MATSUO Osamu 松尾理

Researcher Number	40030879
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Affiliation *help	2013 : 近畿大学, 医学部, 名誉教授 2013 : 近畿大学, 医学部, 教授 2011 – 2013 : 近畿大学, 医学部, 顧問 2011 – 2012 : 近畿大学, 医学部, その他 2011 : 近畿大学, 医学部, 名誉教授 … More
Review Section/Research Field	Principal Investigator General physiology / General physiology / Hematology Except Principal Investigator General physiology / Biomedical engineering/Biological material science / General physiology / Environmental physiology (including Physical medicine and Nutritional physiology) / Cerebral neurosurgery
Keywords	Principal Investigator t-PA / u-PA / 血管内皮細胞 / 血管新生 / PAI-1 / 線溶系 / t-PA受容体 / フィブリン / 線溶系因子欠損マウス / fibrin … More Except Principal Investigator 血管内皮細胞 / プラスミノーゲン / 線溶系 / plasminogen / 抗血栓性 / t-PA / ペプチド / アントシアニン / poly(O-methacryloyl-L-serine) / 遺伝子欠損マウス / poly(2-hydroxypropylmethacrylamide) / 血管新生 / poly(N^ε-methacrylamide-L-lysine) / poly(N^α-methacrylamide-L-lysine) / t-PA受容体 / 動脈硬化 / 脂肪細胞 / poly(N-isopropylacrylamide) / 光刺激細胞剥離 / 天然資源物質 / 線溶因子 / 脳定量障害モデル / アディポネクチン / O-メタクリロイル-L-セリン / 生体分子間相互作用解析 / thermo-sensitive polymer / 低温プラズマ処理・ポスト重合 / プラスミノーゲン結合部位 / Plasminogen activator / 肥満 / ブロックコポリマー / fibrinolytic factor / bFGF / 細胞内シグナル伝達 / 病態生理 / プラスミノーゲンアクチベータ / thermo-stimuli cells detachment / エチルホスホリルコリン / 温度刺激細胞剥離 / アディポサイトカイン / チロシンリン酸化蛋白 / 蛋白分解カスケード / Protein adsorption / α_2-antiplasmin / 血漿タンパク質 / bone marrow / C3G / ミクロ相分離構造 / bEnd.3 / plasminogen binding / 抗血栓性材料 / Polydimethylsiloxane / マクロアゾ開始剤 / α_2-アンチプラスミン / u-PA / 脳浮腫 / マウス / t-PAR / シアニジン / uPAR / α_2ーアンチプラスミン / Vascular endothelial cells / light-stimuli cells detachment / Antithrornbotic property / poly(N-α-methacrylamide-L-lysine) / HeLa cells attachment and proliferation / 血管透過性 / plasma irradiation-post polymerization / 塩基性線維芽細胞増殖因子 / 脳損傷 / plasminogen activator / ポリエーテルウレタン / Brain edema / 肝再生 / Poly(O-methacryloyl-L-serine) / メタクリル酸メチル / poly(isopropylacrylamide) / ポリジメチルシロキサン / ヒドロゲル層 / 細胞培養用基材 / 細胞外基質 / staphylokinase / poly(N-2-hydroxypropylmethacrylamide) / 2-(ヒドロキシプロピル)メタクリルアミド / Mitogen-activated protein kinase (MAPK) / Thrombogenicity / プラスミノーゲンアクチベ / Tyrosine phosphorylation / プラズマ照射-ポスト重合 / 組織再生 / thrombin inhibition / スタヒロキナーゼ / 血液凝固 / Intracellular signal transduction / ECM / 光応答性ポリマー / 遊走 / 脳梗塞 / 創傷治癒 / 2-(メタクリロイルオキシ)エチルホスホリルコリン / Brain injury / 感温性ポリマー / Macroazo initiator / 細胞内伝達系 / プラスミノーゲンアクチベーター / gene deficient mice / Angiogenesis / 感熱性ポリマー / PAI-1 / tPA / ウロキナーゼ / 熱刺激細胞剥離 / 合成発色基質S2238 / 温度応答性ポリマー / ウロキナーゼレセプター / スタフィロキナーゼ / α2-アンチプラスミン / 血管平滑筋細胞 / 骨髄細胞移植 / 血栓溶解 / Polyether urethane / 神経外傷 / Resonant mirror biosensor / フローサイトメトリー / light-sensitive polymer / 酸素グルコース除去 / alpha2-antiplasmin / 線溶系因子 / 能浮腫 / 血液レオロジー / トロンビン活性阻害 / 蛋白分解活性 / HeLa細胞の接着・増殖 / t-PA receptor (t-PAR) / Phospholipid monomer / Fibrinolytic system / プラスミノゲン / tissue-type plasminogen activator (t-PA) / プラスミン活性促進 / チロシンリン酸化 / HeLa細胞 / ミクログリア / フィブリン線溶活性 / liver regeneration / Hydrogel layer / MAPK / uPA / 酸素グルコース除 / 遊走能 / 合成発色基質S2251 / Block copolymer / 線維芽細胞 Less

New synthetic peptide enhances regeneration of tissues
- Principal Investigator
  
  OKADA Kiyotaka
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Study of natural resources improving the interaction between adipocytes and vascular endothelial cells
- Principal Investigator
  
  UESHIMA Shigeru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Kinki University
Analysis of vascular remodeling by t-PA/t-PAR systemPrincipal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Roles of urokinase plasminogen activator receptor expressed in endothelial cells on deterioration of ischemic stroke
- Principal Investigator
  
  NAGAI Nobuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Nagahama Institute of Bio-Science and Technology
  Kinki University
New synthetic peptide enhances plasminogen activation and thrombolysis
- Principal Investigator
  
  OKADA Kiyotaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Studies of food ingredients which improve the physiological function of adipocyte through modulation of adipocytokine secretion
- Principal Investigator
  
  UESHIMA Shigeru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Kinki University
Analysis of regulation by t-PA/t-PAR-mediate protease on regeneration system after tissue damagePrincipal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Analysis of biological function by t-PA receptor gene expression regulationPrincipal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
The role of proteolytic system on the liver regeneration : The analysis of gene deficient mice with transplantation of bone morrow
- Principal Investigator
  
  OKADA Kiyotaka
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Expression of t-PA receptor on the endothelial cell and analysis of its physiological function.Principal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Evaluation of anticoagulant behavior of thrombin-inhibiting polymer with fibrinolytic factor-binding sites and application for biomaterials
- Principal Investigator
  
  SHIRAISHI Kohei
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kinki University
Analysis of the mechanism of angiogenesis regulated by fibrinolytic factorsPrincipal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Development of stimuli-sensitive polymer hydrogel as a scaffold for tissue engineering
- Principal Investigator
  
  SUGIYAMA Kazuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kinki University
Molecular cloning, intracellular siginal transduction and biological significance of PA receptor
- Principal Investigator
  
  FUKAO Hideharu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Department of Physiology, Kinki University School of medicine
Analysis of the biological function of vascular smooth muscle cells regulated by fibrinolytic factorsPrincipal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Department of Physiology, Kinki University School of Medicine
ROLES OF PLASMINOGEN ACTIVATORS UPON BRAIN INJURY
- Principal Investigator
  
  KATAOKA Kazuo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KINKI UNIVERSITY
Analysis of fibrinolytic activation mechanism by staphylokinase in gene deficient mice
- Principal Investigator
  
  OKADA Kiyotaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Analysis of angiogenesis in fibrinolytic factordefficient micePrincipal Investigator
- Principal Investigator
  
  MATSUO Osamu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Department of Physiology, Kinki University School of Medicine
Preparation of dimethylsiloxane type of block copolymer * with nonthrombogenicity as biomedical materials
- Principal Investigator
  
  SUGIYAMA Kazuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  KINKI UNIVERSITY
血管内皮細胞におけるu-PA/u-PAR系による分化制御機構の解析Principal Investigator
- Principal Investigator
  
  松尾理
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
血管内皮細胞からのt-PA受容体(t-PAR)の精製と分子生物学的同定
- Principal Investigator
  
  深尾偉晴
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
血管内皮細胞における細胞性線溶の統御Principal Investigator
- Principal Investigator
  
  松尾理
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
血管内皮細胞上でのstaphylokinaseによる酵素活性発現の解析Principal Investigator
- Principal Investigator
  
  松尾理
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Extracellular matrixの酵素活性制御機序Principal Investigator
- Principal Investigator
  
  松尾理
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kinki University
Pro-UKとt-PAのフィブリン親和性発現機序の差異Principal Investigator
- Principal Investigator
  
  松尾理
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kinki University

All 2011 2010 2009 2008

All Journal Article Book

[Book] Recent Advances in Thrombosis and Hemostasis.(Tanaka K, Davie EW (eds))(Role of fibrinolysis in hepatic regeneration.)2008
- Author(s)
  Okada K, Ueshima S, Matsuo O.
- Publisher
  Tokyo, Springer Japan
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] A synthetic peptide derived from staphylokinase enhances plasminogen activation by tissue-type plasminogen activator.2011
- Author(s)
  岡田清孝, 上嶋繁, 松尾理, 他
- Journal Title
  
  J Thromb Haemost (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] The absence of urokinase-type plasminogen activator receptor plays a role in the insulin-independent glucose metabolism.2011
- Author(s)
  Tomogane K, Ueshima S, Okada K, Matsuo O, 他4
- Journal Title
  
  J Cardiovasc Pharmacol 57(3)
  
  Pages : 334-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] Alpha2-antiplasmin is associated with the progression of fibrosis.2010
- Author(s)
  Kanno Y, Ueshima S, Okada K, Matsuo O, 他
- Journal Title
  
  Am J Pathol 176(1)
  
  Pages : 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] Enhancement of fibrinolytic activity in vascular endothelial cells by heterologous expression of adenine nucleotide translocase-1.2010
- Author(s)
  Ishida C, Ueshima S, Okada K, Matsuo O, 他
- Journal Title
  
  Blood Coagul Fibrinolysis 21(3)
  
  Pages : 272-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] 線溶系因子関連2010
- Author(s)
  上嶋繁、松尾理
- Journal Title
  
  Vasular Lab 7
  
  Pages : 17-21
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] Urokinase-type plasminogen activator receptor is associated with the development of adipose tissue.2010
- Author(s)
  Kanno Y, Ueshima S, Okada K, Matsuo O, 他
- Journal Title
  
  Thromb Haemost 104(6)
  
  Pages : 1124-1132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] 血栓溶解療法のモニター2009
- Author(s)
  上嶋繁、松尾理
- Journal Title
  
  臨床検査 53
  
  Pages : 1181-1185
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] 線溶系:血管外での新しい機能2008
- Author(s)
  上嶋繁、岡田清孝、松尾理、他
- Journal Title
  
  近畿大学医学雑誌 33
  
  Pages : 161-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] 深部静脈血栓症の病態2008
- Author(s)
  上嶋繁、松尾理
- Journal Title
  
  日本病態生理学会雑誌 17
  
  Pages : 37-39
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.2008
- Author(s)
  岡田清孝, 上嶋繁, 松尾理, 他
- Journal Title
  
  Blood Coagul Fibrinolysis 19(6)
  
  Pages : 503-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] 深部静脈血栓症の病態2008
- Author(s)
  上嶋繁、松尾理
- Journal Title
  
  日本血栓止血学会誌 19
  
  Pages : 485-490
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling.2008
- Author(s)
  Hou Y, Okada K, Okamoto C, Ueshima S, Matsuo O
- Journal Title
  
  Arterioscler Thromb Vasc Biol 28(7)
  
  Pages : 1257-1262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241
[Journal Article] The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation.2008
- Author(s)
  Kanno Y, Okada K, Ueshima S, Matsuo O, 他
- Journal Title
  
  Thromb Res 123(2)
  
  Pages : 336-341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590241

1. OKADA Kiyotaka (20185432)

# of Collaborated Projects : 22results

# of Collaborated Products : 10results
2. UESHIMA Shigeru (30193791)

# of Collaborated Projects : 17results

# of Collaborated Products : 14results
3. FUKAO Hideharu (70218874)

# of Collaborated Projects : 10results

# of Collaborated Products : 0results
4. KAWAO Naoyuki (70388510)

# of Collaborated Projects : 8results

# of Collaborated Products : 0results
5. NAGAI Nobuo (90260281)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. SUGIYAMA Kazuo (00088577)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. SHIRAISHI Kohei (10196602)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
8. YAMASHITA Rina (90510876)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. OKAMOTO Chikako (90368291)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. 高石知明 (90268409)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. KATAOKA Kazuo (10221178)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. TANEDA Mamoru (10236713)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. ASAI Toshiharu (20248008)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 板東博志 (20173122)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 酒井鉄博 (40113154)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

MATSUO Osamu 松尾 理

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Analysis of regulation by t-PA/t-PAR-mediate protease on regeneration system after tissue damagePrincipal Investigator

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Analysis of biological function by t-PA receptor gene expression regulationPrincipal Investigator

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Expression of t-PA receptor on the endothelial cell and analysis of its physiological function.Principal Investigator

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Analysis of the mechanism of angiogenesis regulated by fibrinolytic factorsPrincipal Investigator

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Analysis of the biological function of vascular smooth muscle cells regulated by fibrinolytic factorsPrincipal Investigator

MATSUO Osamu 松尾理