Aoki Shuichi 青木修一

Researcher Number	30844451
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 東北大学, 大学病院, 助教 2019 – 2020: 東北大学, 大学病院, 特任助手
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 癌微小環境 / 腫瘍免疫 / 膵癌 / 肝転移 / 肺転移 / マルチオミックス解析 / 腫瘍微小環境 / 膵癌肺転移 / 治療耐性 / 膵癌肝転移 … More / Collagen XVII / MET / 細胞外マトリックス / 化学療法感受性 / hypoxia / extracellular matrix / immunotherapy / pancreatic cancer / tumor microenvironment / 免疫チェックポイント阻害剤 / 免疫治療 / 化学療法 / 腫瘍血管 / CD8 T細胞 / 癌関連線維芽細胞 / 肝内胆管癌 … More Except Principal Investigator 胆道癌 / 膵癌 / 胆管癌 / collagen XVII / COL17A1 / collagen XⅦ / ゲノム変異 / cfDNA / ct-DNA / cf-DNA / 胆汁 / プレシジョンメデジン / 予後予測因子 / ゲノムプロファイリング / がん幹細胞 / 癌幹細胞 / FBXW7 / 休眠がん細胞 / Fbxw7 / 術前化学療法 / メタゲノム解析 / メタボローム / 腸内細菌叢 / メタオミックス解析 / 16S rRNA解析 / microbiome / 術前治療 / 腸内細菌 / 免疫療法 / クロモスリプシス / 染色体不安定性 / テロメア / バイオマーカー / 胆嚢癌 Less

Advocacy for personalized treatment of pancreatic and biliary cancer based on genome evolution and expression type diversity
- Principal Investigator
  
  海野倫明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
膵癌肺転移及び腹膜播種の免疫微小環境をターゲットとした新規治療開発Principal Investigator
- Principal Investigator
  
  青木修一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
膵癌術前治療耐性克服を目指したcollagen XVIIを標的とする新規治療開発
- Principal Investigator
  
  水間正道
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
A novel therapeutic strategy for pancreatic and biliary tract cancer by targeting the intestinal microbiota for anti-tumor immune activation
- Principal Investigator
  
  UNNO MICHIAKI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Elucidation of the mechanism of dormant cancer cells in cholangiocarcinoma
- Principal Investigator
  
  Kunihiro Masuda
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Novel treatment of biliary tract cancer by targeting genomic diversity using Bile cell-free DNA
- Principal Investigator
  
  Nakagawa Kei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Early detection and precision medicine for hepatobiliiary cancer targeting chromosomal instability
- Principal Investigator
  
  Hayashi Hiroki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
The accumulation of extracellular matrix induces immunosuppressive microenvironment and treatment resistance in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Aoki Shuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
A novel therapy to enhance the cancer immunity by remodeling tumor microenvironment in intrahepatic cholangiocarcinomaPrincipal Investigator
- Principal Investigator
  
  Aoki Shuichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Tohoku University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms2024
- Author(s)
  Itoh T, Omori Y, Seino M, Hirose K, Date F, Ono Y, Mizukami Y, Aoki S, Ishida M, Mizuma M, Morikawa T, Higuchi R, Honda G, Okamura Y, Kinoshita K, Unno M, Furukawa T.
- Journal Title
  
  Modern Pathology
  
  Volume: 37 Issue: 1 Pages: 100358-100358
- DOI
  10.1016/j.modpat.2023.100358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0282, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-22K08858, KAKENHI-PROJECT-23K06759, KAKENHI-PROJECT-21H02996, KAKENHI-PROJECT-23K24101
[Journal Article] Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment2023
- Author(s)
  Kashiwagi Ryosuke、Funayama Ryo、Aoki Shuichi、Matsui Aya、Klein Sebastian、Sato Yukihiro、Suzuki Tsubasa、Murakami Keigo、Inoue Koetsu、Iseki Masahiro、Masuda Kunihiro、Mizuma Masamichi、Naito Hisamichi、Duda Dan G.、Unno Michiaki、Nakayama Keiko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 11 Pages: 4286-4298
- DOI
  10.1111/cas.15952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08816, KAKENHI-PROJECT-21K08725, KAKENHI-PROJECT-22K19520, KAKENHI-PLANNED-22H05063, KAKENHI-PROJECT-20H03435, KAKENHI-PROJECT-21H02458, KAKENHI-PROJECT-21H02996
[Journal Article] Co-occurring IPMN and pancreatic cancer: the same or different? An overview from histology to molecular pathology.2023
- Author(s)
  Omori Y, Furukawa T, Scarpa A, Luchini C.
- Journal Title
  
  Journal of Clinical Pathology
  
  Volume: 76 Issue: 1 Pages: 734-739
- DOI
  10.1002/path.6265
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0282, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-21H02996
[Journal Article] Negative prognostic impact of sarcopenia before and after neoadjuvant chemotherapy for pancreatic cancer2023
- Author(s)
  Shimura Mitsuhiro、Mizuma Masamichi、Motoi Fuyuhiko、Kusaka Akiko、Aoki Shuichi、Iseki Masahiro、Inoue Koetsu、Douchi Daisuke、Nakayama Shun、Miura Takayuki、Ishida Masaharu、Ohtsuka Hideo、Nakagawa Kei、Morikawa Takanori、Kamei Takashi、Unno Michiaki
- Journal Title
  
  Pancreatology
  
  Volume: 23 Issue: 1 Pages: 65-72
- DOI
  10.1016/j.pan.2022.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02996
[Journal Article] CA19-9 With Two-stage Resection Is Useful for Conversion Surgery in PDAC With Synchronous Oligometastases2023
- Author(s)
  INOUE KOETSU、MIZUMA MASAMICHI、MOTOI FUYUHIKO、KOKUMAI TAKASHI、SATO HIDEAKI、KUSAKA AKIKO、AOKI SHUICHI、ISEKI MASAHIRO、DOUCHI DAISUKE、MIURA TAKAYUKI、MAEDA SHIMPEI、ISHIDA MASAHARU、OHTSUKA HIDEO、NAKAGAWA KEI、KAMEI TAKASHI、UNNO MICHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 11 Pages: 5223-5234
- DOI
  10.21873/anticanres.16724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02996
[Journal Article] Safety of Combined Division vs Separate Division of the Splenic Vein in Patients Undergoing Distal Pancreatectomy2021
- Author(s)
  Yamada Suguru、Fujii Tsutomu、Sonohara Fuminori、Kawai Manabu、Shibuya Kazuto、Matsumoto Ippei、Fukuzawa Kengo、Baba Hideo、Aoki Takeshi、Unno Michiaki、Satoi Sohei、Kishi Yoji、Hatano Etsuro、Uemura Kenichiro、Horiguchi Akihiko、Sho Masayuki、Takeda Yutaka、Shimokawa Toshio、Kodera Yasuhiro、Yamaue Hiroki
- Journal Title
  
  JAMA Surgery
  
  Volume: 156 Issue: 5 Pages: 418-418
- DOI
  10.1001/jamasurg.2021.0108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02996, KAKENHI-PROJECT-19K12848
[Journal Article] Acinar Cell Carcinoma with Morphological Change in One Month2021
- Author(s)
  Ikeda Mio、Miura Shin、Hamada Shin、Sano Takanori、Matsumoto Ryotaro、Tanaka Yu、Hongo Seiji、Yoshida Naoki、Takikawa Tetsuya、Kikuta Kazuhiro、Kume Kiyoshi、Hata Tatsuo、Unno Michiaki、Omori Yuko、Furukawa Toru、Masamune Atsushi
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 17 Pages: 2799-2806
- DOI
  10.2169/internalmedicine.7121-21
- NAID
  130008082411
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] Gut Microbiota in Pancreatic Cancer and Cholangiocarcinoma: Implications for Anticancer Drug Sensitivity2024
- Author(s)
  Ryosuke Kashiwagi, Shuichi Aoki, Naohiro Hirano, Michiaki Unno
- Organizer
  第36回日本肝胆膵外科学会プレナリーセッション
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] Collagen XVIIはCXCL10/CXCR3の免疫応答経路を介して膵癌腫瘍形成を抑制する2023
- Author(s)
  柏木良介, 舟山亮, 青木修一, 平野直大, 安藤未佳, 井上亨悦, 伊関雅裕, 三浦孝之, 石田晶玄, 大塚英郎, 水間正道, 中川圭, 森川孝則, 亀井尚, 海野倫明, 中山啓子
- Organizer
  第123回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-22K08816
[Presentation] 細胞外マトリックスの蓄積と細胞間接着の増強が膵癌における治療抵抗性を生み出す2023
- Author(s)
  青木修一, 小林実, 堂地大輔, 梶原大輝, 前田晋平, 山村明寛, 唐澤秀明, 水間正道, 大塚英郎, 大沼忍, 海野倫明
- Organizer
  第82回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] 切除可能境界膵癌に対する集学的治療2023
- Author(s)
  青木修一, 水間正道, 三浦孝之, 前田晋平, 中川圭, 海野倫明
- Organizer
  第61回日本癌治療学会
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] 肝内胆管癌においてMET signal は免疫抑制的微小環境を誘導する2022
- Author(s)
  青木修一
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K17672
[Presentation] 膵癌術前治療の耐性克服に向けた新展開2022
- Author(s)
  青木修一
- Organizer
  第122 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K17672
[Presentation] 膵癌術前治療の耐性克服に向けた新展開2022
- Author(s)
  青木修一, 伊関雅裕, 堂地大輔, 三浦孝之, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 水間正道, 中川圭, 森川孝則, 大沼忍, 石田孝宣, 亀井尚, Duda Dan G., 海野倫明
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] Transcriptome analyses to characterize treatment resistance to neoadjuvant therapy for pancreatic cancer2022
- Author(s)
  Shuichi Aoki
- Organizer
  The 26th International Association of Pancreatology
- Data Source
  KAKENHI-PROJECT-20K17672
[Presentation] 切除不能消化器癌に対するconversion surgeryの適応とタイミング　術前治療時代における膵癌微小遠隔転移に対するコンバージョン切除を企図した治療戦略(英語)2021
- Author(s)
  有明恭平, 水間正道, 青木修一, 伊関雅裕, 堂地大輔, 三浦孝之, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 中川圭, 森川孝則, 大沼忍, 亀井尚, 海野倫明
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] Placental growth factor promotes tumor desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma2021
- Author(s)
  Shuichi Aoki
- Organizer
  2021 Cholangiocarcinoma Foundation Annual Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23905
[Presentation] 膵癌に対するnal-IRI療法の治療効果および安全性の検討(英語)2021
- Author(s)
  森川孝則, 青木修一, 伊関雅裕, 三浦孝之, 堂地大輔, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 水間正道, 大塚英郎, 中川圭, 大沼忍, 亀井尚, 海野倫明
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02996
[Presentation] 抗PlGF療法による癌微小環境の再構築が肝内胆管癌における治療耐性を克服する(英語)2021
- Author(s)
  青木修一, 小林実, 梶原大輝, 有明恭平, 山村明寛, 川口桂, 唐澤秀明, 大塚英郎, 水間正道, 大沼忍, 海野倫明
- Organizer
  第80回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21H02996

1. UNNO MICHIAKI (70282043)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. 古川徹 (30282122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 熊田和貴 (10370149)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Hayashi Hiroki (30422124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Kunihiro Masuda (30569645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Nakagawa Kei (20542294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 畠達夫 (30806237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 阿部高明 (80292209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 川口桂 (10700164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 水間正道 (80578675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 中山啓子 (60294972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 舟山亮 (20452295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 安田純 (00281684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 井上亨悦 (30912711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松居彩 (40609632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 村上圭吾 (60742707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大森優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Aoki Shuichi 青木 修一

Research Projects

Research Products

Co-Researchers

Advocacy for personalized treatment of pancreatic and biliary cancer based on genome evolution and expression type diversity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵癌肺転移及び腹膜播種の免疫微小環境をターゲットとした新規治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵癌術前治療耐性克服を目指したcollagen XVIIを標的とする新規治療開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel therapeutic strategy for pancreatic and biliary tract cancer by targeting the intestinal microbiota for anti-tumor immune activation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of dormant cancer cells in cholangiocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel treatment of biliary tract cancer by targeting genomic diversity using Bile cell-free DNA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Early detection and precision medicine for hepatobiliiary cancer targeting chromosomal instability

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The accumulation of extracellular matrix induces immunosuppressive microenvironment and treatment resistance in pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel therapy to enhance the cancer immunity by remodeling tumor microenvironment in intrahepatic cholangiocarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Co-occurring IPMN and pancreatic cancer: the same or different? An overview from histology to molecular pathology.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Negative prognostic impact of sarcopenia before and after neoadjuvant chemotherapy for pancreatic cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CA19-9 With Two-stage Resection Is Useful for Conversion Surgery in PDAC With Synchronous Oligometastases2023

Author(s)

Aoki Shuichi 青木修一

[Presentation] 切除不能消化器癌に対するconversion surgeryの適応とタイミング　術前治療時代における膵癌微小遠隔転移に対するコンバージョン切除を企図した治療戦略(英語)2021