Isobe Taichi 磯部大地

Researcher Number	30838727
Other IDs	https://orcid.org/0000-0001-5686-1940
Affiliation (Current)	2025: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 九州大学, 医学研究院, 助教 2019: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 大腸がん / senolytics / clonal hematopoiesis / aging / gastrointestinal cancer / DNAシークエンス / がん微小環境 / がん免疫 / エピゲノム / 腫瘍免疫 … More / クローン性造血 / 染色体不安定性 / 疾患モデル / 分化 / iPS細胞 / 染色体異常 / 多能性幹細胞 / 発がん / 大腸 / 染色体 / がん Less

User The development of novel senolytics for gastrointestinal cancers with clonal hematopoiesisPrincipal Investigator
- Principal Investigator
  
  磯部大地
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyushu University
Characterization of immune responses in tumor microenvironment of patients with clonal hematopoiesisPrincipal Investigator
- Principal Investigator
  
  Isobe Taichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
Establishment of a new model for human colorectal cancersPrincipal Investigator
- Principal Investigator
  
  Isobe Taichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Preferential B cell differentiation by combined immune checkpoint blockade for renal cell carcinoma is associated with clinical response and autoimmune reactions2023
- Author(s)
  Uehara Koki、Tanoue Kenro、Yamaguchi Kyoko、Ohmura Hirofumi、Ito Mamoru、Matsushita Yuzo、Tsuchihashi Kenji、Tamura Shingo、Shimokawa Hozumi、Isobe Taichi、Shibata Yoshihiro、Ariyama Hiroshi、Tanaka Risa、Kusaba Hitoshi、Yamamoto Hidetaka、Oda Yoshinao、Akashi Koichi、Baba Eishi
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 11 Pages: 3543-3558
- DOI
  10.1007/s00262-023-03505-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07376, KAKENHI-PROJECT-21K07152
[Journal Article] RHAMM marks proliferative subpopulation of human colorectal cancer stem cells2023
- Author(s)
  Nakano Michitaka、Taguchi Ryosuke、Kikushige Yoshikane、Isobe Taichi、Miyawaki Kohta、Mizuno Shinichi、Tsuruta Nobuhiro、Hanamura Fumiyasu、Yamaguchi Kyoko、Yamauchi Takuji、Ariyama Hiroshi、Kusaba Hitoshi、Nakamura Masafumi、Maeda Takahiro、Kuo Calvin J.、Baba Eishi、Akashi Koichi
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 7 Pages: 15795-12
- DOI
  10.1111/cas.15795
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-21K07153, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-19K16852
[Journal Article] Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions2022
- Author(s)
  Ito Mamoru、Nakano Michitaka、Ariyama Hiroshi、Yamaguchi Kyoko、Tanaka Risa、Semba Yuichiro、Sugio Takeshi、Miyawaki Kohta、Kikushige Yoshikane、Mizuno Shinichi、Isobe Taichi、Tanoue Kenro、Taguchi Ryosuke、Ueno Shohei、Kawano Takahito、Murata Masaharu、Baba Eishi、Akashi Koichi
- Journal Title
  
  Cancer Letters
  
  Volume: 532 Pages: 215597-215597
- DOI
  10.1016/j.canlet.2022.215597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-20K08311, KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-21K12685, KAKENHI-PROJECT-21K18325, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K25209, KAKENHI-PROJECT-19K16852, KAKENHI-PROJECT-20K17403
[Journal Article] IMPROVE bleeding score predicts major bleeding in advanced gastrointestinal cancer patients with venous thromboembolism2022
- Author(s)
  Kusaba Hitoshi、Moriyama Shohei、Hieda Michinari、Ito Mamoru、Ohmura Hirofumi、Isobe Taichi、Tsuchihashi Kenji、Fukata Mitsuhiro、Ariyama Hiroshi、Baba Eishi
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 52 Pages: 367-372
- DOI
  10.1093/jjco/hyac103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07152
[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022
- Author(s)
  Hisamori Shigeo、Mukohyama Junko、Koul Sanjay、Hayashi Takanori、Rothenberg Michael Evan、Maeda Masao、Isobe Taichi、Valencia Salazar Luis Enrique、Qian Xin、Johnston Darius Michael、Qian Dalong、Lao Kaiqin、Asai Naoya、Kakeji Yoshihiro、Gennarino Vincenzo Alessandro、Sahoo Debashis、Dalerba Piero、Shimono Yohei
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: Online ahead of print Issue: 6 Pages: 407-422
- DOI
  10.1007/s00535-022-01865-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09076, KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-22K07010, KAKENHI-PROJECT-20K17687, KAKENHI-PROJECT-23K21387
[Journal Article] Inhibition of insulin‐like growth factor‐1 receptor enhances eribulin‐induced <scp>DNA</scp> damage in colorectal cancer2022
- Author(s)
  Yoshihiro Tomoyasu、Ariyama Hiroshi、Yamaguchi Kyoko、Imajima Takashi、Yamaga Satoru、Tsuchihashi Kenji、Isobe Taichi、Kusaba Hitoshi、Akashi Koichi、Baba Eishi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 12 Pages: 4207-4218
- DOI
  10.1111/cas.15558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07152
[Journal Article] 新しいがん治療法　2）抗体薬物複合体（ADC）2022
- Author(s)
  磯部　大地、馬場　英司
- Journal Title
  
  腫瘍内科
  
  Volume: 29 Pages: 535-543
- Data Source
  KAKENHI-PROJECT-21K07152
[Journal Article] 免疫チェックポイント阻害薬の併用療法のエビデンス　2）免疫チェックポイント阻害薬と化学療法2022
- Author(s)
  磯部　大地、馬場　英司
- Journal Title
  
  腫瘍内科
  
  Volume: 30 Pages: 8-17
- Data Source
  KAKENHI-PROJECT-21K07152
[Journal Article] Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model2022
- Author(s)
  Yamaguchi Kyoko、Yoshihiro Tomoyasu、Ariyama Hiroshi、Ito Mamoru、Nakano Michitaka、Semba Yuichiro、Nogami Jumpei、Tsuchihashi Kenji、Yamauchi Takuji、Ueno Shohei、Isobe Taichi、et al
- Journal Title
  
  Gastric Cancer
  
  Volume: 25 Issue: 5 Pages: 862-878
- DOI
  10.1007/s10120-022-01307-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-21K20839
[Journal Article] Predictive impact of C-reactive protein to albumin ratio for recurrent or metastatic head and neck squamous cell carcinoma receiving nivolumab2021
- Author(s)
  Tanoue Kenro、Tamura Shingo、Kusaba Hitoshi、Shinohara Yudai、Ito Mamoru、Tsuchihashi Kenji、Shirakawa Tsuyoshi、Otsuka Taiga、Ohmura Hirofumi、Isobe Taichi、Ariyama Hiroshi、Koreishi Sakuya、Matsushita Yuzo、Shimokawa Hozumi、Tanaka Risa、Mitsugi Kenji、Akashi Koichi、Baba Eishi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 2741-2741
- DOI
  10.1038/s41598-021-82448-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17831
[Journal Article] Prominent PD-L1-positive M2 macrophage infiltration in gastric cancer with hyper-progression after anti-PD-1 therapy2021
- Author(s)
  Yamaguchi Kyoko、Tsuchihashi Kenji、Tsuji Kunihiro、Kito Yosuke、Tanoue Kenro、Ohmura Hirofumi、Ito Mamoru、Isobe Taichi、Ariyama Hiroshi、Kusaba Hitoshi、Akashi Koichi、Baba Eishi
- Journal Title
  
  Medicine
  
  Volume: 100 Issue: 19 Pages: e25773-e25773
- DOI
  10.1097/md.0000000000025773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07152
[Journal Article] Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin2020
- Author(s)
  Tsuchihashi K, Kusaba H, Yoshihiro T, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Imajima T, Shinohara Y, Ito M, Yamaga S, Tanoue K, Arimizu K, Ohmura H, Hanamura F, Yamaguchi K, Isobe T, Ariyama H, Nakashima Y, Akashi K, Baba E.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20896-20896
- DOI
  10.1038/s41598-020-77898-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16627, KAKENHI-PROJECT-18K09067, KAKENHI-PROJECT-19K17831
[Journal Article] miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.2019
- Author(s)
  Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y.
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 20 Pages: 5151-5158
- DOI
  10.1158/0008-5472.can-18-3544
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07231, KAKENHI-PROJECT-19K17831, KAKENHI-PROJECT-16H05415, KAKENHI-PROJECT-17K16172, KAKENHI-PROJECT-17K16555
[Journal Article] Methylation of drug resistance‐related genes in chemotherapy‐sensitive Epstein?Barr virus‐associated gastric cancer2019
- Author(s)
  Ohmura Hirofumi、Ito Mamoru、Uchino Keita、Okada Chihiro、Tanishima Shigeki、Yamada Yuichi、Momosaki Seiya、Komoda Masato、Kuwayama Miyuki、Yamaguchi Kyoko、Okumura Yuta、Nakano Michitaka、Tsuchihashi Kenji、Isobe Taichi、Ariyama Hiroshi、Kusaba Hitoshi、Oda Yoshinao、Akashi Koichi、Baba Eishi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 1 Pages: 147-157
- DOI
  10.1002/2211-5463.12765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17831
[Presentation] TPX2の増幅はCINフェノタイプの大腸癌のオキサリプラチン感受性のバイオマーカーである2023
- Author(s)
  Ueno Shohei, Isobe Taichi, Ryosuke Taguchi, Tsuchihashi Kenji, Akashi Koichi, Baba Eishi
- Organizer
  日本癌学会第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07152
[Presentation] The amplification of TPX2 is a potential biomarker of oxaliplatin-susceptibility in colorectal cancer with CIN phenotype2023
- Author(s)
  Shohei Ueno, Isobe Taichi, Ryosuke Taguchi, Kenji Tsuchihashi, Hiroshi Ariyama, Koichi Akashi, Eishi Baba
- Organizer
  第20回　日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07152
[Presentation] Outcome of parameningeal head and neck rhabdomyosarcoma in adults: Kyushu Medical Oncology Group Study2023
- Author(s)
  Taichi Isobe, Kenji Tsuchihashi, Shohei Ueno, Ryosuke Taguchi, Mamoru Ito, Michitaka Nakano, Hiroshi Ariyama, Fumiyasu Hanamura, Yuta Okumura, Masato Komoda, Taito Esaki, Shuji Arita, Kenta Nio, Hitoshi Kusaba, Kazuki Hashimoto, Tadamasa Yoshitake, Yoshinao Oda, Koichi Akashi, Eishi Baba
- Organizer
  第20回　日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07152
[Presentation] DNMT3B maintains the organoid-formation ability of left-sided colorectal cancer derived from patients2022
- Author(s)
  Ryosuke Taguchi, Isobe Taichi, Yoshikane Kikushige, Shohei Ueno, Kenji Tsuchihashi, Hiroshi Ariyama, Koichi Akashi, Eishi Baba
- Organizer
  第81回　日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07152
[Presentation] The amplification of TPX2 is a potential biomarker of oxaliplatin-susceptibility in colorectal cancer2022
- Author(s)
  Shohei Ueno, Isobe Taichi, Ryosuke Taguchi, Kenji Tsuchihashi, Hiroshi Ariyama, Koichi Akashi, Eishi Baba
- Organizer
  第81回　日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07152
[Presentation] DNMT3B contributes to the stemness of left-sided colorectal cancer derived from patients2022
- Author(s)
  Ryosuke Taguchi, Isobe Taichi, Yoshikane Kikushige, Shohei Ueno, Kenji Tsuchihashi, Hiroshi Ariyama, Koichi Akashi, Eishi Baba
- Organizer
  第19回　幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-21K07152

1. 菊繁吉謙 (40619706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 赤司浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 久森重夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 遠藤誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山口享子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 馬場英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 下野洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Isobe Taichi 磯部 大地

Research Projects

Research Products

Co-Researchers

User The development of novel senolytics for gastrointestinal cancers with clonal hematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of immune responses in tumor microenvironment of patients with clonal hematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a new model for human colorectal cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Preferential B cell differentiation by combined immune checkpoint blockade for renal cell carcinoma is associated with clinical response and autoimmune reactions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RHAMM marks proliferative subpopulation of human colorectal cancer stem cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IMPROVE bleeding score predicts major bleeding in advanced gastrointestinal cancer patients with venous thromboembolism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of insulin‐like growth factor‐1 receptor enhances eribulin‐induced <scp>DNA</scp> damage in colorectal cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 新しいがん治療法 2）抗体薬物複合体（ADC）2022

Author(s)

Journal Title

Data Source

[Journal Article] 免疫チェックポイント阻害薬の併用療法のエビデンス 2）免疫チェックポイント阻害薬と化学療法2022

Author(s)

Journal Title

Data Source

[Journal Article] Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictive impact of C-reactive protein to albumin ratio for recurrent or metastatic head and neck squamous cell carcinoma receiving nivolumab2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prominent PD-L1-positive M2 macrophage infiltration in gastric cancer with hyper-progression after anti-PD-1 therapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin2020

Author(s)

Journal Title

DOI

Data Source

Isobe Taichi 磯部大地

[Journal Article] 新しいがん治療法　2）抗体薬物複合体（ADC）2022

[Journal Article] 免疫チェックポイント阻害薬の併用療法のエビデンス　2）免疫チェックポイント阻害薬と化学療法2022