Kobayashi Alisa 小林亜利紗

Researcher Number	30773931
Other IDs
Affiliation (Current)	2021: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 研究員
Affiliation (based on the past Project Information) *help	2021: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 研究員 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, 研究員(任常) 2017 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所加速器工学部, 技術員(任常)
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 放射線誘発バイスタンダー効果 / ヒドロキシラジカル / がん細胞 / 放射線がん治療 / 肺がん / 放射線抵抗性 / 線質依存性 Except Principal Investigator マイクロビーム / 異種細胞間 / イオントラック構造 … More

Bidirectional cellular signaling between microbeam targeted cancer cells and normal cells.Ongoing
- Principal Investigator
  
  小西輝昭
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
陽子線マイクロビームを活用した重イオントラック構造依存的な細胞致死効果の解明Ongoing
- Principal Investigator
  
  大澤大輔
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
放射線誘発バイスタンダー効果による放射線抵抗性獲得機序の解明Principal InvestigatorOngoing
- Principal Investigator
  
  小林亜利紗
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Role of defensive cellular response mechanism against chromothrispsis.Ongoing
- Principal Investigator
  
  小西輝昭
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
単一細胞標的照射で誘発される細胞内酸素動態観察のための蛍光寿命顕微システムの構築Ongoing
- Principal Investigator
  
  大澤大輔
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Study on the radiation quality dependence of the bystander effect in radiation cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Kobayashi Alisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Studies on radiation induced bidirectional response between cancer and normal cells
- Principal Investigator
  
  Konishi Teruaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation2019
- Author(s)
  Narongchai Autsavapromporn , Cuihua Liu , Alisa Kobayashi , Tengku Ahbrizal Farizal Tengku Ahmad , Masakazu Oikawa , Nahathai Dukaew , Jun Wang , Ariyaphong Wongnoppavich , Teruaki Konishi
- Journal Title
  
  Radiation Research
  
  Volume: 191(2) Pages: 211-216
- DOI
  10.1667/rr15155.1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10409, KAKENHI-PROJECT-17H04268
[Journal Article] Role of Endoplasmic Reticulum and Mitochondrion in Proton Microbeam Radiation-Induced Bystander Effect2019
- Author(s)
  Dong Chen、Tu Wenzhi、He Mingyuan、Fu Jiamei、Kobayashi Alisa、Konishi Teruaki、Shao Chunlin
- Journal Title
  
  Radiation Research
  
  Volume: 193 Pages: 63-63
- DOI
  10.1667/rr15469.1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Journal Article] BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION2018
- Author(s)
  Alisa Kobayashi、Narongchai Autsavapromporn、Tengku Ahbrizal Farizal Tengku Ahmad、Masakazu Oikawa、Shino Homma-Takeda、Yoshiya Furusawa、Jun Wang、Teruaki Konishi
- Journal Title
  
  Radiation Protection Dosimetry
  
  Volume: -
- DOI
  10.1093/rpd/ncy249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16496, KAKENHI-PROJECT-17H04268
[Journal Article] Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells2018
- Author(s)
  Alisa Kobayashi、Teruaki Konishi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 59 Pages: 183-189
- DOI
  10.1093/jrr/rry065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16496, KAKENHI-PROJECT-17H04268
[Journal Article] Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling2017
- Author(s)
  Kobayashi Alisa、Tengku Ahmad Tengku Ahbrizal Farizal、Autsavapromporn Narongchai、Oikawa Masakazu、Homma-Takeda Shino、Furusawa Yoshiya、Wang Jun、Konishi Teruaki
- Journal Title
  
  Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
  
  Volume: 803-805 Pages: 1-8
- DOI
  10.1016/j.mrfmmm.2017.06.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Proton induced fluorescence microscopy of single living cells utilizing advanced microbeam irradiation system (SPICE)2020
- Author(s)
  Daisuke Ohsawa, Alisa Kobayashi, Teruaki Konishi
- Organizer
  ABiS Symposium Forefront and Future of Electron Microscopic Imaging
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Advanced microbeam technology for single cell radiation biology2019
- Author(s)
  Teruaki Konishi, Alisa Kobayashi, Daisuke Ohsawa, Masakazu Oikawa
- Organizer
  3rd QST International Symposium on Quantum Life Science, Institute for Quantum Life Science
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Activation of defensive cellular response triggered by microbeam induced cytoplasmic damage.2019
- Author(s)
  Teruaki Konishi, Alisa Kobayashi, Daisuke Ohsawa, Narongchai Autsavapormporn, Tengku Ahbrizal Farizal Tengku Ahmad, Masakazu Oikawa, Jun Wang
- Organizer
  16th International Congress of Radiation Research, International Congress of Radiation Research (ICRR2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Spatial distribution of DNA double-strand breaks from focused proton tracks in human cells following SPICE microbeam irradiation2019
- Author(s)
  Daisuke Ohsawa, Alisa Kobayashi, Teruaki Konishi
- Organizer
  3rd QST International Symposium on Quantum Life Science, Institute for Quantum Life Science, QST, 2019-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Radiation quality modulates NF-κB mediated COX-2 expression in bystander cells2019
- Author(s)
  A Kobayashi, TAFT. Ahmad, D Ohsawa, T Konishi,
- Organizer
  16th International Congress of Radiation Research, Manchester
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] Hypoxia and proton microbeams: Role of gap junction communication in inducing bystander response on human lung cancer and normal human lung cells2019
- Author(s)
  Narongchai Autsavapromporn, Cuihua Liu, Alisa Kobayashi, Tengku Ahbrizal Farizal Tengku Ahmad, Teruaki Konish
- Organizer
  16th International Congress of Radiation Research, International Congress of Radiation Research (ICRR2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] COX-2を指標とした重粒子線誘発バイスタンダー応答における線質依存性の解析2019
- Author(s)
  小林亜利紗、大澤大輔、小西輝昭
- Organizer
  日本宇宙生物科学会第33回大会
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] Advanced microbeam irradiation system for single cell analysis of defensive cellular response against radiation2019
- Author(s)
  Teruaki Konishi, Daisuke Ohsawa, Alisa Kobayashi, Masakazu Oikawa
- Organizer
  日本顕微鏡学会第６２回シンポジウム, 日本顕微鏡学会
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Radiation quality modulates NF-κB mediated COX-2 expression in bystander cells2019
- Author(s)
  Alisa Kobayashi, Teruaki Konishi, Daisuke Ohsawa, Tengku Ahbrizal Farizal Tengku Ahamd
- Organizer
  16th International Congress of Radiation Research, International Congress of Radiation Research (ICRR2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] COX-2を指標とした重粒子線誘発バイスタンダー応答における線質依存性の解析2019
- Author(s)
  小林　亜利紗, 大澤　大輔, 小西　輝昭
- Organizer
  日本宇宙生物科学会第33回大会, 一般社団法人日本宇宙生物科学会, 2019-09-21
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] 細胞質損傷を起因とした防御的細胞応答2019
- Author(s)
  小西　輝昭, 小林　亜利紗, 大澤　大輔, 及川　将一, Jun Wang
- Organizer
  日本宇宙生物科学会第33回大会, 一般社団法人日本宇宙生物科学会, 2019-09-21
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] マイクロビーム照射細胞の蛍光画像解析マクロの開発とバイスタンダー研究への応用2019
- Author(s)
  大澤大輔, 小林亜利紗, 小西輝昭
- Organizer
  日本宇宙生物科学会第33回大会, 一般社団法人日本宇宙生物科学会, 2019-09-21
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Analysis of radiation-induced bystander response between human normal cells and cancer cells using SPICE-NIRS microbeam2019
- Author(s)
  Alisa Kobayashi, Teruaki Konishi, Daisuke Ohsawa
- Organizer
  The Joint Workshop of QST-NIRS, CEA and IRSN, QST-NIRS, 2019-10-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] Analysis of radiation-induced bystander response between human normal cells and cancer cells using SPICE-NIRS microbeam2018
- Author(s)
  Alisa Kobayashi
- Organizer
  International Open Laboratory Symposium 2018
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] 放医研マイクロビーム照射装置SPICEを用いたヒト正常及びヒトがん細胞間における放射線誘発バイスタンダー細胞応答の解析2018
- Author(s)
  小林　亜利紗、Tengku Ahbrizal Farizal Tengku Ahmad 、 Narongchai Autsavapromporn、及川　将一、古澤　佳也、小西　輝昭
- Organizer
  量子生命科学研究会第２回学術集会
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] Bystander WI-38 normal lung fibroblast cells modulate DNA double-strand break repair in microbeam-targeted A549 cells through gap junction intercellular communication2017
- Author(s)
  Kobayashi A, Autsavapromporn N, Tengku Ahmad TAF, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T
- Organizer
  MICROS 2017 17th International Symposium on Microdosimetry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] 陽子線マイクロビーム照射法を利用した異種細胞間の放射線誘発細胞応答に関する研究2017
- Author(s)
  小林　亜利紗、及川　将一、古澤　佳也、武田　志乃、テングゥ　アーマッド　テングゥ　アブリザル　ファリザル、アッサワプロンポーン　ナロンチャイ、ワン　ジュン、小西　輝昭
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] Bi-directional cellular signaling between microbeam targeted cancer cells and non-targeted normal cells2017
- Author(s)
  Kobayashi A, Autsavapromporn N, Tengku Ahmad TAF, Homma-Takeda S, Furusawa Y, Wang J, Konishi
- Organizer
  1st QST International Symposium "Quantum Life Science" -The path breaking life-scientists with quantum eyes and hands. National Institutes for Quantum and Radiological Science and Technology (QST)
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] SPICE-NIRS microbeam：マイクロビームのアドバンテージを活用した放射線生物研究2017
- Author(s)
  小西　輝昭, 小林　亜利紗, 大澤　大輔, 劉　翠華, 古澤　佳也, 及川　将一
- Organizer
  日本放射線影響学会, 第60回大会、千葉、2017年10月27日
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] The Importance of the Primary-and Secondary Bystander Responses Cross-Talk between Human Lung Cancer and Lung Normal Cells after Proton Microbeam Irradiation2017
- Author(s)
  Narongchai Autsavapromporn, Alisa Kobayashi, Yoshiya Furusawa, Teruaki Konishi
- Organizer
  5th International Symposium on Space Radiation and Particle Radiotherapy, Sochow, Shianghai, 2017-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268
[Presentation] NOSとCOX-2を指標としたバイスタンダー効果因子誘発機序に対する間接作用の寄与の解析2017
- Author(s)
  小林　亜利紗、小西　輝昭
- Organizer
  日本放射線影響学会第60回学術年会
- Data Source
  KAKENHI-PROJECT-17K16496
[Presentation] Bystander WI-38 normal lung fibroblast cells modulate DNA double-strand break repair in microbeam-targeted A549 cells through gap junction intercellular communication2017
- Author(s)
  Alisa Kobayashi, Narongchai Autsavapromporn, Tengku Ahbrizal Farizal Tengku Ahmad, Masakazu Oikawa, Shino Homma-Takeda, Yoshiya Furusawa, Jun Wang, Teruaki Konishi
- Organizer
  MICROS 2017,INFN-Laboratori Nazionali di Legnaro, 2017, Nov 7th
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04268

1. Konishi Teruaki (70443067)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
2. 大澤大輔 (90324681)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 劉翠華 (00512427)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 及川将一 (10391301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. 平山亮一 (90435701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 楠本多聞 (90825499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Alisa 小林 亜利紗

Research Projects

Research Products

Co-Researchers

Bidirectional cellular signaling between microbeam targeted cancer cells and normal cells.Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

陽子線マイクロビームを活用した重イオントラック構造依存的な細胞致死効果の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

放射線誘発バイスタンダー効果による放射線抵抗性獲得機序の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of defensive cellular response mechanism against chromothrispsis.Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

単一細胞標的照射で誘発される細胞内酸素動態観察のための蛍光寿命顕微システムの構築Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the radiation quality dependence of the bystander effect in radiation cancer treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on radiation induced bidirectional response between cancer and normal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Endoplasmic Reticulum and Mitochondrion in Proton Microbeam Radiation-Induced Bystander Effect2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Proton induced fluorescence microscopy of single living cells utilizing advanced microbeam irradiation system (SPICE)2020

Author(s)

Organizer

Data Source

[Presentation] Advanced microbeam technology for single cell radiation biology2019

Author(s)

Organizer

Data Source

[Presentation] Activation of defensive cellular response triggered by microbeam induced cytoplasmic damage.2019

Kobayashi Alisa 小林亜利紗

[Presentation] マイクロビーム照射細胞の蛍光画像解析マクロの開発とバイスタンダー研究への応用2019