Zaharieva Elena ZAHARIEVA ELENA

Researcher Number	30766697
Affiliation (based on the past Project Information) *help	2020: 広島大学, 原爆放射線医科学研究所, 特任助教 2020: 広島大学, 原爆放射線医科学研究所, 研究員 2019: 広島大学, 原爆放射線医科学研究所, Specially Appointed Assistant Professor 2017 – 2018: 広島大学, 原爆放射線医科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related Except Principal Investigator Risk sciences of radiation and chemicals / Health science and related fields
Keywords	Principal Investigator chronic radiation / low dose/low dose rate / endothelial cells / cardiovascular disease / atherosclerosis / monocyte adhesion / low dose rate radiation / heart disease risk / endothelial dysfunction / chronic inflammation … More / endothelial senescence / cardio-vascular disease / low dose radiation / inflammatory cytokines / adhesion molecules / radiation … More Except Principal Investigator 放射線発がん / 低線量・低線量率 / 細胞老化 / 遺伝子改変マウス / 低線量、低線量率 / 低線量 / 老化 / SASP / 健康寿命延伸 / 放射線持続照射 / モデルマウス / 細胞老化関連分泌物質 / 細胞老化関連分泌形質(SASP) / 細胞老化関連分泌物質(SASP) / 細胞老化関連分泌形質（SASP） Less

Development of mice model for elucidating the mechanism of healthy life expectancy extension
- Principal Investigator
  
  Kamiya Kenji
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  Health science and related fields
- Research Institution
  Hiroshima University
Mechanisms of low-dose/low-dose-rate radiation-induced cardiovascular diseasePrincipal Investigator
- Principal Investigator
  
  Zaharieva Elena
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
A novel study on the mechanisms of low-dose radiation-induced aging and carcinogenesis
- Principal Investigator
  
  Kamiya Kenji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Kinetics of DNA Repair Under Chronic Irradiation at Low and Medium Dose Rates in Repair Proficient and Repair Compromised Normal Fibroblasts2021
- Author(s)
  Zaharieva Elena、Sasatani Megumi、Kamiya Kenji
- Journal Title
  
  Radiation Research
  
  Volume: 197 Pages: 332-349
- DOI
  10.1667/rade-21-00158.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20310
[Journal Article] Formation of DNA Damage Foci in Human and Mouse Primary Fibroblasts Chronically Exposed to Gamma Radiation at 0.1 mGy/min2021
- Author(s)
  Zaharieva Elena、Sasatani Megumi、Matsumoto Ryoga、Kamiya Kenji
- Journal Title
  
  Radiation Research
  
  Volume: in press
- DOI
  10.1667/rade-20-00059.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-20K21846, KAKENHI-PROJECT-17H00785
[Journal Article] Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.2021
- Author(s)
  Meng Qingmei、Zaharieva Elena Karamfilova、Sasatani Megumi、Kobayashi Junya
- Journal Title
  
  Redox Report
  
  Volume: 26 Pages: 160-169
- DOI
  10.1080/13510002.2021.1971363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-20K12162
[Journal Article] Formation of DNA damage foci in human and mouse primary fibroblasts chronically exposed to gamma radiation at 0.1mGy/min2021
- Author(s)
  Zaharieva Elena, Sasatani Megumi, Matsumoto Ryoga, Kamiya Kenji
- Journal Title
  
  Radiation Research
  
  Volume: in print Pages: 1-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18194
[Journal Article] The in vivo role of Rev1 in mutagenesis and carcinogenesis2020
- Author(s)
  Sasatani Megumi、Zaharieva Elena Karamfilova、Kamiya Kenji
- Journal Title
  
  Genes and Environment
  
  Volume: 42 Pages: 9-9
- DOI
  10.1186/s41021-020-0148-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-18K18194
[Journal Article] Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK22020
- Author(s)
  Cao L.、Wang M.、Dong Y.、Xu B.、Chen J.、Ding Y.、Qiu S.、Li L.、Zaharieva E.K.、Zhou X.、Xu Y.
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Pages: 1-10
- DOI
  10.1038/s41419-020-2336-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18194
[Journal Article] Serial image changes in ultrasonography after the excision of benign breast lesions by mammotome biopsy system2019
- Author(s)
  Ding Yu、Cao Lili、Chen Ju、Zaharieva Elena Karamfilova、Xu Yanbin、Li Liang
- Journal Title
  
  Saudi Journal of Biological Sciences
  
  Volume: 26 Pages: 178-182
- DOI
  10.1016/j.sjbs.2018.08.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18194
[Journal Article] Inflammatory profile dysregulation in nuclear workers occupationally exposed to low-dose gamma radiation2019
- Author(s)
  Aneva, N., Zaharieva, E., Katsarska, O., Savova, G., Stankova, K., Djounova, J., Boteva, R.
- Journal Title
  
  J. of Radiation Research
  
  Volume: 60 Pages: 768-779
- DOI
  10.1093/jrr/rrz059
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18194
[Presentation] Effects of dose, dose rate and repair capacity on the formation and resolution of DNA damage foci under conditions of chronic irradiation2021
- Author(s)
  Elena Zaharieva, Megumi Sasatani, Kenji Kamiya, Effects of dose, dose rate and repair capacity on the formation and resolution of DNA damage foci under conditions of chronic irradiation
- Organizer
  International Conference on Radiation Applications
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] ApcMin/+マウスでは小児期における被ばくが放射線発がんに高感受性を示す2021
- Author(s)
  笹谷めぐみ、ZAHARIEVA Elena、神谷研二
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Investigation of radiation dose rate effect on loss of heterozygosity in mouse F1 hybrid embryonic stem cells2021
- Author(s)
  Matsui Ako, Sasatani Megumi, Zaharieva Elena, Kamiya Kenji
- Organizer
  The 5th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Investigation of radiation dose rate effect on loss of heterozygosity in mouse F1 hybrid embryonic stem cells2021
- Author(s)
  Ako Matsui, Megumi Sasatani, Elena Zaharieva, Kenji Kamiya
- Organizer
  The 5th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] The effect of dose rate on intestinal adenoma development in ApcMin/+ mice2020
- Author(s)
  Megumi Sasatani, Elena Zaharieva, Kenji Kamiya
- Organizer
  4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] マウスモデルを用いた放射線発がんの機構解明2020
- Author(s)
  神代紗央理、笹谷めぐみ、Elena K Zaharieva、松井亜子、神谷研二
- Organizer
  第45回中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] The effect of dose rate on intestinal adenoma development in ApcMin/+ mice2020
- Author(s)
  Megumi Sasatani, Elena Zaharieva, Kenji, Kamiya
- Organizer
  4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] The effect of age at exposure on radiation-induced carcinogenesis in ApcMin/+ mice2020
- Author(s)
  Megumi Sasatani, Elena Karamfilova Zaharieva, Saori Kakomi, Ako Matsui and Kenji Kamiya
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] マウスモデルを用いた放射線発がんの機構解明2020
- Author(s)
  神代紗央理、笹谷めぐみ、Elena K Zaharieva、松井亜子、神谷研二
- Organizer
  第45回中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] DNA damage and oxidative stress in primary murine fibroblasts subjected to acute or chronic gamma radiation.2020
- Author(s)
  Zaharieva, E., Sasatani, M., Kamiya, K.
- Organizer
  The 60th Annual Research Conference of Atomic Bomb Disease
- Data Source
  KAKENHI-PROJECT-18K18194
[Presentation] Investigation of radiation dose rate effect on loss of heterozygosity in mouse F1 hybrid embryonic stem cells2020
- Author(s)
  Matsui Ako, Sasatani Megumi, Zaharieva Elena, Kamiya Kenji
- Organizer
  The 5th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-18K18194
[Presentation] The effect of age at exposure on radiation-induced carcinogenesis in ApcMin/+ mice2020
- Author(s)
  Megumi Sasatani, Elena Karamfilova Zaharieva, Saori Kakomi, Ako Matsui and Kenji Kamiya
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Differential Radiation Dose Rate Effects in Primary Murine Fibroblasts isolated from Kidney, Lung and Small Intestine2019
- Author(s)
  Elena Zaharieva, Megumi Sasatani, Kenji Kamiya
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2019
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2019
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Estimation of radiation-induced cancer risk at low doses and low dose rates using ApcMin/+ mice2019
- Author(s)
  Megumi Sasatani, Daisuke Iizuka, Hidehiko Kawai, Elena Zaharieva, Kenji Kamiya
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Differential Radiation Dose Rate Effects in Primary Murine Fibroblasts isolated from Kidney, Lung and Small Intestine2019
- Author(s)
  Elena Zaharieva, Megumi Sasatani, Kenji Kamiya
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Response of primary murine fibroblasts to low-dose-rate versus acute gamma radiation exposures.2019
- Author(s)
  Zaharieva, E., Sasatani, M., Kamiya, K.
- Organizer
  Joint QST-NIRS Workshop (to advance France-Japan collaboration in Radiation Research)
- Data Source
  KAKENHI-PROJECT-18K18194
[Presentation] Effects of dose-rate on the radiation response of primary fibroblasts2019
- Author(s)
  Zaharieva, E., Sasatani, M., Kamiya, K.
- Organizer
  16th International Congress of Radiation Research
- Data Source
  KAKENHI-PROJECT-18K18194
[Presentation] Estimation of radiation-induced cancer risk at low doses and low dose rates using ApcMin/+ mice2019
- Author(s)
  Megumi Sasatani, Daisuke Iizuka, Hidehiko Kawai, Elena Zaharieva, Kenji Kamiya
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2018
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 持続的DNA損傷に対する細胞応答の解析2018
- Author(s)
  河合秀彦, 笹谷めぐみ, ザハリエバエレナ, 紙谷浩之, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2018
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 持続的DNA損傷に対する細胞応答の解析2018
- Author(s)
  河合秀彦, 笹谷めぐみ, ザハリエバエレナ, 紙谷浩之, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Oxidative stress and DNA damage in primary murine fibroblasts subjected to acute or chronic gamma radiation2018
- Author(s)
  Zaharieva, E., Sasatani, M., Kamiya, K.
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-18K18194
[Presentation] ガンマ線持続照射環境を用いた細胞運命制御メカニズムの解析2017
- Author(s)
  河合秀彦、曹麗麗、笹谷めぐみ、ザハリエバエレナ、金井昭教、稲葉俊哉、神谷研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] ApcMin/+マウスを用いた低線量、低線量率放射線発がんリスク評価の試みとその腫瘍解析2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Elena　Zaharieva, 神谷研二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] マウス個体を用いた低線量率放射線被ばくの生物影響について2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  第42回中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] ガンマ線持続照射環境を用いた細胞運命制御メカニズムの解析2017
- Author(s)
  河合秀彦、曹麗麗、笹谷めぐみ、ザハリエバエレナ、金井昭教、稲葉俊哉、神谷研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Inflammatory response in primary human endothelial cells subjected to acute or protracted gamma irradiation2017
- Author(s)
  Zaharieva E, Kawai H, Inaba T, Matsuura S, Kamiya K
- Organizer
  第58回原爆後障害研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた低線量、低線量率放射線発がんリスク評価2017
- Author(s)
  笹谷　めぐみ、飯塚　大輔、河合　秀彦、Zaharieva Elena、神谷　研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 持続的なDNA損傷による生物影響の網羅的解析研究2017
- Author(s)
  河合秀彦、笹谷めぐみ、ザハリエバエレナ、紙谷浩之、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Apc Min/+マウスを用いた低線量、低線量率放射線発がんリスク評価2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 遺伝的背景が放射線発がん高感受性モデルマウスの腫瘍形成に与える影響について2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第58回原子爆弾後障害研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異の検出2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異の検出.2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Inflammatory response to acute and chronic gamma irradiation in primary human endothelial cells.2017
- Author(s)
  Elena Zaharieva, Hidehiko Kawai, Megumi Sasatani, Toshiya Inaba, Shinya Matsuura, Kenji Kamiya
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 持続的なDNA損傷による生物影響の網羅的解析研究2017
- Author(s)
  河合秀彦、笹谷めぐみ、ザハリエバエレナ、紙谷浩之、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] ApcMin/+マウスを用いた低線量、低線量率放射線発がんリスク評価の試みとその腫瘍解析2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Elena　Zaharieva, 神谷研二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-20K20310

1. Kamiya Kenji (60116564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 37 results
2. 河合秀彦 (30379846)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
3. 笹谷めぐみ (80423052)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 林田耕臣 (10882061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 神代紗央理 (60882058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 長町安希子 (20585153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 本庶仁子 (80614106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TOYOSHIMA Megumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 37 results
9. 小林純也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zaharieva Elena ZAHARIEVA ELENA

Research Projects

Research Products

Co-Researchers

Development of mice model for elucidating the mechanism of healthy life expectancy extension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of low-dose/low-dose-rate radiation-induced cardiovascular diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel study on the mechanisms of low-dose radiation-induced aging and carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Kinetics of DNA Repair Under Chronic Irradiation at Low and Medium Dose Rates in Repair Proficient and Repair Compromised Normal Fibroblasts2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Formation of DNA Damage Foci in Human and Mouse Primary Fibroblasts Chronically Exposed to Gamma Radiation at 0.1 mGy/min2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Formation of DNA damage foci in human and mouse primary fibroblasts chronically exposed to gamma radiation at 0.1mGy/min2021

Author(s)

Journal Title

Data Source

[Journal Article] The in vivo role of Rev1 in mutagenesis and carcinogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK22020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serial image changes in ultrasonography after the excision of benign breast lesions by mammotome biopsy system2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammatory profile dysregulation in nuclear workers occupationally exposed to low-dose gamma radiation2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Effects of dose, dose rate and repair capacity on the formation and resolution of DNA damage foci under conditions of chronic irradiation2021

Author(s)

Organizer

Data Source

[Presentation] ApcMin/+マウスでは小児期における被ばくが放射線発がんに高感受性を示す2021

Author(s)

Organizer

Data Source

[Presentation] Investigation of radiation dose rate effect on loss of heterozygosity in mouse F1 hybrid embryonic stem cells2021

Author(s)

Organizer

Data Source

[Presentation] Investigation of radiation dose rate effect on loss of heterozygosity in mouse F1 hybrid embryonic stem cells2021

Author(s)

Organizer

Data Source

[Presentation] The effect of dose rate on intestinal adenoma development in ApcMin/+ mice2020

Author(s)

Organizer