Tokuyama Takeshi 徳山剛士

… Alternative Names

徳山剛士トクヤマタケシ

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Researcher Number	30808093
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 自治医科大学, 医学部, 助教 2021: 自治医科大学, 医学部, ポスト・ドクター 2019: 東京薬科大学, 生命科学部, 嘱託助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator ミトコンドリア形態異常 / 疾患iPS / BOLA3 / ミトコンドリア心筋症 / ミトコンドリア形態制御 / ミトコンドリア / 心不全 / ミトコンドリアダイナミクス / 疾患モデリング / iPSC … More / 心筋症 / ミトコンドリア病 / ミトコンドリア創薬 / 疾患iPS細胞 / MITOL/MARCH5 / 心疾患 / MITOL / 心臓老化 / ユビキチンリガーゼ / ミトコンドリア動態 / 遺伝子治療 / Drp1 / MITOL / MARCH5 / 心筋梗塞 / 老化 Less

疾患iPS・モデル動物を用いたBOLA3変異ミトコンドリア心筋症の新規病態機構の解明Principal Investigator
- Principal Investigator
  
  徳山剛士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Jichi Medical University
Study of the Pathological Significance of Enlarged Mitochondria in BOLA3 Mutations Using iPSCs.Principal Investigator
- Principal Investigator
  
  Tokuyama Takeshi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Jichi Medical University
Elucidation of the Common Basis of Physiological and Pathological Aging of the Heart Focusing on Mitochondrial DynamicsPrincipal Investigator
- Principal Investigator
  
  Tokuyama Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Jichi Medical University
  Tokyo University of Pharmacy and Life Science

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 実験医学増刊 Vol.41 No.5 ミトコンドリア疾患治療の新時代2023
- Author(s)
  徳山剛士, 魚崎英毅
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  9784758104098
- Data Source
  KAKENHI-PROJECT-22K15397
[Book] 実験医学増刊 Vol.41 No.5 ミトコンドリア　疾患治療の新時代2023
- Author(s)
  徳山剛士, 魚崎英毅
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  9784758104098
- Data Source
  KAKENHI-PROJECT-19K16527
[Book] 生体の科学 2023 Oct 15; 74(5):396-3972023
- Author(s)
  徳山剛士、魚崎英毅
- Total Pages
  2
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22K15397
[Book] 小児内科2022
- Author(s)
  徳山　剛士, 安済　達也, 魚崎　英毅
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-19K16527
[Journal Article] Role of Mitochondrial Dynamics in Heart Diseases2023
- Author(s)
  Tokuyama Takeshi、Yanagi Shigeru
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 10 Pages: 1876-1876
- DOI
  10.3390/genes14101876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15397
[Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023
- Author(s)
  Hino Tomohiro、Omura Satoshi N.、Nakagawa Ryoya、Togashi Tomoki、Takeda Satoru N.、Hiramoto Takafumi、Tasaka Satoshi、Hirano Hisato、Tokuyama Takeshi、Uosaki Hideki、Ishiguro Soh、Kagieva Madina、Yamano Hiroyuki、Ozaki Yuki、Motooka Daisuke、Mori Hideto、Kirita Yuhei、Kise Yoshiaki et al.
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 22 Pages: 4920-4935
- DOI
  10.1016/j.cell.2023.08.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19263, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-22K15397, KAKENHI-PROJECT-22KJ0608, KAKENHI-PROJECT-23K23819, KAKENHI-PROJECT-23K24332
[Journal Article] Total and reduced/oxidized forms of coenzyme Q10 in fibroblasts of patients with mitochondrial disease2023
- Author(s)
  Watanabe, C., Osaka, H., Watanabe, M., Miyauchi, A., Jimbo, E. F., Tokuyama, T., Uosaki, H., Kishita, Y., Okazaki, Y., Onuki, T., Ebihara, T., Aizawa, K., Murayama, K., Ohtake, A., & Yamagata, T.
- Journal Title
  
  Mol Genet Metab Rep
  
  Volume: 34 Pages: 100951-100951
- DOI
  10.1016/j.ymgmr.2022.100951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15397, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-20H03648, KAKENHI-PROJECT-23K24334, KAKENHI-PROJECT-19K16527
[Journal Article] Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles2022
- Author(s)
  Ahmed Razan E.、Tokuyama Takeshi、Anzai Tatsuya、Chanthra Nawin、Uosaki Hideki
- Journal Title
  
  Philosophical Transactions of the Royal Society B: Biological Sciences
  
  Volume: 377 Issue: 1864 Pages: 20210325-20210325
- DOI
  10.1098/rstb.2021.0325
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08150, KAKENHI-PROJECT-22K15397, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-23K24334, KAKENHI-PROJECT-19K16527
[Journal Article] Disease Modeling of Mitochondrial Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells2021
- Author(s)
  Tokuyama Takeshi、Ahmed Razan Elfadil、Chanthra Nawin、Anzai Tatsuya、Uosaki Hideki
- Journal Title
  
  Biology
  
  Volume: 10 Issue: 10 Pages: 981-981
- DOI
  10.3390/biology10100981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16527, KAKENHI-PROJECT-19KK0219
[Journal Article] MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis2021
- Author(s)
  Kitakata Hiroki、Endo Jin、Matsushima Hirokazu、Yamamoto Shoichi、Ikura Hidehiko、Hirai Akeo、Koh Seien、Ichihara Genki、Hiraide Takahiro、Moriyama Hidenori et al.
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 161 Pages: 116-129
- DOI
  10.1016/j.yjmcc.2021.08.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08134, KAKENHI-PROJECT-19K16527, KAKENHI-PROJECT-21K08038, KAKENHI-PROJECT-19K17579
[Journal Article] MITOL promotes cell survival by degrading Parkin during mitophagy2021
- Author(s)
  Shiiba Isshin、Takeda Keisuke、Nagashima Shun、Ito Naoki、Tokuyama Takeshi、Yamashita Shun‐Ichi、Kanki Tomotake、Komatsu Toru、Urano Yasuteru、Fujikawa Yuuta、Inatome Ryoko、Yanagi Shigeru
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 3
- DOI
  10.15252/embr.201949097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22419, KAKENHI-PLANNED-19H05712, KAKENHI-PUBLICLY-20H04694, KAKENHI-PUBLICLY-20H04911, KAKENHI-PROJECT-19H02846, KAKENHI-PROJECT-20H03454, KAKENHI-PROJECT-19K16527
[Journal Article] Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients2020
- Author(s)
  Tokuyama Takeshi、Hirai Asei、Shiiba Isshin、Ito Naoki、Matsuno Keigo、Takeda Keisuke、Saito Kanata、Mii Koki、Matsushita Nobuko、Fukuda Toshifumi、Inatome Ryoko、Yanagi Shigeru
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 3 Pages: 450-450
- DOI
  10.3390/biom10030450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16527
[Journal Article] MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress2019
- Author(s)
  Nagashima Shun、Takeda Keisuke、Ohno Nobuhiko、Ishido Satoshi、Aoki Motohide、Saitoh Yurika、Takada Takumi、Tokuyama Takeshi、Sugiura Ayumu、Fukuda Toshifumi、Matsushita Nobuko、Inatome Ryoko、Yanagi Shigeru
- Journal Title
  
  Life Science Alliance
  
  Volume: 2 Issue: 4 Pages: e201900308-e201900308
- DOI
  10.26508/lsa.201900308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Journal Article] Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies.2019
- Author(s)
  Nagashima S, Takeda K, Shiiba I, Higashi M, Fukuda T, Tokuyama T, Matsushita N, Nagano S, Araki T, Kaneko M, Shioi G, Inatome R, Yanagi S.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 20107-20107
- DOI
  10.1038/s41598-019-56559-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Journal Article] MITOL prevemts ER stress-induced apoptosis by IRE1 ubiquitylation at mitochondrial-ER contact sites.2019
- Author(s)
  Takeda, K., Nagashima, S., Shiiba, I., Uda, A., Tokuyama, T., Ito, N., Fukuda, T., Matsushita, N., Ishido, S., Iwawaki, T., Uehara, T., Inatome, R., and Yanagi, S.
- Journal Title
  
  EMBO J.
  
  Volume: 38 Issue: 15
- DOI
  10.15252/embj.2018100999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22498, KAKENHI-PUBLICLY-18H04869, KAKENHI-PROJECT-17H04053, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Presentation] Gene Therapy for Mybpc3 Mutant Cardiomyopathy Models2024
- Author(s)
  魚崎英毅, 安済達也, 川上亮, 徳山剛士, AHMED Razan, TORIZAL F Gandhi, 石井秀樹, 小板橋紀通
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] ヒト肥大型心筋症遺伝子変異ノックインマウスにおける遺伝子治療による病的な心臓リモデリングの改善2023
- Author(s)
  小板橋紀通, 川上亮, 徳山剛士, 安済達也, Ahmed Ranzan, Torizal Fuad Gandhi, 長尾恭光, 魚崎英毅, 石井秀樹
- Organizer
  第71 回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] 疾患iPS細胞を用いたBOLA3ミトコンドリア心筋症の病態と新規形態異常Mito-Ballの解明2023
- Author(s)
  徳山剛士、魚崎英毅
- Organizer
  第22回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] The mitochondrial ubiquitin ligase MITOL is downregulated in myocardial infarction and induces mitophagy via mitochondrial fission.2023
- Author(s)
  Takeshi Tokuyama
- Organizer
  第87回日本循環器学会学術集会(JCS2023)
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] The mitochondrial ubiquitin ligase MITOL is downregulated in myocardial infarction and induces mitophagy via mitochondrial fission.2023
- Author(s)
  Takeshi Tokuyama
- Organizer
  第87回日本循環器学会学術集会(JCS2023)
- Data Source
  KAKENHI-PROJECT-19K16527
[Presentation] Combinations of Nuclear Receptor Activations Revealed Disease Phenotype in iPSC-CMs Derived from Patients with Mitochondrial Cardiomyopathy.2023
- Author(s)
  Razan E Ahmed, Nawin Chanthra, Kumiko A Iwabuchi, Takeshi Tokuyama, Hideki Uosaki
- Organizer
  Cardiovascular Bioenginnering (CVBE) Symposium 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] 肥大型心筋症モデルマウスに対する遺伝子治療と病的リモデリングの抑制2023
- Author(s)
  魚崎英毅, 安済達也, 川上亮, 徳山剛士, AHMED Razan, TORIZAL F Gandhi, 長尾恭光, 石井秀樹, 小板橋紀通
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] Gene Therapy Improves Pathological Cardiac Remodeling in Human Hypertrophic Cardiomyopathy Gene Variant Knock-in Mice2023
- Author(s)
  Norimichi Koitabashi, Ryo Kawakami, Takeshi Tokuyama, Razan E Ahmed, Fuad Gandhi Torizal, Tatsuya Anzai, Yasumitsu Nagao, Hideki Ishii, Hideki Uosaki
- Organizer
  American Heart Association
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] Maturation Culture Exaggerated Disease Phenotype in Mitochondrial Cardiomyopathy iPSC-derived Cardiomyocytes2023
- Author(s)
  Razan E Ahmed, Nawin Chanthra, Kumiko A Iwabuchi, Takeshi Tokuyama, Hideki Uosaki
- Organizer
  Weinstein Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] ミトコンドリア酵素MITOLの低下は心臓老化や心筋梗塞を増悪し、 MITOLの活性化は心筋梗塞の重症化を抑制する2022
- Author(s)
  徳山剛士, 魚崎英毅, 柳茂
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16527
[Presentation] ミトコンドリア酵素MITOLの低下は心臓老化や心筋梗塞を増悪し、 MITOLの活性化は心筋梗塞の重症化を抑制する2022
- Author(s)
  徳山剛士, 魚崎英毅, 柳茂
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] ミトコンドリア外膜上の掃除機構の破綻が心筋梗塞の病態を悪化させる2022
- Author(s)
  徳山剛士, 魚崎英毅, 柳茂
- Organizer
  第51回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-19K16527
[Presentation] ミトコンドリア外膜上の掃除機構の破綻が心筋梗塞の病態を悪化させる2022
- Author(s)
  徳山剛士, 魚崎英毅, 柳茂
- Organizer
  第51回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-22K15397
[Presentation] Protective roles of MITOL in ischemic heart disease and heart aging partly via Drp1 regulation2019
- Author(s)
  徳山剛士
- Organizer
  The 16th Conference of Asian Society for Mitochondrial Research and Medicine [ASMRM] ー&ー The 19th Conference of Japanese Society of Mitochondrial Research and Medicine[J-mit]
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16527

1. 福田敏史

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2. 遠藤仁

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3. 神吉智丈

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4. 木瀬孔明

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5. 長野清一

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6. 上原孝

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7. 魚崎英毅

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Tokuyama Takeshi 徳山 剛士

徳山 剛士 トクヤマ タケシ

Research Projects

Research Products

Co-Researchers

疾患iPS・モデル動物を用いたBOLA3変異ミトコンドリア心筋症の新規病態機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the Pathological Significance of Enlarged Mitochondria in BOLA3 Mutations Using iPSCs.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Common Basis of Physiological and Pathological Aging of the Heart Focusing on Mitochondrial DynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学増刊 Vol.41 No.5 ミトコンドリア 疾患治療の新時代2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学増刊 Vol.41 No.5 ミトコンドリア 疾患治療の新時代2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 生体の科学 2023 Oct 15; 74(5):396-3972023

Author(s)

Total Pages

Publisher

Data Source

[Book] 小児内科2022

Author(s)

Publisher

Data Source

[Journal Article] Role of Mitochondrial Dynamics in Heart Diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Total and reduced/oxidized forms of coenzyme Q10 in fibroblasts of patients with mitochondrial disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disease Modeling of Mitochondrial Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MITOL promotes cell survival by degrading Parkin during mitophagy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients2020

Tokuyama Takeshi 徳山剛士

徳山剛士トクヤマタケシ

[Book] 実験医学増刊 Vol.41 No.5 ミトコンドリア疾患治療の新時代2023

[Book] 実験医学増刊 Vol.41 No.5 ミトコンドリア　疾患治療の新時代2023

[Presentation] ミトコンドリア外膜上の掃除機構の破綻が心筋梗塞の病態を悪化させる2022

[Presentation] ミトコンドリア外膜上の掃除機構の破綻が心筋梗塞の病態を悪化させる2022