Hira Asuka 平明日香

… Alternative Names

HIRA Asuka 平明日香

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Researcher Number	30772777
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 研究員
Affiliation (based on the past Project Information) *help	2015 – 2017: 京都大学, 放射線生物研究センター, 研究員
Review Section/Research Field	Principal Investigator Human genetics Except Principal Investigator Biological Sciences
Keywords	Principal Investigator フォルムアルデヒド / 骨髄不全 / ファンコニ貧血 / 小児骨髄不全 / ALDH2 / ADH5 / アルデヒド Except Principal Investigator ATRIP-ATR / クロマチン / 染色体ストレス … More / DNA複製フォーク / 非コードDNA / ファンコニ貧血 / 染色体脆弱部位 / FANCD2 / 複製フォーク / 相同組換え / DNA複製 / チェックポイント / ファンコニ貧血経路 / ゲノム安定性 / 複製ストレス Less

Identification of a novel childhood hematopoietic failure syndrome caused by combined mutations in ADH5 and ALDH2 that function in aldehyde metabolism.Principal Investigator
- Principal Investigator
  
  HIRA Asuka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human genetics
- Research Institution
  Kyoto University
Analysis of disorders defective in the mechanisms for fork stabilization
- Principal Investigator
  
  Minoru Takata
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

All 2016 2015 2013 2012 Other

All Journal Article Presentation Book

[Book] 遺伝子医学MOOK別冊　シリーズ1, 最新遺伝性腫瘍・家族性腫瘍研究と遺伝カウンセリング2016
- Author(s)
  平　明日香、稲野　将二郎、髙田　穰
- Total Pages
  328
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-16K15243
[Journal Article] The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.2016
- Author(s)
  Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M.
- Journal Title
  
  Br J Haematol.
  
  Volume: 175 Issue: 3 Pages: 457-461
- DOI
  10.1111/bjh.14243
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-26253041, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-16K15243
[Journal Article] Pluripotent cell models of Fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.2015
- Author(s)
  Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK
- Journal Title
  
  Stem Cells Transl Med
  
  Volume: 4 Issue: 4 Pages: 333-338
- DOI
  10.5966/sctm.2013-0172
- NAID
  120005980869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-15K06921, KAKENHI-PLANNED-23114010, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-26550026
[Journal Article] Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.2015
- Author(s)
  Takahashi D, Sato K, Hirayama E, Takata M, Kurumizaka H.
- Journal Title
  
  J Biochem
  
  Volume: 158 Issue: 3 Pages: 263-70
- DOI
  10.1093/jb/mvv043
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23114010, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-14J06948, KAKENHI-PROJECT-26550026
[Journal Article] Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.2015
- Author(s)
  Hira A, Yoshida K, Sato K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Shimamoto A, Tahara H, Ito E, Kojima S, Kurumizaka H, Ogawa S, Takata M, Yabe H, Yabe M.
- Journal Title
  
  Am J Hum Genet.
  
  Volume: 96(6) Issue: 6 Pages: 1001-7
- DOI
  10.1016/j.ajhg.2015.04.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PLANNED-23114010, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-26830128, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106
[Journal Article] Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.2013
- Author(s)
  Hira A, Yoshida K
- Journal Title
  
  Blood
  
  Volume: 122 Issue: 18 Pages: 3206-3209
- DOI
  10.1182/blood-2013-06-507962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04216, KAKENHI-PLANNED-23114010, KAKENHI-PROJECT-24310042, KAKENHI-PROJECT-24390262
[Presentation] Myelodysplastic syndrome and acute myeloid leukemia in Japanese Fanconi anemia patients.2016
- Author(s)
  Miharu Yabe, Tsuyoshi Morimoto, Akiko Fukumura, Keisuke Ohtsubo, Takashi Koike, Takashi Shimizu, Hiromitsu Takakura, Katsuyoshi Koh, Etsuro Ito, Seiji Kojima, Asuka Hira, Minoru Takata and Hiromasa Yabe.
- Organizer
  28th Annual Fanconi Anemia research frund Scientific Symposium.
- Place of Presentation
  Bellevue, WA USA
- Year and Date
  2016-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15243
[Presentation] Common variable immunodeficiency caused by FANC mutations.2016
- Author(s)
  Yujin Sekinaka,Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, and Shigeaki Nonoyama
- Organizer
  The 17th Biennial Meeting of the European Society for Immunodeficiencies (ESID 2016)
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15243
[Presentation] Identification of UBE2T as a novel Fanconi anemia gene.2015
- Author(s)
  Asuka Hira, Kenichi Yoshida, Koichi Sato, Akita Shimamoto, Hidetoshi Tahara, Hitoshi Kurumizaka, Seishi Ogawa, Minoru Takata, Hiromasa Yabe, Miharu Yabe.
- Organizer
  ICRR2015
- Place of Presentation
  京都国際会館
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.2015
- Author(s)
  A. Hira, K. Yoshida, K.Sato, Y. Shiraishi, K. Chiba, H. Tanaka, S. Miyano, A. Shimamoto, H.Tahara, E.Ito, S.Kojima, H. Kurumizaka, S.Ogawa, M.Takata, H.Yabe, M. Yabe
- Organizer
  The 27th Annual Fanconi anemia research fund Scientific Symposium.
- Place of Presentation
  Toronto, Canada
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] UBE2T/FANCT is a novel FA gene identified in Japanese Fanconi anemia patients.2015
- Author(s)
  Minoru Takata, Asuka Hira, Kenichi Yoshida, Koichi Sato, Akira Shimamoto, Hitoshi Kurumizaka, Seishi Ogawa, Hiromasa Yabe, and Miharu Yabe.
- Organizer
  The 16th Ataxia-Teleangiectasia Workshop.
- Place of Presentation
  Beijing, China
- Year and Date
  2015-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] “Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans”2012
- Author(s)
  Minoru Takata, Asuka Hira, Naoya Suzuki, Akira Niwa, Tatsutoshi Nakahata, Hiromasa Yabe, Megumu K. Saito, Keitaro Matsuo, Miharu Yabe
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県）
- Year and Date
  2012-11-25
- Invited
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans2012
- Author(s)
  Minoru Takata, Asuka Hira1, Naoya Suzuki, Akira Niwa, Tatsutoshi Nakahata, Hiromasa Yabe, Megumu K. Saito, Keitaro Matsuo, Miharu Yabe
- Organizer
  28th RBC-NIRS INTERNATIONAL SYMPOSIUM
- Place of Presentation
  コープイン京都（京都府）
- Year and Date
  2012-11-29
- Invited
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] UBE2T is a novel FA gene identified in Japanese Fanconi anemia patients
- Author(s)
  Minoru Takata, Asuka Hira1, Naoya Suzuki, Akira Niwa, Tatsutoshi Nakahata, Hiromasa Yabe, Megumu K. Saito, Keitaro Matsuo, Miharu Yabe
- Organizer
  The 9th 3R Symposium
- Place of Presentation
  Gotemba Kogen Hotel
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] Infant Japanese Fanconi anemia patients with the ALDH2-AA genotype.
- Author(s)
  M. Yabe, A. Hira, H, Yabe, T. Morimoto, A. Fukumura, M. Miyashita, K. Ohtsubo, K. Matsuo, M. Takata.
- Organizer
  26th Annual Fanconi Anemia Research Fund Scientific Symposium.
- Place of Presentation
  Bethesda MA, USA
- Year and Date
  2014-09-18 – 2014-09-21
- Data Source
  KAKENHI-PLANNED-23114010
[Presentation] 日本人ファンコニ貧血患者における新規原因遺伝子UBE2Tの同定
- Author(s)
  平明日香, 吉田健一, 佐藤浩一, 嶋本顕, 田原栄俊, 胡桃坂仁志, 小川誠司, 高田穣, 矢部普正, 矢部みはる
- Organizer
  第37回日本分子生物学会年会　ワークショップ
- Place of Presentation
  横浜市みなとみらいパシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PLANNED-23114010

1. Minoru Takata (30281728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. Ishiai Masamichi (90298844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SAITO Megumu (90535486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 勝木陽子 (00645377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TANAKA Hideo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. ITO Hidemi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小川勝洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 田中恵太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 田中祐吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 田中勇悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 田原栄俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hira Asuka 平 明日香

HIRA Asuka 平 明日香

Research Projects

Research Products

Co-Researchers

Identification of a novel childhood hematopoietic failure syndrome caused by combined mutations in ADH5 and ALDH2 that function in aldehyde metabolism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of disorders defective in the mechanisms for fork stabilization

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 遺伝子医学MOOK別冊 シリーズ1, 最新遺伝性腫瘍・家族性腫瘍研究と遺伝カウンセリング2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pluripotent cell models of Fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Myelodysplastic syndrome and acute myeloid leukemia in Japanese Fanconi anemia patients.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Common variable immunodeficiency caused by FANC mutations.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Identification of UBE2T as a novel Fanconi anemia gene.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] UBE2T/FANCT is a novel FA gene identified in Japanese Fanconi anemia patients.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] “Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans”2012

Author(s)

Hira Asuka 平明日香

HIRA Asuka 平明日香

[Book] 遺伝子医学MOOK別冊　シリーズ1, 最新遺伝性腫瘍・家族性腫瘍研究と遺伝カウンセリング2016