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Hiratsuka Toru  平塚 徹

ORCIDConnect your ORCID iD *help
Researcher Number 30893028
Other IDs
Affiliation (Current) 2026: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 腫瘍増殖制御学部 主任研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 腫瘍増殖制御学部 主任研究員
2022: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 腫瘍増殖制御学部研究員
2021: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), 分子細胞生物学部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / 0702:Biology at cellular to organismal levels, and related fields
Except Principal Investigator
Basic Section 50010:Tumor biology-related
Keywords
Principal Investigator
膵がん / オルガノイド / ゆらぎ / ライブイメージング / ERK / 不均一性 / がん不均一性 / 揺らぎ / 膵臓癌 / 皮膚癌 … More / 微小環境 / 膵癌 / 癌 / 膵臓 / 皮膚 … More
Except Principal Investigator
HER1/2 陽性がん / HER2 / EGFR / Phosphatase / ユビキチンリガーゼ / RhoB / 乳がん / CNKSR1 / プロテインチロシンホスファターゼ / HER Less
  • Research Projects

    (4 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (5 People)
  •  受容体型チロシンキナーゼHERの新規活性抑制機構に基づく創薬とがん治療応用

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Ehime University
  •  細胞間のERK MAPK不均一性を指標とするがんの病態理解Principal Investigator

    • Principal Investigator
      平塚 徹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka International Cancer Institute
  •  Observation and regulation of fluctuating ERK signal in pancreatic cancerPrincipal Investigator

    • Principal Investigator
      Hiratsuka Toru
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka International Cancer Institute
  •  Multi-tumor analysis of ERK signal dynamics during oncogenesisPrincipal Investigator

    • Principal Investigator
      Hiratsuka Toru
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0702:Biology at cellular to organismal levels, and related fields
    • Research Institution
      Osaka International Cancer Institute

All 2025 2024 2023 2022

All Journal Article Presentation Book

  • [Book] 型で実践する生物画像解析 ImageJ・Python・napari (実験医学別冊)2025

    • Author(s)
      三浦 耕太, 塚田 祐基, 黄 承宇, 戸田 陽介, 河合 宏紀, 平塚 徹, 菅原 皓, 遠里 由佳子, 京田 耕司, 大浪 修一, 土田 マーク 彰
    • Total Pages
      28
    • Publisher
      羊土社
    • ISBN
      9784758122801
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Journal Article] A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription2025

    • Author(s)
      Weisheng Zhang、Nakayama Jun、Inomata Yukino、Higashiyama Shigeki、Hiratsuka Toru
    • Journal Title

      Cell Struct. Funct.

      Volume: 50 Issue: 1 Pages: 15-24

    • DOI

      10.1247/csf.24070

    • ISSN
      0386-7196, 1347-3700
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Journal Article] Quantitative Live Imaging Reveals Phase Dependency of <scp>PDAC</scp> Patient‐Derived Organoids on <scp>ERK</scp> and <scp>AMPK</scp> Activity2024

    • Author(s)
      Tsukamoto Shoko、Huaze Ye、Weisheng Zhang、Machinaga Akihito、Kakiuchi Nobuyuki、Ogawa Seishi、Seno Hiroshi、Higashiyama Shigeki、Matsuda Michiyuki、Hiratsuka Toru
    • Journal Title

      Cancer Science

      Volume: 116 Issue: 3 Pages: 724-735

    • DOI

      10.1111/cas.16439

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24H00009, KAKENHI-PLANNED-20H05898, KAKENHI-PROJECT-23K27582, KAKENHI-PROJECT-24K10301
  • [Presentation] ERK and AMPK activity in PDAC organoids supports the efficacy of targeted therapy to cell growth and autophagy signal2024

    • Author(s)
      塚本祥子、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行、平塚徹
    • Organizer
      第83回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] ERKの高感度蛍光プローブを用いた低濃度EGF刺激下のキナーゼ活性化の検出と転写への意義2024

    • Author(s)
      張 偉生、中山 淳、猪俣 友紀乃、東山 繁樹、平塚 徹
    • Organizer
      第47回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] Wide-area 3D live imaging of pancreatic cancer organoid and its quantitative analysis2024

    • Author(s)
      平塚 徹 、Ye Huaze 、Zhang Weisheng 、塚本 祥子 、Al Koussa Houssam 、待永 明仁 、垣内 伸行 ,、小川 誠司、妹尾 浩 、東山 繁樹 、松田 道行
    • Organizer
      第6回がん三次元培養研究会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] In vivo ERK MAPK signaling dynamics in an orthotopic xenograft model of human patient-derived pancreatic cancer cells2024

    • Author(s)
      Houssam K Alkoussa、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行、平塚徹
    • Organizer
      第83回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] Live imaging of ERK MAPK and AMPK activity in patient-derived pancreatic cancer organoids in vitro and in vivo2024

    • Author(s)
      平塚徹、塚本祥子、Houssam Al Koussa、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行
    • Organizer
      第83回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] ERK MAPKシグナルの細胞間伝搬から見た皮膚正常細胞とがん細胞の相互作用2024

    • Author(s)
      平塚 徹
    • Organizer
      第97回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] 患者由来膵癌オルガノイドにおけるERK MAPKおよびAMPKシグナルの定量的ライブイメージング2024

    • Author(s)
      平塚徹、塚本祥子、Houssam Al Koussa、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行
    • Organizer
      第47回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] Live imaging of ERK MAPK and AMPK activity in patient-derived pancreatic cancer organoids reveals heterogeneous growth and drug responses in vitro and in vivo2024

    • Author(s)
      平塚徹、塚本祥子、Houssam Al Koussa、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行
    • Organizer
      第75回日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] Cell-to-cell propagation of ERK signaling is deregulated in epidrmal cancer cells.2024

    • Author(s)
      Wang Ziwei, Toru Hiratsuka
    • Organizer
      第97回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-24K10301
  • [Presentation] 膵癌オルガノイドにおけるERK MAPKシグナルの不均一性のライブイメージング2023

    • Author(s)
      塚本祥子、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行、平塚徹
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] ヒト膵がんオルガノイドにおける包括的ライブイメージングアプローチ2023

    • Author(s)
      平塚徹
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] 患者由来の膵がんオルガノイドにおける定量的かつ包括的なERK MAPKシグナルダイナミクス解析2023

    • Author(s)
      塚本祥子、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行、平塚徹
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] In vivo ERK MAPK signaling dynamics in the orthotopic xenograft model of human patient-derived pancreatic cancer cells2023

    • Author(s)
      Houssam K Alkoussa、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行、平塚徹
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] 膵癌オルガノイドにおけるERK MAPKシグナルの不均一性のクローン進化過程2023

    • Author(s)
      平塚徹、塚本祥子、Houssam Al Koussa、待永明仁、垣内伸之、小川誠司、妹尾浩、東山繁樹、松田道行
    • Organizer
      第75回日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] The quantitative landscape of ERK MAPK signal dynamics in patient-derived pancreatic cancer organoids.2022

    • Author(s)
      Shoko Tsukamoto, Akihito Machinaga, Nobuyuki Kakiuchi, Seishi Ogawa, Hiroshi Seno, Shigeki Higashiyama, Michiyuki Matsuda, Toru Hiratsuka
    • Organizer
      第81回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] The Quantitative Landscape of ERK MAPK Signal Dynamics in Patient-Derived Pancreatic Cancer Organoids2022

    • Author(s)
      Shoko Tsukamoto, Akihito Machinaga, Nobuyuki Kakiuchi, Seishi Ogawa, Hiroshi Seno, Shigeki Higashiyama, Michiyuki Matsuda, Toru Hiratsuka
    • Organizer
      The 7th JCA AACR Special Joint Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] The quantitative landscape of ERK MAPK signal dynamics in patient-derived pancreatic cancer organoids.2022

    • Author(s)
      Shoko Tsukamoto, Akihito Machinaga, Nobuyuki Kakiuchi, Seishi Ogawa, Hiroshi Seno, Shigeki Higashiyama, Michiyuki Matsuda, Toru Hiratsuka
    • Organizer
      第95回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21K20656
  • [Presentation] Fluctuating ERK signal during epidermal stem cell proliferation and differentiation2022

    • Author(s)
      Toru Hiratsuka, Ignacio Bordeau, Gunnar Preussner, Fiona Watt
    • Organizer
      第74回 日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] Spatiotemporal dynamics of ERK activity in human and mouse epidermal cells2022

    • Author(s)
      平塚 徹, Ignacio Bordeau, Gunnar Preussner, Fiona Watt
    • Organizer
      第81回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K20656
  • [Presentation] Fluctuating ERK signal during epidermal stem cell proliferation and differentiation2022

    • Author(s)
      Toru Hiratsuka, Ignacio Bordeau, Gunnar Preussner, Fiona Watt
    • Organizer
      第74回 日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-21K20656
  • [Presentation] Spatiotemporal dynamics of ERK activity in human and mouse epidermal cells2022

    • Author(s)
      平塚 徹, Ignacio Bordeau, Gunnar Preussner, Fiona Watt
    • Organizer
      第95回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-22K15510
  • [Presentation] The Quantitative Landscape of ERK MAPK Signal Dynamics in Patient-Derived Pancreatic Cancer Organoids2022

    • Author(s)
      Shoko Tsukamoto, Akihito Machinaga, Nobuyuki Kakiuchi, Seishi Ogawa, Hiroshi Seno, Shigeki Higashiyama, Michiyuki Matsuda, Toru Hiratsuka
    • Organizer
      The 7th JCA AACR Special Joint Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K20656
  • 1.  東山 繁樹 (60202272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  中山 淳 (30801237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  田手 壮太 (90939638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  望月 直樹 (30311426)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  小川 誠司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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