Yoshinaga Tsuneaki 吉長恒明

Researcher Number	30770226
Other IDs	https://orcid.org/0000-0002-4323-0557
Affiliation (based on the past Project Information) *help	2016 – 2018: 信州大学, 学術研究院医学系(医学部附属病院), 助教
Review Section/Research Field	Principal Investigator Kidney internal medicine / Pathological medical chemistry
Keywords	Principal Investigator アミロイドーシス / 腎アミロイドーシス / フィブリノーゲン / 遺伝性アミロイドーシス / フィブリノーゲン型アミロイドーシス / 蛋白質 / 細胞・組織 / プロテオーム

Elucidation of molecular pathogenesis of AFib amyloidosis and therapeutic developmentPrincipal Investigator
- Principal Investigator
  
  Yoshinaga Tsuneaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
  Pathological medical chemistry
- Research Institution
  Shinshu University

All 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Monitoring treatment response to tafamidis by serialnative T1 and extracellular volume in transthyretinamyloid cardiomyopathy2019
- Author(s)
  Shintani Yasuhiro、Okada Atsushi、Morita Yoshiaki、Hamatani Yasuhiro、Amano Masashi、Takahama Hiroyuki、Amaki Makoto、Hasegawa Takuya、Ohta-Ogo Keiko、Kanzaki Hideaki、Ishibashi-Ueda Hatsue、Yasuda Satoshi、Shimazaki Chihiro、Yoshinaga Tsuneaki、Yazaki Masahide、Sekijima Yoshiki、Izumi Chisato
- Journal Title
  
  ESC Heart Fail
  
  Volume: 6 Pages: 232-236
- DOI
  10.1002/ehf2.12382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08739, KAKENHI-PROJECT-16K21066
[Journal Article] Late-onset Transthyretin (TTR)-familial Amyloid Polyneuropathy (FAP) with a Long Disease Duration from Non-endemic Areas in Japan2019
- Author(s)
  Miyake Z, Nakamagoe K, Ezawa N, Yoshinaga T, Hashimoto R, Sato T, Sekijima Y, Tamada A
- Journal Title
  
  Internal Medicine
  
  Volume: 58 Issue: 5 Pages: 214-216
- DOI
  10.2169/internalmedicine.1457-18
- NAID
  130007606248
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21066
[Journal Article] Nationwide survey on cerebrotendinous xanthomatosis in Japan2018
- Author(s)
  Sekijima Y, Koyama S, Yoshinaga T, Koinuma M, Inaba Y.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Pages: 271-280
- DOI
  10.1038/s10038-017-0389-4
- Data Source
  KAKENHI-PROJECT-16K21066
[Journal Article] Visualisation of multiple organ amyloid involvement in systemic amyloidosis using 11C-PiB-PET imaging2018
- Author(s)
  Ezawa N, Katoh N, Oguchi K, Yoshinaga T, Yazaki M, Sekijima Y
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 45 Pages: 452-461
- DOI
  10.1007/s00259-017-3814-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08739, KAKENHI-PROJECT-16K21066, KAKENHI-PROJECT-15K09336
[Journal Article] Hereditary Fibrinogen Aα-chain amyloidosis in Asia: clinical andmolecular characteristics.2018
- Author(s)
  Yazaki M、Yoshinaga T、Sekijima Y、Kametani F、Okumura N
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 19 Pages: 320-320
- DOI
  10.3390/ijms19010320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08739, KAKENHI-PROJECT-16K21066, KAKENHI-PROJECT-17K09009
[Journal Article] Cardiac Amyloidosis Associated With Amyloidogenic Transthyretin V122I Variant in an Elderly Japanese Woman2017
- Author(s)
  Yoshinaga T, Yazaki M, 他4名
- Journal Title
  
  Circulation Journal
  
  Volume: 81 Issue: 6 Pages: 839-894
- DOI
  10.1253/circj.cj-16-1202
  10.1253/circj.CJ-16-1202
- NAID
  130005679610
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08739, KAKENHI-PROJECT-16K21066, KAKENHI-PROJECT-15K09336
[Journal Article] A novel frameshift mutation of SYNE1 in a Japanese family with autosomal recessive cerebellar ataxia type 82017
- Author(s)
  Yoshinaga T, Nakamura K, Ishikawa M, Yamaguchi T, Takano K, Wakui K, Kosho T, Yoshida K, Fukushima Y, Sekijima Y
- Journal Title
  
  Human Genome Variation
  
  Volume: 4 Pages: 17052-17052
- DOI
  10.1038/hgv.2017.52
- Open Access
- Data Source
  KAKENHI-PROJECT-16K21066
[Journal Article] Marked biochemical difference in amyloid proportion between intra- and extraocular tissues in a liver-transplanted patient with hereditary ATTR amyloidosis2017
- Author(s)
  Yoshinaga T, Yazaki M, Kametani F, Sekijima Y, Iesato Y, Miyahara T, Tsuchiya-Suzuki A, Sano K, Higuchi K, Ikeda SI.
- Journal Title
  
  Amyloid
  
  Volume: 13 (1) Pages: 17-23
- DOI
  10.1080/13506129.2016.1276055
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293084, KAKENHI-PROJECT-26670152, KAKENHI-PROJECT-16K21066, KAKENHI-PROJECT-17K08739, KAKENHI-PROJECT-15K09336
[Journal Article] 日本人で見出された遺伝性腎アミロイドーシス2016
- Author(s)
  吉長　恒明、矢崎　正英
- Journal Title
  
  医学のあゆみ
  
  Volume: 258 Pages: 739-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21066
[Journal Article] Carpal tunnel syndrome: a common initial symptom of systemic wild-type ATTR (ATTRwt)2016
- Author(s)
  Nakagawa M, Sekijima Y, Yazaki M, Tojo K, Yoshinaga T, Doden T, Koyama J,
- Journal Title
  
  Amyloid
  
  Volume: 23 Pages: 58-63
- DOI
  10.3109/13506129.2015.1135792
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461275, KAKENHI-PROJECT-15K09336, KAKENHI-PROJECT-16K21066
[Journal Article] Primary AL amyloidosis presenting with systemic lymphadenopathy with calcification2016
- Author(s)
  Fujita T, Ichikawa S, Okitsu Y, Fukuhara N, Yoshinaga T, Yazaki M, Harigae H
- Journal Title
  
  International Journal of Hematology
  
  Volume: 104 Pages: 641-643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21066
[Journal Article] 第Ⅹ因子欠乏症を伴って再燃した原発性マクログロブリン血症2016
- Author(s)
  大原　慎、荻原　政夫、華　見、井上　盛浩、内田　智之、吉長　恒明、矢崎　正英、関島　良樹、亀谷　富由樹
- Journal Title
  
  臨床血液
  
  Volume: 57 Pages: 359-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21066
[Journal Article] Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis2016
- Author(s)
  Sekijima Y, Yazaki M, Oguchi K, Ezawa N, Yoshinaga T, Yamada M, Yahikozawa H, Watanabe M, Kametani F, Ikeda SI
- Journal Title
  
  Neurology
  
  Volume: 87 Pages: 773-781
- DOI
  10.1212/wnl.0000000000003001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09336, KAKENHI-PROJECT-16K21066
[Journal Article] The pathological and biochemical identification of possibleseed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation2016
- Author(s)
  Yoshinaga, T, Yazaki M, Sekijima Y, Kametani F, Miyashita K, Hachiya N, Tanaka T, Koaudo N, Higuchi K, Ikeda S.
- Journal Title
  
  Journal of Pathology Clinical Research
  
  Volume: 1 Pages: 72-79
- DOI
  10.1002/cjp2.36
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26660176, KAKENHI-PROJECT-26670152, KAKENHI-PROJECT-25461275, KAKENHI-PROJECT-26293084, KAKENHI-PROJECT-15K09336, KAKENHI-PROJECT-16K21066
[Presentation] ドミノ移植後レシピエントにおける医原性アミロイドーシスの臨床病理学的検討（第2報）2018
- Author(s)
  吉長　恒明, 矢崎　正英, 亀谷　富由樹, 関島　良樹
- Organizer
  第59回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] 消化管アミロイドーマ患者から同定した野生型シスタチンC型アミロイドーシス(第2報)2018
- Author(s)
  吉長恒明、矢崎正英、上原剛、亀谷富由樹、小松修、関島良樹
- Organizer
  第6回日本アミロイドーシス研究会
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] A Wild-Type Cystatin Type C Amyloidosis Identified from Gastrointestinal Amyloidoma2018
- Author(s)
  T.Yoshinaga, M.Yazaki, F.Kametani, O, Komatsu, Y.Sekijima
- Organizer
  The 16th International symposium on amyloidosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] 肝腎精巣アミロイドーシスを呈した遺伝性AApoA1 型アミロイドーシスの一例2018
- Author(s)
  吉長恒明、加藤修明、上野賢一、佐藤充人、矢崎正英、亀谷富由樹、安田日出夫、渡邉恭平、関島良樹
- Organizer
  第142回信越地方会
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] 本邦初の遺伝性アミロイドーシス患者の同定：Lasermicrodissection(LMD)を用いたアミロイド蛋白解析の有効性2018
- Author(s)
  吉長　恒明, 加藤　修明 , 矢崎　正英, 関島　良樹
- Organizer
  第115回日本内科学会総会
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] Production and biochemical analysis of mutated fibrinogen Aα produced by CHO cells with Δ523 AGTC in FGA ‘Japan original mutation’2018
- Author(s)
  T Yoshinaga, M Yazaki, Y Sekijima, F Kametani, N Okumura
- Organizer
  The 16th International symposium on amyloidosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] Clinicopathological characterizations of transmitted transthyretin amyloidosis after domino liver transplantation: a single-center experience2016
- Author(s)
  T Yoshinaga, M Yazaki, Y Sekijima, T. Ikegami, S Miyagawa, S Ikeda
- Organizer
  ⅩⅤth International Synposium on Amyloidosis
- Place of Presentation
  Uppsala Konsert＆Kongress, Uppsala, Sweden
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] The first pathological and biochemical identification of seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation2016
- Author(s)
  T Yoshinaga, M Yazaki, Y Sekijima, F Kametani, N Hachiya, K Higuchi, S Ikeda
- Organizer
  ⅩⅤth International Synposium on Amyloidosis
- Place of Presentation
  Uppsala Konsert＆Kongress, Uppsala, Sweden
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] The first Ostertag type amyloidosis in Japan : a sporadic case of hereditary fibrinogen amyloidosis associated with a novel frameshift variant2016
- Author(s)
  M Yazaki, T Yoshinaga, Y Sekijima, F Kametani, S Nishio, Y Kanizawa, S Ikeda
- Organizer
  ⅩⅤth International Synposium on Amyloidosis
- Place of Presentation
  Uppsala Konsert＆Kongress, Uppsala, Sweden
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] ドミノ移植後アミロイドーシスの臨床病理学的検討　一施設検討2016
- Author(s)
  吉長恒明、矢崎正英、関島良樹、亀谷富由樹、池田修一
- Organizer
  第4回日本アミロイドーシス研究会学術集会
- Place of Presentation
  ＫＫＲホテル東京
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] De novo amyloidosis(医原性FAP)における生化学的解析とその臨床像2016
- Author(s)
  吉長恒明、矢崎正英、関島良樹、亀谷富由樹、池田修一
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K21066
[Presentation] ドミノ肝移植レシピエントにおける医原性アミロイドーシスの臨床生化学的検討2016
- Author(s)
  吉長恒明、矢崎正英、関島良樹、亀谷富由樹、池田修一
- Organizer
  第34回日本神経治療学会総会
- Place of Presentation
  米子コンベンションセンター
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K21066

1. Okumura Nobuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. Yazaki Masaide

# of Collaborated Projects: 1 results

# of Collaborated Products: 31 results
3. SEKIJIMA Yoshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. SUZUKI Kayo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KAMETANI Kiyokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 樋口京一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 亀谷富由樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 八谷如美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshinaga Tsuneaki 吉長 恒明

Research Projects

Research Products

Co-Researchers

Elucidation of molecular pathogenesis of AFib amyloidosis and therapeutic developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Monitoring treatment response to tafamidis by serialnative T1 and extracellular volume in transthyretinamyloid cardiomyopathy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Late-onset Transthyretin (TTR)-familial Amyloid Polyneuropathy (FAP) with a Long Disease Duration from Non-endemic Areas in Japan2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Nationwide survey on cerebrotendinous xanthomatosis in Japan2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visualisation of multiple organ amyloid involvement in systemic amyloidosis using 11C-PiB-PET imaging2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hereditary Fibrinogen Aα-chain amyloidosis in Asia: clinical andmolecular characteristics.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiac Amyloidosis Associated With Amyloidogenic Transthyretin V122I Variant in an Elderly Japanese Woman2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] A novel frameshift mutation of SYNE1 in a Japanese family with autosomal recessive cerebellar ataxia type 82017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marked biochemical difference in amyloid proportion between intra- and extraocular tissues in a liver-transplanted patient with hereditary ATTR amyloidosis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 日本人で見出された遺伝性腎アミロイドーシス2016

Author(s)

Journal Title

Data Source

[Journal Article] Carpal tunnel syndrome: a common initial symptom of systemic wild-type ATTR (ATTRwt)2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary AL amyloidosis presenting with systemic lymphadenopathy with calcification2016

Author(s)

Journal Title

Data Source

[Journal Article] 第Ⅹ因子欠乏症を伴って再燃した原発性マクログロブリン血症2016

Author(s)

Journal Title

Data Source

[Journal Article] Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The pathological and biochemical identification of possibleseed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation2016

Author(s)

Yoshinaga Tsuneaki 吉長恒明

[Presentation] ドミノ移植後アミロイドーシスの臨床病理学的検討　一施設検討2016