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Ochi Yosuke  越智 洋輔

ORCIDConnect your ORCID iD *help
Researcher Number 30826102
Other IDs
Affiliation (based on the past Project Information) *help 2018 – 2019: 大阪薬科大学, 薬学部, 研究員
Review Section/Research Field
Principal Investigator
0801:Pharmaceutical sciences and related fields
Keywords
Principal Investigator
炎症性副作用 / オリゴ核酸合成後修飾 / ApoB / 家族性高コレステロール血症 / 修飾核酸 / apoB / プロドラッグ / siRNA / RNA干渉 / ジスルフィド / 核酸医薬
  • Research Projects

    (1 results)
  • Research Products

    (4 results)
  •  Development of prodrug-type siRNA reduced inflammatory adverse effectPrincipal Investigator

    • Principal Investigator
      Ochi Yosuke
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0801:Pharmaceutical sciences and related fields
    • Research Institution
      Osaka University of Pharmaceutical Sciences

All 2019 2018

All Journal Article Presentation

  • [Journal Article] Syntheses of prodrug-type 2'-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2'-hydroxy oligonucleotides under reducing condition2018

    • Author(s)
      Hayashi Junsuke、Ochi Yosuke、Morita Yasuyuki、Soubou Katsuma、Ohtomo Yuhei、Nishigaki Misa、Tochiyama Yuko、Nakagawa Osamu、Wada Shun-ichi、Urata Hidehito
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Issue: 22 Pages: 5838-5844

    • DOI

      10.1016/j.bmc.2018.10.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K21234, KAKENHI-PROJECT-16K08331
  • [Presentation] 還元環境に応答するプロドラッグ型 RNA の配列拡張を指向した合成研究2019

    • Author(s)
      越智洋輔、林淳祐、森田康之、西垣美沙、和田俊一、浦田秀仁
    • Organizer
      日本薬学会 第139年会
    • Data Source
      KAKENHI-PROJECT-19K21234
  • [Presentation] General synthesis and knockdown activity of prodrug-type 2'-O-methyldithiomethyl oligonucleotide2018

    • Author(s)
      越智洋輔、林淳祐、森田康之、西垣美沙、和田俊一、浦田秀仁
    • Organizer
      第45回 国際核酸化学シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K21234
  • [Presentation] 配列拡張を指向した 2'-O-メチルジチオメチル-オリゴヌクレオチドの合成2018

    • Author(s)
      越智洋輔、森田康之、林淳祐、和田俊一、浦田秀仁
    • Organizer
      第68回 日本薬学会近畿支部総会・大会
    • Data Source
      KAKENHI-PROJECT-19K21234

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