Hirabayashi Shigeki 平林茂樹

Researcher Number	30910947
Other IDs
Affiliation (Current)	2026: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2022 – 2026: 九州大学, 医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator ゲノム編集 / トランスクリプトーム / 遺伝性血液腫瘍 / CRISPRスクリーニング / 血液腫瘍 / がん Except Principal Investigator t(8;21) / 胎児型造血 / １細胞全ゲノム解析 / 急性骨髄性白血病 / 白血病

革新的技術基盤構築による分子標的薬の治療抵抗性機序解明と克服戦略の実証Principal Investigator
- Principal Investigator
  
  平林茂樹
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
Exploring synthetic lethality as a therapeutic target for refractory cancer
- Principal Investigator
  
  前田高宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
Exploring the origins of t(8;21) AML: Elucidating the relationship between adult AML pathogenesis and the fetal hematopoietic program.
- Principal Investigator
  
  前田高宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
遺伝性血液腫瘍の変異が病態に及ぼす本質的な意義の解明Principal Investigator
- Principal Investigator
  
  平林茂樹
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
Search for Novel Cancer Therapeutic Targets Based on Large-Scale Genomics and Functional ScreeningPrincipal Investigator
- Principal Investigator
  
  Hirabayashi Shigeki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Myeloablative conditioning in cord blood transplantation for acute myeloid leukemia patients is efficacious only until age 552025
- Author(s)
  Oshima Shinichiro, Arai Yasuyuki, Kondo Tadakazu, Yano Shingo, Hirabayashi Shigeki, Uchida Naoyuki, Onizuka Makoto, Miyakoshi Shigesaburo, Tanaka Masatsugu, Takahashi Satoshi, Hayashi Masayuki, Kawakita Toshiro, Uehara Yasufumi, Ota Shuichi, Izumi Toru, et al.
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 60 Issue: 4 Pages: 458-466
- DOI
  10.1038/s41409-025-02508-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K18518
[Journal Article] HLA‐matched related peripheral blood stem cell and bone marrow transplantation with RIC regimens yield comparable outcomes for adult AML2025
- Author(s)
  Mitsuyoshi Takaya、Arai Yasuyuki、Kondo Tadakazu、Kawata Takahito、Hirabayashi Shigeki、Tanaka Masatsugu、Mori Yasuo、Doki Noriko、Nishida Tetsuya、Kotani Takeharu、Ogata Masao、Tabayashi Takayuki、Eto Tetsuya、Sawa Masashi、Imada Kazunori、Kanda Junya、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
- Journal Title
  
  eJHaem
  
  Volume: 6 Issue: 1
- DOI
  10.1002/jha2.1088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K18518
[Journal Article] Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells2024
- Author(s)
  Imanaga Hiroshi、Semba Yuichiro、Sasaki Kensuke、Setoguchi Kiyoko、Maniriho Hillary、Yamauchi Takuji、Terasaki Tatsuya、Hirabayashi Shigeki、Nakao Fumihiko、Nogami Jumpei、Izraeli Shai、Akashi Koichi、Maeda Takahiro
- Journal Title
  
  Blood Neoplasia
  
  Volume: 1 Issue: 2 Pages: 100015-100015
- DOI
  10.1016/j.bneo.2024.100015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-22K16303, KAKENHI-PROJECT-23K07816, KAKENHI-PROJECT-24K18518
[Journal Article] An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases2024
- Author(s)
  Oguchi Akiko、Suzuki Akari、Komatsu Shuichiro、...、Ishigaki Kazuyoshi、Ishikawa Yuki、Komatsu Shuichiro、Kono Michihiro、Murakawa Yasuhiro、Nakano Masahiro、Oguchi Akiko、Son Raku、Suzuki Akari、Takeuchi Kazuhiro、Tanaka Nao、Terao Chikashi、Tomizuka Kohei、Yamamoto Kazuhiko、Yoshino Soichiro、ITEC Consortium‡
- Journal Title
  
  Science
  
  Volume: 385 Issue: 6704
- DOI
  10.1126/science.add8394
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-24K18518
[Journal Article] Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells2024
- Author(s)
  Imanaga H, Semba Y, Sasaki K, Setoguchi K, Maniriho H, Yamauchi T, Terasaki T, Hirabayashi S, Nakao F, Nogami J, Izraeli S, Akashi K, Maeda T
- Journal Title
  
  Blood Neoplasia
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Journal Article] The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells2024
- Author(s)
  Terasaki Tatsuya、Semba Yuichiro、Sasaki Kensuke、Imanaga Hiroshi、Setoguchi Kiyoko、Yamauchi Takuji、Hirabayashi Shigeki、Nakao Fumihiko、Akahane Koshi、Inukai Takeshi、Sanda Takaomi、Akashi Koichi、Maeda Takahiro
- Journal Title
  
  Leukemia
  
  Volume: 38 Issue: 9 Pages: 1918-1928
- DOI
  10.1038/s41375-024-02343-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-24H00639, KAKENHI-PROJECT-23K24298, KAKENHI-PROJECT-22K16303, KAKENHI-PROJECT-23K07816, KAKENHI-PROJECT-24K18518
[Journal Article] HTLV-1 bZIP factor impairs DNA mismatch repair system2023
- Author(s)
  Sakurada-Aono Maki、Sakamoto Takashi、Kobayashi Masayuki、Takiuchi Yoko、Iwai Fumie、Tada Kohei、Sasanuma Hiroyuki、Hirabayashi Shigeki、Murakawa Yasuhiro、Shirakawa Kotaro、Sakamoto Chihiro、Shindo Keisuke、Yasunaga Jun-ichirou、Matsuoka Masao、Pommier Yves、Takeda Shunichi、Takaori-Kondo Akifumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 657 Pages: 43-49
- DOI
  10.1016/j.bbrc.2023.03.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-20H03514, KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-23K24365
[Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023
- Author(s)
  Nakao Fumihiko、Setoguchi Kiyoko、Semba Yuichiro、Yamauchi Takuji、Nogami Jumpei、Sasaki Kensuke、Imanaga Hiroshi、Terasaki Tatsuya、Miyazaki Manaka、Hirabayashi Shigeki、Miyawaki Kohta、Kikushige Yoshikane、Masuda Takeshi、Akashi Koichi、Maeda Takahiro
- Journal Title
  
  Leukemia
  
  Volume: - Issue: 5 Pages: 1028-1038
- DOI
  10.1038/s41375-023-01879-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K07816, KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-21H04827
[Journal Article] Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ ALL: A retrospective nationwide study2023
- Author(s)
  Hirabayashi S, Kondo T, Nishiwaki S, Mizuta S, Doki N, Fukuda T, Uchida N, Ozawa Y, Kanda Y, Imanaka R, Takahashi S, Ishikawa J, Yano S, Nakamae H, Eto T, Kimura T, Tanaka J, Ichinohe T, Atsuta Y, Kako S.
- Journal Title
  
  American Journal of Hematology
  
  Volume: 98 Issue: 10 Pages: 1606-1618
- DOI
  10.1002/ajh.27041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323
[Journal Article] Advantages of peripheral blood stem cells from unrelated donors versus bone marrow transplants in outcomes of adult acute myeloid leukemia patients2022
- Author(s)
  Jo Tomoyasu、Arai Yasuyuki、Kondo Tadakazu、Mizuno Shohei、Hirabayashi Shigeki et al.
- Journal Title
  
  Cytotherapy
  
  Volume: 24 Issue: 10 Pages: 1013-1025
- DOI
  10.1016/j.jcyt.2022.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323
[Journal Article] Effect of Multiple HLA Locus Mismatches on Outcomes after Single Cord Blood Transplantation.2022
- Author(s)
  Kanda J, Hirabayashi S, Yokoyama H, Kawase T, Tanaka H, Uchida N, Taniguchi S, Takahashi S, Onizuka M, Tanaka M, Sugio Y, Eto T, Kanda Y, Kimura T, Ichinohe T, Atsuta Y, Morishima S.
- Journal Title
  
  Transplant Cell Ther.
  
  Volume: 28 Issue: 7 Pages: 398-398
- DOI
  10.1016/j.jtct.2022.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08737, KAKENHI-PROJECT-22K08488, KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-17K09934
[Journal Article] Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia2022
- Author(s)
  Shimomura Y, Takahashi S., et al.
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 4 Pages: 1132-1138
- DOI
  10.1038/s41375-021-01474-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-21K15579, KAKENHI-PROJECT-22K16323
[Presentation] Comprehensive identification of resistant mutations to KRAS G12D inhibitor and pan-KRAS inhibitor in human pancreatic ductal adenocarcinoma using prime editing screening2025
- Author(s)
  Shigeki Hirabayashi, Kyoko Fukushi, Momoka Tsuruhara, Keisuke Uchikawa, Shoko Tarumoto, Takuya Yamamoto, Taro Tsujimura, Masahito Ohue, Takahiro Maeda
- Organizer
  13TH AACR-JCA JOINT CONFERENCE: FROM CANCER DISCOVERY SCIENCE TO THERAPEUTIC INNOVATION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K18518
[Presentation] 新規ロングリードRNA-seq法を用いた急性白血病における転写産物の全長解明2024
- Author(s)
  和田　典也、加藤匠矢、Shruti Bhagat、Zhiwei Zhang、平林茂樹、永田佳代子、岩崎惇、孫楽、小口綾貴子、竹内一博、関戸翔、平井公也、竹田淳恵、諫田淳也、阪本貴士、白川康太郎、高折晃史、村川泰裕
- Organizer
  第86回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-24K18518
[Presentation] DDX41バリアントの機能的なアノテーションを行うシステムの開発2024
- Author(s)
  平林　茂樹、鶴原百香、福士恭子、辻村太郎、宮田喜代子、前田高宏
- Organizer
  第86回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-24K18518
[Presentation] Functional Annotation of DDX41 Variants Using Base-Editing and cDNA Expression Library Screenings2024
- Author(s)
  Shigeki Hirabayashi, Momoka Tsuruhara, Kyoko Fukushi, Shoko Tarumoto, Moe Shinagawa, Yuichiro Semba, Takuya Yamamoto, Yuichi Shiraishi, Kiyoko Miyata, Taro Tsujimura, Takahiro Maeda
- Organizer
  66th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K18518
[Presentation] Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia2023
- Author(s)
  Wada F, Kato S, Bhagat S, Hirabayashi S, Son R, Oguchi A, Takeuchi K, Sekito S, Hirai T, Zhang Z, Horisawa Y, Iwasaki M, Takeda J, Kanda J, Sakamoto T, Shirakawa K, Takaori-Kondo A, Murakawa Y
- Organizer
  65th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization2023
- Author(s)
  Terasaki T, Semba Y, Sasaki K, Miyata K, Yamauchi T, Imanaga H, Nakao F, Hirabayashi S, Nogami J, Akahane K, Inukai T, Akashi K, and Maeda T
- Organizer
  65th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia2022
- Author(s)
  Hiroshi Imanaga, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Tatsuya Terasaki, Fumihiko Nakao, Shigeki Hirabayashi et al.
- Organizer
  64th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] Mitochondrial E3 ligase complex regulates venetoclax sensitivity via modulating BAX equilibrium2022
- Author(s)
  中尾文彦、仙波雄一郎、宮田喜代子、山内拓司、野上順平、今永博、寺崎達也、宮崎眞佳、平林茂樹、増田豪、赤司浩一、前田高宏
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] GATOR1 complex is a critical regulator of glucocorticoid sensitivity in B-ALL cells2022
- Author(s)
  今永博、仙波雄一郎、佐々木謙介、宮田喜代子、山内拓司、寺崎達也、中尾文彦、平林茂樹、野上順平、赤司浩一、前田高宏
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16323
[Presentation] CRISPRスクリーンによりB-ALLにおけるグルココルチコイド感受性の制御因子としてGATOR1complexを同定2022
- Author(s)
  今永博、平林茂樹、赤司浩一、前田高宏
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16323

1. 前田高宏 (00791972)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 仙波雄一郎 (90816787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 米満吉和 (40315065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 野上順平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山内拓司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 森島聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石垣和慶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirabayashi Shigeki 平林 茂樹

Research Projects

Research Products

Co-Researchers

革新的技術基盤構築による分子標的薬の治療抵抗性機序解明と克服戦略の実証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring synthetic lethality as a therapeutic target for refractory cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the origins of t(8;21) AML: Elucidating the relationship between adult AML pathogenesis and the fetal hematopoietic program.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝性血液腫瘍の変異が病態に及ぼす本質的な意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for Novel Cancer Therapeutic Targets Based on Large-Scale Genomics and Functional ScreeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Myeloablative conditioning in cord blood transplantation for acute myeloid leukemia patients is efficacious only until age 552025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HLA‐matched related peripheral blood stem cell and bone marrow transplantation with RIC regimens yield comparable outcomes for adult AML2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Central role of the mTORC1 pathway in glucocorticoid activity against B-ALL cells2024

Author(s)

Journal Title

Data Source

[Journal Article] The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1 bZIP factor impairs DNA mismatch repair system2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph+ ALL: A retrospective nationwide study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Advantages of peripheral blood stem cells from unrelated donors versus bone marrow transplants in outcomes of adult acute myeloid leukemia patients2022

Author(s)

Hirabayashi Shigeki 平林茂樹