Nishizawa Hironari 西澤弘成

Researcher Number	30846655
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2023: 東北大学, 医学系研究科, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / 0702:Biology at cellular to organismal levels, and related fields Except Principal Investigator Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator BACH1 / フェロトーシス / 線維芽細胞 / 転写因子 / 細胞老化 / 鉄依存性細胞死 / 腫瘍 / 微小環境 / がん増殖 / FGF21 … More / Bach因子 / Notchシグナル / フェロトーシス伝播現象 / Notch / 血液腫瘍 / 細胞死伝播 / 小細胞肺癌 / 悪性リンパ腫 / NOTCH遺伝子 / BACH2 / 老化 / 転写因子BACH1 / パラクライン / 過酸化脂質 / 脂質過酸化 … More Except Principal Investigator 液性免疫 / メチル化 / S-アデノシルメチオニン / 代謝 / エピゲノム / エピジェネティクス / 転写因子 / 頭頸部癌 / 乳癌 / 膵癌 Less

Regulation of acquired immune cell responses by S-adenosylmethionine metabolism and its subcellular localization
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
The elucidation of the cancer-fibroblast vicious cycle in the tumor microenvironment has revealed a critical mechanism underlying cancer progression and resistance to therapy.Principal Investigator
- Principal Investigator
  
  西澤弘成
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Search for therapeutic target factors for small cell lung cancer, focusing on similarity to hematologic tumors and transcriptional regulation of NOTCH familyPrincipal Investigator
- Principal Investigator
  
  Nishizawa Hironari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of anti-cancer strategy by exploiting BACH1 addiction
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
"Dead-cells-derived anti-aging-signal model" and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  Nishizawa Hironari
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0702:Biology at cellular to organismal levels, and related fields
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO222024
- Author(s)
  Liu Liang、Matsumoto Mitsuyo、Watanabe-Matsui Miki、Nakagawa Tadashi、Nagasawa Yuko、Pang Jingyao、Callens Bert K. K.、Muto Akihiko、Ochiai Kyoko、Takekawa Hirotaka、Alam Mahabub、Nishizawa Hironari、Shirouzu Mikako、Shima Hiroki、Nakayama Keiko、Igarashi Kazuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 8 Pages: 4141-4141
- DOI
  10.3390/ijms25084141
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0176, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-23K24156
[Journal Article] Ferroptosis model system by the re-expression of BACH12023
- Author(s)
  Irikura Riko、Nishizawa Hironari、Nakajima Kazuma、Yamanaka Mie、Chen Guan、Tanaka Kozo、Onodera Masafumi、Matsumoto Mitsuyo、Igarashi Kazuhiko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 3 Pages: 239-252
- DOI
  10.1093/jb/mvad036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14556, KAKENHI-PROJECT-20KK0176, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-23K23877, KAKENHI-PROJECT-23K24156
[Journal Article] Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal2022
- Author(s)
  Nishizawa Hironari、Yamanaka Mie、Igarashi Kazuhiko
- Journal Title
  
  The FEBS Journal
  
  Volume: Preprint Issue: 7 Pages: 1688-1704
- DOI
  10.1111/febs.16382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16296, KAKENHI-PROJECT-20KK0176
[Journal Article] BACH1 Expression Is Promoted by Tank Binding Kinase 1 (TBK1) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin.2022
- Author(s)
  Liu, L., Matsumoto M., Matsui-Watanabe, M., Ochiai, K., Callens, B.K.K., Nguyen,. L.C., Kozuki, Y., Tanaka, M., Nishizawa, H. and Igarashi, K.
- Journal Title
  
  Antioxidants (Basel)
  
  Volume: 11 Issue: 8 Pages: 1460-1460
- DOI
  10.3390/antiox11081460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0176, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-23K24156
[Journal Article] The transcription factor BACH1 at the crossroads of cancer biology: From epithelial mesenchymal transition to ferroptosis2021
- Author(s)
  Igarashi Kazuhiko、Nishizawa Hironari、Saiki Yuriko、Matsumoto Mitsuyo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 3 Pages: 101032-101032
- DOI
  10.1016/j.jbc.2021.101032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07680, KAKENHI-PROJECT-20K16296
[Journal Article] Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells2021
- Author(s)
  Nishizawa Hironari、Matsumoto Mitsuyo、Chen Guan、Ishii Yusho、Tada Keisuke、Onodera Masafumi、Kato Hiroki、Muto Akihiko、Tanaka Kozo、Igarashi Kazuhiko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 12 Issue: 4 Pages: 332-332
- DOI
  10.1038/s41419-021-03613-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16296, KAKENHI-PROJECT-18H02434, KAKENHI-PROJECT-19K23738, KAKENHI-PROJECT-19K07680
[Journal Article] 転写因子BACH1によるフェロトーシスの促進機構とフェロトーシスの伝播現象2021
- Author(s)
  西澤弘成、山中美慧、五十嵐和彦
- Journal Title
  
  同仁ニュース
  
  Volume: 178 Pages: 1-4
- Data Source
  KAKENHI-PROJECT-20K16296
[Journal Article] Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH12019
- Author(s)
  Nishizawa Hironari、Matsumoto Mitsuyo、Shindo Tomohiko、Saigusa Daisuke、Kato Hiroki、Suzuki Katsushi、Sato Masaki、Ishii Yusho、Shimokawa Hiroaki、Igarashi Kazuhiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 1 Pages: 69-82
- DOI
  10.1074/jbc.ra119.009548
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-19K23738, KAKENHI-PROJECT-19K07680
[Presentation] 鉄は老化もつかさどる!! 生体の抗老化機構としてのフェロトーシス2023
- Author(s)
  西澤弘成
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K14556
[Presentation] 鉄は老化もつかさどる!! 　生体の抗老化機構としてのフェロトーシス2023
- Author(s)
  西澤弘成
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0176
[Presentation] BACH1-controlled ferroptotic cell-derived anti-aging signaling model2022
- Author(s)
  Hironari Nishizawa, Kazuhiko Igarashi
- Organizer
  2022 Cold Spring Harbor Asia Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16296
[Presentation] Mechanistic connection of ferroptosis and cancer cell metastasis involving BACH12022
- Author(s)
  Kazuhiko Igarashi, Hironari Nishizawa, Liang Liu, Mitsuyo Matsumoto
- Organizer
  2022 Cold Spring Harbor Asia Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16296
[Presentation] Regulation of heterogeneity and metastasis of pancreatic cancer cells by the BACH1 gene regulatory network2021
- Author(s)
  Kazuhiko Igarashi, Hironari Nishizawa, Mitsuyo Matsumoto
- Organizer
  日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0176
[Presentation] ビリベルジン結合型シアノバクテリアクロムを用いたフェロトーシス高感受性細胞の検出2021
- Author(s)
  中島一真、西澤弘成、成川礼、松本光代、五十嵐和彦
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16296
[Presentation] 転写因子BACH1が活性化するフェロトーシス細胞由来抗老化シグナルモデル2021
- Author(s)
  西澤弘成、松本光代、五十嵐和彦
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16296
[Presentation] 転写因子BACH1がつかさどるフェロトーシス制御ネットワークとフェロトーシスの伝播現象2021
- Author(s)
  西澤弘成
- Organizer
  2021がん研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K16296
[Presentation] The gene regulatory network of ferroptosis controlled by the transcription factor BACH12020
- Author(s)
  西澤弘成
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16296
[Presentation] The gene regulatory network of ferroptosis controlled by the transcription factor BACH12020
- Author(s)
  西澤弘成
- Organizer
  第93回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19K23738

1. 五十嵐和彦 (00250738)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 島弘季 (00448268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 落合恭子 (10455785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 松本光代 (80400448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 加藤浩貴 (50801677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nishizawa Hironari 西澤 弘成

Research Projects

Research Products

Co-Researchers

Regulation of acquired immune cell responses by S-adenosylmethionine metabolism and its subcellular localization

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the cancer-fibroblast vicious cycle in the tumor microenvironment has revealed a critical mechanism underlying cancer progression and resistance to therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for therapeutic target factors for small cell lung cancer, focusing on similarity to hematologic tumors and transcriptional regulation of NOTCH familyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anti-cancer strategy by exploiting BACH1 addiction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

"Dead-cells-derived anti-aging-signal model" and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO222024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ferroptosis model system by the re-expression of BACH12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BACH1 Expression Is Promoted by Tank Binding Kinase 1 (TBK1) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The transcription factor BACH1 at the crossroads of cancer biology: From epithelial mesenchymal transition to ferroptosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 転写因子BACH1によるフェロトーシスの促進機構とフェロトーシスの伝播現象2021

Author(s)

Journal Title

Data Source

[Journal Article] Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH12019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 鉄は老化もつかさどる!! 生体の抗老化機構としてのフェロトーシス2023

Author(s)

Organizer

Data Source

[Presentation] 鉄は老化もつかさどる!! 生体の抗老化機構としてのフェロトーシス2023

Author(s)

Organizer

Nishizawa Hironari 西澤弘成

[Presentation] 鉄は老化もつかさどる!! 　生体の抗老化機構としてのフェロトーシス2023

[Presentation] 転写因子BACH1がつかさどるフェロトーシス制御ネットワークとフェロトーシスの伝播現象2021