SAKUTA HIROKI 作田浩輝

… Alternative Names

Hiroki Sakuta 作田浩輝

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Researcher Number	30876206
Other IDs	https://orcid.org/0000-0001-8473-6370
Affiliation (Current)	2026: 東京大学, 大学院総合文化研究科, 特任助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 東京大学, 大学院総合文化研究科, 特任助教 2021: 同志社大学, 研究開発推進機構, 助教
Review Section/Research Field	Principal Investigator Basic Section 13040:Biophysics, chemical physics and soft matter physics-related / Basic Section 43040:Biophysics-related
Keywords	Principal Investigator 人工細胞 / 液－液相分離 / 細胞モデル / 混雑環境 / 分子拡散 / リポソーム / 高分子混雑効果 / モータータンパク質 / 細胞骨格 / 水－水相分離 … More / アミロイド形成 / ミクロ液滴 / アミロイド / 自発運動 / 骨格タンパク質 / モータタンパク質 / 高分子混雑 / 液ー液相分離 Less

Modulation mechanisms of liquid-liquid phase separation: promotion and inhibition by cell- sized spacePrincipal Investigator
- Principal Investigator
  
  作田浩輝
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  The University of Tokyo
Autonomous emergence of artificial cellular model by micro phase separation of macromolecular solutionPrincipal Investigator
- Principal Investigator
  
  Hiroki Sakuta
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
  Doshisha University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Progress in Phase Separation Research Inspired by Intracellular Phase Separation2025
- Author(s)
  Yanagisawa Miho、Sakuta Hiroki
- Journal Title
  
  POLYMERS
  
  Volume: 74 Issue: 2 Pages: 84-85
- DOI
  10.1295/kobunshi.74.2_84
- ISSN
  0454-1138, 2185-9825
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15057
[Journal Article] Accelerated amyloid fibril formation at the interface of liquid-liquid phase-separated droplets by depletion interactions2025
- Author(s)
  Yamaguchi Keiichi、Mima Joji、Nakajima Kichitaro、Sakuta Hiroki、Yoshikawa Kenichi、Goto Yuji
- Journal Title
  
  Protein Science
  
  Volume: 34 Issue: 2
- DOI
  10.1002/pro.5163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21K15057, KAKENHI-PROJECT-23K23848
[Journal Article] Marangoni Droplets of Dextran in PEG Solution and Its Motile Change Due to Coil?Globule Transition of Coexisting DNA2024
- Author(s)
  Furuki Tomohiro、Sakuta Hiroki、Yanagisawa Naoya、Tabuchi Shingo、Kamo Akari、Shimamoto Daisuke S.、Yanagisawa Miho
- Journal Title
  
  ACS Applied Materials & Interfaces
  
  Volume: 16 Issue: 32 Pages: 43016-43025
- DOI
  10.1021/acsami.4c09362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15057, KAKENHI-PROJECT-23K22459
[Journal Article] 膜で覆われた高分子液滴に見られる細胞サイズの空間効果2024
- Author(s)
  柳澤実穂, 作田浩輝
- Journal Title
  
  化学工学
  
  Volume: 88 Pages: 158-161
- Data Source
  KAKENHI-PROJECT-21K15057
[Journal Article] Behavior of Biopolymers, Cytoskeleton, DNA, and Phospholipids, that Exert Self-organization, Shown in the Liquid-Liquid Phase Separation2023
- Author(s)
  Kingo TAKIGUCHI, Hiroki SAKUTA, Masahito HAYASHI, Tatsuyuki WAIZUMI, Kanta TSUMOTO, Kenichi YOSHIKAWA
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 63 Issue: 1 Pages: 5-11
- DOI
  10.2142/biophys.63.5
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18952, KAKENHI-PROJECT-21K15057, KAKENHI-PUBLICLY-21H05891, KAKENHI-PROJECT-19K06540, KAKENHI-PLANNED-20H05972, KAKENHI-PROJECT-20H01877
[Journal Article] Self-emergent vortex flow of microtubule and kinesin in cell-sized droplets under water/water phase separation2023
- Author(s)
  Sakuta Hiroki、Nakatani Naoki、Torisawa Takayuki、Sumino Yutaka、Tsumoto Kanta、Oiwa Kazuhiro、Yoshikawa Kenichi
- Journal Title
  
  Communications Chemistry
  
  Volume: 6 Issue: 1 Pages: 1-9
- DOI
  10.1038/s42004-023-00879-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15057, KAKENHI-PUBLICLY-21H00409, KAKENHI-PROJECT-20H01877, KAKENHI-PROJECT-23K21301
[Journal Article] Emergence of uniform linearly-arranged micro-droplets entrapping DNA and living cells through water/water phase-separation2021
- Author(s)
  Shono Mayu、Ito Ritsuki、Fujita Fumika、Sakuta Hiroki、Yoshikawa Kenichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 23570-23570
- DOI
  10.1038/s41598-021-02990-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15057, KAKENHI-PROJECT-20H01877
[Journal Article] Polymerization/depolymerization of actin cooperates with the morphology and stability of cell-sized droplets generated in a polymer solution under a depletion effect2021
- Author(s)
  Waizumi Tatsuyuki、Sakuta Hiroki、Hayashi Masahito、Tsumoto Kanta、Takiguchi Kingo、Yoshikawa Kenichi
- Journal Title
  
  The Journal of Chemical Physics
  
  Volume: 155 Issue: 7 Pages: 075101-075101
- DOI
  10.1063/5.0055460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06540, KAKENHI-PROJECT-21K15057, KAKENHI-PROJECT-20H01877
[Presentation] Dynamic Behaviors of Aqueous Droplets: Mimicking Cellular Motility and Intracellular Dynamics2025
- Author(s)
  Hiroki Sakuta,Miho Yanagisawa
- Organizer
  SLMP2025, IIS Symposium Soft and Liquid Matter Physics: Past, Present and Future
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Chain Length-Dependent Phase Separation: Insights from DNA Partitioning in PEG-Dextran Solutions2025
- Author(s)
  Yuki Akamine,Hiroki Sakuta,Norikazu Ichihashi,Miho Yanagisawa
- Organizer
  SLMP2025, IIS Symposium Soft and Liquid Matter Physics: Past, Present and Future
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 高分子混雑した細胞サイズ空間に起因する分子拡散挙動の変化2024
- Author(s)
  作田浩輝
- Organizer
  第76回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 相分離液滴に局在するDNAの鎖長に対する分配依存性2024
- Author(s)
  赤嶺柚希, 作田浩輝, 市橋伯一, 柳澤実穂
- Organizer
  定量生物学の会　第十一回年会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 動く相分離液滴：共存するDNAの構造転移に伴うパターンと移動速度の変化2024
- Author(s)
  古木智大, 作田浩輝, 田渕辰悟, 嶋本大祐, 柳澤実穂
- Organizer
  日本物理学会2024年春季大会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 液液相分離液滴で再構成する細胞様構造2024
- Author(s)
  作田浩輝
- Organizer
  定量生物学の会　第十一回年会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 液ー液相分離で形成する細胞サイズ空間における生体分子の自己組織化2024
- Author(s)
  作田浩輝
- Organizer
  溶液化学研究会若手の会第3回冬季発表会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 水／水相分離ミクロ液滴に局在する微小管・キネシンの自発的対流生成2024
- Author(s)
  作田浩輝、中谷真規、鳥澤嵩征、住野豊、湊元幹太、大岩和弘、吉川研一
- Organizer
  第11回ソフトマター研究会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Microtubule/kinesin complexes spontaneously emerge vortices in cell-sized droplet generated by water/water phase separation2024
- Author(s)
  Hiroki Sakuta,Naoki Nakatani,Takayuki Torisawa,Yutaka Sumino,Kanta Tsumoto,Kazuhiro Oiwa,Kenichi Yoshikawa
- Organizer
  IUPAB2024 (joint congress of 21st IUPAB and 62nd BSJ)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 共存する DNA のコイル・グロビュール転移による自走液滴の運動制御2024
- Author(s)
  古木智大, 作田浩輝, 田渕辰悟, 嶋本大祐, 柳澤実穂
- Organizer
  第11回ソフトマター研究会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 相分離ミクロ液滴への生体分子の局在とダイナミクス2023
- Author(s)
  作田浩輝
- Organizer
  第22回関東ソフトマター研究会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 液-液相分離によるαシヌクレインのアミロイド線維形成2023
- Author(s)
  三間穣治, 山口圭一, 作田浩輝, 中島吉太郎, 吉川研一, 後藤祐児
- Organizer
  第10回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Myosin or its fragments influences F-actin dynamics and deformation of droplets under2023
- Author(s)
  Waizumi Tatsuyuki, Sakuta Hiroki, Kikumoto Mahito, Hayashi Masahito, Tsumoto Kanta, Takiguchi Kingo, Yoshikawa Kenichi
- Organizer
  第 61 回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Self-Emerging Vortex Flow of Microtubule/Kinesin in the Microdroplet of Water/Water Phase Separation2023
- Author(s)
  Hiroki Sakuta, Naoki Nakatani, Takayuki Torisawa, Yutaka Sumino, Kanta Tsumoto, Kazuhiro Oiwa, Kenichi Yoshikawa
- Organizer
  The 7th Internatinal Soft Matter Conference (ISMC2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Microtubule-kinesin complexes spontaneously generate vortex flow in the cell-sized droplets created by water/water phase separation2023
- Author(s)
  Hiroki Sakuta, Naoki Nakatani, Takayuki Torisawa, Yutaka Sumino, Kanta Tsumoto, Kazuhiro Oiwa, Kenichi Yoshikawa
- Organizer
  第 61 回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Self-emergence of cell-like structure in microdroplet generated through the liquid/liquid phase separation2023
- Author(s)
  Hiroki Sakuta
- Organizer
  11th ELSI Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 自己創生し規則配列する水/水相分離液滴：DNAや細胞の自発的取り込み2022
- Author(s)
  庄野真由、伊藤立樹、藤田ふみか、作田浩輝、塩井章久、吉川研一
- Organizer
  日本化学会第102回春季年会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] 高分子混雑溶液中での水／水ミクロ相分離による細胞様構造の自発的生成2021
- Author(s)
  藤田ふみか、作田浩輝、湊元幹太、剣持貴弘、貞包浩一朗、吉川研一
- Organizer
  第72回コロイドおよび界面化学討論会
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Self-generation of cell-like structure through water/water micro phase-separation in a crowding macromolecular solution2021
- Author(s)
  Fumika Fujita、Hiroki Sakuta、Kanta Tsumoto、Koichiro Sadakane、Takahiro Kenmotsu、Kenichi Yoshikawa
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021 (Pacifichem 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Self-organization of protocell ac-companied by micro phase segregation in a crowding solution2021
- Author(s)
  Fumika Fujita、Hiroki Sakuta、Kanta Tsumoto、Koichiro Sadakane、Takahiro Kenmotsu、Kenichi Yoshikawa
- Organizer
  20th IUPAB Congress, 45th Annual SBBf Meeting, and 50th Annual SBBq Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057
[Presentation] Spontaneous Construction of Cellular Assembly through Aqueous/Aqueous Micro Phase-Separa- tion2021
- Author(s)
  Hiroki Sakuta、Ritsuki Ito、Mayu Shono、Fumika Fujita、Kenichi Yoshikawa
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021 (Pacifichem 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15057

1. 山口圭一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 瀧口金吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 湊元幹太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKUTA HIROKI 作田 浩輝

Hiroki Sakuta 作田 浩輝

Research Projects

Research Products

Co-Researchers

Modulation mechanisms of liquid-liquid phase separation: promotion and inhibition by cell- sized spacePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Autonomous emergence of artificial cellular model by micro phase separation of macromolecular solutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Progress in Phase Separation Research Inspired by Intracellular Phase Separation2025

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Accelerated amyloid fibril formation at the interface of liquid-liquid phase-separated droplets by depletion interactions2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marangoni Droplets of Dextran in PEG Solution and Its Motile Change Due to Coil?Globule Transition of Coexisting DNA2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 膜で覆われた高分子液滴に見られる細胞サイズの空間効果2024

Author(s)

Journal Title

Data Source

[Journal Article] Behavior of Biopolymers, Cytoskeleton, DNA, and Phospholipids, that Exert Self-organization, Shown in the Liquid-Liquid Phase Separation2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Self-emergent vortex flow of microtubule and kinesin in cell-sized droplets under water/water phase separation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emergence of uniform linearly-arranged micro-droplets entrapping DNA and living cells through water/water phase-separation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polymerization/depolymerization of actin cooperates with the morphology and stability of cell-sized droplets generated in a polymer solution under a depletion effect2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Dynamic Behaviors of Aqueous Droplets: Mimicking Cellular Motility and Intracellular Dynamics2025

Author(s)

Organizer

Data Source

[Presentation] Chain Length-Dependent Phase Separation: Insights from DNA Partitioning in PEG-Dextran Solutions2025

Author(s)

Organizer

Data Source

[Presentation] 高分子混雑した細胞サイズ空間に起因する分子拡散挙動の変化2024

Author(s)

Organizer

Data Source

[Presentation] 相分離液滴に局在するDNAの鎖長に対する分配依存性2024

Author(s)

Organizer

Data Source

[Presentation] 動く相分離液滴：共存するDNAの構造転移に伴うパターンと移動速度の変化2024

Author(s)

Organizer

Data Source

SAKUTA HIROKI 作田浩輝

Hiroki Sakuta 作田浩輝