Endo Kentaro 遠藤健太郎

Researcher Number	30844378
Other IDs	https://orcid.org/0000-0003-4790-4632
Affiliation (Current)	2025: 東京科学大学, 総合研究院, プロジェクト助教
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 総合研究院, プロジェクト助教 2021 – 2024: 東京医科歯科大学, 統合研究機構, プロジェクト助教 2019 – 2020: 東京医科歯科大学, 統合研究機構, プロジェクト研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / 0906:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 変形性膝関節症 / 滑膜 / 間葉系幹細胞 / 軟骨 / ABT-263 / 老化細胞除去薬 / 細胞老化 / 再生医療 / 滑膜幹細胞 / 細胞治療 … More / 再生 / 関節 / 脱分化 / 脂肪細胞 / senolytic drug / 半月板 / 関節軟骨 / スクリーニング / 細胞遊走 / PDGF / 遊走 / 関節液 / 変形性関節症 … More Except Principal Investigator 変形性膝関節症 / 細胞治療 / 再生医療 / 滑膜伸張 / 膝関節 / メカニカルストレス / 滑膜間葉系幹細胞 Less

Structural improvement of knee osteoarthritis using synovium-specific stem cell subsets: moving beyond symptomatic treatmentPrincipal Investigator
- Principal Investigator
  
  遠藤健太郎
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Institute of Science Tokyo
Reprogramming of Adipocytes in the Joint by Mechanical Stress; Innovative Strategies for Joint RegenerationPrincipal Investigator
- Principal Investigator
  
  遠藤健太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tokyo Medical and Dental University
変形性膝関節症における移植後滑膜幹細胞のメカノアクチベーションによる治療効果増強
- Principal Investigator
  
  松田純平
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Improvement of biological functions and therapeutic efficacy of synovial stem cells from osteoarthritis using senolytic drugsPrincipal Investigator
- Principal Investigator
  
  Endo Kentaro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Development of efficient treatment of knee osteoarthritis by the combination of senolytic drug and synovial stem cell injectionPrincipal Investigator
- Principal Investigator
  
  Endo Kentaro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Development of a novel synovial stem cell migration model for exploring disease-modifying osteoarthritis drugsPrincipal Investigator
- Principal Investigator
  
  Endo Kentaro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0906:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa2024
- Author(s)
  Miura Yugo、Endo Kentaro、Sekiya Ichiro
- Journal Title
  
  Tissue and Cell
  
  Volume: 88 Pages: 102370-102370
- DOI
  10.1016/j.tice.2024.102370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16708
[Journal Article] Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model2023
- Author(s)
  Ozeki Nobutake、Mizuno Mitsuru、Yanada Shinobu、Okada Takuya、Kubota Rei、Kushida Yoshihisa、Furuoka Hideto、Endo Kentaro、Katano Hisako、Nakamura Kentaro、Ohya Shoji、Koga Hideyuki、Sekiya Ichiro
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 55 Issue: 2 Pages: 470-480
- DOI
  10.1016/j.transproceed.2023.01.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11284, KAKENHI-PROJECT-22K09301, KAKENHI-PROJECT-22K16708
[Journal Article] Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis2023
- Author(s)
  Furuoka Hideto、Endo Kentaro、Sekiya Ichiro
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 14 Issue: 1
- DOI
  10.1186/s13287-023-03487-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08693, KAKENHI-PROJECT-22K16708
[Journal Article] Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence2023
- Author(s)
  Yagi Misaki、Endo Kentaro、Komori Keiichiro、Sekiya Ichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-34825-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16708
[Journal Article] Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads2022
- Author(s)
  Fujii Shunichi、Endo Kentaro、Matsuta Seiya、Komori Keiichiro、Sekiya Ichiro
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 611-619
- DOI
  10.1016/j.reth.2022.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16708
[Journal Article] Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients2022
- Author(s)
  Yugo Miura, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17990
[Journal Article] Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes2022
- Author(s)
  Fujii Shunichi、Endo Kentaro、Ozeki Nobutake、Sakamaki Yuriko、Kohno Yuji、Mizuno Mitsuru、Katano Hisako、Tsuji Kunikazu、Koga Hideyuki、Sekiya Ichiro
- Journal Title
  
  BMC Molecular and Cell Biology
  
  Volume: 23 Issue: 1 Pages: 53-53
- DOI
  10.1186/s12860-022-00456-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11284, KAKENHI-PROJECT-22K16708
[Journal Article] Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage2022
- Author(s)
  Tanimoto Takahiro、Endo Kentaro、Sakamaki Yuriko、Ozeki Nobutake、Katano Hisako、Mizuno Mitsuru、Koga Hideyuki、Sekiya Ichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 16619-16619
- DOI
  10.1038/s41598-022-20386-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11284, KAKENHI-PROJECT-22K16708
[Journal Article] Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients2022
- Author(s)
  Miura Yugo、Endo Kentaro、Komori Keiichiro、Sekiya Ichiro
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 13 Issue: 1 Pages: 222-222
- DOI
  10.1186/s13287-022-02901-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16708
[Journal Article] Intra‐articular Injection of PDGF-BB Explored in a Novel in Vitro Model Mobilizes Mesenchymal Stem Cells From the Synovium Into Synovial Fluid in Rats2021
- Author(s)
  Endo Kentaro、Horiuchi Kiyotaka、Katano Hisako、Ozeki Nobutake、Sakamaki Yuriko、Koga Hideyuki、Sekiya Ichiro
- Journal Title
  
  Stem Cell Reviews and Reports
  
  Volume: in press Issue: 5 Pages: 1768-1779
- DOI
  10.1007/s12015-021-10156-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K24026
[Journal Article] Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF2020
- Author(s)
  Watanabe Naoto、Endo Kentaro、Komori Keiichiro、Ozeki Nobutake、Mizuno Mitsuru、Katano Hisako、Kohno Yuji、Tsuji Kunikazu、Koga Hideyuki、Sekiya Ichiro
- Journal Title
  
  Stem Cell Reviews and Reports
  
  Volume: 16 Issue: 6 Pages: 1305-1315
- DOI
  10.1007/s12015-020-10047-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22996, KAKENHI-PROJECT-19K24026
[Presentation] Single-cell RNA Sequencing Analysis Of Human Synovial And Adipose Mesenchymal Stem Cells For Knee Osteoarthritis Treatment2024
- Author(s)
  Yuki Hidaka, Kentaro Endo, Ichiro Sekiya
- Organizer
  ORS 2024 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] Single-cell RNA sequencingによるヒト滑膜・脂肪間葉系幹細胞のサブセット解析2024
- Author(s)
  遠藤健太郎, 日髙由貴, 関矢一郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] Piperlongumine Attenuates Osteoarthritis Progression By Clearing Senescent Chondrocytes And Meniscus Cells2024
- Author(s)
  Kentaro Endo, Ichiro Sekiya
- Organizer
  ORS 2024 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 滑膜由来間葉系幹細胞を用いた治療開発の現状と今後の展望2024
- Author(s)
  遠藤健太郎、片野尚子、水野満、大関信武、関矢一郎
- Organizer
  第23回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] シングルセルRNA解析によるヒト滑膜および脂肪由来間葉系細胞のサブセット比較2024
- Author(s)
  日髙由貴, 遠藤健太郎, 関矢一郎
- Organizer
  第36回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] Piperlongumineは老化軟骨・半月板細胞を除去することで変形性膝関節症の進行を抑制する2024
- Author(s)
  遠藤健太郎, 関矢一郎
- Organizer
  第36回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] ラット半月板自然修復過程における細胞老化の役割の検討2024
- Author(s)
  四十物佑介, 遠藤健太郎, 関矢一郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis2024
- Author(s)
  Hideto Furuoka, Kentaro Endo, Ichiro Sekiya
- Organizer
  ORS 2024 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 急性期炎症膝においてマクロファージが滑膜間葉系幹細胞の数および機能に与える影響2024
- Author(s)
  児玉隼人, 遠藤健太郎, 関矢一郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] ラット変形性膝関節症モデルにおける関節液中間葉系幹細胞の数・質的変化の解析2023
- Author(s)
  古岡秀人, 遠藤健太郎, 関矢一郎
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] ラット変形性膝関節症モデルへ投与後のヒト滑膜・脂肪由来間葉系幹細胞の液性因子発現の比較2023
- Author(s)
  松多誠也, 遠藤健太郎, 大関信武, 水野満, 片野尚子, 関矢一郎
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 滑膜間葉系幹細胞は脂肪間葉系幹細胞よりも変形性膝関節症モデルへ注射後に高いPRG4 発現を示す2023
- Author(s)
  松多誠也、遠藤健太郎、大関信武、水野満、片野尚子、古賀英之、関矢一郎
- Organizer
  第38回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 伸展刺激がヒト滑膜由来間葉系幹細胞の増殖に与える影響2023
- Author(s)
  目黒智子, 遠藤健太郎, 松田純平, 大関信武, 関矢一郎
- Organizer
  日本整形外科学会
- Data Source
  KAKENHI-PROJECT-23K08693
[Presentation] ラット半月板自然修復過程における老化細胞およびリプログラミング因子の評価2023
- Author(s)
  四十物佑介、遠藤健太郎、大関信武、水野満、片野尚子、古賀英之、関矢一郎
- Organizer
  第38回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 老化軟骨・半月板細胞を標的とした変形性膝関節症治療薬の開発2023
- Author(s)
  遠藤健太郎, 関矢一郎
- Organizer
  第13回Orthopedic Research Club
- Invited
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 細胞移植による半月板温存治療2023
- Author(s)
  関矢一郎、古賀英之、片野尚子、水野満、遠藤健太郎、大関信武、吉井俊貴
- Organizer
  第38回日本整形外科基礎学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 老化細胞除去薬ABT-263による変形性膝関節症由来滑膜間葉系幹細胞の高品質化2022
- Author(s)
  三浦雄悟、関矢一郎、遠藤健太郎
- Organizer
  第12回 Orthopedic Research Club
- Data Source
  KAKENHI-PROJECT-20K17990
[Presentation] 滑膜間葉系幹細胞の損傷軟骨への接着におけるmicrospikesの役割の検討2022
- Author(s)
  谷本貴大, 遠藤健太郎, 大関信武, 水野満, 片野尚, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] ラット変形性膝関節症モデルへ投与後のヒト滑膜・脂肪由来間葉系幹細胞の液性因子関連遺伝子発現の比較2022
- Author(s)
  松多誠也, 遠藤健太郎, 大関信武, 水野満, 片野尚子, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] ラット変形性膝関節症モデルにおける関節液中間葉系幹細胞の数・質的変化の解析2022
- Author(s)
  古岡秀人, 遠藤健太郎, 大関信武, 片野尚子, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 老化細胞除去薬ABT-263による変形性膝関節症由来滑膜間葉系幹細胞の高品質化2022
- Author(s)
  三浦雄悟、遠藤健太郎、小森啓一郎、大関信武、片野尚子、関矢一郎
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K17990
[Presentation] 膝蓋下脂肪体由来の脱分化脂肪細胞と間葉系幹細胞の特性の比較2022
- Author(s)
  藤井俊一, 遠藤健太郎, 小森啓一郎, 大関信武, 水野満, 片野尚子, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 老化細胞除去による、質の高い滑膜間葉系幹細胞の作製2022
- Author(s)
  三浦雄悟, 遠藤健太郎, 大関信武, 片野尚子, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] 酸化ストレスと炎症ストレスが軟骨細胞の老化に与える影響の比較2022
- Author(s)
  八木美咲, 遠藤健太郎, 小森啓一郎, 大関信武, 水野満, 片野尚子, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K16708
[Presentation] PDGF-BBの関節内注射は間葉系幹細胞を滑膜から関節液中へ動員させる2021
- Author(s)
  遠藤健太郎, 堀内聖剛, 片野尚子, 大関信武, 関矢一郎
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K24026
[Presentation] 変性半月板断裂膝の関節液中間葉系幹細胞は内在性CGRPとHGFを介して手術後に増加する2020
- Author(s)
  渡部直人, 遠藤健太郎, 小森啓一郎, 大関信武, 水野満, 河野佑二, 片野尚子, 辻邦和, 古賀英之, 大川淳, 関矢一郎
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K24026

1. 松田純平 (00535271)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 関矢一郎 (10345291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 大関信武 (10755359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 古賀英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 中村智祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 辻邦和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 渡部直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Endo Kentaro 遠藤 健太郎

Research Projects

Research Products

Co-Researchers

Structural improvement of knee osteoarthritis using synovium-specific stem cell subsets: moving beyond symptomatic treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reprogramming of Adipocytes in the Joint by Mechanical Stress; Innovative Strategies for Joint RegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

変形性膝関節症における移植後滑膜幹細胞のメカノアクチベーションによる治療効果増強

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of biological functions and therapeutic efficacy of synovial stem cells from osteoarthritis using senolytic drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of efficient treatment of knee osteoarthritis by the combination of senolytic drug and synovial stem cell injectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel synovial stem cell migration model for exploring disease-modifying osteoarthritis drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients2022

Author(s)

Journal Title

Data Source

[Journal Article] Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes2022

Author(s)

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[Journal Article] Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage2022

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[Journal Article] Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients2022

Endo Kentaro 遠藤健太郎