ARAI JUN 荒井潤

… Alternative Names

Jun Arai 荒井潤

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Researcher Number	30766176
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2026: 愛知医科大学, 医学部, 准教授 2023 – 2024: 愛知医科大学, 医学部, 准教授 2020 – 2023: 昭和大学, 医学部, 講師 2019: 昭和大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator NK細胞 / NKp30 / B7H6 / 自然免疫 / 抗腫瘍免疫 / 癌免疫療法 / レゴラフェニブ / ADAM9 / レチノイド / ロイコトリエン拮抗薬 / 癌免疫 / 肝細胞癌 / MICA … More Except Principal Investigator … More NK細胞 / 腫瘍 / 自然免疫 / 肝癌 / シェダ－ぜ阻害薬 / シェダーゼ阻害薬 / 大規模化合物ライブラリ / シェダーゼ阻害 / MICA / がん薬物療法 / 新規薬剤開発 / 肝細胞癌 Less

B7-H6を標的としたMASHの病態進展を抑制する新規治療法開発Principal Investigator
- Principal Investigator
  
  荒井潤
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Aichi Medical University
モノクローナル抗体を用いた自然免疫の賦活化による新規抗腫瘍治療法の開発Principal Investigator
- Principal Investigator
  
  荒井潤
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Medical University
Exploration of Novel Therapeutic Agents Based on Sheddase Inhibition of the Hepatocarcinoma Susceptibility Gene MICA
- Principal Investigator
  
  Tawada Akinobu
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba Prefectural University of Health Sciences
  Chiba University
Development of anticancer therapy targeting ADAM9 and NK cells in HCCPrincipal Investigator
- Principal Investigator
  
  Jun Arai
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Showa University

All 2025 2024 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease2025
- Author(s)
  Arai Jun、Okumura Akinori、Kimoto Satoshi、Sakamoto Kazumasa、Kitada Tomoya、Kitano Rena、Inoue Tadahisa、Nishimura Sayaka、Inden Noriko、Muraki Yukiko、Kato Naoya、Ito Kiyoaki
- Journal Title
  
  Hepatology International
  
  Volume: - Issue: 4 Pages: 836-845
- DOI
  10.1007/s12072-025-10800-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27577, KAKENHI-PROJECT-23K06657
[Journal Article] Deciphering the dual nature of the Fibrosis‐4 index in predicting hepatocellular carcinoma risk among hepatitis B patients undergoing nucleos(t)ide analog therapy2024
- Author(s)
  Arai Jun、Ito Kiyoaki
- Journal Title
  
  Hepatology Research
  
  Volume: 54 Issue: 2 Pages: 120-121
- DOI
  10.1111/hepr.13997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06657, KAKENHI-PROJECT-23K24323
[Journal Article] Natural killer group?2D‐major histocompatibility complex class?I polypeptide‐related sequence?A activation enhances natural killer cell‐mediated immunity against hepatocellular carcinoma: A review2024
- Author(s)
  Arai Jun、Okumura Akinori、Kato Naoya、Ito Kiyoaki
- Journal Title
  
  Hepatology Research
  
  Volume: 54 Issue: 5 Pages: 420-428
- DOI
  10.1111/hepr.14038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06657
[Journal Article] Current status of medical oncology in Japan and changes over the most recent 7-year period: results of a questionnaire sent to designated cancer care hospitals2021
- Author(s)
  Arai Makoto、Tawada Akinobu、Takiguchi Yuichi et al
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 51 Issue: 11 Pages: 1622-1627
- DOI
  10.1093/jjco/hyab135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08561
[Journal Article] Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding2021
- Author(s)
  Arai J, Goto K, Otoyama Y, Nakajima Y, Sugiura I, Kajiwara A, Tojo M, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Nozawa H, Nakagawa R, Muroyama R, Kato N, Yoshida H.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 70 Issue: 1 Pages: 203-213
- DOI
  10.1007/s00262-020-02660-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03633, KAKENHI-PROJECT-18K07996, KAKENHI-PROJECT-19K16723
[Journal Article] Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma2021
- Author(s)
  Ao Junjie、Tawada Akinobu、Kato Naoya et al
- Journal Title
  
  Journal of Cancer
  
  Volume: 12 Issue: 9 Pages: 2694-2701
- DOI
  10.7150/jca.56436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08276
[Journal Article] Rapid Response to Pembrolizumab in a Chemo-Refractory Testicular Germ Cell Cancer with Microsatellite Instability-High2021
- Author(s)
  Kawai Koji、Tawada Akinobu、Miyazaki Jun et al
- Journal Title
  
  OncoTargets and Therapy
  
  Volume: Volume 14 Pages: 4853-4858
- DOI
  10.2147/ott.s323898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08412
[Journal Article] Decreased expression of interferon‐stimulated genes in B cells of patients with chronic hepatitis C during interferon‐free therapy potentially suggests the eradication of hepatitis C virus in the B cells: A cohort study2020
- Author(s)
  Arai Jun、Ito Takayoshi、Shimozuma Yuu、Uchikoshi Manabu、Nakajima Yoko、Sakaki Masashi、Uozumi Shojiro、Kajiwara Atsushi、Sugiura Ikuya、Otoyama Yumi、Nozawa Hisako、Kurihara Toshikazu、Eguchi Junichi、Nomura Norihiro、Sakuma Dai、Sato Masashi、Deguchi Yoshio、Yoshida Hitoshi
- Journal Title
  
  Health Science Reports
  
  Volume: 3 Issue: 3 Pages: 1-10
- DOI
  10.1002/hsr2.176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16723
[Journal Article] Laparoscopic Treatment of a Hepatoduodenal Ligament Schwannoma With Infrared Indocyanine Green Fluorescence2020
- Author(s)
  Tomioka K, Aoki T, Koizumi T, Elewa A, Kusano T, Matsuda K, Nogaki K, Tashiro Y, Wada Y, Hakozaki T, Shibata H, Hirai T, Yamazaki T, Saito K, Enami Y, Sugiura I, Nakajima Y, Arai J, Kajiwara A, Uozumi S, Shimozuma YU, Uchikoshi M, Sakaki M, Yoshida H, Miura S, Murakami M
- Journal Title
  
  In Vivo
  
  Volume: 34 Issue: 4 Pages: 2037-2041
- DOI
  10.21873/invivo.12004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08658, KAKENHI-PROJECT-19K12848, KAKENHI-PROJECT-19K16723
[Journal Article] Three cases of histologically proven hepatic epithelioid hemangioendothelioma evaluated using a second-generation microbubble contrast medium in ultrasonography: case reports2019
- Author(s)
  Jun Arai, Yuu Shimozuma, Yumi Otoyama, Ikuya Sugiura, Yoko Nakajima, et al
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 19 Issue: 1 Pages: 187-194
- DOI
  10.1186/s12876-019-1113-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16723
[Presentation] INT-767の作用機序に基づいた胆汁酸誘導体による新規抗HBV薬の開発2024
- Author(s)
  奥村彰規、荒井潤、池田和由、山下ユキコ、井口裕介、横川真梨子、梅澤一夫、宇根瑞穂、大澤匡範、伊藤清顕
- Organizer
  第110回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] Development of novel anti-HBV drugs based on AI technology using bile acid derivatives to inhibit HBV and NTCP binding2024
- Author(s)
  Akinori Okumura, Kazuyoshi Ikeda, Jun Arai, Kazumasa Sakamoto, Yukiko Muraki, Sayaka Nishimura, Noriko Inden, Mariko Yokogawa, Yukiko Yamashita, Yusuke Iguchi, Hirofumi Ohashi, Koichi Watashi, Takaji Wakita, Mizuho Une, Masanori Osawa, Kiyoaki Ito
- Organizer
  2024 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] The prediction of advanced pathogenesis in MASLD by natural killer activating receptor ligands2024
- Author(s)
  Jun Arai, Akinori Okumura, Kazumasa Sakamoto, Satoshi Kimoto, Tomoya Kitada, Naoya Kato, Kiyoaki Ito
- Organizer
  第32回日本消化器病関連学会JDDW2024
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] Development of a novel anti-HBV agent using bile acid derivatives that inhibit the binding of HBV and NTCP / HBVとNTCPの結合を阻害する胆汁酸誘導体による新規抗HBV薬の開発2024
- Author(s)
  奥村彰規、荒井潤、伊藤清顕
- Organizer
  第60回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] B型肝炎ウイルス侵入を阻害する胆汁酸誘導体INT-767のpreS1結合様式の解析2024
- Author(s)
  奥村彰規、荒井潤、伊藤清顕
- Organizer
  第9回Gastro-PLUS
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease2024
- Author(s)
  Jun Arai, Akinori Okumura, Satoshi Kimoto, Kazumasa Sakamoto, Tomoya Kitada, Rena Kitano, Tadahisa Inoue, Yukiko Muraki, Sayaka Nishimura, Noriko Inden, Naoya Kato, Kiyoaki Ito
- Organizer
  APASL Oncology 2024 Chiba
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] 胆汁アルコールとその誘導体による抗HBV作用の検討2024
- Author(s)
  奥村彰規、村木由起子、井口裕介、荒井潤、山下ユキコ、西村さやか、位田法子、宇根瑞穂、伊藤清顕
- Organizer
  第45回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] The efficacy of measuring natural killer activating receptor ligands to predict the pathogenesis of MASLD2024
- Author(s)
  Jun Arai, Akinori Okumura, Satoshi Kimoto, Kazumasa Sakamoto, Tomoya Kitada, Mayu Ibusuki, Rena Kitano, Tadahisa Inoue, Yukiko Muraki, Sayaka Nishimura, Noriko Inden, Naoya Kato, Kiyoaki Ito
- Organizer
  The Liver Meeting 2024 (AASLD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] Novel monoclonal antibody and ADAM17 enzymatic inhibitor could induce NK cell-mediated cytotoxicity in HCC by targeting NKG2D ligands2023
- Author(s)
  Jun Arai, Kazumasa Sakamoto, Akinori Okumura, Mayu Ibusuki, Rena Kitano, Satoshi Kimoto, Tadahisa Inoue, Yuji Kobayashi, Yukiomi Nakade, Naoya Kato and Kiyoaki Ito
- Organizer
  APASL ONCOLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06657
[Presentation] レチノイン酸による肝発癌感受性分子MICAの制御効果2020
- Author(s)
  音山裕美,荒井潤,杉浦育也,中島陽子,梶原敦,市川雪,魚住祥二郎,下間祐,打越学,坂木理,後藤覚,中川良,室山良介,加藤直也,吉田仁
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K16723
[Presentation] レゴラフェニブ治療が大腸癌に与えるNK細胞活性化シグナルへの影響2020
- Author(s)
  荒井潤,後藤覚,音山裕美,杉浦育也,中島陽子,梶原敦,市川雪,魚住祥二郎,下間祐,打越学,坂木理,中川良,室山良介,加藤直也,吉田仁
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K16723
[Presentation] ADAM9酵素活性阻害によるMICA-NK axisを標的とした肝癌治療戦略2020
- Author(s)
  荒井潤,後藤覚,音山裕美,杉浦育也,中島陽子,梶原敦,市川雪,魚住祥二郎,下間祐,打越学,坂木理,中川良,室山良介,加藤直也,吉田仁
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K16723
[Presentation] 肝発癌感受性分子MICAの切断阻害を目的としたADAM9酵素活性抑制薬の探索2020
- Author(s)
  音山裕美,荒井潤,吉田仁
- Organizer
  第43回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-19K16723

1. Tawada Akinobu (10596159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 室山良介 (50549459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MURAKAMI Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 加藤直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 青木武士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田代良彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 榎並延太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ARAI JUN 荒井 潤

Jun Arai 荒井 潤

Research Projects

Research Products

Co-Researchers

B7-H6を標的としたMASHの病態進展を抑制する新規治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

モノクローナル抗体を用いた自然免疫の賦活化による新規抗腫瘍治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of Novel Therapeutic Agents Based on Sheddase Inhibition of the Hepatocarcinoma Susceptibility Gene MICA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anticancer therapy targeting ADAM9 and NK cells in HCCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deciphering the dual nature of the Fibrosis‐4 index in predicting hepatocellular carcinoma risk among hepatitis B patients undergoing nucleos(t)ide analog therapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Natural killer group?2D‐major histocompatibility complex class?I polypeptide‐related sequence?A activation enhances natural killer cell‐mediated immunity against hepatocellular carcinoma: A review2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current status of medical oncology in Japan and changes over the most recent 7-year period: results of a questionnaire sent to designated cancer care hospitals2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid Response to Pembrolizumab in a Chemo-Refractory Testicular Germ Cell Cancer with Microsatellite Instability-High2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased expression of interferon‐stimulated genes in B cells of patients with chronic hepatitis C during interferon‐free therapy potentially suggests the eradication of hepatitis C virus in the B cells: A cohort study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Laparoscopic Treatment of a Hepatoduodenal Ligament Schwannoma With Infrared Indocyanine Green Fluorescence2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three cases of histologically proven hepatic epithelioid hemangioendothelioma evaluated using a second-generation microbubble contrast medium in ultrasonography: case reports2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] INT-767の作用機序に基づいた胆汁酸誘導体による新規抗HBV薬の開発2024

ARAI JUN 荒井潤

Jun Arai 荒井潤