Harada Aiko 原田愛子 (石木愛子)

… Alternative Names

石木愛子

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Researcher Number	30778634
Other IDs
Affiliation (Current)	2025: 東北医科薬科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 東北医科薬科大学, 医学部, 助教 2021 – 2022: 東北大学, 加齢医学研究所, 非常勤講師 2016 – 2020: 東北大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic / Social brain science Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator PET / タウ / アルツハイマー病 / MAO-B / アミロイド / 神経炎症 / 血液バイオマーカー / 加齢 / アルツハイマー / グリオーシス … More / 診断 / 老年医学 / 脳・神経 / 認知症 / 日常生活動作 … More Except Principal Investigator PET / アルツハイマー病 / アストロサイト / バイオマーカー / 神経炎症 / モノアミン酸化酵素B / グリオーシス / ミスフォールディング / 神経変性疾患 / 分子イメージング Less

18F-SMBT1を用いた生理的・病的脳内神経炎症の病態解明Principal Investigator
- Principal Investigator
  
  原田愛子 (石木愛子)
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
神経炎症を生体画像化する新規画像バイオマーカーの開発研究
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku Medical and Pharmaceutical University
Development of protein-specific PET molecular imaging in neurodegenerative disorders
- Principal Investigator
  
  Yanai Kazuhiko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
Tau-Gliosis Interaction in Tauopathies using Pathological ImagingPrincipal Investigator
- Principal Investigator
  
  Harada Aiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tohoku University
association between activity of daily living and tau deposition in alzheimers diseasePrincipal Investigator
- Principal Investigator
  
  Harada Aiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Basic / Social brain science
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] 4.Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers.2023
- Author(s)
  Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Kudo K, Ezura M, Ishikawa Y, Iwata R, Shidahara M, Ishiki A, Kikuchi A, Hatano Y, Ishihara T, Onodera O, Iwasaki Y, Yoshida M, Taki Y, Arai H, Kudo Y, Yanai K, Furumoto S, Okamura N.
- Journal Title
  
  J Nucl Med
  
  Volume: 64 Issue: 9 Pages: 1495-1501
- DOI
  10.2967/jnumed.123.265593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15647, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-23K06947, KAKENHI-PROJECT-23K07069
[Journal Article] Evaluation of 18F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model2023
- Author(s)
  Morito Takahiro、Harada Ryuichi、Iwata Ren、Ishikawa Yoichi、Okamura Nobuyuki、Kudo Yukitsuka、Furumoto Shozo、Yanai Kazuhiko、Tashiro Manabu
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 6 Pages: 0287047-0287047
- DOI
  10.1371/journal.pone.0287047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-23K07069, KAKENHI-PROJECT-21K19320, KAKENHI-PROJECT-23K21420, KAKENHI-PROJECT-23K24070
[Journal Article] In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study2023
- Author(s)
  Ryota Kobayashi , Tadaho Nakamura, Fumito Naganuma, Ryuichi Harada, Daichi Morioka, Masafumi Kanoto, Shozo Furumoto, Yukitsuka Kudo, Takanobu Kabasawa, Koichi Otani, Mitsuru Futakuchi , Shinobu Kawakatsu, Nobuyuki Okamura
- Journal Title
  
  J Neuropathol Exp Neurol .
  
  Volume: - Issue: 5 Pages: 427-437
- DOI
  10.1093/jnen/nlad018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-22K07373, KAKENHI-PROJECT-22K07552, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K07922, KAKENHI-PROJECT-20K09204, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-23K06646, KAKENHI-PROJECT-23K07129, KAKENHI-PROJECT-20K07619
[Journal Article] A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model2023
- Author(s)
  Naganuma Fumito、Murata Daiki、Inoue Marie、Maehori Yuri、Harada Ryuichi、Furumoto Shozo、Kudo Yukitsuka、Nakamura Tadaho、Okamura Nobuyuki
- Journal Title
  
  Molecular Imaging and Biology
  
  Volume: 25 Issue: 6 Pages: 1115-1124
- DOI
  10.1007/s11307-023-01843-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-22K07373, KAKENHI-PROJECT-23K07069, KAKENHI-PROJECT-23K08342, KAKENHI-PROJECT-23K24070
[Journal Article] Assessing reactive astrogliosis with 18F-SMBT-1 across the Alzheimer’s disease spectrum2022
- Author(s)
  Villemagne Victor L、Harada Ryuichi、Dore Vincent、Furumoto Shozo、Mulligan Rachel、Kudo Yukitsuka、Burnham Samantha、Krishnadas Natasha、Bourgeat Pierrick、Xia Ying、Laws Simon、Bozinovski Svetlana、Huang Kun、Ikonomovic Milos D、Fripp Jurgen、Yanai Kazuhiko、Okamura Nobuyuki、Rowe Christopher C
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: - Issue: 10 Pages: 1560-1569
- DOI
  10.2967/jnumed.121.263255
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771
[Journal Article] The Role of Chirality of [18F]SMBT-1 in Imaging of Monoamine Oxidase-B2022
- Author(s)
 Harada Ryuichi、Shimizu Yuki、Du Yiqing、Ishikawa Yoichi、Iwata Ren、Kudo Yukitsuka、Yanai Kazuhiko、Okamura Nobuyuki、Furumoto Shozo
- Journal Title
 
 ACS Chemical Neuroscience
 
 Volume: 13 Issue: 3 Pages: 322-329
- DOI
 10.1021/acschemneuro.1c00655
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-23K21420
[Journal Article] Imaging of Reactive Astrogliosis by Positron Emission Tomography2022
- Author(s)
  Harada Ryuichi、Furumoto Shozo、Kudo Yukitsuka、Yanai Kazuhiko、Villemagne Victor L.、Okamura Nobuyuki
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 807435-807435
- DOI
  10.3389/fnins.2022.807435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-23K21420, KAKENHI-PROJECT-23K24070
[Journal Article] First-in-human evaluation of 18F-SMBT-1, a novel 18F-labeled MAO-B PET tracer for imaging reactive astrogliosis2022
- Author(s)
 Villemagne Victor L、Harada Ryuichi、Dore Vincent、Furumoto Shozo、Mulligan Rachel、Kudo Yukitsuka、Burnham Samantha、Krishnadas Natasha、Bozinovski Svetlana、Huang Kun、Lopresti Brian J、Yanai Kazuhiko、Rowe Christopher C、Okamura Nobuyuki
- Journal Title
 
 Journal of Nuclear Medicine
 
 Volume: - Issue: 10 Pages: 1551-1559
- DOI
 10.2967/jnumed.121.263254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771
[Journal Article] 18F-THK5351 PET imaging in neurodegenerative tauopathies2021
- Author(s)
  Ezura M, Kikuchi A, Okamura N, Ishiki A, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Ishiyama S, Nakamura T, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Journal Title
  
  Front Aging Neurosci
  
  Volume: 13 Pages: 761010-761010
- DOI
  10.3389/fnagi.2021.761010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-20K07830, KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-21K19320, KAKENHI-PROJECT-18K15357, KAKENHI-PROJECT-19KK0212
[Journal Article] Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody2021
- Author(s)
  Morito Takahiro、Harada Ryuichi、Iwata Ren、Du Yiqing、Okamura Nobuyuki、Kudo Yukitsuka、Yanai Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 2588-2588
- DOI
  10.1038/s41598-021-82037-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21564, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-18H02771
[Journal Article] タンパク質医薬品開発のためのポジトロン放出核種標識タンパク質2020
- Author(s)
  原田龍一、盛戸貴裕、谷内一彦
- Journal Title
  
  日本薬理学会雑誌
  
  Volume: 155 Pages: 159-163
- NAID
  130007839036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0212
[Journal Article] 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging2020
- Author(s)
  Harada Ryuichi、Hayakawa Yoshimi、Ezura Michinori、Lerdsirisuk Pradith、Du Yiqing、Ishikawa Yoichi、Iwata Ren、Shidahara Miho、Ishiki Aiko、Kikuchi Akio、Arai Hiroyuki、Kudo Yukitsuka、Yanai Kazuhiko、Furumoto Shozo、Okamura Nobuyuki
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 62 Issue: 2 Pages: 253-258
- DOI
  10.2967/jnumed.120.244400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-18K15357, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K07879
[Journal Article] Longitudinal changes in 18F-THK5351 PET in corticobasal syndrome2019
- Author(s)
  Ezura M, Kikuchi A, Ishiki A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Journal Title
  
  Eur J Neurol
  
  Volume: 26 Issue: 9 Pages: 1205-1211
- DOI
  10.1111/ene.13966
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-18K15538, KAKENHI-PROJECT-18H02771
[Journal Article] ポジトロン放出核種標識タンパク質の新規合成方法の開発2019
- Author(s)
  原田龍一、盛戸貴裕、谷内一彦
- Journal Title
  
  バイオインダストリー
  
  Volume: 36 Pages: 46-54
- Data Source
  KAKENHI-PROJECT-19KK0212
[Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease.2018
- Author(s)
  Harada R, Furukawa K, et al.
- Journal Title
  
  J Nucl Med
  
  Volume: 59 Issue: 4 Pages: 671-674
- DOI
  10.2967/jnumed.117.197426
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-17K20083, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-16H06621, KAKENHI-PROJECT-16H07486, KAKENHI-PROJECT-15K08127
[Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy.2017
- Author(s)
  Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
- Journal Title
  
  Eur J Neurol.
  
  Volume: 24 Issue: 1 Pages: 130-136
- DOI
  10.1111/ene.13164
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16H06621
[Journal Article] Erratum to: Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351.2017
- Author(s)
  Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
- Journal Title
  
  Eur J Nucl Med Mol Imaging
  
  Volume: 44 Pages: 177-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06621
[Patent] タウを画像化する新規化合物2019
- Inventor(s)
  原田龍一他
- Industrial Property Rights Holder
  原田龍一他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-240189
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Analysis of [18F]SMBT-1 binding to reactive astrogliosis in postmortem brain tissues from patients with Alzheimer's disease and frontotemporal lobar degeneration.2023
- Author(s)
  Okamura N, Harada R, Du Y, Yokoyama Y, Kudo Y, Tashiro M, Furumoto S.
- Organizer
  SNMMI 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] 新規タウPETトレーサー[18F]SNFT-1の前臨床評価2023
- Author(s)
  岡村信行，原田龍一，ルーッスィリスックプラディット，清水悠暉，横山裕香，堵怡青，工藤幸司，古本祥三．
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Development of a highly sensitive tau tracer 18F-SNFT-1 for imaging early tau pathology in Alzheimer’s disease2023
- Author(s)
  Okamura N, Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Ezura M, Arai H, Kudo Y, Furumoto S
- Organizer
  AD/PD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 新規PET薬剤[18F]SMBT-1を用いたAD疾患連続体の進行予後予測に関する早期観察結果.2023
- Author(s)
  田代学, 平岡宏太良, 冨田尚希, 石木愛子, TEKEA Berihu, WU Yingying, 原田龍一, 菊池飛鳥, 武田和子, 草場美津江, 菊池昭夫, 古川勝敏, 渡部浩司, 麦倉俊司, 小林良太, 川勝忍, 石井賢二, 加藤隆司, 古本祥三, 岡村信行
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15647
[Presentation] Radiosynthesis and evaluation of [18F]SNFT-1 for imaging early tau deposition2023
- Author(s)
  Ryuichi Harada, Yuki Shimizu, Pradith Lerdsirisu, Yuka Yokoyama, Aiko Ishiki, Youichi Ishikawa, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Nobuyuki Okamura, Shozo Furumoto.
- Organizer
  International Symposium of Society of Radiopharmaceutical Science 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15647
[Presentation] Development of a highly sensitive tau tracer 18F-SNFT-1 for imaging early tau pathology in Alzheimer’s disease.2023
- Author(s)
  Okamura N, Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Ezura M, Arai H, Kudo Y, Furumoto S.
- Organizer
  AD/PD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] ヒト剖検脳を用いたTDP-43型前頭側頭葉変性症における[18F]SMBT-1の有用性の検討2022
- Author(s)
  横山裕香, 原田龍一, 石川洋一, 岩田錬, 工藤幸司, 岩崎靖, 谷内一彦, 岡村信行, 古本祥三
- Organizer
  第5回日本核医学会分科会　放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 第二世代タウPETトレーサーの結合性比較2022
- Author(s)
  横山裕香，原田龍一，Pradith Lerdsirisuk，清水悠暉，堵怡青，石川洋一，工藤幸司，岡村信行，荒井啓行，谷内一彦
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] フェルラ酸誘導体のαシヌクレイン凝集・抑制効果の検討2022
- Author(s)
  原田龍一, 陳梦格, 工藤幸司, 谷内一彦, 岡村信行
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 神経炎症イメージングのための新規PET薬剤[18F]SMBT-1の動態解析（Work in Progress）2022
- Author(s)
  平岡宏太良、メスフィン・ベリフ、石岡有生、四月朔日聖一、石川洋一、船木善仁、稲村瑛仁、原田龍一、石木愛子、古本祥三、岡村信行、渡部浩司、田代学.
- Organizer
  第42回日本医学放射線学会北日本地方会／日本核医学会北日本地方会
- Data Source
  KAKENHI-PROJECT-18K15357
[Presentation] 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告20222022
- Author(s)
  田代学, 平岡宏太良, 冨田尚希, 石木愛子, 小林良太, 四月朔日聖一, メスフィン・ベリフ, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 麦倉俊司, 古川勝敏, 加藤隆司, 石井賢二, 川勝忍, 原田龍一, 古本祥三, 岡村信行.
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15357
[Presentation] アストログリオーシスを画像化するための PETプローブの開発とその応用2022
- Author(s)
  原田龍一
- Organizer
  第95回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 神経炎症モデルラットにおけるグリア線維性酸性タンパク質イメージング手法の開発2022
- Author(s)
  盛戸貴裕, 原田龍一, 岩田錬, 岡村信行, 谷内一彦
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] [18F]SNFT-1の結合選択性評価および第二世代タウPET トレーサーとのADタウに対する結合性比較2022
- Author(s)
  清水悠暉，原田龍一，横山裕香，Pradith Lerdsirisuk，石川洋一，岩田錬，工藤幸司，谷内一彦，岡村信行，古本祥三
- Organizer
  第5回日本核医学会分科会　放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告 20222022
- Author(s)
  田代学, 平岡宏太良, 平岡宏太良, 冨田尚希, 石木愛子, 小林良太, 四月朔日聖一, メスフィンベリフ, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 麦倉俊司, 古川勝敏, 加藤隆司, 石井賢二, 川勝忍, 原田龍一, 古本祥三, 岡村信行．
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Physiological uptake of [18F]SMBT-1, a new astrogliosis tracer, in whole-body organs2022
- Author(s)
  Tashiro M, Ishioka Y, Mesfin B, Watanuki S, Hiraoka K, Harada R, Furumoto S, Okamura N, Yanai K, Watabe H
- Organizer
  13th Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] レビー小体型認知症(DLB)剖検脳を用いた神経炎症PETプローブの結合性評価2022
- Author(s)
  横山裕香, 原田龍一, 石川洋一, 岩田錬, 工藤幸司, 谷内一彦, 村山繁雄, 岡村信行, 古本祥三
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告20222022
- Author(s)
  田代学, 平岡宏太良, 冨田尚希, 石木愛子, 小林良太, 四月朔日聖一, メスフィンベリフ, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 麦倉俊司, 古川勝敏, 加藤隆司, 石井賢二, 川勝忍, 原田龍一, 古本祥三, 岡村信行.
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15647
[Presentation] PETプローブを用いた神経病理画像化に関する研究2022
- Author(s)
  原田龍一
- Organizer
  第95回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Off-target結合のない新規タウPETプローブの開発2021
- Author(s)
  清水悠暉, 原田龍一, Pradith Lerdsirisuk, 堵怡青, 工藤幸司, 石川洋一, 岩田錬, 岡村信行, 谷内一彦, 古本祥三
- Organizer
  第61回日本核医学会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アストロサイト画像化を目的とした PETプローブ[18F]SMBT-1の代謝特性の検討2021
- Author(s)
  原田龍一、堵怡青、工藤幸司、岡村信行、古本祥三、谷内一彦
- Organizer
  日本分子イメージング学会・第15回総会・学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Advances in MAO-B Imaging2021
- Author(s)
  Ryuichi Harada
- Organizer
  34th Annual Congress of the European Association of Nuclear Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 前頭側頭型変性症で認めるアストロサイト様構造物に対するアミロイド・タウPETプローブの結合性評価2021
- Author(s)
  横山裕香，原田龍一，荒井啓行，工藤幸司，古本祥三，岡村信行，谷内一彦
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] ヒト剖検脳に対するMAO-B PETプローブ[18F]SMBT-1の結合2021
- Author(s)
  原田龍一、堵怡青、横山裕香、古本祥三、工藤幸司、荒井啓行、畠野雄也4 、石原智彦4 、小野寺理、吉田眞理、北本哲之、岩崎靖、谷内一彦、岡村信行
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 嗜銀顆粒性認知症に対するPETバイオマーカーの探索2021
- Author(s)
  原田龍一，堵恰青， Pradith Lerdsirisuk, 工藤幸司，古本祥三，岡村信行，谷内一彦
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Amyloid, tau and reactive astrocytosis imaging in aging and Alzheimer’s disease2021
- Author(s)
  Victor L Villemagne Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, and Nobuyuki Okamura
- Organizer
  ADPD2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 第二世代タウPETトレーサーの結合性の比較2021
- Author(s)
  原田龍一，Pradith Lerdsirisuk，清水悠暉，堵怡青，石川洋一, 荒井啓行, 工藤幸司，岩田錬, 谷内一彦，古本祥三，岡村信行
- Organizer
  第61回日本核医学会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アミロイド・タウPETプローブのアストロサイト様構造物に対する結合性評価2021
- Author(s)
  横山裕香, 原田龍一, 荒井啓行, 工藤幸司, 古本祥三, 岡村信行&, 谷内一彦
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] オフターゲット結合を示さない高感度タウPETプローブの開発2021
- Author(s)
  原田龍一，Pradith Lerdsirisuk，清水悠暉，堵怡青，石川洋一, 荒井啓行, 工藤幸司，谷内一彦，岩田錬, 古本祥三，岡村信行
- Organizer
  放射性薬品科学研究会2021
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 反応性アストロサイトを標的としたPET プローブ [18F]SMBT-12021
- Author(s)
  原田龍一, 工藤幸司, 荒井啓行, 田代学, 古本祥三, 岡村信行, 谷内一彦
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] PHFタウへの感度・特異度に優れた新規タウプローブ[18F]SNFT-1の開発2021
- Author(s)
  岡村信行、原田龍一、清水悠暉、Pradith Lerdsirisuk、堵怡青、石川洋一、荒井啓行、谷内一彦、工藤幸司、古本祥三
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 健常者を対象としたPET診断薬18F-SMBT-1の全身臓器における生理的集積の観察2021
- Author(s)
  石岡有生、四月朔日聖一、平岡宏太良、石川洋一、船木善仁、原田龍一、岡村信行、荒井啓行、古本祥三、谷内一彦、渡部浩司、田代学
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Development and Identification of [18F]SNFT-1 (THK-5562), a Promising Candidate for Selective Tau PET Tracer in Alzheimer’s Disease2020
- Author(s)
  Pradith Lerdsirisuk, Ryuichi Haradac, Yuki Shimizub, Yiqing Du, Yoichi Ishikawa, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Nobuyuki Okamurab, Shozo Furumoto
- Organizer
  EANM2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Preclinical characterization of [18F]THK-5562, a novel tau PET tracer with little off-target binding2020
- Author(s)
  Harada R, Lerdsirisuk P, Du Y, Ezura M, Shimizu Y, Morito T, Arai H, Yanai K,Kudo Y, Furumoto S, Okamura N
- Organizer
  HUMAN AMYLOID IMAGING CONFERENCE 2020（マイアミ）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Development of 18F-SNFT1, a novel tau PET tracer with little off-target binding2020
- Author(s)
  Aiko Ishiki, Ryuichi Harada, Pradith Lerdsirisuk, Yiqing Du, Michinori Ezura, Kazuhiko Yanai, Shozo Furumoto, Yukitsuka Kudo, Hiroyuki Arai, Nobuyuki Okamura
- Organizer
  Alzheimer Association International conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15357
[Presentation] Evaluation of the novel 18F-labeled PET tracer SMBT-1 for imaging astrogliosis in healthy elderly controls and in Alzheimer’s disease2020
- Author(s)
  Victor L Villemagne Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, and Nobuyuki Okamura
- Organizer
  AAIC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Monoamine oxidase-B for Imaging of Reactive Astrocytes2020
- Author(s)
  原田龍一
- Organizer
  第60回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Preclinical characterization of [18F]THK-5562, a novel tau PET tracer with little off-target binding.2020
- Author(s)
  Ryuichi Harada
- Organizer
  14th Human Amyloid Imaging
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15357
[Presentation] Discovery and evaluation of a novel tau PET tracer [F-18]THK-5562 for Alzheimer's disease2020
- Author(s)
  Du Y, Harada R, Lerdsirisuk P, Ezura M, Shimizu Y, Morito T, Arai H, Kudo Y, Furumoto S, Yanai K
- Organizer
  第93回日本薬理学会（横浜）
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Assessing Abe-a, tau, and reactive astrocytosis in aging and AD2020
- Author(s)
  Victor L Villemagne, Ryuichi Harada, Kazuhiko Yanai, et al.
- Organizer
  HUMAN AMYLOID IMAGING CONFERENCE 2020（マイアミ）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Discovery of [18F]SMBT-1: a novel selective MAO-B PET tracer for imaging astrogliosis.2019
- Author(s)
  Ryuichi Harada
- Organizer
  13th Human Amyloid Imaging
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15357
[Presentation] 脳内PETイメージングに向けたBBB透過性ペプチド融合affibodyの薬物動態2019
- Author(s)
  盛戸貴裕、原田龍一、堵怡青、岩田錬、古本祥三、谷内一彦
- Organizer
  第70回日本薬理学会北部会（札幌）
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アストロサイトのPETトレーサー2019
- Author(s)
  原田龍一
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] [18F]THK-5351 accumulation in patients with Alzheimer’s disease.2017
- Author(s)
  Aiko Ishiki, Katsutoshi Furukawa, Naoki Tomita, Ryuichi Harada, Nobuyuki Okamura, Yukitsuka Kudo, Hiroyuki Arai
- Organizer
  Alzheimer’s Association International Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06621

1. 古本祥三 (00375198)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
2. 岡村信行 (40361076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
3. 原田龍一 (60735455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 45 results
4. Yanai Kazuhiko (50192787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
5. KIKUCHI Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 古川勝敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田代学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harada Aiko 原田 愛子 (石木 愛子)

石木愛子

Research Projects

Research Products

Co-Researchers

18F-SMBT1を用いた生理的・病的脳内神経炎症の病態解明Principal Investigator

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神経炎症を生体画像化する新規画像バイオマーカーの開発研究

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Development of protein-specific PET molecular imaging in neurodegenerative disorders

Principal Investigator

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Tau-Gliosis Interaction in Tauopathies using Pathological ImagingPrincipal Investigator

Principal Investigator

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association between activity of daily living and tau deposition in alzheimers diseasePrincipal Investigator

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[Journal Article] 4.Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers.2023

Author(s)

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DOI

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[Journal Article] Evaluation of 18F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model2023

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Journal Title

DOI

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[Journal Article] In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model2023

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Journal Title

DOI

Data Source

[Journal Article] Assessing reactive astrogliosis with 18F-SMBT-1 across the Alzheimer’s disease spectrum2022

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DOI

Data Source

[Journal Article] The Role of Chirality of [<sup>18</sup>F]SMBT-1 in Imaging of Monoamine Oxidase-B2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Imaging of Reactive Astrogliosis by Positron Emission Tomography2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First-in-human evaluation of <sup>18</sup>F-SMBT-1, a novel <sup>18</sup>F-labeled MAO-B PET tracer for imaging reactive astrogliosis2022

Author(s)

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[Journal Article] 18F-THK5351 PET imaging in neurodegenerative tauopathies2021

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Data Source

Harada Aiko 原田愛子 (石木愛子)