Takahashi Yu 高橋裕

Researcher Number	30835377
Other IDs
Affiliation (Current)	2026: 東京大学, 大学院農学生命科学研究科(農学部), 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 東京大学, 大学院農学生命科学研究科(農学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields
Keywords	Principal Investigator iPS細胞 / 栄養素代謝 / 肝細胞機能 / 培養技術 / 肝臓オルガノイド / 分子細胞生物学 / 食品成分 / オルガノイド / CRISPR/Cas9 / ヒト小腸オルガノイド … More / ゲノム編集 / スクリーニング / CYP誘導 / レンチウイルス / Caco-2細胞 / 小腸オルガノイド … More Except Principal Investigator コレステロール / ヒトiPS細胞 / 小腸オルガノイド Less

Establishment of culture methods of human liver organoids for nutrition metabolism studiesPrincipal Investigator
- Principal Investigator
  
  高橋裕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  The University of Tokyo
ヒトiPS細胞由来小腸オルガノイドを用いた次世代食品栄養学・食品科学研究の開拓
- Principal Investigator
  
  佐藤隆一郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokyo
Establishment of novel research platform for food and nutrition science using physiologically-relevant human intestinal organoidsPrincipal Investigator
- Principal Investigator
  
  Takahashi Yu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation Book Patent

[Book] アグリバイオ2025
- Author(s)
  高橋裕，佐藤隆一郎
- Total Pages
  5
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-23K05070
[Book] 単層化を介した腸管上皮オルガノイドへの遺伝子導入2020
- Author(s)
  佐藤慎太郎，高橋裕
- Total Pages
  11
- Publisher
  羊土社
- ISBN
  9784758103879
- Data Source
  KAKENHI-PROJECT-19K05928
[Book] iPS細胞を活用した生理機能の高いヒトモデルの構築とその応用2020
- Author(s)
  高橋裕，佐藤慎太郎，佐藤隆一郎
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  9784758103879
- Data Source
  KAKENHI-PROJECT-19K05928
[Journal Article] Modeling statin-induced myopathy with hiPSC-derived myocytes reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention2025
- Author(s)
  Zhao Xiaolin、Ni Liyang、Kubo Miharu、Matsuto Mariko、Sakurai Hidetoshi、Shimizu Makoto、Takahashi Yu、Sato Ryuichiro、Yamauchi Yoshio
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: 328 Issue: 4 Pages: C1247-C1259
- DOI
  10.1152/ajpcell.00714.2024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-23K05070, KAKENHI-PROJECT-22K18342, KAKENHI-PROJECT-24KJ0612
[Journal Article] Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening2024
- Author(s)
  Maruyama Takashi、Takahashi Yu、Hiro Kahori、Murase Kohji、Kojima Hirotatsu、Okabe Takayoshi、Yamauchi Yoshio、Sato Ryuichiro
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 15 Issue: 5 Pages: 667-676
- DOI
  10.1021/acsmedchemlett.4c00067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-23K05070, KAKENHI-PROJECT-22K18342
[Journal Article] Human colon organoid differentiation from induced pluripotent stem cells using an improved method2024
- Author(s)
  Lee I‐Ting、Takahashi Yu、Sasaki Takashi、Yamauchi Yoshio、Sato Ryuichiro
- Journal Title
  
  FEBS Letters
  
  Volume: 599 Issue: 6 Pages: 912-924
- DOI
  10.1002/1873-3468.15082
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-23K05070, KAKENHI-PROJECT-22K18342
[Journal Article] Transcriptome analysis reveals selectively high expression of beige adipocyte marker genes in mouse perinephric fat2024
- Author(s)
  Misawa Yoshinori、Takahashi Yu、Sasaki Takashi、Sato Ryuichiro、Yamauchi Yoshio
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 88 Issue: 12 Pages: 1449-1452
- DOI
  10.1093/bbb/zbae143
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-23K05070, KAKENHI-PROJECT-22K18342
[Journal Article] Establishment of a cell culture platform for human liver organoids and its application for lipid metabolism research2023
- Author(s)
  Kuboyama‐Sasaki Ayane、Takahashi Yu、Xia Chen、Hiro Kahori、Kobayashi Tsuyoshi、Ohdan Hideki、Shimizu Makoto、Yamauchi Yoshio、Kiyono Hiroshi、Sato Ryuichiro
- Journal Title
  
  Biotechnology Journal
  
  Volume: 19 Issue: 1 Pages: 5407-5407
- DOI
  10.1002/biot.202300365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18342, KAKENHI-PROJECT-23K05070, KAKENHI-PROJECT-20H00408
[Journal Article] Lactic acid bacteria?derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids2022
- Author(s)
  Noguchi Makoto、Shimizu Makoto、Lu Peng、Takahashi Yu、Yamauchi Yoshio、Sato Shintaro、Kiyono Hiroshi、Kishino Shigenobu、Ogawa Jun、Nagata Koji、Sato Ryuichiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 11 Pages: 102534-102534
- DOI
  10.1016/j.jbc.2022.102534
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18342, KAKENHI-PROJECT-21K19066, KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-18H05280
[Journal Article] Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies2022
- Author(s)
  Takahashi Yu、Noguchi Makoto、Inoue Yu、Sato Shintaro、Shimizu Makoto、Kojima Hirotatsu、Okabe Takayoshi、Kiyono Hiroshi、Yamauchi Yoshio、Sato Ryuichiro
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 104542-104542
- DOI
  10.1016/j.isci.2022.104542
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18342, KAKENHI-PROJECT-21K19066, KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-18H05280
[Journal Article] Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids2021
- Author(s)
  Takahashi Yu、Inoue Yu、Kuze Keitaro、Sato Shintaro、Shimizu Makoto、Kiyono Hiroshi、Yamauchi Yoshio、Sato Ryuichiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 10 Pages: 2137-2144
- DOI
  10.1093/bbb/zbab136
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05928, KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-19H02906, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-21K19066
[Patent] 肝臓オルガノイド成熟培地2024
- Inventor(s)
  高橋裕、佐々木（久保山）文音、佐藤隆一郎
- Industrial Property Rights Holder
  高橋裕、佐々木（久保山）文音、佐藤隆一郎
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23K05070
[Patent] 肝臓オルガノイドを増殖させるための培地2023
- Inventor(s)
  高橋裕、佐藤隆一郎、山口愛
- Industrial Property Rights Holder
  高橋裕、佐藤隆一郎、山口愛
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] ヒトiPS細胞由来小腸オルガノイドの細胞老化モデル構築と食品成分の機能評価2025
- Author(s)
  綾部達宏、高橋裕、菱田幸宏、小久保健、山内祥生、佐藤隆一郎
- Organizer
  日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22K18342
[Presentation] ヒトオルガノイドを用いた病態モデルの構築と腸炎改善作用を持つ天然物の同定2025
- Author(s)
  廣佳穂里、高橋裕、チャンチャンウエイ、田中和、リイテイ、岡部隆義、小島宏建、倉島洋介、佐藤隆一郎、山内祥生
- Organizer
  日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22K18342
[Presentation] ヒトiPS細胞から樹立した肝臓オルガノイドの培養技術開発および肝細胞機能評価2025
- Author(s)
  山口愛，高橋裕，久保山文音，山内祥生，佐藤隆一郎
- Organizer
  第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会　合同大会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] ヒト特有の生理的な栄養素代謝機構の解明を目指した肝臓オルガノイドの研究基盤構築2024
- Author(s)
  高橋裕，久保山文音，XIA Chen，山内祥生，佐藤隆一郎
- Organizer
  日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] ヒトiPS細胞由来肝臓オルガノイドの増殖用・成熟化培地の開発2024
- Author(s)
  山口愛，高橋裕，久保山文音，XIA Chen，山内祥生，佐藤隆一郎
- Organizer
  第37回日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] ヒト肝臓オルガノイドを日常的に大量使用するための培養技術基盤の確立2024
- Author(s)
  高橋裕, 久保山文音, Chen XIA, 山内祥生, 佐藤隆一郎
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K18342
[Presentation] 肝臓オルガノイドの培養技術開発と機能評価2024
- Author(s)
  山口愛，高橋裕，久保山文音，XIA Chen，山内祥生，佐藤隆一郎
- Organizer
  第51回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] ヒト肝臓オルガノイドの培養技術開発と生理機能評価2024
- Author(s)
  XIA Chen，高橋裕，久保山文音，廣佳穂里，山内祥生，佐藤隆一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] SREBP-1特異的阻害剤創製を目指したバインダースクリーニング2024
- Author(s)
  廣佳穂里、高橋裕、丸山貴史、岡部隆義、小島宏建、山内祥生、佐藤隆一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-22K18342
[Presentation] ヒト肝臓オルガノイドを日常的に大量使用するための培養技術基盤の確立2024
- Author(s)
  高橋裕，久保山文音，XIA Chen，山内祥生，佐藤隆一郎
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] 肝細胞の生理機能評価に有用なヒトiPS細胞由来ヒト肝臓オルガノイドの培養技術開発2023
- Author(s)
  山口愛，高橋裕，久保山文音，XIA Chen，山内祥生，佐藤隆一郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] Establishment of a cell culture platform for human liver organoids for evaluating physiological hepatocyte function2023
- Author(s)
  Ai Yamaguchi, Yu Takahashi, Ayane Kuboyama-Sasaki, Yoshio Yamauchi, Ryuichiro Sato
- Organizer
  日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] 従来の細胞株では再現できないヒト肝細胞の生理的機能を有する肝臓オルガノイドの培養技術開発2023
- Author(s)
  山口愛，高橋裕，久保山文音，山内祥生，佐藤隆一郎
- Organizer
  第14回スクリーニング学研究会
- Data Source
  KAKENHI-PROJECT-23K05070
[Presentation] 腸オルガノイド由来単層上皮細胞の生理学的特性評価2022
- Author(s)
  高橋裕，山内祥生，佐藤隆一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-19K05928
[Presentation] 安価で安定的なヒト小腸オルガノイド培養技術の開発2021
- Author(s)
  久世圭太朗，高橋裕，山内祥生，佐藤隆一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-19K05928
[Presentation] ヒトiPS細胞からの小腸オルガノイドおよび単層上皮細胞の樹立2021
- Author(s)
  高橋裕，山内祥生，佐藤隆一郎
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-19K05928

1. 佐藤隆一郎 (50187259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 清水誠 (40409008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Takahashi Yu 高橋 裕

Research Projects

Research Products

Co-Researchers

Establishment of culture methods of human liver organoids for nutrition metabolism studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトiPS細胞由来小腸オルガノイドを用いた次世代食品栄養学・食品科学研究の開拓

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel research platform for food and nutrition science using physiologically-relevant human intestinal organoidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] アグリバイオ2025

Author(s)

Total Pages

Publisher

Data Source

[Book] 単層化を介した腸管上皮オルガノイドへの遺伝子導入2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] iPS細胞を活用した生理機能の高いヒトモデルの構築とその応用2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Modeling statin-induced myopathy with hiPSC-derived myocytes reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human colon organoid differentiation from induced pluripotent stem cells using an improved method2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptome analysis reveals selectively high expression of beige adipocyte marker genes in mouse perinephric fat2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of a cell culture platform for human liver organoids and its application for lipid metabolism research2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lactic acid bacteria?derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 肝臓オルガノイド成熟培地2024

Takahashi Yu 高橋裕