腎白質ジストロフィー / AOM/DSS / 脂肪酸合成酵素 / ガスダミンD / 癌治療、予防 / マルチモードオートファジー / オートファジー / マクロオートファジー / 選択的オートファジー / UFM1システム / p62 / 液―液相分離 / KEAP1 / ユビキチン / 液ー液相分離 / 液-液相分離 / NCoR1 / 脂肪酸不飽和化酵素 / PTEN / 肝癌 / 自然免疫 / アミノ酸 / 肝がん / 脂質合成 / 抗酸化物質 / 脂肪酸代謝 / アルコール性肝障害 / 脂肪酸伸長酵素 / パーキンソン病 / 慢性虫垂炎 / αシニクレイン / ASシード / 虫垂炎 / αシヌクレイン / 脂肪酸合成蛋白 Less
  • Research Projects

    (9 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (24 People)
  •  極長鎖脂肪酸をターゲットとした新規抗癌治療戦略

    • Principal Investigator
      折田 創
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  ドコサヘキサエン酸選択的細胞内輸送経路の生理的意義の解明Principal Investigator

    • Principal Investigator
      李 賢哲
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Juntendo University
  •  Mechanism elucidation for influences of the Parkinson disease after appendectomy

    • Principal Investigator
      福永 哲
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  Mechanism of enhanced hepatotoxicity through fatty acid metabolic imbalance in the progression of fatty liver disease

    • Principal Investigator
      今 一義
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Juntendo University
  •  Anticancer treatment targeted fot VLCFA

    • Principal Investigator
      Orita Hajime
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  Selective autophagy-mediated cellular regulations

    • Principal Investigator
      小松 雅明
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  Elucidation of physiological roles of fatty acyl species of late endosome-specific phospholipid BMPPrincipal Investigator

    • Principal Investigator
      LEE-OKADA Hyeon-Cheol
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Juntendo University
  •  The impact of lipid composition alteration via beta-oxidation failure on the pathophysiological linkage between nonalcoholic steatohepatitis and sarcopenia

    • Principal Investigator
      Kon Kazuyoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Functional analysis of docosahexaenoic acids in late-endosome specific phospholipid BMPPrincipal Investigator

    • Principal Investigator
      LEE Hyeon-Cheol
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Biological pharmacy
    • Research Institution
      Juntendo University

All 2021 2020 2019 2018 2016

All Journal Article Presentation

  • [Journal Article] Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice2021

    • Author(s)
      Y. Hayashi, HC. Lee-Okada, E. Nakamura, N. Tada, T. Yokomizo, Y. Fujiwara, I. Ichi
    • Journal Title

      FEBES Letters

      Volume: Accepted Pages: 1920-1932

    • DOI

      10.1002/1873-3468.14134

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K02383, KAKENHI-PROJECT-21H04798, KAKENHI-PROJECT-18K02252, KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-21K08565, KAKENHI-PROJECT-19KK0199
  • [Journal Article] Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids2021

    • Author(s)
      Lee-Okada Hyeon-Cheol、Hama Kotaro、Yokoyama Kazuaki、Yokomizo Takehiko
    • Journal Title

      The Journal of Biochemistry

      Volume: 170 Pages: 389-397

    • DOI

      10.1093/jb/mvab054

    • NAID

      40022721885

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H04798, KAKENHI-PROJECT-19K11777, KAKENHI-PROJECT-20K08218, KAKENHI-PROJECT-21K08565, KAKENHI-PROJECT-19KK0199
  • [Journal Article] Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability2020

    • Author(s)
      Gemma Aragones, Kalavathi Dasuri, Opeoluwa Olukorede, Sarah G Francisco, Carol Renneburg, et al.
    • Journal Title

      Aging Cell

      Volume: 19

    • DOI

      10.1111/acel.13257

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06549, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611
  • [Journal Article] A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy2020

    • Author(s)
      Cabrera-Serrano Macarena、Coote David Joseph、Azmanov Dimitar、Goullee Hayley、Andersen Erik、McLean Catriona、Davis Mark、Ishimura Ryosuke、Stark Zornitza、Vallat Jean-Michel、Komatsu Masaaki、Kornberg Andrew、Ryan Monique、Laing Nigel G、Ravenscroft Gina
    • Journal Title

      J Med Genet.

      Volume: - Pages: 835-842

    • DOI

      10.1136/jmedgenet-2019-106496

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K15061, KAKENHI-PROJECT-20K16161
  • [Journal Article] Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice2020

    • Author(s)
      Ishizuka Kei、Kon Kazuyoshi、Lee‐Okada Hyeon‐Cheol、Arai Kumiko、Uchiyama Akira、Yamashina Shunhei、Yokomizo Takehiko、Ikejima Kenichi
    • Journal Title

      journal of gastroenterology and hepatology

      Volume: In press Pages: 1437-1448

    • DOI

      10.1111/jgh.15006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-17K09440, KAKENHI-PROJECT-20K17032
  • [Journal Article] Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence2020

    • Author(s)
      Kaji S, Irino T, Kusuhara M, Makuuchi R, Yamakawa Y, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Kami K, Ohashi Y, Zhang S, Orita H, Lee-Okada HC, Fukunaga T, Terashima M.
    • Journal Title

      Gastric Cancer

      Volume: - Pages: 874-883

    • DOI

      10.1007/s10120-020-01065-5

    • NAID

      40022329548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-19K09227, KAKENHI-PROJECT-19KK0199, KAKENHI-PROJECT-18H02627
  • [Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.2020

    • Author(s)
      Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
    • Journal Title

      Life Sci Alliance.

      Volume: 3 Pages: 201900513-201900513

    • DOI

      10.26508/lsa.201900513

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-16H06276
  • [Journal Article] Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis2019

    • Author(s)
      Lee H. C., Tominaga M., Yasukawa K., Ohba M., Takahashi N., Honda K., Okuno T., Takamori K., Yokomizo T.
    • Journal Title

      Journal of Dermatological Science

      Volume: 95 Pages: 130-133

    • DOI

      10.1016/j.jdermsci.2019.07.010

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07357, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-16K08596, KAKENHI-PROJECT-18K16246
  • [Journal Article] Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses.2019

    • Author(s)
      Hirakata T., Lee H. C., Ohba M., Saeki K., Okuno T., Murakami A., Matsuda A., Yokomizo T.
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 3392-3403

    • DOI

      10.1096/fj.201801805r

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08596, KAKENHI-PROJECT-18K06923, KAKENHI-PROJECT-18K16246, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-15K08316
  • [Journal Article] Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation2019

    • Author(s)
      Zhang Shun、Kohira Yoshinori、Orita Hajime、Ishimine Momoko、Kobayashi Toshiyuki、Buendia Chua Sharlyn Mae、Nakaoka Hirofumi、Inoue Ituro、Hino Okio、Yokomizo Takehiko、Fukunaga Tetsu、Lee-Okada Hyeon-Cheol
    • Journal Title

      BPB Reports

      Volume: 2 Pages: 130-133

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Journal Article] 【生理活性脂質とアレルギー炎症】 脂肪酸由来の脂質メディエーターによるアレルギー炎症の制御2018

    • Author(s)
      平形 寿彬、李 賢哲、横溝 岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 69 Pages: 569-575

    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Journal Article] Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond2018

    • Author(s)
      Shin Myungsun、Ware Timothy B.、Lee Hyeon-Cheol、Hsu Ku-Lung
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 907-921

    • DOI

      10.1016/j.bbalip.2018.08.007

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Presentation] 三連四重極型質量分析計を用いた簡便な遊離脂肪酸測定法の開発とその応用2021

    • Author(s)
      李賢哲
    • Organizer
      第46回日本医用マススペクトル学会
    • Data Source
      KAKENHI-PROJECT-21K08565
  • [Presentation] カルボキシルエステラーゼ2の消化器癌における発現調節機構の解明2020

    • Author(s)
      張 順、伊志嶺 百々子、小平 佳典、折田 創、小林 敏之、樋野 興夫、横溝 岳彦、福永 哲、李 賢哲
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Presentation] C型肝炎治療薬ソホスブビルのカルボキシルエステラーゼ阻害活性の検討2020

    • Author(s)
      李 賢哲、伊志嶺 百々子、横溝 岳彦
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Presentation] Age-related enhancement of cellular stresses and lipotoxicity exacerbates dietary steatohepatitis in mice.2019

    • Author(s)
      Ishizuka K, Kon K, Lee HC, Arai K, Uchiyama A, Fukuo H, Yamashina S, Yokomizo T, Ikejima K.
    • Organizer
      American Association for the Study of Liver Disease (AASLD) Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09440
  • [Presentation] 脂肪酸不飽和化酵素FADS2欠損マウスにおける脂質プロファイル異常2019

    • Author(s)
      李 賢哲、李 慶賢、平形 寿彬、横溝 岳彦
    • Organizer
      第61回 日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Presentation] 高度不飽和脂肪酸欠乏時における脂質関連遺伝子発現の変動2019

    • Author(s)
      李 慶賢、李 賢哲、横溝 岳彦
    • Organizer
      第61回 日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Presentation] Regulatory mechanism of expression of polyunsaturated fatty acids-related genes2019

    • Author(s)
      李 慶賢、李 賢哲、横溝 岳彦
    • Organizer
      第60回 国際脂質生物科学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16246
  • [Presentation] N-アシルリン脂質代謝酵素ABHD4の生化学的解析および脂質解析2016

    • Author(s)
      李賢哲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-15H06600
  • 1.  Orita Hajime (50465069)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 2.  小林 敏之 (40260070)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  Kon Kazuyoshi (30398672)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  池嶋 健一 (20317382)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  小松 雅明 (90356254)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  和栗 聡 (30244908)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  杉浦 悠毅 (30590202)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  千葉 麻子 (40532726)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  福永 哲 (20245731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  波田野 琢 (60338390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  ICHI Ikuyo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  FUJIWARA Yoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  HAMA Kotaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  奥野 利明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 15.  横溝 岳彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 16.  多田 昇弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  横山 和明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  石村 亮輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  寺島 雅典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  楠原 正俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  佐伯 和子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  曽 友深
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  小池 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  高橋 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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