SHIMIZU Fujio 清水不二雄

Researcher Number	40012728
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2005: Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 2001 – 2004: Graduate School of Medical and Dental Sciences, NIIGATA UNIVERSITY, Professor, 大学院・医歯学総合研究科, 教授 1995 – 2001: Department of Immunology, Institute of Nephrology, Niigata University School of, 医学部, 教授 1995: 新潟大学, 医学部・腎研究施設免疫病態学部門, 教授 1994: 新潟大学, 医学部・腎研究施設, 教授 … More 1989 – 1992: 新潟大学, 医学部, 教授 1987: Department of Immunology, Institute of Nephroiogy Niigata University School of Medicine Professor, 医学部, 教授 1986: 新大, 医学部, 教授 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Kidney internal medicine / Kidney internal medicine Except Principal Investigator Kidney internal medicine / Experimental pathology
Keywords	Principal Investigator 蛋白尿 / proteinuria / 単クローン抗体 / スリット膜 / monoclonal antibody / Proteinuria / 糸球体上皮細胞 / podocyte / fractalkine / FTY720 … More / FK506 / slit membrane / ZO-1 / p51 / Podocyte / 糸球体透過性 / glomerulosclerosis / 補体 / 腎糸球体硬化 / 単クロ-ン抗体 / メサンギウム増殖性腎炎 / Autoimmune membranous nephropathy / heymann nephritis / EHS nephropathy / Monoclonal antibodies / Streptococcal cationic antigen / Fx1A抗原 / EHS肉腫 / 溶連菌由来塩基性抗原 / slit diaphragma / 自己免疫性膜性病変 / Heymann腎炎 / EHS腎症 / モノクローナル抗体 / 容蓮菌由来塩基性抗原 / anti-Thy-1monoclonal antibody 1-22-3 / irreversible glomerulonephritis / Thy-1 nephritis / mesangioproliferative glomerulonephritis / IP-10 / franktalkine / 抗Thy-1単クローン抗体1-22-3 / 不可逆性腎炎モデル / Thy-1腎炎 / nephrotic syndrome / nephrin / glomerular epithelial cell / ネフローゼ症候群 / ネフリン / macrophage / extracellular matrix / cytokine / adhesivemolecule / ACE阻害剤 / マクロファージ / 単球 / 細胞間物質 / サイトカイン / 接着分子 / 糸球体硬化 / glomerular permeability / tyrosine phosphorylation / チロシンリン酸化 / Cultured glomerular epithelial cell / Functional molecule / Glomerular permeability / Slit diaphragm / Monoclona antibody / 培養糸球体上皮細胞 / 機能分子 / タコ足細胞 / mechanism of chronic progression / 慢性化機序 / Cultured Cell / Mesangiolysis / Mesangium / Glomerular Epithelial Cell / Monoclonal Antibody / アミノヌクレオシド腎症 / 腎糸球体上皮細胞 / slit diaphragm / 培養細胞 / メサンギオライシス / メサンギウム / 陰極蛍光(カソードルミネッセンス) / スリット膜関連分子 / 蛍光色素 / FITC / 蛍光走査電子顕微鏡法 / 陰極(カソードルミネッセンス) / 細胞障害マーカー / 半月体形成性腎炎 / メサンギウム細胞 / HATセレクション / ウサギ由来骨髄株細胞 / ウサギモノクローナル抗体 / アミノプテリン / 8-アザグアニン / 細胞融合 / 240E-1 … More Except Principal Investigator proteinuria / slit diaphragm / 蛋白尿 / スリット膜 / nephrin / ネフリン / ZO-1 / podocyte / 糸球体上皮細胞 / IP-10 / NEPH1 / CD2AP / podocin / ポドシン / AGE / epithelial cell / glomerulus / p51 / tight junction / 上皮細胞 / 糸球体 / SLE / DNA / IgA nephropathy / membranous nephropathy / minimal change type nephritic syndrome / メサンギウム増殖性腎炎 / IgA腎症 / 膜性腎症 / 微小変化型ネフローゼ症候群 / mAb 5-1-6 / 5-1-6抗体 / tissue engineering / diabetic nephropathy / dialysis-related amyloidosis / uremic toxin protein / β_2-microglobulin / proximal tubule / megalin / Heymann腎炎 / ELISA / 尿 / 血液浄化療法 / PI3キナーゼ / ゲンタマイシン腎症 / β_2-ミクログロブリン / 尿中マーカー / エンドサイトーシス / advanced glycation endproduct / 透析アミロイドーシス / β_2ミクログロブリン / 再生医学 / 糖尿病性腎症 / 透析アミロードーシス / 尿毒素蛋白 / β2-ミクログロブリン / 近位尿細管 / メガリン / glomerular basement membrane (GBM) / immune complexes / histones / amyloid P component / nucleosome / lupus nephritis / 血清アミロイドP蛋白 / 糸球体基底膜 / Immune complex / ヒストン / アミロイドP蛋白 / ヌクレオソーム / ループス腎炎 / glomerulonephritis. / crescent-forming cells / 1,25-dihydroxyvitamin D_3 / colony-stimulating factors / macrophage / IFN / M-CSF / サイトカイン / 糸球体培養 / 糸球体腎炎 / 半月体形成細胞 / 活性型ビタミンD_3 / コロニー刺激因子 / マクロファージ Less

カソードルミネッセンスを用いた蛍光SEM法の腎組識への応用Principal Investigator
- Principal Investigator
  
  清水不二雄
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Identification and regulation of factors related to progression of renalPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Mechanism of proteinuria resulted from the dysfunction of podocyte slit diaphragm
- Principal Investigator
  
  KAWACHI Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
腎病変進行性予知の為の新しい糸球体細胞障害マーカーの開発Principal Investigator
- Principal Investigator
  
  清水不二雄
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Analysis on the mechanism of proteinuria induced by glomerular epithelial cell lesionsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  NIIGATA UNIVERSITY
Establishment of a novel diagnostic method with a slit diaphragm functional marker, nephrin
- Principal Investigator
  
  KAWACHI Hiroshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  NIIGATA UNIVERSITY
Barrier function of the slit diaphragm of glomerular epithelial cell
- Principal Investigator
  
  KAWACHI Hiroshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  NIIGATA UNIVERSITY
Function of glomerular epithelial cell slit membrane
- Principal Investigator
  
  KAWACHI Hiroshi
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University
Analysis of physiological and pathophysiological functions of megalin in the proximal tubules and clinical application of its molecular features
- Principal Investigator
  
  SAITO Akihiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
ウサギ由来単クローン抗体による糸球体腎炎発症機序の解明Principal Investigator
- Principal Investigator
  
  清水不二雄
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University
Functional Molecules on Glomerular Epithelial CellsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Niigata Univeisity
Analysis of glomerulosclerotic mechanism by monoclonal antibody-induced progressive renal lesion model in ratsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Functional molecules on glomerular epithelial cellsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Niigata University
A ROLE OF AMYLOID P COMPONENT AND NUCLEOSOME IN THE INITIATION OF LUPUS NEPHRITIS
- Principal Investigator
  
  MORIOKA Tetsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University School of Medicine
Regulation of macrophage functions by cytokine and 1,25-dihydroxyvtamin D_3 on glomerulonephritis
- Principal Investigator
  
  ORIKASA Michiaki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University
Analysis of the mechanism of renal injury at molecular levels by application of monoclonal antibodiesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University
Analysis of the Mechanism of Renal Injury by Application of Monoclonal Antibodies.Principal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University
Studies on the human glomerulonephritis inducing antigenic molecules using new nephritis models and monoclonal antibodies.Principal Investigator
- Principal Investigator
  
  SHIMIZU Fujio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University

All 2006 2005 2004 2003 2002 Other

All Journal Article Book

[Book] 新潟日報事業社2003
- Author(s)
  清水不二雄
- Total Pages
  8
- Publisher
  第3章糸球体の病気ブックレット新潟大学腎臓の病気とその研究
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] IFN-Inducible Protein 10 Plays a Pivotal Role in Maintaining Slit-Diaphragm Function by Regulating Podocyte Cell-Cycle Balance.2006
- Author(s)
  Han GD, Suzuki K, Koike H, Siziki K, Yoneyama H, Narumi S, Shimizu f, Kawachi H.
- Journal Title
  
  Journal of the American Society of Nephrology. 17
  
  Pages: 442-453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors.2005
- Author(s)
  Takazawa Y, Maeshima Y, Kitayama H, Yamamoto Y, Kawachi H, Shimizu F, Matsui H, Sugiyama H, Yamasaki Y, Makino H.
- Journal Title
  
  Kidney International. 68
  
  Pages: 704-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in experimental glomemlonephritis.2005
- Author(s)
  Uchimura H, Marumo T, Takase O, Kawachi H, Shimizu F, Hayashi M, Saruta T, Hishikawa K, Fujita T.
- Journal Title
  
  J Am Soc Nephrol. 16
  
  Pages: 997-1004
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Therapeutic mechanism of Saikosaponin-d in anti-Thy-1 mAb 1-22-3-induced rat model of glomerulonephritis.2005
- Author(s)
  Li P, Gong Y, Zu N, Li Y, Wang B, Shimizu F.
- Journal Title
  
  Nephron Experimental Nephrology 101
  
  Pages: 111-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril.2005
- Author(s)
  Kramer S, Loof T, Martini S, Ruckert M, Wang Y, Bohler T, Shimizu F, Kawachi H, Neumayer HH, Peters H.
- Journal Title
  
  American Journal of Physiology Renal Physiology. 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis.2005
- Author(s)
  Ikezumi Y, Suzuki T, Hayafuji S, Okubo S, Nikolic-Paterson DJ, Kawchi H, Shimizu F, Uchiyama M.
- Journal Title
  
  Nephrology Dialysis Transplantation. 20
  
  Pages: 2704-2713
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in Experimental glomerulonephrities.2005
- Author(s)
  Uchimura H., Marumo T., Takase O., Kawachi H., Shimizu F., Hayashi M., Saruta T., Hoshikawa K., Fujita T.
- Journal Title
  
  Journal of the American Society of Nephrology. 16
  
  Pages: 997-1004
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody.2005
- Author(s)
  Wan Y, Gu L, Suzuki K, Karasawa T, Fujioka Y, Han GD, Koike H, Kawachi H, Shimizu F.
- Journal Title
  
  Nephron Experimental Nephrology. 99
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin.2005
- Author(s)
  Hirabayashi S, Mori H, Kansaku A, Kurihara H, Sakai T, Shimizu F, Kawachi H, Hata Y.
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 1528-1543
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy.2005
- Author(s)
  Nakatsue T, Koike H, Han GD, Suzuki K, Miyauchi N, Yuan H, Salant DJ, Gejyo F, Shimizu F, Kawachi H.
- Journal Title
  
  Kidney International. 67
  
  Pages: 2239-2253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Exploring RNA interference as a therapeutic strategy for renal disease.2005
- Author(s)
  Takabatake Y, Isaka Y, Mizui M, Kawachi H, Shimizu F, Ito T, Hori M, Imai E.
- Journal Title
  
  Gene Ther. 12
  
  Pages: 965-973
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Enchancing cGMP in experimental progressive renal fibrosis : soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition.2005
- Author(s)
  Wang Y, Kramer S, Loof T, Martini S, Kron S, Kawachi H, Shimizu F, Neumayer HH, Peters H.
- Journal Title
  
  American Journal of Physiology Renal Physiology 290
  
  Pages: 167-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo.2005
- Author(s)
  Meng Y, Kasai A, Hiramatsu N, Hayakawa K, Takeda M, Shimizu F, Kawachi H, Yao J, Kitamura M.
- Journal Title
  
  Kidney International 68
  
  Pages: 886-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] スリット膜関連分子と蛋白尿のメカニズム2005
- Author(s)
  清水不二雄
- Journal Title
  
  腎と透析臨時増刊号 52
  
  Pages: 52-56
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome.2005
- Author(s)
  Koshikawa M, Mukoyama M, Mori K, Suganami T, Sawai K, Yoshioka T, Nagae T, Yokoi H, Kawachi H, Shimizu F, Sugawara A, Nakao K.
- Journal Title
  
  Journal of the American Society of Nephrology. 16
  
  Pages: 2690-2701
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor.2005
- Author(s)
  Meng Y, Kasai A, Hiramatsu N, Hayakawa K, Yamauchi K, Takeda M, Kawachi H, Shimizu F, Yao J, Kitamura M
- Journal Title
  
  Laboratory Investigation 85
  
  Pages: 1429-1439
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis.2005
- Author(s)
  Wang Y, Kramer S, Loof T, Martini S, Kron S, Kawachi H, Shimizu F, Neumayer HH, Peters H.
- Journal Title
  
  Kidney International 68
  
  Pages: 47-61
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Monoclonal antibody 1-22-3-induced glomerulonephritis in uninephrectomized rats as a model of progressive renal failure.2005
- Author(s)
  Tomita M, Sogabe H, Nakazato S, Nakatsuji S, Noto T, Hamada K S, Kawachi H, Shimizu F, Matsuo M, Mutoh S
- Journal Title
  
  Nephrology Dialysis Transplantation. 20
  
  Pages: 2358-2367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Altered expression of junctional adhesion molecule 4 (JAM4) in injured podocytes.2005
- Author(s)
  Harita Y, Miyauchi N, Karasawa T, Suzuki K, Han GD, Koike H, Igarashi T, Shimizu F, Kawachi H.
- Journal Title
  
  American Journal of Physiology Renal Physiology 290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis.2004
- Author(s)
  Isaka Y, Nakamura H, Mizui M, Takabatake Y, Horio M, Kawachi H, Shimizu F, Imai E, Hori M.
- Journal Title
  
  Kidney International 66
  
  Pages: 586-590
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis.2004
- Author(s)
  Isaka Y, Nakamura H, Mizui M, Takabatake Y, Horio M, Kawachi H, Shimizu F, Imai E, Hori M.
- Journal Title
  
  Kidney Int 66
  
  Pages: 586-590
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] The role of lymphocytes in the experimental progressive glomerulonephritis.2004
- Author(s)
  Ikezumi Y, Kanno K, Karasawa T, Han GD, Ito Y, Koike H, Toyabe S, Uchiyama M, Shimizu F, Kawachi H.
- Journal Title
  
  Kidney International 66
  
  Pages: 1036-1048
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Novel expression of sodium/myo-inositol co-transporter in pdoocytes in puromycin aminonucleoside nephrosis.2004
- Author(s)
  Watanabe Y, Kobayashi T, Yaoita E, Kawachi H, Yamauchi a, Inoue T, Shimizu F, Yoshida Y, EI-Shemi AG, Okada H, Suzuki H, Yamamoto T.
- Journal Title
  
  Nephrology Dialysis Transplantation 19
  
  Pages: 817-822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] オーバービュー腎疾患の実験医学2004
- Author(s)
  清水不二雄
- Journal Title
  
  現代医療社 36
  
  Pages: 22-30
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] オーバービュー腎疾患の実験医学2004
- Author(s)
  清水不二雄
- Journal Title
  
  現代医療社 36
  
  Pages: 22-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Decreased collagen degrading activity could be a marker of prolonged mesangial matrix expansion.2004
- Author(s)
  Tomita M, Koike H, Han GD, Shimizu F, Kawachi H
- Journal Title
  
  Clinical and Experimental Nephrology 8
  
  Pages: 17-26
- NAID
  80016556943
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis.2004
- Author(s)
  Asai M, Monkawa T, Marumo T, Fukuda S, Tsuji M, Yoshino J, Kawachi H, Shimizu F, Hayashi M, Saruta T.
- Journal Title
  
  Hypertension Research. 27
  
  Pages: 971-978
- NAID
  10014466958
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.2004
- Author(s)
  Peters H, Martini S, Wang Y, Shimizu F, Kawachi H, Kramer S, Neumayer HH.
- Journal Title
  
  Kidney International 66
  
  Pages: 1434-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Role of mesangial factor V expression mesangioproliferative glomerulonephritis.2004
- Author(s)
  Ono T, Liu N, Makino T, Nogaki F, Nomura K, Muso E, Shimizu F, Honda G, Kita T.
- Journal Title
  
  Journal of Pathology 204
  
  Pages: 229-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Local actions of endogenous angiotensin II in injured glomeruli.2004
- Author(s)
  Ma Ji, Matsusaka T, Yang H, Kawachi H, Shimizu F, Isaka Y, Imai E, Kon V, Ichikawa I.
- Journal Title
  
  Journal of the American Society of Nephrology 15
  
  Pages: 1268-1276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomemlonephritis of the rat.2004
- Author(s)
  Schaier M, Liebler S, Schade K, Shimizu F, Kawachi H, Grone HJ, Chandraratna R, Ritz E, Wagner J.
- Journal Title
  
  J Mol Med. 82
  
  Pages: 116-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Decreased collagen-degrading activity could be a marker of prolonged mesangial matrix expansion.2004
- Author(s)
  Tomita M, Koike H, Han GD, Shimizu F, Kawachi H.
- Journal Title
  
  Clin Exp Nephrol 8
  
  Pages: 17-26
- NAID
  80016556943
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] The role of lymphocytes in the experimental progressive glomerulonephritis.2004
- Author(s)
  Ikezumi Y, Kanno K, Karasawa T, Han GD, Ito Y, Koike H, Toyabe S, Uchiyama M, Shimizu F, Kawachi H.
- Journal Title
  
  Kidney Int 66
  
  Pages: 1036-1048
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] 蛋白尿発現の責任遺伝子と治療概念2004
- Author(s)
  清水不二雄
- Journal Title
  
  日本臨床 62
  
  Pages: 1800-1804
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Novel expression of sodium/myo-inositol co-transporter in pdoocytes in puromycin aminonucleoside nephrosis.2004
- Author(s)
  Watanabe Y, Kobayashi T, Yaoita E, Kawachi H, Yamauchi a, Inoue T, Shimizu F, Yoshida Y, EI-Shemi AG, Okada H, Suzuki H, Yamamoto T.
- Journal Title
  
  Nephrol Dial Transplant 19
  
  Pages: 817-822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.2004
- Author(s)
  Peters H, Martini S, Wang Y, Shimizu F, Kawachi H, Kramer S, Neumayer HH.
- Journal Title
  
  Kidney Int 66
  
  Pages: 1434-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.2004
- Author(s)
  Schaier M, Liebler S, Schade K, Shimizu F, Kwachi H, Grone HJ.
- Journal Title
  
  Journal of Molecular Medicine 82
  
  Pages: 116-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Role of mesangial factor V expression mesangioproliferative glomerulonephritis.2004
- Author(s)
  Ono T, Liu N, Makino T, Nogaki F, Nomura K, Muso E, Shimizu F, Honda G. Kita T.
- Journal Title
  
  J Pathol 204
  
  Pages: 229-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis.2003
- Author(s)
  Han GD., Koike H, Nakatsue T, Suzuki K, Yoneyama H, Narumi S, Kobayashi N, Mundel P, Shimizu F, Kawachi H.
- Journal Title
  
  J Am Soc Nephrol. 14
  
  Pages: 3111-3126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy.2003
- Author(s)
  Narita I, Goto s, Saito N, Song J, Kondo D, Omori K, Kawachi H, Shimizu F, Sakatsume M, Ueno M, Gejyo F.
- Journal Title
  
  Lab Invest. 83
  
  Pages: 1193-1200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] 共焦点レーザー顕微鏡(第2回)2003
- Author(s)
  清水不二雄
- Journal Title
  
  Nephrology Frontier 2
  
  Pages: 51-54
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Monoclonal antibody against rat podocyte-derived macrophagic cells react with crescent-forming cells in an experimental model2003
- Author(s)
  Orikasa M, Iwanaga T, Kawachi H, Oyanagi A, Li P, Su Q, Kobayashi H, Nakayama H, Kikuchi H, Shimizu F.
- Journal Title
  
  NEPHROLOGY 8
  
  Pages: 217-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Urinary sediment podocalyxin in children with glomerular diseases.2003
- Author(s)
  Kanno K, Kawachi H, Uchida Y, Hara M, Shimizu F, Uchiyama M.
- Journal Title
  
  Nephron Clinical Practice 95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Kinetic analysis of the development of pancreatic lesions in mice infected with a murine retrovirus.2003
- Author(s)
  Watanabe S, Suzuki K, Kawauchi Y, Yamagiwa S, Yoneyama H, Kawachi H, Okada Y, Shimizu F, Asakura H, Aoyagi Y.
- Journal Title
  
  Clin Immunol. 109
  
  Pages: 212-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] 蛋白尿:その成因と腎障害機序2003
- Author(s)
  清水不二雄
- Journal Title
  
  腎と透析 54
  
  Pages: 1268-1276
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] 共焦点レーザー顕微鏡(第1回)2003
- Author(s)
  清水不二雄
- Journal Title
  
  Nephrology Frontier 2
  
  Pages: 68-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] ポドサイト研究の最近の動向と今後の展望2003
- Author(s)
  清水不二雄
- Journal Title
  
  腎と透析 55
  
  Pages: 691-695
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Moderate alcohol intake has no impact on acute and chronic progressive anti-Thy-1 glomerulonephritis.2003
- Author(s)
  Peters H, Martini S, Woydt R, Ruckert M, Shimizu F, Kawachi H, Liefeldt L, Kramer S, Neumayer HH.
- Journal Title
  
  Am J Physiol Renal Physiol. 284
  
  Pages: 1105-1114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] 蛋白尿の分子機構:ネフリンのネフローゼ症候群における臨床的意義2003
- Author(s)
  清水不二雄
- Journal Title
  
  日本内科学会誌 92
  
  Pages: 159-165
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Cloning of rat homologue of podocin : Expression in proteinuric states and in developing glomeruli.2003
- Author(s)
  Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F.
- Journal Title
  
  Journal of the American Society of Nephrology 14
  
  Pages: 46-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Cloning of rat homologue of podocin : Expression in proteinuric states and in developing glomeruli.2003
- Author(s)
  Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F.
- Journal Title
  
  J Am Soc Nephrol 13
  
  Pages: 46-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Moderate alcohol intake has no impact on acute and chronic progressive anti Thy-1 glomerulonephritis.2003
- Author(s)
  Peters H, Martini S, Woydt R, Ruckert M, Shimizu F, Kawachi H, Liefeldt L, Kramer S, Neumayer HH.
- Journal Title
  
  American Journal of physiology Renal Physiology 284
  
  Pages: 1105-1114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Pathways to recovery and loss of nephrons in anti-Thy-1 nephritis.2003
- Author(s)
  Kriz W, Hahne B, Hosser H, Ostendorf T, Gaertner S, Krainzlin B, Gretz N, Shimizu F, Floege J.
- Journal Title
  
  Journal of the American Society of Nephrology 14
  
  Pages: 1904-1926
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Role of megalin in endocytosis of advanced glycation end products : Implications for a novel protein binding to both megalin and advanced glycation end products.2003
- Author(s)
  Saito A, Nagai R, Tanuma A, Hama H, Cho K, Takeda T, Yoshida Y, Toda T, Shimizu F, Horiuchi S, Gejyo F.
- Journal Title
  
  J Am Soc Nephrol. 14
  
  Pages: 1123-1131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Role of megalin in endocytosis of advanced glycation end products : Implications for a novel protein binding to both megalin and advanced glycation end products2003
- Author(s)
  Saito A, Nagai R, Tanuma A, Hama H, Cho K, Takeda T, Yoshida Y, Toda T, Shimizu F, Horiuchi S, Gejyo F.
- Journal Title
  
  Journal of the American Society of Nephrology 14
  
  Pages: 1123-1131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Bioengineered implantation of megalin-expressing cells : A potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure.2003
- Author(s)
  Saito A, Kazama J.J, Iino N, Cho K, Sato N, Yamazaki H, Oyama Y, Takeda T, Orlando R.A, Narita I, Goto s, Saito N, Song J, Kondo D, Omori K, Shimizu F, Tabata Y, Gejyo F
- Journal Title
  
  Journal of the American Society of Nephrology Laboratory Investigation 14
  
  Pages: 2025-2032
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis.2003
- Author(s)
  Han GD, Koike H, Nakatsue T, Suzuki K, Yoneyama H, Narumi S, Kobayashi N, Mundel P, Shimizu F, Kawachi H.
- Journal Title
  
  Journal of the American Society of Nephrology 14
  
  Pages: 3111-3126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Monoclonal antibody against rat podocyte-derived macrophagic cells reacts with crescent-forming cells in an experimental model.2003
- Author(s)
  Orikasa M, Iwanaga T, Kawachi H, Oyanagi A, Li P, Su Q, Kobayashi H, Nakayama H, Kikuchi H, Shimizu F.
- Journal Title
  
  Nephrology 8
  
  Pages: 217-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Bioengineered implantation of megalin-expressing cells : A potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure.2003
- Author(s)
  Saito A, Kazama J.J, Iino N, Cho K, Sato N, Yamazaki H, Oyama Y, Takeda T, Orlando R.A, shimizu F, Tabata Y, Gejyo F.
- Journal Title
  
  J Am Soc Nephrol. 14
  
  Pages: 2025-2032
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Pathways to recovery and loss of nephrons in anti-Thy-1 nephritis.2003
- Author(s)
  Kriz W, Hahne B, Hosser H, Ostendorf T, Gaertner S, Krainzlin B, Gretz N, Shimizu F, Floege J.
- Journal Title
  
  J Am Soc Nephrol. 14
  
  Pages: 1904-1926
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] 《糸球体疾患》先天性ネフローゼ症候群2003
- Author(s)
  清水不二雄
- Journal Title
  
  内科 92
  
  Pages: 9-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] Urinary sediment podocalyxin in children with glomemlar diseases.2003
- Author(s)
  Kanno K, Kawachi H, Uchida Y, Kara M, Shimizu F, Uchiyama M.
- Journal Title
  
  Nephron Clin Pract. 95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Genetic polymorphism of NPHS1 modifies the clinical manifestations of IgA nephropathy.2003
- Author(s)
  Narita I, Goto s, Saito N, Song J, Kondo D, Omori K, Kawachi H, Shimizu F, Sakatsume M, Ueno M, Gejyo F.
- Journal Title
  
  Laboratory Investigation 83
  
  Pages: 1193-1200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390268
[Journal Article] FK506 ameliorates proteinuria and glomerular lesions induced by anti-Thy 1.1 monoclonal antibody 1-22-3.2002
- Author(s)
  Ikezumi Y, Kanno K, Koike H, Tomita M, Uchiyama M, Shimizu F, Kawachi H.
- Journal Title
  
  Kidney Int 61
  
  Pages: 1339-1350
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Molecular structure and of the slit diaphragm : expression of nephrin in proteinuric states and in developing glomeruli.2002
- Author(s)
  Kawachi H, Koike H, Shimizu F.
- Journal Title
  
  Nephrol Dial Transplant 17
  
  Pages: 1-3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis.2002
- Author(s)
  Matsuda M, Shikata K, Shimizu F, Suzuki Y, Miyasaka M, Kawachi H, Kawashima H, Wada J, Sugimoto H, Shikata Y, Ogawa D, Tojo S.J, Akima K, Makino H.
- Journal Title
  
  J Pathol 198
  
  Pages: 407-414
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Rapidly progressive, pauci-immune diffuse Crescentic glomerulonephritis in an infant.2002
- Author(s)
  Tanaka H, Waga S, Suzuki K, Nakahata T, Kawachi H, Shimizu F, Ito E.
- Journal Title
  
  Pediatr Nephrol 17
  
  Pages: 730-732
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Fractalkine expression and the recruitment of CX_3CR1^+ cells in the prolonged mesangial proliferative glomerulonephritis.2002
- Author(s)
  Ito Y, Kawachi H, Morioka Y, Nakatsue T, Koike H, Nakamura T, Gejyo F, Shimizu F.
- Journal Title
  
  Kidney Int 61
  
  Pages: 2044-2057
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] mAb 5-1-6 nephropathy and Nephrin.2002
- Author(s)
  Kawachi H, Koike H, Shimizu F.
- Journal Title
  
  Microsc Res Tech. 57
  
  Pages: 236-240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317
[Journal Article] Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy.
- Author(s)
  Nakatsue T, Koike H, Han GD, Suzuki K, Yuan H, Salant DJ, Gejyo F, Shimizu F, Kawachi H.
- Journal Title
  
  Kidney Int (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370317

1. KAWACHI Hiroshi (60242400)

# of Collaborated Projects: 10 results

# of Collaborated Products: 49 results
2. ORIKASA Michiaki (30185681)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
3. NARITA Ichiei (20272817)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. MORIOKA Tetsuo (00210146)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. OITE Takashi (60018744)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. OKUBO Soichiro (20301856)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. SALANT David j.

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KOIKE Hiroko (90323964)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
9. SHIA Michael A

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SAITO Akihiko (80293207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. GEJYO Fumitake (20126410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAOITA Eishinn (00157950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YOSHIDA Kazikiyo (70174919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 上野光博 (90260546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 牛木辰男 (40184999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 荒川正昭 (80069012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 鈴木康仁 (40179263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YAMAZAKI Hajime

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OTA Yosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Fujio 清水 不二雄

Research Projects

Research Products

Co-Researchers

カソードルミネッセンスを用いた蛍光SEM法の腎組識への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and regulation of factors related to progression of renalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of proteinuria resulted from the dysfunction of podocyte slit diaphragm

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腎病変進行性予知の為の新しい糸球体細胞障害マーカーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis on the mechanism of proteinuria induced by glomerular epithelial cell lesionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a novel diagnostic method with a slit diaphragm functional marker, nephrin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Barrier function of the slit diaphragm of glomerular epithelial cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of glomerular epithelial cell slit membrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of physiological and pathophysiological functions of megalin in the proximal tubules and clinical application of its molecular features

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ウサギ由来単クローン抗体による糸球体腎炎発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Molecules on Glomerular Epithelial CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of glomerulosclerotic mechanism by monoclonal antibody-induced progressive renal lesion model in ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional molecules on glomerular epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

SHIMIZU Fujio 清水不二雄