Umemura Atsushi 楳村敦詩

Researcher Number	30759585
Other IDs
Affiliation (Current)	2022: 京都府立医科大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help	2021: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2020: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2019: 京都府立医科大学, 医学(系)研究科(研究院), 学内講師 2015 – 2016: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Tumor biology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝癌 / p62 / NRF2 / mTOR / 癌 / 医療・福祉 / シグナル伝達 / 肝細胞癌 / EGFR / 慢性肝障害 … More / Glucocorticoid receptor / ERRFI1 / MIG6 / NASH / ホノキオール / 肝発癌 / 慢性肝障 / HCC Less

The development of NASH-HCC prevention targeting EGFRPrincipal Investigator
- Principal Investigator
  
  Umemura Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
The role of p62 in the HCC initiation and progressionPrincipal Investigator
- Principal Investigator
  
  Umemura Atsushi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2021 2020 2019 2017 2016 2015

All Journal Article Presentation

[Journal Article] Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress.2021
- Author(s)
  Okuda K, Umemura A, Kataoka S, Yano K, Takahashi A, Okishio S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Nakagawa H, Liu Y, Mitsumoto Y, Kanbara Y, Shima T, Okanoue T, Itoh Y.
- Journal Title
  
  Front Oncol.
  
  Volume: 11 Pages: 758549-758549
- DOI
  10.3389/fonc.2021.758549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08377, KAKENHI-PROJECT-20K08337
[Journal Article] Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis2021
- Author(s)
  Okuda Keiichiro、Umemura Atsushi、Umemura Shiori、Kataoka Seita、Taketani Hiroyoshi、Seko Yuya、Nishikawa Taichiro、Yamaguchi Kanji、Moriguchi Michihisa、Kanbara Yoshihiro、Arbiser Jack L.、Shima Toshihide、Okanoue Takeshi、Karin Michael、Itoh Yoshito
- Journal Title
  
  Cancers (Basel) .
  
  Volume: 13 Pages: 1515-1515
- DOI
  10.3390/cancers13071515
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08377, KAKENHI-PROJECT-20K08337
[Journal Article] Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells.2021
- Author(s)
  Kataoka S, Umemura A, Okuda K, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, Shima T, Okanoue T, Itoh Y.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22 Pages: 13354-13354
- DOI
  10.3390/ijms222413354
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08377, KAKENHI-PROJECT-20K08337
[Journal Article] ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.2017
- Author(s)
  Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M.
- Journal Title
  
  Cancer Letters
  
  Volume: 29 Pages: 52-61
- DOI
  10.1016/j.canlet.2017.04.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-15K09017, KAKENHI-PROJECT-16K10512, KAKENHI-PROJECT-15K19040
[Journal Article] Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease2017
- Author(s)
  Mitsuyoshi H, Yasui K, Hara T, Taketani H, Ishiba H, Okajima A, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Minami M, Itoh Y.
- Journal Title
  
  Hepatology Research
  
  Volume: - Pages: 1459-1468
- DOI
  10.1111/hepr.12883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-26461016, KAKENHI-PROJECT-15K09017
[Journal Article] 肝細胞癌とオートファジー2016
- Author(s)
  楳村敦詩、山口寛二、Michael Karin、伊藤義人
- Journal Title
  
  肝胆膵
  
  Volume: 73 Pages: 201-206
- Data Source
  KAKENHI-PROJECT-15H06547
[Journal Article] Current status and future prospects of chemotherapy for advanced hepatocellular carcinoma.2016
- Author(s)
  Moriguchi M, Umemura A, Itoh Y.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 9 Pages: 184-190
- DOI
  10.1007/s12328-016-0670-7
- Data Source
  KAKENHI-PROJECT-15H06547
[Journal Article] Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression.2016
- Author(s)
  Seko Y, Sumida Y, Tanaka S, Mori K, Taketani H, Ishiba H, Hara T, Okajima A, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Kanemasa K, Yasui K, Imai S, Shimada K, Itoh Y.
- Journal Title
  
  Hepatol Res
  
  Volume: -
- DOI
  10.1111/hepr.12840
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-15K09017
[Journal Article] NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.2016
- Author(s)
  Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR,McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.
- Journal Title
  
  Cell
  
  Volume: 164(5) Pages: 896-910
- DOI
  10.1016/j.cell.2015.12.057
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547
[Journal Article] Genome-wide DNA methylation analysis in hepatocellular carcinoma.2016
- Author(s)
  Yamada N, Yasui K, Dohi O, Gen Y, Tomie A, Kitaichi T, Iwai N, Mitsuyoshi H, Sumida Y, Moriguchi M, Yamaguchi K, Nishikawa T, Umemura A, Naito Y, Tanaka S, Arii S, Itoh Y.
- Journal Title
  
  Oncol Rep
  
  Volume: 35 Pages: 2228-2236
- DOI
  10.3892/or.2016.4619
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09017, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-15H06547
[Presentation] グルタミン代謝は肝線維化および肝癌の治療・予防標的になり得る2021
- Author(s)
  楳村敦詩
- Organizer
  第107回消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K08377
[Presentation] 治療・予防法の確立を目指したNASH背景肝における発癌機構の解明2020
- Author(s)
  楳村　敦詩
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08377
[Presentation] EGFRをターゲットとしたNASH発癌予防法の探求2019
- Author(s)
  楳村　敦詩
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08377
[Presentation] The Effect of mTORC1 Inhibition on NAFLD and subsequent HCC Development2016
- Author(s)
  Atsushi Umemura, Yoshito Itoh, Michael Karin.
- Organizer
  The international congress 2016, European Association for the Study of the Liver (EASL)
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547
[Presentation] 肝発癌・進展における，mTORC1およびp62-Nrf2シグナルの役割2016
- Author(s)
  楳村敦詩、山口寛二、伊藤義人
- Organizer
  第52回日本肝臓学会総会（幕張）
- Place of Presentation
  幕張
- Year and Date
  2016-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547
[Presentation] p62, a Key Regulator for Initiation and Development of HCC2015
- Author(s)
  Atsushi Umemura, Yoshito Itoh, Maria T. Diaz-Meco, Jorge Moscat, and Michael Karin
- Organizer
  AASLD Liver meeting 2015
- Place of Presentation
  Moscone Center in San Francisco
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547
[Presentation] 肝癌および慢性肝疾患の病態におけるmTORC1阻害の影響2015
- Author(s)
  楳村敦詩、山口寛二、伊藤義人
- Organizer
  第41回日本肝臓学会西部会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15H06547

1. MINAMI Masahito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. NISHIKAWA Taichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 安居幸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 小西英幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 玄泰行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Umemura Atsushi 楳村 敦詩

Research Projects

Research Products

Co-Researchers

The development of NASH-HCC prevention targeting EGFRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of p62 in the HCC initiation and progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 肝細胞癌とオートファジー2016

Author(s)

Journal Title

Data Source

[Journal Article] Current status and future prospects of chemotherapy for advanced hepatocellular carcinoma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide DNA methylation analysis in hepatocellular carcinoma.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] グルタミン代謝は肝線維化および肝癌の治療・予防標的になり得る2021

Author(s)

Organizer

Data Source

[Presentation] 治療・予防法の確立を目指したNASH背景肝における発癌機構の解明2020

Author(s)

Organizer

Data Source

[Presentation] EGFRをターゲットとしたNASH発癌予防法の探求2019

Author(s)

Organizer

Data Source

[Presentation] The Effect of mTORC1 Inhibition on NAFLD and subsequent HCC Development2016

Author(s)

Organizer

Umemura Atsushi 楳村敦詩